{"id":30297,"date":"2025-04-10T07:05:36","date_gmt":"2025-04-09T22:05:36","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=30297"},"modified":"2025-04-10T07:06:17","modified_gmt":"2025-04-09T22:06:17","slug":"%e7%b3%96%e8%b3%aa%e5%88%b6%e9%99%90%e3%81%ab%e3%82%88%e3%82%8b%e9%ab%98ldl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e3%81%af%e5%bf%83%e7%96%be%e6%82%a3%e3%81%ae%e4%ba%88","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=30297","title":{"rendered":"\u7cd6\u8cea\u5236\u9650\u306b\u3088\u308b\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5fc3\u75be\u60a3\u306e\u4e88\u6e2c\u56e0\u5b50\u3067\u306f\u306a\u3044"},"content":{"rendered":"<p>\u7cd6\u8cea\u5236\u9650\u3092\u3059\u308b\u3068\u3001\u5c11\u306a\u304f\u306a\u3044\u5272\u5408\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4e0a\u6607\u3057\u307e\u3059\u3002\u305d\u306e\u5f8c\u4e0b\u304c\u308b\u4eba\u3082\u3044\u307e\u3059\u304c\u3001\u305a\u3063\u3068\u9ad8\u3044\u307e\u307e\u306e\u4eba\u3082\u591a\u3044\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306a\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u304c\u8d77\u304d\u308b\u3053\u3068\u3067\u3001\u5c02\u9580\u5bb6\u305f\u3061\u306f\u5927\u9a12\u304e\u3057\u3066\u3001\u7cd6\u8cea\u5236\u9650\u306e\u5371\u967a\u6027\u3092\u717d\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u30b1\u30c8\u30f3\u98df\u306e\u6442\u53d6\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u305f\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u793a\u3057\u305f\u4eba\u306e\u5fc3\u81d3\u306e\u8a55\u4fa1\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u4ee5\u524d\u306e\u8a18\u4e8b\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=27521\" target=\"_blank\" rel=\"noopener\">\u7cd6\u8cea\u5236\u9650\u306b\u3088\u308bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u3068\u52d5\u8108\u786c\u5316<\/a>\u300d\u306e\u7d9a\u304d\u3067\u3057\u3087\u3046\u304b\u306d\u3002<\/p>\n<p>\u30b1\u30c8\u30f3\u98df\u8a98\u767a\u6027LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u2265190 mg\/dL\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb \u226560 mg\/dL\u3001\u4e2d\u6027\u8102\u80aa\u226480 mg\/dL\u3092\u793a\u3059100\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u51a0\u52d5\u8108\u30ab\u30eb\u30b7\u30a6\u30e0\u304a\u3088\u3073\u51a0\u52d5\u8108CT\u8840\u7ba1\u9020\u5f71\u3092\u4f7f\u7528\u3057\u30661\u5e74\u9593\u8ffd\u8de1\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u30b1\u30c8\u30f3\u98df\u7fa4\u53c2\u52a0\u8005\u306e\u53c2\u52a0\u57fa\u6e96\u306f\u3001\u30b1\u30c8\u30f3\u98df\u309224\u304b\u6708\u4ee5\u4e0a\u7d99\u7d9a\u3057\u3066\u3044\u308b\u3001\u30b1\u30c8\u30f3\u98df\u3092\u63a1\u7528\u3059\u308b\u524d\u306e\u6700\u5f8c\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u2264160 mg\/dL\u3001\u6700\u65b0\u306e\u691c\u67fb\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c190 mg\/dL\u4ee5\u4e0a\u3001\u30b1\u30c8\u30f3\u98df\u5c0e\u5165\u5f8c\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e50%\u4ee5\u4e0a\u306e\u5897\u52a0\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u226560 mg\/dL\u3001\u4e2d\u6027\u8102\u80aa\u226480 mg\/dL\u3001HbA1c&lt;6.0%\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u5024&lt;110 mg\/dL\u3001\u9ad8\u611f\u5ea6CRP&lt;2 mg\/L\u3067\u3059\u3002<\/p>\n<p>\u4e00\u65b9\u3001\u9664\u5916\u57fa\u6e96\u306f\u3001\u9ad8\u8840\u5727\u30012\u578b\u7cd6\u5c3f\u75c5\u307e\u305f\u306f\u751f\u6daf\u306b\u308f\u305f\u308b\u6297\u7cd6\u5c3f\u75c5\u85ac\u306e\u4f7f\u7528\u3001\u814e\u4e0d\u5168\u3001\u809d\u9175\u7d20\u304c\u6b63\u5e38\u4e0a\u9650\u5024\u306e2\u500d\u4ee5\u4e0a\u307e\u305f\u306f\u7dcf\u30d3\u30ea\u30eb\u30d3\u30f3\u304c1.5\u4ee5\u4e0a\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4e0a\u6607\u3055\u305b\u308b\u85ac\u5264\u306e\u4f7f\u7528\uff08\u30a2\u30ca\u30dc\u30ea\u30c3\u30af\u30b9\u30c6\u30ed\u30a4\u30c9\u3001\u30a4\u30bd\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\u3001\u514d\u75ab\u6291\u5236\u5264\u3001\u30a2\u30df\u30aa\u30c0\u30ed\u30f3\u3001\u30c1\u30a2\u30b8\u30c9\u7cfb\u5229\u5c3f\u85ac\u3001\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u3001\u30c1\u30a2\u30be\u30ea\u30b8\u30f3\u30b8\u30aa\u30f3\uff09\u3001\u8102\u8cea\u4f4e\u4e0b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u307e\u305f\u306f\u85ac\u5264\u306e\u4f7f\u7528\uff08\u30b9\u30bf\u30c1\u30f3\u3001\u7d05\u9eb9\u3001\u30cb\u30f3\u30cb\u30af\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u3001\u30d9\u30eb\u30d9\u30ea\u30f3\u3001PCSK9\u963b\u5bb3\u5264\uff09\u3001\u907a\u4f1d\u7684\u306b\u5b9a\u7fa9\u3055\u308c\u305f\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306a\u3069\u3067\u3059\u3002<\/p>\n<p>\u30b1\u30c8\u30f3\u98df\u306e\u9075\u5b88\u306b\u3064\u3044\u3066\u306f\u3001\u6bce\u65e5\u306e\u30b1\u30c8\u30f3\u4f53\u3067\u3042\u308b\u03b2-\u30d2\u30c9\u30ed\u30ad\u30b7\u916a\u9178\u306e\u30c7\u30fc\u30bf\u3092\u53d6\u3063\u3066\u3044\u308b\u306e\u3067\u3001\u5927\u4e08\u592b\u3067\u3057\u3087\u3046\u300287%\u304c\u5927\u90e8\u5206\u306e\u6e2c\u5b9a\u3067\u03b2-\u30d2\u30c9\u30ed\u30ad\u30b7\u916a\u9178\u22650.3 mmol\/L \u3092\u8d85\u3048\u308b\u5024\u3092\u8a18\u9332\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u5e73\u5747\u3067\u304a\u3088\u305d4.5\u5e74\u306e\u30b1\u30c8\u30f3\u98df\u671f\u9593\u306a\u306e\u3067\u3001\u9577\u671f\u306e\u9069\u5fdc\u3067\u5b9a\u5e38\u72b6\u614b\u306e\u4f4e\u4e0b\u3092\u8003\u3048\u308b\u3068\u3001\u3053\u308c\u304f\u3089\u3044\u306e\u5024\u3067\u554f\u984c\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u4e0b\u306e\u8868\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u72b6\u614b\u306e\u5e73\u5747\u00b1SD\u3001\u307e\u305f\u306f\u4e2d\u592e\u5024\u3067\u3059\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n<table class=\"table article-section__table\">\n<caption>\n<p id=\"tspara0010\">\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7279\u6027<\/p>\n<\/caption>\n<tbody>\n<tr valign=\"top\">\n<td>\u7537<\/td>\n<td colspan=\"2\">59%<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>\u5e74\u9f62\uff08\u6b73\uff09<\/td>\n<td align=\"center\">55.3 \u00b1 10.6<\/td>\n<td align=\"center\">57.0 (50.8-63.0)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>\u30b1\u30c8\u30f3\u98df\u671f\u9593\uff08\u65e5\uff09<\/td>\n<td align=\"center\">1,642.7 \u00b1 913.5<\/td>\n<td align=\"center\">1,427 (1,002-1,938)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>BMI\uff08kg\/m\u00a0<sup>2<\/sup>\uff09<\/td>\n<td align=\"center\">22.5\u00b12.7<\/td>\n<td align=\"center\">22.3 (20.6-24.4)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>\u53ce\u7e2e\u671f\u8840\u5727\uff08mmHg\uff09<\/td>\n<td align=\"center\">121.8\u00b121.1<\/td>\n<td align=\"center\">120 (112-135)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08mg\/dL\uff09<\/td>\n<td align=\"center\">355.1\u00b189.9<\/td>\n<td align=\"center\">338 (301-337)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>LDL-C (mg\/dL)<\/td>\n<td align=\"center\">253.7\u00b184.7<\/td>\n<td align=\"center\">237 (202-308)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>HDL-C (mg\/dL)<\/td>\n<td align=\"center\">88.8 \u00b1 20.0<\/td>\n<td align=\"center\">88 (74-102)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>\u4e2d\u6027\u8102\u80aa\uff08mg\/dL\uff09<\/td>\n<td align=\"center\">66.7 \u00b1 30.4<\/td>\n<td align=\"center\">61 (52-77)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaB (mg\/dL)<\/td>\n<td align=\"center\">185.0 \u00b1 50.8<\/td>\n<td align=\"center\">178 (149-214)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>\u975e\u77f3\u7070\u5316\u30d7\u30e9\u30fc\u30af\u91cf\uff08mm\u00a0<sup>3<\/sup>\uff09<\/td>\n<td align=\"center\">75.9 \u00b1 88.3<\/td>\n<td align=\"center\">44 (15.4-102.3)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>\u51a0\u52d5\u8108\u30ab\u30eb\u30b7\u30a6\u30e0\u30b9\u30b3\u30a2<\/td>\n<td align=\"center\">50.3 \u00b1 100.9<\/td>\n<td align=\"center\">0 (0-54)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>\u30a2\u30c6\u30ed\u30fc\u30e0\u5bb9\u7a4d\u7387<\/td>\n<td align=\"center\">3.2 \u00b1 3.8<\/td>\n<td align=\"center\">1.25 (0.5-3.6)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>\u7dcf\u30d7\u30e9\u30fc\u30af\u30b9\u30b3\u30a2<\/td>\n<td align=\"center\">1.7\u00b12.6<\/td>\n<td align=\"center\">0 (0-2.0)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td>10\u5e74\u9593\u306eCVD\u30ea\u30b9\u30af\uff08MESA\u00a0<sub>ETH-CAC\u3001%<\/sub>\uff09<\/td>\n<td align=\"center\">5.2\u00b15.3<\/td>\n<td align=\"center\">3.4\uff082.0-5.9\uff09<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u5e73\u5747\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f253.7\u306a\u306e\u3067\u3001\u5c02\u9580\u5bb6\u304c\u898b\u305f\u3089\u5927\u9a12\u304e\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n<table class=\"table article-section__table\">\n<caption>\n<p id=\"tspara0025\">\u98df\u4e8b\u69cb\u6210<\/p>\n<\/caption>\n<tbody>\n<tr valign=\"top\">\n<td colspan=\"1\" rowspan=\"1\">\u70ad\u6c34\u5316\u7269\uff08g\/\u65e5\uff09<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\">39.5\u00b129.8<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\">30.8 (12.6-51.1)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td colspan=\"1\" rowspan=\"1\">\u8102\u8cea\uff08g\/\u65e5\uff09<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\">120.2\u00b146.4<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\">113.1 (89.8-139.3)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td colspan=\"1\" rowspan=\"1\">\u98fd\u548c\u8102\u80aa\uff08g\/\u65e5\uff09<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\">44.7\u00b118.9<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\">39.4 (29.9-52.6)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td colspan=\"1\" rowspan=\"1\">\u7cd6\u8cea\uff08g\/\u65e5\uff09<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\">20.2\u00b118.5<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\">11.1 (6.3-22.2)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td colspan=\"1\" rowspan=\"1\">\u98df\u7269\u7e4a\u7dad\uff08g\/\u65e5\uff09<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\">6.9\u00b16.5<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\">6.9 (1.3-11.3)<\/td>\n<\/tr>\n<tr valign=\"top\">\n<td colspan=\"1\" rowspan=\"1\">\u30ca\u30c8\u30ea\u30a6\u30e0\uff08mg\/\u65e5\uff09<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\">3,292.5 \u00b1 1,263.0<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\">2,931.4 (2,217.7-3,265.7)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u7cd6\u8cea\u306e1\u65e5\u306e\u6442\u53d6\u91cf\u306e\u5e73\u5747\u304c20g\u3001\u4e2d\u592e\u5024\u306711g\u3068\u3001\u3055\u3059\u304c\u30b1\u30c8\u30f3\u98df\u3067\u3059\u306d\u3002\uff08\u81ea\u5df1\u7533\u544a\u3067\u3059\u304c\uff09<\/p>\n<p>1\u5e74\u5f8c\u3001ApoB\u3068BMI\u306e\u3069\u3061\u3089\u306b\u3082\u6709\u610f\u306a\u5909\u5316\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u307b\u3068\u3093\u3069\u306e\u53c2\u52a0\u8005\u306e\u975e\u77f3\u7070\u5316\u30d7\u30e9\u30fc\u30af\u91cf\uff08NCPV\uff09\u306f\u5b89\u5b9a\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u4e00\u65b9\u30011\u4eba\u3067\u306fNCPV\u304c\u4f4e\u4e0b\u3057\u30016\u4eba\u3067\u306f1\u5e74\u9593\u3067\u7dcf\u30d7\u30e9\u30fc\u30af\u30b9\u30b3\u30a2\uff08TPS\uff09\u304c\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u5bb9\u7a4d\u7387 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style=\"color: #3366ff;\">\u300cPlaque Begets Plaque, ApoB Does Not: Longitudinal Data From the KETO-CTA Trial\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300c\u30d7\u30e9\u30fc\u30af\u306f\u30d7\u30e9\u30fc\u30af\u3092\u751f\u3080\u304c\u3001ApoB\u306f\u305d\u3046\u3067\u306f\u306a\u3044\uff1aKETO-CTA\u8a66\u9a13\u306e\u7e26\u65ad\u7684\u30c7\u30fc\u30bf\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40192608\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7cd6\u8cea\u5236\u9650\u3092\u3059\u308b\u3068\u3001\u5c11\u306a\u304f\u306a\u3044\u5272\u5408\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4e0a\u6607\u3057\u307e\u3059\u3002\u305d\u306e\u5f8c\u4e0b\u304c\u308b\u4eba\u3082\u3044\u307e\u3059\u304c\u3001\u305a\u3063\u3068\u9ad8\u3044\u307e\u307e\u306e\u4eba\u3082\u591a\u3044\u3067\u3059\u3002 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