{"id":30971,"date":"2025-07-02T17:05:45","date_gmt":"2025-07-02T08:05:45","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=30971"},"modified":"2025-07-02T17:05:45","modified_gmt":"2025-07-02T08:05:45","slug":"%e3%83%a9%e3%82%ab%e3%83%b3%e3%83%88%ef%bc%88%e3%82%a8%e3%83%aa%e3%82%b9%e3%83%aa%e3%83%88%e3%83%bc%e3%83%ab%ef%bc%89%e3%81%ae%e8%84%b3%e5%8d%92%e4%b8%ad%e3%81%ae%e3%83%aa%e3%82%b9%e3%82%af%e3%82%92","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=30971","title":{"rendered":"\u30e9\u30ab\u30f3\u30c8\uff08\u30a8\u30ea\u30b9\u30ea\u30c8\u30fc\u30eb\uff09\u306e\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u306f\u672c\u5f53\uff1f"},"content":{"rendered":"

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\u4eca\u56de\u306f\u9055\u3046\u30b0\u30eb\u30fc\u30d7\u304c\u3001\u30a8\u30ea\u30b9\u30ea\u30c8\u30fc\u30eb\u306f\u8133\u306e\u5fae\u5c0f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u6a5f\u80fd\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8a00\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u30d2\u30c8\u8133\u5fae\u5c0f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3092\u57f9\u990a\u3057\u3001\u4e00\u822c\u7684\u306a\u98f2\u6599\u6442\u53d6\u91cf\u306b\u76f8\u5f53\u3059\u308b\u91cf\u306e\u30a8\u30ea\u30b9\u30ea\u30c8\u30fc\u30eb\u306b\u66dd\u9732\u3057\u305f\u5b9f\u9a13\u3067\u3059\u3002\u3042\u304f\u307e\u3067\u5b9f\u9a13\u3067\u3059\u3002\u4eba\u5de5\u7518\u5473\u6599\u5165\u308a\u98f2\u6599\u306b\u542b\u307e\u308c\u308b\u5178\u578b\u7684\u306a\u30a8\u30ea\u30b9\u30ea\u30c8\u30fc\u30eb\u91cf\uff0830g\uff09\u306b\u76f8\u5f53\u3059\u308b6mM\u306e\u30a8\u30ea\u30b9\u30ea\u30c8\u30fc\u30eb\u30673\u6642\u9593\u51e6\u7406\u3057\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

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ROS\u304c\u7d0475%\u5897\u52a0\u3057\u3001SOD-1\u306f\u7d0445%\u3001\u30ab\u30bf\u30e9\u30fc\u30bc\u306f\u7d0425%\u5897\u52a0\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u30a8\u30ea\u30b9\u30ea\u30c8\u30fc\u30eb\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u5897\u52a0\u3055\u305b\u3001\u305d\u308c\u306b\u53cd\u5fdc\u3057\u3066\u6297\u9178\u5316\u30bf\u30f3\u30d1\u30af\u8cea\u306eSOD-1\u3001\u30ab\u30bf\u30e9\u30fc\u30bc\u304c\u5897\u52a0\u3057\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u3001\u30a8\u30ea\u30b9\u30ea\u30c8\u30fc\u30eb\u304c\u8133\u5fae\u5c0f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u304a\u3051\u308b\u30ea\u30f3\u9178\u5316eNOS\uff08\u5185\u76ae\u578b\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\uff09\uff08Ser1177\uff09\u304a\u3088\u3073\u30ea\u30f3\u9178\u5316eNOS\uff08Thr495\uff09\u306e\u767a\u73fe\u3001NO\u7523\u751f\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002NO\uff08\u4e00\u9178\u5316\u7a92\u7d20\uff09\u306f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u304b\u3089\u7523\u751f\u3055\u308c\u3001\u8840\u7ba1\u306e\u62e1\u5f35\u3084\u8840\u5c0f\u677f\u306e\u63a5\u7740\u3092\u6291\u5236\u3059\u308b\u306a\u3069\u3001\u52d5\u8108\u786c\u5316\u3092\u6291\u5236\u3059\u308b\u91cd\u8981\u306a\u7269\u8cea\u3067\u3059\u3002NO\u306feNOS\u306b\u3088\u3063\u3066\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u5185\u3067\u5408\u6210\u3055\u308c\u307e\u3059\u3002<\/p>\n

Ser1177\u306e\u30ea\u30f3\u9178\u5316\u306f\u3001eNOS\u306e\u6700\u5927\u306e\u6d3b\u6027\u5316\u3092\u8a98\u5c0e\u3059\u308b\u4e00\u65b9\u3001Thr495\u306e\u30ea\u30f3\u9178\u5316\u306feNOS\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u3057\u307e\u3059\u3002\u30a8\u30ea\u30b9\u30ea\u30c8\u30fc\u30eb\u306f\u3001p-eNOS\uff08Ser1177\uff09\u306e\u767a\u73fe\u304c\u7d0435%\u4f4e\u4e0b\u3057\u3001p-eNOS\uff08Thr495\uff09\u306e\u767a\u73fe\u304c\u7d0440%\u5897\u52a0\u3057\u3001NO\u7523\u751f\u306f\u7d0420%\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

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ET-1\u306f\u3001\u5185\u76ae\u7d30\u80de\u306b\u3088\u3063\u3066\u7523\u751f\u3055\u308c\u308b\u6700\u3082\u5f37\u529b\u306a\u8840\u7ba1\u53ce\u7e2e\u7269\u8cea\u3067\u3059\u3002ET-1\u306e\u904e\u5270\u767a\u73fe\u306f\u5236\u5fa1\u3055\u308c\u306a\u3044\u8133\u8840\u7ba1\u53ce\u7e2e\u3092\u8a98\u767a\u3057\u3001\u6025\u6027\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u3068\u91cd\u75c7\u5ea6\u3092\u9ad8\u3081\u307e\u3059\u3002\u8133\u8840\u6d41\u306e\u6df1\u523b\u306a\u6e1b\u5c11\u3068\u3088\u308a\u5927\u304d\u306a\u795e\u7d4c\u5b66\u7684\u640d\u50b7\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

ECE\u306f\u30a8\u30ea\u30b9\u30ea\u30c8\u30fc\u30eb\u306e\u5f71\u97ff\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001Big ET-1\u304a\u3088\u3073ET-1\u7523\u751f\u306f\u5927\u304d\u304f\u5897\u52a0\u3057\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\u3053\u306e\u7d50\u679c\u306f\u3082\u3061\u308d\u3093\u3001\u5b9f\u9a13\u7684\u306a\u3082\u306e\u3067\u3042\u308a\u3001\u751f\u4f53\u5185\u3067\u306f\u3069\u3046\u306a\u308b\u304b\u306f\u3088\u304f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u4ee5\u524d\u306b\u3082\u66f8\u304d\u307e\u3057\u305f\u304c\u3001\u6bce\u65e530g\u3092\u4e00\u6c17\u306b\u6442\u53d6\u3059\u308b\u3088\u3046\u306a\u5927\u91cf\u306e\u30a8\u30ea\u30b9\u30ea\u30c8\u30fc\u30eb\u3067\u306a\u3051\u308c\u3070\u3001\u6050\u3089\u304f\u306f\u5168\u304f\u554f\u984c\u306a\u3044\u3068\u8003\u3048\u307e\u3059\u3002\u5927\u91cf\u6442\u53d6\u3084\u983b\u56de\u6442\u53d6\u306f\u6c17\u3092\u4ed8\u3051\u305f\u65b9\u304c\u826f\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u300cThe non-nutritive sweetener erythritol adversely affects brain microvascular endothelial cell function\u300d<\/span><\/p>\n

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