{"id":31015,"date":"2025-07-23T11:48:53","date_gmt":"2025-07-23T02:48:53","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=31015"},"modified":"2025-07-23T11:48:53","modified_gmt":"2025-07-23T02:48:53","slug":"%e9%ab%98%e8%a1%80%e5%9c%a7%e3%81%ae%e8%96%ac%e3%81%a7%e3%81%8c%e3%82%93%e3%83%aa%e3%82%b9%e3%82%af%e3%81%8c%e5%a2%97%e5%8a%a0%e3%81%99%e3%82%8b%e3%80%80%e3%81%9d%e3%81%ae2%e3%80%80%e4%b9%b3%e3%81%8c","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=31015","title":{"rendered":"\u9ad8\u8840\u5727\u306e\u85ac\u3067\u304c\u3093\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u3000\u305d\u306e2\u3000\u4e73\u304c\u3093"},"content":{"rendered":"<p>\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=31010\" target=\"_blank\" rel=\"noopener\">\u305d\u306e1<\/a>\u300d\u3067\u306f\u3001\u9ad8\u8840\u5727\u306e\u85ac\u3067\u306e\u814e\u81d3\u304c\u3093\u306e\u30ea\u30b9\u30af\u5897\u52a0\u306b\u3064\u3044\u3066\u66f8\u304d\u307e\u3057\u305f\u3002\u4eca\u56de\u306f\u4e73\u304c\u3093\u306b\u3064\u3044\u3066\u3067\u3059\u3002<\/p>\n<p>\u307e\u305a\u306f\u30011,736\u4eba\u306e\u4e73\u304c\u3093\u75c7\u4f8b\u30681,895\u4eba\u306e\u5065\u5eb7\u306a\u5bfe\u7167\u7fa4\u306b\u304a\u3051\u308b\u964d\u5727\u85ac\u3068\u4e73\u304c\u3093\u306e\u95a2\u4fc2\u3092\u5206\u6790\u3057\u305f\u7814\u7a76\u3067\u3059\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27508297\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff09\u3044\u305a\u308c\u304b\u306e\u9ad8\u8840\u5727\u306e\u85ac\u306e\u4f7f\u7528\u306f\u3001\u9589\u7d4c\u524d\u306e\u5973\u6027\u306b\u304a\u3051\u308b\u4e73\u304c\u3093\u767a\u75c7\u306e\u53ef\u80fd\u6027\u304c2.15\u500d\u3067\u3057\u305f\u3002\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u30d6\u30ed\u30c3\u30ab\u30fc\u306e\u4f7f\u7528\u306f\u9589\u7d4c\u5f8c\u306b\u304a\u3051\u308b\u4e73\u304c\u3093\u767a\u75c7\u306e\u53ef\u80fd\u6027\u304c1.72\u500d\u3001BMI\u304c25\u4ee5\u4e0a\u306e\u5973\u6027\u3067\u306f2.05\u500d\u3067\u3057\u305f\u3002\u300195%\u4fe1\u983c\u533a\u95931.16\uff5e3.63\uff09\u306b\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3II\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\uff08ARB\uff09\u306f\u3001\u9589\u7d4c\u524d\u5973\u6027\u306b\u304a\u3051\u308b\u4e73\u304c\u3093\u767a\u75c7\u306e\u53ef\u80fd\u6027\u304c4.27\u500d\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u964d\u5727\u85ac\u306e\u4f7f\u7528\u306f\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u4e73\u304c\u3093\u306e\u767a\u75c7\u306e\u53ef\u80fd\u6027\u304c2.21\u500d\u3001\u81e8\u5e8a\u30b9\u30c6\u30fc\u30b8III\uff5eIV\u306e\u53ef\u80fd\u6027\u304c1.62\u500d\u3001\u975e\u4e73\u7ba1\u304c\u3093\u306f1.49\u500d\u3001\u6d78\u6f64\u304c\u3093\u306f1.26\u500d\u3067\u3057\u305f\u3002<\/p>\n<p>\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u30d6\u30ed\u30c3\u30ab\u30fc\u306f\u3088\u308a\u60aa\u6027\u5ea6\u306e\u9ad8\u3044\u816b\u760d\u3068\u306e\u95a2\u9023\u304c\u3055\u3089\u306b\u5f37\u304f\u3001\u30b9\u30c6\u30fc\u30b8III\uff5eIV\u306e\u816b\u760d\u767a\u751f\u306e\u53ef\u80fd\u6027\u304c2.70\u500d\u3001\u975e\u4e73\u7ba1\u304c\u3093\u306f2.63\u500d\u3001ERBB2\uff08HER2\uff09\u967d\u6027\u304c\u3093\u306f2.52\u500d\u3001\u6d78\u6f64\u304c\u30931.67\u500d\u3067\u3057\u305f\u3002<\/p>\n<p>\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\u963b\u5bb3\u5264\uff08ACEI\uff09\u306f\u975e\u4e73\u7ba1\u304c\u3093\u306e\u53ef\u80fd\u6027\u304c1.78\u500d\u3067\u3057\u305f\u3002<\/p>\n<p>\u3082\u3046\u4e00\u3064\u7814\u7a76\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23921840\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\uff0955\uff5e74\u6b73\u306e\u5973\u6027\u3067\u3001\u6d78\u6f64\u6027\u4e73\u7ba1\u304c\u3093\u60a3\u8005880\u4eba\u3001\u6d78\u6f64\u6027\u5c0f\u8449\u6027\u4e73\u304c\u3093\u60a3\u80051,027\u4eba\u3001\u304c\u3093\u306e\u306a\u3044\u5bfe\u7167\u7fa4856\u4eba\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u73fe\u5728\u4f7f\u7528\u4e2d\u306e\u964d\u5727\u85ac\u306e\u4f7f\u7528\u671f\u9593\u306e\u5f71\u97ff\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u30d6\u30ed\u30c3\u30ab\u30fc\u309210\u5e74\u4ee5\u4e0a\u4f7f\u7528\u3057\u3066\u3044\u308b\u5834\u5408\u306b\u306e\u307f\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u304c\u8a8d\u3081\u3089\u308c\u3001\u6d78\u6f64\u6027\u4e73\u7ba1\u304c\u3093\u767a\u75c7\u306e\u53ef\u80fd\u6027\u306f2.4\u500d\u3001\u6d78\u6f64\u6027\u5c0f\u8449\u6027\u4e73\u304c\u3093\u306e\u53ef\u80fd\u6027\u306f2.6\u500d\u3067\u3057\u305f\u3002<\/p>\n<p>\u6b21\u306f\u3001\u767a\u75c7\u30ea\u30b9\u30af\u3067\u306f\u306a\u304f\u3001\u518d\u767a\u3084\u6b7b\u4ea1\u7387\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u3067\u3059\u3002\u307e\u305a\u306f\u3001\u521d\u56de\u306e\u539f\u767a\u6027\u6d78\u6f64\u6027\u4e73\u304c\u3093\u3068\u8a3a\u65ad\u3055\u308c\u305f20\u6b73\u304b\u308969\u6b73\uff08\u5168\u4f53\u306e\u5e74\u9f62\u4e2d\u592e\u5024\u306f52\u6b73\uff09\u306e\u5973\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u3067\u3059\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34347212\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\u3001\u8868\u306f\u3053\u3053\u3088\u308a\u6539\u5909\uff09\u30eb\u30df\u30ca\u30fc\u30eb\u578b\u4e73\u304c\u3093\u60a3\u80052,383\u4eba\u3001\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u4e73\u304c\u3093\u60a3\u80051,559\u4eba\u3001HER2 \u904e\u5270\u767a\u73fe\u578b\u4e73\u304c\u3093\u60a3\u8005615\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<table class=\"content\" style=\"width: 107.567%; height: 459px;\" frame=\"above\" rules=\"cols\">\n<colgroup span=\"1\">\n<col span=\"1\" align=\"left\" valign=\"middle\" \/>\n<col span=\"1\" align=\"left\" valign=\"middle\" \/>\n<col span=\"1\" align=\"left\" valign=\"middle\" \/>\n<col span=\"1\" align=\"left\" valign=\"middle\" \/>\n<col span=\"1\" align=\"left\" valign=\"middle\" \/>\n<col span=\"1\" align=\"left\" valign=\"middle\" \/>\n<col span=\"1\" align=\"left\" valign=\"middle\" \/>\n<col span=\"1\" align=\"left\" valign=\"middle\" \/>\n<col span=\"1\" align=\"left\" valign=\"middle\" \/><\/colgroup>\n<thead>\n<tr>\n<th style=\"width: 225px;\" align=\"center\" valign=\"middle\"><\/th>\n<th style=\"width: 365px;\" colspan=\"3\" align=\"center\" valign=\"middle\">\u30eb\u30df\u30ca\u30fc\u30eb<\/th>\n<th style=\"width: 365px;\" colspan=\"3\" align=\"center\" valign=\"middle\">\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6<\/th>\n<th style=\"width: 248px;\" colspan=\"2\" align=\"center\" valign=\"middle\">HER2\u904e\u5270\u767a\u73fe<\/th>\n<\/tr>\n<tr>\n<th style=\"width: 225px;\" align=\"center\" valign=\"middle\"><\/th>\n<th style=\"width: 117px;\" align=\"center\" valign=\"middle\">\u518d\u767a<\/th>\n<th style=\"width: 131px;\" align=\"center\" valign=\"middle\">\u4e73\u304c\u3093\u7279\u7570\u7684\u6b7b\u4ea1<\/th>\n<th style=\"width: 117px;\" align=\"center\" valign=\"middle\">\u5168\u539f\u56e0\u6b7b\u4ea1<\/th>\n<th style=\"width: 117px;\" align=\"center\" valign=\"middle\">\u518d\u767a<\/th>\n<th style=\"width: 131px;\" align=\"center\" valign=\"middle\">\u4e73\u304c\u3093\u7279\u7570\u7684\u6b7b\u4ea1<\/th>\n<th style=\"width: 117px;\" align=\"center\" valign=\"middle\">\u5168\u539f\u56e0\u6b7b\u4ea1<\/th>\n<th style=\"width: 131px;\" align=\"center\" valign=\"middle\">\u4e73\u304c\u3093\u7279\u7570\u7684\u6b7b\u4ea1<\/th>\n<th style=\"width: 117px;\" align=\"center\" valign=\"middle\">\u5168\u539f\u56e0\u6b7b\u4ea1<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"width: 225px;\" align=\"left\" valign=\"middle\"><strong>\u964d\u5727\u85ac<\/strong><\/td>\n<th style=\"width: 117px;\" align=\"center\" valign=\"middle\">HR\uff0895\uff05CI\uff09<\/th>\n<th style=\"width: 131px;\" align=\"center\" valign=\"middle\">HR\uff0895\uff05CI\uff09<\/th>\n<th style=\"width: 117px;\" align=\"center\" valign=\"middle\">HR\uff0895\uff05CI\uff09<\/th>\n<th style=\"width: 117px;\" align=\"center\" valign=\"middle\">HR\uff0895\uff05CI\uff09<\/th>\n<th style=\"width: 131px;\" align=\"center\" valign=\"middle\">HR\uff0895\uff05CI\uff09<\/th>\n<th style=\"width: 117px;\" align=\"center\" valign=\"middle\">HR\uff0895\uff05CI\uff09<\/th>\n<th style=\"width: 131px;\" align=\"center\" valign=\"middle\">HR\uff0895\uff05CI\uff09<\/th>\n<th style=\"width: 117px;\" align=\"center\" valign=\"middle\">HR\uff0895\uff05CI\uff09<\/th>\n<\/tr>\n<tr>\n<td style=\"width: 225px;\" align=\"left\" valign=\"middle\">\u73fe\u5728\u964d\u5727\u5264\u3092\u4f7f\u7528\u3057\u3066\u3044\u306a\u3044<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1<\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1<\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1<\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 225px;\" align=\"left\" valign=\"middle\">\u3044\u305a\u308c\u304b\u306e\u964d\u5727\u5264<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1.5 (0.96, 2.4)<\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1.2 (0.8, 1.8)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\"><span style=\"color: #ff0000;\">1.4 (1.04, 1.8)<\/span><\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1.3 (0.9, 1.9)<\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1.2 (0.9, 1.6)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\"><span style=\"color: #ff0000;\">1.4 (1.1, 1.8)<\/span><\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">0.8 (0.4, 1.5)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1.1 (0.6, 1.9)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 225px;\" align=\"left\" valign=\"middle\">\u5229\u5c3f\u85ac<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1.4 (0.8, 2.5)<\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1.1 (0.7, 1.7)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1.3 (0.9, 1.8)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1.2 (0.8, 1.8)<\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1.1 (0.8, 1.6)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\"><span style=\"color: #ff0000;\">1.4 (1.01, 1.8)<\/span><\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">0.5 (0.2, 1.2)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">0.9 (0.5, 1.8)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 225px;\" align=\"left\" valign=\"middle\">\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u30d6\u30ed\u30c3\u30ab\u30fc<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\"><\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1.8 (0.7, 4.3)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\"><span style=\"color: #ff0000;\">2.1\uff081.2\u30013.6\uff09<\/span><\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1.4 (0.7, 2.8)<\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1.4 (0.7, 2.7)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\"><span style=\"color: #ff0000;\">1.9 (1.2, 3.0)<\/span><\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1.8 (0.6, 5.4)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">2.5 (0.96, 6.3)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 225px;\" align=\"left\" valign=\"middle\">\u03b2\u30d6\u30ed\u30c3\u30ab\u30fc<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1.3 (0.6, 2.8)<\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1.3 (0.7, 2.4)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\"><span style=\"color: #ff0000;\">1.7\uff081.2\u30012.5\uff09<\/span><\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1.3 (0.8, 2.2)<\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1.3 (0.8, 2.0)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\"><span style=\"color: #ff0000;\">1.8 (1.3, 2.5)<\/span><\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">0.8 (0.3, 2.1)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1.0 (0.4, 2.2)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 225px;\" align=\"left\" valign=\"middle\">\u00a0ACEI<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\"><span style=\"color: #ff0000;\">2.5\uff081.5\u30014.3\uff09<\/span><\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\"><span style=\"color: #ff0000;\">1.9 (1.2, 3)<\/span><\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\"><span style=\"color: #ff0000;\">1.6 (1.1, 2.4)<\/span><\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1.5 (0.9, 2.3)<\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">1.4 (0.8, 2.2)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\"><span style=\"color: #ff0000;\">1.5 (1.02, 2.2)<\/span><\/td>\n<td style=\"width: 131px;\" align=\"center\" valign=\"middle\">0.9 (0.4, 2.1)<\/td>\n<td style=\"width: 117px;\" align=\"center\" valign=\"middle\">1.3 (0.6, 2.7)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u4e0a\u306e\u8868\u306e\u3088\u3046\u306b\u3001\u3044\u305a\u308c\u304b\u306e\u9ad8\u8840\u5727\u306e\u85ac\u306e\u73fe\u5728\u306e\u4f7f\u7528\u306f\u3001\u30eb\u30df\u30ca\u30fc\u30eb\u3068\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u306e\u4e73\u304c\u3093\u306e\u5168\u539f\u56e0\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e1.4\u500d\u306e\u5897\u52a0\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u964d\u5727\u85ac\u306e\u7a2e\u985e\u5225\u3067\u306f\u3001\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\u963b\u5bb3\u85ac\uff08ACEI\uff09\u306e\u73fe\u5728\u4f7f\u7528\u306f\u3001\u30eb\u30df\u30ca\u30fc\u30eb\u4e73\u304c\u3093\u60a3\u8005\u306b\u304a\u3051\u308b\u518d\u767a\u30ea\u30b9\u30af\u304c2.5\u500d\u3001\u4e73\u304c\u3093\u7279\u7570\u7684\u6b7b\u4ea1\u30ea\u30b9\u30af\u306f1.9\u500d\u3001\u5168\u539f\u56e0\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c1.6\u500d\u3067\u3057\u305f\u3002\u307b\u3068\u3093\u3069\u306e\u964d\u5727\u85ac\u306f\u5168\u539f\u56e0\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u3082\u3046\u4e00\u3064\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28807926\/\" target=\"_blank\" 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