{"id":31077,"date":"2025-07-01T20:02:38","date_gmt":"2025-07-01T11:02:38","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=31077"},"modified":"2025-07-01T20:02:38","modified_gmt":"2025-07-01T11:02:38","slug":"%e5%86%85%e6%9c%8d%e8%96%ac%e3%81%ae%e4%bd%b5%e7%94%a8%e3%81%ab%e3%82%88%e3%82%8b%e8%85%8e%e8%87%93%e3%81%b8%e3%81%ae%e3%83%88%e3%83%aa%e3%83%97%e3%83%ab%e3%83%91%e3%83%b3%e3%83%81%e3%81%ae%e5%a4%a7","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=31077","title":{"rendered":"\u5185\u670d\u85ac\u306e\u4f75\u7528\u306b\u3088\u308b\u814e\u81d3\u3078\u306e\u30c8\u30ea\u30d7\u30eb\u30d1\u30f3\u30c1\u306e\u5927\u30c0\u30e1\u30fc\u30b8\u300c\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\u300d"},"content":{"rendered":"

Triple Whammy\uff08\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\uff09\u3068\u3044\u3046\u8a00\u8449\u3092\u77e5\u3063\u3066\u3044\u307e\u3059\u304b\uff1fWhammy\u306b\u306f\u546a\u3044\u3068\u304b\u9b54\u529b\u3068\u3044\u3046\u610f\u5473\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u4e0d\u904b\u3084\u81f4\u547d\u7684\u306a\u4e00\u6483\u3068\u3044\u3046\u610f\u5473\u3082\u3042\u308a\u307e\u3059\u3002\u300cdouble whammy\u300d\u3068\u3044\u3046\u5f62\u3067\u4f7f\u308f\u308c\u308b\u3068\u300c\u30c0\u30d6\u30eb\u30d1\u30f3\u30c1\u300d\u3084\u300c\u4e8c\u91cd\u82e6\u300d\u3068\u3044\u3046\u610f\u5473\u3067\u3059\u3002\u3060\u304b\u3089Triple Whammy\u306f\u300c\u30c8\u30ea\u30d7\u30eb\u30d1\u30f3\u30c1\u300d\u3084\u300c\u4e09\u91cd\u82e6\u300d\u3068\u3044\u3046\u610f\u5473\u3067\u3059\u3002\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u3068\u3093\u3067\u3082\u306a\u3044\u6253\u6483\u3092\u53d7\u3051\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u8a00\u8449\u304c\u533b\u7642\u306e\u4e2d\u3067\u4f7f\u308f\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u30ec\u30cb\u30f3-\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\u963b\u5bb3\u85ac\u3001\u5229\u5c3f\u85ac\u3001\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u6027\u6297\u708e\u75c7\u85ac\uff08NSAIDs\uff09\u306e\uff13\u3064\u304b\u3089\u304b\u3089\u306a\u308b\u85ac\u7269\u7642\u6cd5\u306b\u95a2\u9023\u3059\u308b\u6025\u6027\u814e\u969c\u5bb3\uff08AKI\uff09\u3092\u300c\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\u300d\u3068\u547c\u3093\u3067\u3044\u308b\u306e\u3067\u3059\u3002\u3069\u308c\u3082\u814e\u81d3\u306b\u5f71\u97ff\u3092\u3082\u305f\u3089\u3059\u85ac\u3067\u3059\u304c\u3001\u3053\u306e3\u3064\u3092\u4f75\u7528\u3059\u308b\u3068\u3001\u814e\u81d3\u304c\u5927\u304d\u306a\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u3082\u3061\u308d\u3093\u3059\u3079\u3066\u306e\u4eba\u4f53\u306b\u5bfe\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u89e3\u660e\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u305d\u308c\u305e\u308c\u306e\u85ac\u306b\u306f\u52b9\u679c\u304c\u3042\u308a\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u826f\u3044\u52b9\u679c\u306b\u5bfe\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u526f\u4f5c\u7528\u3092\u3082\u305f\u3089\u3059\u30e1\u30ab\u30cb\u30ba\u30e0\u3082\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u826f\u3044\u52b9\u679c\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u4ed6\u306e\u85ac\u3068\u4f75\u7528\u3057\u305f\u5834\u5408\u3001\u60aa\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u5909\u308f\u3063\u3066\u3057\u307e\u3046\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u3053\u308c\u30893\u3064\u306e\u85ac\u306f\u3001\u305d\u308c\u305e\u308c\u7570\u306a\u308b\u4f5c\u7528\u306b\u3088\u3063\u3066\u814e\u8840\u6d41\u91cf\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002<\/p>\n

\u2460ARB\/ACE\u963b\u5bb3\u85ac\uff1a\u814e\u81d3\u306e\u8f38\u51fa\u7d30\u52d5\u8108\u306e\u53ce\u7e2e\u3092\u6291\u5236\u3055\u305b\u308b\u7d50\u679c\u3001\u7cf8\u7403\u4f53\u5185\u5727\u304c\u6e1b\u5c11\u3057\u3001\u814e\u8840\u6d41\u91cf\u304c\u4f4e\u4e0b\u3059\u308b\u3002<\/p>\n

\u2461\u5229\u5c3f\u85ac\uff1a\u5faa\u74b0\u8840\u6d41\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u814e\u8840\u6d41\u91cf\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3002<\/p>\n

\u2462NSAIDs\uff1a\u814e\u81d3\u306e\u8f38\u5165\u7d30\u52d5\u8108\u3092\u53ce\u7e2e\u3055\u305b\u308b\u7d50\u679c\u3001\u814e\u8840\u6d41\u91cf\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3002<\/p>\n

ARB\/ACE\u963b\u5bb3\u85ac\u306f\u814e\u4fdd\u8b77\u4f5c\u7528\u304c\u3042\u308b\u3088\u3046\u306b\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u85ac\u5264\u6027\u814e\u969c\u5bb3\u3092\u8d77\u3053\u3059\u85ac\u3068\u3057\u3066\u6709\u540d\u3067\u3059\u306d\u3002\u3053\u306e\u30d6\u30ed\u30b0\u3067\u3082\u3044\u308d\u3044\u308d\u66f8\u3044\u3066\u3044\u307e\u3059\u304c\u3001\u69d8\u3005\u306a\u30ea\u30b9\u30af\u3082\u5897\u52a0\u3055\u305b\u308b\u85ac\u3067\u3059\u3002<\/p>\n

\u5229\u5c3f\u85ac\u306b\u3082\u3044\u308d\u3044\u308d\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u3002\u30eb\u30fc\u30d7\u5229\u5c3f\u85ac\uff08\u6709\u540d\u306a\u306e\u306f\u30e9\u30b7\u30c3\u30af\u30b9\u3001\u4e00\u822c\u540d\u30d5\u30ed\u30bb\u30df\u30c9\uff09\u306f\u814e\u8840\u6d41\u91cf\u3092\u4f4e\u4e0b\u3055\u305b\u306b\u304f\u3044\u306e\u3067\u3001\u814e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u305f\u60a3\u8005\u306b\u964d\u5727\u76ee\u7684\u3067\u4f7f\u3044\u3084\u3059\u3044\u3001\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3042\u308b\u7814\u7a76\u3067\u306f\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\u6025\u6027\u814e\u969c\u5bb3\u306e\u539f\u56e0\u306e\u5229\u5c3f\u85ac\u3068\u3057\u3066\u3001\u30b5\u30a4\u30a2\u30b6\u30a4\u30c9\u7cfb\u5229\u5c3f\u85ac\u30671.98\u500d\u3001\u30a2\u30eb\u30c9\u30b9\u30c6\u30ed\u30f3\u62ee\u6297\u85ac\u30672.19\u500d\u3001\u3001\u30eb\u30fc\u30d7\u5229\u5c3f\u85ac\u30674.40\u500d\u3082\u6025\u6027\u814e\u969c\u5bb3\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3057\u305f\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\u306b\u95a2\u3057\u3066\u5229\u5c3f\u85ac\u306e\u7acb\u3061\u4f4d\u7f6e\u306f\u3042\u304f\u307e\u3067\u5faa\u74b0\u8840\u6d41\u91cf\u306e\u6e1b\u5c11\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\uff08\u305f\u3060\u3057\u3001\u30d0\u30bd\u30d7\u30ec\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u306f\u6025\u6027\u814e\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u3092\u4e0a\u3052\u307e\u305b\u3093\u3067\u3057\u305f\uff09<\/p>\n

\u590f\u306f\u6c57\u3092\u304b\u3044\u3066\u3001\u8131\u6c34\u306b\u6c17\u3092\u4ed8\u3051\u3066\u3001\u3068\u8a00\u308f\u308c\u307e\u3059\u3002\u7279\u306b\u9ad8\u9f62\u8005\u306f\u8131\u6c34\u306b\u306a\u308a\u3084\u3059\u3044\u306a\u3069\u3068\u3082\u8a00\u308f\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u9ad8\u9f62\u8005\u306e\u4e2d\u306b\u306f\u666e\u6bb5\u304b\u3089\u9ad8\u8840\u5727\u306e\u6cbb\u7642\u3068\u306f\u3044\u3048\u3001\u5229\u5c3f\u85ac\u3092\u51e6\u65b9\u3055\u308c\u3066\u5faa\u74b0\u8840\u6d41\u91cf\u3092\u4f4e\u4e0b\u3055\u305b\u3089\u308c\u3066\u3044\u308b\u4eba\u3082\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u672c\u5f53\u306b\u5229\u5c3f\u85ac\u306f\u5fc5\u8981\u306a\u85ac\u3067\u3057\u3087\u3046\u304b\uff1f\u6691\u3044\u304b\u3089\u6c34\u5206\u88dc\u7d66\u306b\u5869\u5206\u88dc\u7d66\u3067\u3001\u5229\u5c3f\u85ac\u3067\u6c34\u5206\u3082\u5869\u5206\u3082\u6392\u6cc4\u3063\u3066\u4f55\u3092\u3084\u3063\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u7279\u306b\u9ad8\u9f62\u8005\u306a\u3069\u306f\u75db\u307f\u6b62\u3081\u306b\u983c\u3063\u3066\u3044\u308b\u4eba\u3082\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u6574\u5f62\u5916\u79d1\u306a\u3069\u3067\u306f\u6bd4\u8f03\u7684\u5b89\u6613\u306b\u75db\u307f\u6b62\u3081\u306eNSAIDs\u306f\u51e6\u65b9\u3055\u308c\u307e\u3059\u3002\u69d8\u3005\u306a\u75c5\u6c17\u3084\u75c7\u72b6\u304c\u3042\u308b\u305f\u3081\u306b\u3001\u3044\u304f\u3064\u3082\u306e\u79d1\u306b\u53d7\u8a3a\u3057\u3066\u3044\u308b\u4eba\u3082\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u305d\u308c\u305e\u308c\u306e\u79d1\u306e\u533b\u5e2b\u306f\u305d\u308c\u305e\u308c\u304c\u51fa\u3057\u305f\u3044\u85ac\u3092\u3060\u3057\u307e\u3059\u306e\u3067\u3001\u4ed6\u306e\u79d1\u306e\u85ac\u306a\u3093\u3066\u3042\u307e\u308a\u8003\u3048\u307e\u305b\u3093\u3002\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\u306e\u51e6\u65b9\u306f\u7c21\u5358\u306b\u8d77\u304d\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u306e3\u3064\u306e\u85ac\u306e\u6025\u6027\u814e\u969c\u5bb3\u306f\u3001\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u73fe\u5728\u306e\u85ac\u306e\u4f7f\u7528\u306f\u3001\u6025\u6027\u814e\u969c\u5bb3\u306e\u767a\u751f\u73871.31\u500d\u3001\u4f7f\u7528\u958b\u59cb\u5f8c30\u65e5\u9593\u306b1.82\u500d\u3068\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09<\/p>\n

\u65e5\u672c\u306e\u533b\u85ac\u54c1\u526f\u4f5c\u7528\u5831\u544a\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u3088\u308b\u7814\u7a76\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u6025\u6027\u814e\u969c\u5bb3\u306f18,415\u4ef6\u5831\u544a\u3055\u308c\u3001\u305d\u306e\u3046\u30617,466\u4ef6\u3067\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\u85ac\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u4e0b\u306e\u8868\u306f\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\u85ac\u306a\u3057\u3068\u6bd4\u8f03\u3057\u305f\u5358\u4e00\u85ac\u7fa4\u30012\u85ac\u7fa4\u30013\u85ac\u7fa4\u306e\u8abf\u6574ROR\uff08\u5831\u544a\u30aa\u30c3\u30ba\u6bd4\uff09\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\n\n\n\n\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
RAS\u963b\u5bb3\u85ac<\/th>\n\u5229\u5c3f\u5264<\/th>\nNSAIDs<\/th>\n\u8abf\u6574\u6e08\u307fROR [95% CI]<\/th>\n<\/tr>\n<\/thead>\n
–<\/td>\n–<\/td>\n–<\/td>\n1<\/td>\n<\/tr>\n
\u30b7\u30f3\u30b0\u30eb<\/td>\n<\/td>\n<\/tr>\n
+<\/td>\n–<\/td>\n–<\/td>\n1.43 [1.35\u20131.50]<\/span><\/td>\n<\/tr>\n
–<\/td>\n+<\/td>\n–<\/td>\n1.76 [1.66\u20131.88]<\/span><\/td>\n<\/tr>\n
–<\/td>\n–<\/td>\n+<\/td>\n1.18 [1.12\u20131.25]<\/span><\/td>\n<\/tr>\n
\u5408\u8a08<\/td>\n1.41 [1.36\u20131.46]<\/span><\/td>\n<\/tr>\n
\u30c0\u30d6\u30eb<\/td>\n<\/td>\n<\/tr>\n
+<\/td>\n+<\/td>\n–<\/td>\n2.41 [2.27\u20132.56]<\/span><\/td>\n<\/tr>\n
+<\/td>\n–<\/td>\n+<\/td>\n1.55 [1.40\u20131.71]<\/span><\/td>\n<\/tr>\n
–<\/td>\n+<\/td>\n+<\/td>\n1.70 [1.50\u20131.93]<\/span><\/td>\n<\/tr>\n
\u5408\u8a08<\/td>\n2.13 [2.02\u20132.24]<\/span><\/td>\n<\/tr>\n
\u30c8\u30ea\u30d7\u30eb<\/td>\n<\/td>\n<\/tr>\n
+<\/td>\n+<\/td>\n+<\/td>\n2.44 [2.14\u20132.77]<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u5358\u4e00\u85ac\u7fa4\u30671.41\u30012\u85ac\u7fa4\u30672.13\u30013\u85ac\u7fa4\u30672.44\u500d\u3067\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\u85ac\u306e\u6700\u5f8c\u306e\u85ac\u304c\u51e6\u65b9\u3055\u308c\u3066\u304b\u3089\u306e\u7d4c\u904e\u65e5\u6570\u3068\u6025\u6027\u814e\u969c\u5bb3\u306e\u7d2f\u7a4d\u767a\u75c7\u7387\u3067\u3059\u30023\u5264\u4f75\u7528\u304a\u3088\u3073\u5358\u5264\u3067\u306f\u30012\u5264\u4f75\u7528\u3068\u6bd4\u8f03\u3057\u3066\u6025\u6027\u814e\u969c\u5bb3\u306e\u767a\u75c7\u304c\u6709\u610f\u306b\u65e9\u304f\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\u300cTime until onset of acute kidney injury by combination therapy with “Triple Whammy” drugs obtained from Japanese Adverse Drug Event Report database\u300d<\/span><\/p>\n

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