{"id":31137,"date":"2025-07-31T07:12:25","date_gmt":"2025-07-30T22:12:25","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=31137"},"modified":"2025-07-31T07:12:25","modified_gmt":"2025-07-30T22:12:25","slug":"%e6%80%a5%e6%80%a7%e8%85%8e%e9%9a%9c%e5%ae%b3%e3%82%92%e3%82%82%e3%81%9f%e3%82%89%e3%81%99%e3%83%88%e3%83%aa%e3%83%97%e3%83%ab%e3%83%af%e3%83%bc%e3%83%9f%e3%83%bc%e8%96%ac%e3%81%ab%e3%83%97%e3%83%ad","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=31137","title":{"rendered":"\u6025\u6027\u814e\u969c\u5bb3\u3092\u3082\u305f\u3089\u3059\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\u85ac\u306b\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff08PPI\uff09\u3092\u4f75\u7528\u3057\u3066\u30af\u30a2\u30c9\u30e9\u30d7\u30eb\u30ef\u30fc\u30df\u30fc"},"content":{"rendered":"

\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u5185\u670d\u85ac\u306e\u4f75\u7528\u306b\u3088\u308b\u814e\u81d3\u3078\u306e\u30c8\u30ea\u30d7\u30eb\u30d1\u30f3\u30c1\u306e\u5927\u30c0\u30e1\u30fc\u30b8\u300c\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\u300d<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u30ec\u30cb\u30f3-\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\u963b\u5bb3\u85ac\u3001\u5229\u5c3f\u85ac\u3001\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u6027\u6297\u708e\u75c7\u85ac\uff08NSAIDs\uff09\u306e\uff13\u3064\u304b\u3089\u304b\u3089\u306a\u308b\u85ac\u7269\u7642\u6cd5\u306b\u95a2\u9023\u3059\u308b\u6025\u6027\u814e\u969c\u5bb3\uff08AKI\uff09\u3092\u300c\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\u300d\u3068\u547c\u3093\u3067\u3044\u308b\u306e\u3067\u3059\u3002\u3069\u308c\u3082\u814e\u81d3\u306b\u5f71\u97ff\u3092\u3082\u305f\u3089\u3059\u85ac\u3067\u3059\u304c\u3001\u3053\u306e3\u3064\u3092\u4f75\u7528\u3059\u308b\u3068\u3001\u814e\u81d3\u304c\u5927\u304d\u306a\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u3055\u3089\u306b\u3001NSAIDs\u306e\u526f\u4f5c\u7528\u3068\u3057\u3066\u6709\u540d\u3067\u3042\u308b\u3001\u4e0a\u90e8\u6d88\u5316\u7ba1\u51fa\u8840\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306b\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff08PPI\uff09\u304c\u51e6\u65b9\u3055\u308c\u308b\u3053\u3068\u3082\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u526f\u4f5c\u7528\u4e88\u9632\u3067\u306a\u304f\u3066\u3082\u3001\u9006\u6d41\u6027\u98df\u9053\u708e\u306a\u3069\u3067\u9577\u671f\u306bPPI\u304c\u51e6\u65b9\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3082\u73cd\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u305d\u3057\u3066\u3001\u30c8\u30ea\u30d7\u30eb\u30ef\u30fc\u30df\u30fc\u306e3\u5264\u306bPPI\u3092\u52a0\u3048\u308b\u3068\u3001\u3055\u3089\u306b\u814e\u81d3\u306b\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u3001\u30af\u30a2\u30c9\u30e9\u30d7\u30eb\uff08quadruple\uff09\u30ef\u30fc\u30df\u30fc\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

PPI\u306f\u3001\u6025\u6027\u814e\u969c\u5bb3\u3001\u6025\u6027\u9593\u8cea\u6027\u814e\u708e\u3001\u6162\u6027\u814e\u81d3\u75c5\u306e\u767a\u75c7\u3001\u814e\u81d3\u75c5\u306e\u9032\u884c\u3001\u814e\u4e0d\u5168\u3001\u5168\u6b7b\u4ea1\u30ea\u30b9\u30af\u304a\u3088\u3073\u6162\u6027\u814e\u81d3\u75c5\u306b\u3088\u308b\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306a\u3069\u3001\u591a\u304f\u306e\u814e\u81d3\u306e\u6709\u5bb3\u4e8b\u8c61\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

PPI\u306e\u6709\u5bb3\u6027\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u8272\u3005\u898b\u3066\u3044\u304d\u307e\u3057\u3087\u3046\u3002<\/p>\n

\u6025\u6027\u814e\u969c\u5bb3\u3092\u767a\u75c7\u3057\u305f93,335\u4eba\u3001\u6162\u6027\u814e\u81d3\u75c584,600\u4eba\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3057\u305f\u3042\u308b\u7814\u7a76\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09\u3067\u306f\u3001PPI\u66dd\u9732\u306f\u6025\u6027\u814e\u969c\u5bb3\u767a\u75c7\u306e\u53ef\u80fd\u6027\u304c4.35\u500d\u3001\u6162\u6027\u814e\u81d3\u75c5\u767a\u75c7\u306e\u53ef\u80fd\u6027\u304c1.20\u500d\u3067\u3057\u305f\u3002<\/p>\n

PPI\u3092\u958b\u59cb\u3057\u305f66\u6b73\u4ee5\u4e0a\u3092\u5bfe\u8c61\u306b\u3057\u305f\u7814\u7a76\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09\u3067\u306f\u3001PPI\u3092\u958b\u59cb\u3057\u305f290,592\u4eba\u3068\u3001\u540c\u6570\u306e\u5bfe\u7167\u7fa4\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001PPI\u6295\u4e0e\u7fa4\u306e\u65b9\u304c\u6025\u6027\u814e\u969c\u5bb3\u767a\u75c7\u7387\u306f2.52\u500d\u3001\u6025\u6027\u9593\u8cea\u6027\u814e\u708e\u306f3.00\u500d\u3067\u3057\u305f\u3002<\/p>\n

\u307e\u305f\u30017\u4ef6\u306e\u89b3\u5bdf\u7814\u7a76\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09\u3067\u306f\u3001PPI\u4f7f\u7528\u60a3\u8005\u306b\u304a\u3051\u308b\u6025\u6027\u814e\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u306f1.61\u500d\u3067\u3057\u305f\u3002<\/p>\n

\u3055\u3089\u306b\u300111\u4ef6\u306ePPI\u4f7f\u7528\u306e\u6709\u7121\u304a\u3088\u3073H2\u30d6\u30ed\u30c3\u30ab\u30fc\u3068\u3092\u6bd4\u8f03\u3057\u305f\u7814\u7a76\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09\u3067\u306f\u3001PPI\u4f7f\u7528\u8005\u306f\u975e\u4f7f\u7528\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6162\u6027\u814e\u81d3\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u304c1.26\u500d\u3001PPI\u4f7f\u7528\u8005\u306fH2\u30d6\u30ed\u30c3\u30ab\u30fc\u4f7f\u7528\u8005\u3068\u6bd4\u8f03\u3057\u3066\u6162\u6027\u814e\u81d3\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u304c1.34\u500d\u3067\u3057\u305f\u3002<\/p>\n

\u4ed6\u306e\u7814\u7a76\u3082\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\uff08\u3053\u3053<\/a>\u53c2\u7167\u3001\u8868\u306f\u3053\u3053\u3088\u308a\u6539\u5909\uff09PPI\u306e\u4f7f\u7528\u3092\u65b0\u305f\u306b\u958b\u59cb\u3057\u305f\u3001\u814e\u75be\u60a3\u306e\u75c5\u6b74\u306e\u306a\u3044\u60a3\u8005572,661\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u6025\u6027\u9593\u8cea\u6027\u814e\u708e\uff08\u814e\u7d44\u7e54\u5b66\u7684\u691c\u67fb\u3067\u78ba\u5b9a\u3057\u305f46\u4eba\u3001\u8a18\u9332\u306e\u307f\u3067\u53ef\u80fd\u6027\u3042\u308a26\u4eba\uff09\u3068\u521d\u3081\u3066\u8a3a\u65ad\u3055\u308c\u305f72\u4eba\u3068\u3001\u751f\u5e74\u304a\u3088\u3073\u6027\u5225\u304c\u4e00\u81f4\u3059\u308b\u5bfe\u7167\u3068\u3092\u6bd4\u8f03\u3057\u305f\u7814\u7a76\u3067\u3059\u3002PPI\u306e\u4f7f\u7528\u306b\u3064\u3044\u3066\u306f\u3001\u4f7f\u7528\u7d42\u4e86\u5f8c 31\uff5e90\u65e5\u3092\u6700\u8fd1\u306e\u4f7f\u7528\u3001\u7d42\u4e86\u5f8c91\u65e5\u4ee5\u4e0a\u3092\u904e\u53bb\u306e\u4f7f\u7528\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4e0b\u306e\u8868\u306e\u3088\u3046\u306b\u3001PPI\u306e\u904e\u53bb\u306e\u4f7f\u7528\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001\u73fe\u5728\u306e\u4f7f\u7528\u306f\u3001\u78ba\u5b9a\u3057\u305f\u30b1\u30fc\u30b9\u3067\u306f\u3001\u6025\u6027\u9593\u8cea\u6027\u814e\u708e\u306e\u53ef\u80fd\u6027\u304c5.16\u500d\u3067\u3057\u305f\u3002<\/p>\n

\n
\n
\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n\u4e8b\u4f8b<\/th>\n\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/th>\n\u30de\u30c3\u30c1\u30f3\u30b0\u30aa\u30c3\u30ba\u6bd4\uff0895% CI\uff09<\/th>\n<\/tr>\n<\/thead>\n
\u78ba\u5b9a\u3057\u305f\u30b1\u30fc\u30b9<\/i><\/td>\n46\u4eba<\/i><\/td>\nn=460<\/i><\/td>\n<\/td>\n<\/tr>\n
\u73fe\u5728\u306e\u4f7f\u7528<\/td>\n35<\/td>\n207<\/td>\n5.16 (2.21\u201312.05)<\/span><\/td>\n<\/tr>\n
\u6700\u8fd1\u306e\u4f7f\u7528<\/td>\n4<\/td>\n56<\/td>\n2.38 (0.65\u20138.67)<\/td>\n<\/tr>\n
\u904e\u53bb\u306e\u4f7f\u7528<\/td>\n7<\/td>\n197<\/td>\n1.0<\/td>\n<\/tr>\n
\u3059\u3079\u3066\u306e\u30b1\u30fc\u30b9<\/i><\/td>\nn=72<\/i><\/td>\nn=719<\/i><\/td>\n<\/td>\n<\/tr>\n
\u73fe\u5728\u306e\u4f7f\u7528<\/td>\n55<\/td>\n332<\/td>\n4.82 (2.43\u20139.58)<\/span><\/td>\n<\/tr>\n
\u6700\u8fd1\u306e\u4f7f\u7528<\/td>\n5<\/td>\n89<\/td>\n1.72 (0.57\u20135.22)<\/td>\n<\/tr>\n
\u904e\u53bb\u306e\u4f7f\u7528<\/td>\n12<\/td>\n298<\/td>\n1.0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>
\n
\n
<\/div>\n<\/div>\n<\/figcaption><\/figure>\n<\/div>\n

\u3059\u3079\u3066\u306e\u30b1\u30fc\u30b9\u3092\u542b\u3081\u3066\u3082PPI\u306e\u73fe\u5728\u4f7f\u7528\uff48\u904e\u53bb\u306e\u4f7f\u7528\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6025\u6027\u9593\u8cea\u6027\u814e\u708e\u306e\u53ef\u80fd\u6027\u304c4.82\u500d\u3067\u3057\u305f\u3002<\/p>\n

\u4e0b\u306e\u8868\u306e\u3088\u3046\u306b\u3001\u6025\u6027\u9593\u8cea\u6027\u814e\u708e\u306e10\u4e07\u4eba\u5e74\u3042\u305f\u308a\u306e\u767a\u751f\u7387\u306f\u3001\u73fe\u5728\u4f7f\u7528\u8005\u3067\u306f\u904e\u53bb\u4f7f\u7528\u8005\u3068\u6bd4\u8f03\u3057\u3066\u5927\u5e45\u306b\u9ad8\u304f11.98\u4eba\u5bfe1.68\u4eba\u3067\u3057\u305f\u3002<\/div>\n
\n
\n
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n10\u4e07\u4eba\u5e74\u3042\u305f\u308a\u306e\u767a\u751f\u7387\uff0895%\u4fe1\u983c\u533a\u9593\uff09<\/th>\n<\/tr>\n<\/thead>\n
\u7814\u7a76\u30b3\u30db\u30fc\u30c8\u5168\u4f53<\/i><\/td>\n<\/td>\n<\/tr>\n
\u73fe\u5728\u306e\u4f7f\u7528<\/td>\n11.98 (9.11\u201315.47)<\/td>\n<\/tr>\n
\u6700\u8fd1\u306e\u4f7f\u7528<\/td>\n4.28 (1.57\u20139.49)<\/td>\n<\/tr>\n
\u904e\u53bb\u306e\u4f7f\u7528<\/td>\n1.68 (0.91\u20132.86)<\/td>\n<\/tr>\n
\u5e74\u9f62\uff08\u6b73\uff09\u5225\u306e\u73fe\u5728\u306e\u4f7f\u7528<\/i><\/td>\n<\/td>\n<\/tr>\n
15\uff5e49\u6b73<\/td>\n2.22 (0.56\u20136.03)<\/td>\n<\/tr>\n
50\uff5e59\u6b73<\/td>\n8.89 (4.33\u201316.31)<\/td>\n<\/tr>\n
60\uff5e69\u6b73<\/td>\n19.08 (11.83\u201329.25)<\/td>\n<\/tr>\n
70\uff5e79\u6b73<\/td>\n20.41 (11.86\u201332.92)<\/td>\n<\/tr>\n
80\u6b73\u4ee5\u4e0a<\/td>\n22.23 (10.84\u201340.79)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>
\n
\n
<\/div>\n<\/div>\n<\/figcaption><\/figure>\n<\/div>\n

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PPI\u3068\u4f75\u7528\u85ac\u306b\u3088\u308b\u6025\u6027\u814e\u969c\u5bb3\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\uff08\u3053\u3053<\/a>\u53c2\u7167\uff09\u3067\u306f\u3001\u814e\u75be\u60a3\u306e\u65e2\u5f80\u6b74\u306e\u306a\u3044\u60a3\u8005219,082\u4eba\uff08\u5e73\u5747\u5e74\u9f62\u306f45\u6b73\uff09\u304c\u5bfe\u8c61\u3067\u3057\u305f\u3002PPI\u306e\u904e\u53bb\u306e\u4f7f\u7528\u3068\u6bd4\u8f03\u3057\u3066\u3001PPI\u3092\u73fe\u5728\u4f7f\u7528\u3057\u3066\u3044\u308b\u5834\u5408\u306e\u6025\u6027\u814e\u969c\u5bb3\u306e\u53ef\u80fd\u6027\u306f2.79\u500d\u3067\u3057\u305f\u3002\u73fe\u5728\u306ePPI\u4f7f\u7528\u8005\u306b\u304a\u3051\u308bNSAIDs\u3001\u6297\u751f\u7269\u8cea\u306e\u30bb\u30d5\u30a1\u30ed\u30b9\u30dd\u30ea\u30f3\u3001\u30d5\u30eb\u30aa\u30ed\u30ad\u30ce\u30ed\u30f3\u306e\u4f75\u7528\u306b\u3088\u308b\u6025\u6027\u814e\u969c\u5bb3\u306e\u53ef\u80fd\u6027\u306fNSAIDs\u30673.12\u500d\u3001\u30bb\u30d5\u30a1\u30ed\u30b9\u30dd\u30ea\u30f31.88\u500d\u3001\u30d5\u30eb\u30aa\u30ed\u30ad\u30ce\u30ed\u30f32.35\u500d\u3067\u3057\u305f\u3002<\/p>\n

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