{"id":3165,"date":"2017-12-16T00:00:09","date_gmt":"2017-12-15T15:00:09","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=3165"},"modified":"2017-12-16T00:00:09","modified_gmt":"2017-12-15T15:00:09","slug":"post-3165","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=3165","title":{"rendered":"PPI\uff08\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff09\u306e\u6697\u9ed2\u9762\u3000\u305d\u306e1\u3000\u85ac\u3092\u6b62\u3081\u3089\u308c\u306a\u304f\u3059\u308b\u4ed5\u7d44\u307f"},"content":{"rendered":"<p>\u5c11\u3057\u524d\u306e\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u6c5f\u90e8\u5148\u751f\u306e\u30d6\u30ed\u30b0\u3067\u9006\u6d41\u6027\u98df\u9053\u708e\u306e\u65b9\u304c\u8cea\u554f\u3057\u3001\u305d\u308c\u306b\u6a2a\u304b\u3089\u5931\u793c\u3057\u3066\u3001\u30a2\u30c9\u30d0\u30a4\u30b9\u3092\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002\uff08\u305d\u306e\u8a18\u4e8b\u3078\u306e\u30b3\u30e1\u30f3\u30c8\u306f<a href=\"http:\/\/koujiebe.blog95.fc2.com\/blog-entry-4381.html#comment\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\uff09<\/p>\n<p>\u305d\u306e\u65b9\u306f\u3001\u9006\u6d41\u6027\u98df\u9053\u708e\u3067PPI\u3092\u4f7f\u7528\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u6c5f\u90e8\u5148\u751f\u306e\u30d6\u30ed\u30b0\u3067\u9006\u6d41\u6027\u98df\u9053\u708e\u306f\u7cd6\u8cea\u5236\u9650\u958b\u59cb\u5f8c\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306b\u6539\u5584\u3059\u308b\u3068\u306e\u3053\u3068\u3092\u8aad\u3093\u3067\u3001\u671f\u5f85\u3057\u3066\u7cd6\u8cea\u5236\u9650\u3092\u59cb\u3081\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u30b9\u30fc\u30d1\u30fc\u7cd6\u8cea\u5236\u9650\u958b\u59cb\u3057\u3066\u6570\u65e5\u5f8c\u306b\u3001\u6bce\u65e5\u670d\u7528\u3057\u3066\u3044\u305fPPI\u3092\u81ea\u5df1\u5224\u65ad\u3067\u4e2d\u65ad\u3057\u3066\u307f\u307e\u305f\u3068\u3053\u308d\u3001\u670d\u7528\u4e2d\u306f\u3082\u3061\u308d\u3093\u3001\u9006\u6d41\u6027\u98df\u9053\u708e\u6cbb\u7642\u4ee5\u524d\u3092\u542b\u3081\u3066\u5168\u304f\u81ea\u899a\u3057\u305f\u3053\u3068\u306e\u306a\u3044\u98df\u4e8b\u76f4\u5f8c\u306e\u5f37\u3044\u80f8\u713c\u3051\u3092\u3001\u98df\u4e8b\u306e\u5185\u5bb9\u30fb\u91cf\u306b\u95a2\u308f\u3089\u305a\u611f\u3058\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<p>\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001PPI\u4e2d\u6b62\u306b\u3088\u308b\u80c3\u9178\u5206\u6ccc\u306e\u30ea\u30d0\u30a6\u30f3\u30c9\u306f\u3001\u75c7\u72b6\u518d\u71c3\u3067\u306f\u306a\u304f\u526f\u4f5c\u7528\u3067\u3042\u308b\u3001\u3068\u3044\u3046\u8a71\u3092\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u306e\u65b9\u306f\u3001\u85ac\u3092\u3084\u3081\u305f\u307e\u307e\u7d4c\u904e\u3092\u307f\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u7d042\u9031\u9593\u5f8c\u306b\u5287\u7684\u306b\u6539\u5584\u3057\u305f\u3088\u3046\u3067\u3059\u3002\uff08\u305d\u306e\u8a18\u4e8b\u306f<a href=\"http:\/\/koujiebe.blog95.fc2.com\/blog-entry-4400.html\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\uff09<\/p>\n<p>PPI\u306f\u5f37\u529b\u306b\u80c3\u9178\u306e\u7523\u751f\u3092\u6291\u3048\u307e\u3059\u3002\u3067\u3059\u304b\u3089\u3001\u9006\u6d41\u3059\u308b\u80c3\u9178\u3082\u975e\u5e38\u306b\u5c11\u306a\u304f\u306a\u308b\u5834\u5408\u304c\u3042\u308a\u3001\u5287\u7684\u306b\u75c7\u72b6\u304c\u6539\u5584\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u4e2d\u6b62\u3092\u3059\u308b\u3068\u3001PPI\u3092\u98f2\u3080\u304d\u3063\u304b\u3051\u3068\u306a\u3063\u305f\u80f8\u3084\u3051\u306a\u3069\u306e\u75c7\u72b6\u304c\u975e\u5e38\u306b\u5f37\u304f\u51fa\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3053\u3068\u3092\u75c7\u72b6\u304c\u300c\u518d\u71c3\u300d\u3057\u305f\u3068\u6349\u3048\u308b\u3068\u3001\u4e00\u751fPPI\u3092\u98f2\u307f\u7d9a\u3051\u308b\u7834\u76ee\u306b\u306a\u308a\u307e\u3059\u3002PPI\u4e2d\u6b62\u5f8c\u306e\u9006\u6d41\u75c7\u72b6\u306f\u300c\u518d\u71c3\u300d\u3067\u306f\u306a\u304f\u3001PPI\u3092\u98f2\u3093\u3060\u3053\u3068\u306b\u3088\u308b\u526f\u4f5c\u7528\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306a\u73fe\u8c61\u306fRAHS\uff08Rebound acid hypersecretion\uff1a\u30ea\u30d0\u30a6\u30f3\u30c9\u80c3\u9178\u904e\u591a\u5206\u6ccc\uff09\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u975e\u5e38\u306b\u91cd\u8981\u306a\u526f\u4f5c\u7528\u306a\u306e\u3067\u3059\u3002\u5065\u5eb7\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u3092\u4f7f\u3063\u305f\u7814\u7a76\u3067\u3082\u975e\u5e38\u306b\u9ad8\u983b\u5ea6\u306b\u73fe\u308c\u308b\u526f\u4f5c\u7528\u3067\u3059\u3002<\/p>\n<p><span style=\"color: #0000ff;\">\u300cProton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy\u300d<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u300c\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264\u7642\u6cd5\u306f\u3001\u6cbb\u7642\u3092\u4e2d\u6b62\u3057\u305f\u5f8c\u3001\u5065\u5eb7\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u306b\u9178\u95a2\u9023\u75c7\u72b6\u3092\u8a98\u767a\u3059\u308b\u300d\uff08\u539f\u6587\u306f<a style=\"color: #0000ff;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19362552\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u80cc\u666f\u304a\u3088\u3073\u76ee\u7684\uff1a\u30ea\u30d0\u30f3\u30c9\u9178\u5206\u6ccc\u904e\u591a\uff08RAHS\uff09\u306f\u30018\u9031\u9593\u306e\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264\uff08PPI\uff09\u3067\u306e\u6cbb\u7642\u5f8c\u306b\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u308b\u3002 RAHS\u304c\u9178\u95a2\u9023\u75c7\u72b6\u3092\u8a98\u767a\u3059\u308b\u5834\u5408\u3001\u3053\u308c\u306fPPI\u4f9d\u5b58\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3057\u305f\u304c\u3063\u3066\u91cd\u8981\u306a\u610f\u5473\u3092\u6709\u3059\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u65b9\u6cd5\uff1a120\u4eba\u306e\u5065\u5eb7\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7121\u4f5c\u70ba\u5316\u3001\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u305f\u3002\u53c2\u52a0\u8005\u306f12\u9031\u9593\u306e\u30d7\u30e9\u30bb\u30dc\u307e\u305f\u306f8\u9031\u9593\u306e\u30a8\u30bd\u30e1\u30d7\u30e9\u30be\u30fc\u30eb40mg \/\u65e5\u3001\u7d9a\u3044\u30664\u9031\u9593\u306e\u30d7\u30e9\u30bb\u30dc\u3067\u7121\u4f5c\u70ba\u5316\u3055\u308c\u305f\u3002\u80c3\u8178\u75c7\u72b6\u8a55\u4fa1\u5c3a\u5ea6\uff08GSRS\uff09\u306f\u6bce\u9031\u8a18\u5165\u3055\u308c\u305f\u3002\u80f8\u713c\u3051\u3001\u9178\u9006\u6d41\u3001\u307e\u305f\u306f\u6d88\u5316\u4e0d\u826f\u306b\u95a2\u3059\u308b\u8cea\u554f\u306e1\/2\u306e\u30b9\u30b3\u30a2\u306f\u3001\u81e8\u5e8a\u7684\u306b\u95a2\u9023\u3059\u308b\u9178\u95a2\u9023\u75c7\u72b6\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u7d50\u679c\uff1aGSRS\u30b9\u30b3\u30a2\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u30b0\u30eb\u30fc\u30d7\u9593\u306b\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\u3002\u9178\u95a2\u9023\u75c7\u72b6\u306eGSRS\u30b9\u30b3\u30a2\u306f\u3001PPI\u7fa4\u306710\u9031\u76ee\uff081.4\u5bfe1.2\uff09\u300111\u9031\u76ee\uff081.4\u5bfe1.2\uff09\u3001\u304a\u3088\u307312\u9031\u76ee\uff081.3\u5bfe1.0\uff09\u3002PPI\u7fa4\u306e\u60a3\u8005\u306e44\uff05\uff0826\/59\uff09\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e15\uff05\uff089\/59\uff09\u3068\u6bd4\u8f03\u3057\u3066\u30019\u301c12\u9031\u3067\u95a2\u9023\u3059\u308b\u9178\u95a2\u9023\u75c7\u72b6\u3092\u5831\u544a\u3057\u305f\u3002 PPI\u7fa4\u306e\u6d88\u5316\u4e0d\u826f\u3001\u80f8\u3084\u3051\u3001\u9178\u9006\u6d41\u306e\u5272\u5408\u306f\u300110\u9031\u306759\u4f8b\uff0822\uff05\uff09\u300111\u9031\u306759\u4f8b\uff0822\uff05\uff09\u300112\u9031\u306758\u4f8b\u4e2d12\u4f8b\uff0821\uff05\uff09\u3067\u3042\u3063\u305f\u3002\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f\u300110\u9031\u76ee\u30677\uff05\u300111\u9031\u76ee\u30675\uff05\u3001\u304a\u3088\u307312\u9031\u76ee\u30672\uff05\u3067\u3042\u3063\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u7d50\u8ad6\uff1a8\u9031\u9593\u306ePPI\u7642\u6cd5\u306f\u3001\u6cbb\u7642\u4e2d\u6b62\u5f8c\u3001\u5065\u5eb7\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u306b\u9178\u95a2\u9023\u75c7\u72b6\u3092\u8a98\u767a\u3059\u308b\u3002\u3053\u306e\u7814\u7a76\u306f\u3001PPI\u96e2\u8131\u306e\u8a8d\u8b58\u3055\u308c\u306a\u3044\u5074\u9762\u3092\u793a\u3057\u3001RAHS\u304c\u81e8\u5e8a\u4e0a\u306e\u610f\u5473\u3092\u6709\u3059\u308b\u3068\u3044\u3046\u4eee\u8aac\u3092\u652f\u6301\u3059\u308b\u3002<\/span><\/p>\n<p>\u3064\u307e\u308a\u3001\u3082\u3068\u3082\u3068\u75c7\u72b6\u304c\u306a\u3044\u4eba\u3067\u3082\u3001PPI\u30928\u9031\u9593\u4f7f\u7528\u3059\u308b\u3068\u3001\u305d\u306e\u5f8c\u4e2d\u6b62\u3057\u305f\u3068\u304d\u306b\u534a\u6570\u8fd1\u304f\u306b\u3001\u80f8\u713c\u3051\u306a\u3069\u306e\u80c3\u9178\u9006\u6d41\u75c7\u72b6\u304c\u8d77\u3053\u308b\u306e\u3067\u3059\u3002\u3057\u304b\u3082\u3001\u4e2d\u6b62\u5f8c4\u9031\u9593\u5f8c\u3067\u3082\u3053\u306e\u30ea\u30d0\u30a6\u30f3\u30c9\u75c7\u72b6\u306f\u6301\u7d9a\u3057\u3066\u3044\u308b\u4eba\u304c\u304a\u308a\u3001\u9577\u304f\u7d99\u7d9a\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4ed6\u306e\u7814\u7a76\u3067\u306f8\u9031\u9593\u6301\u7d9a\u3059\u308b\u3068\u3044\u3046\u3082\u306e\u304c\u3042\u308b\u3088\u3046\u3067\u3059\u3002\u3082\u3068\u3082\u3068\u75c7\u72b6\u304c\u306a\u3044\u306e\u3067\u3059\u304b\u3089\u3001\u300c\u518d\u71c3\u300d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u660e\u3089\u304b\u306bPPI\u304c\u8d77\u3053\u3057\u305f\u526f\u4f5c\u7528\u3067\u3059\u3002<\/p>\n<p>\u4eba\u9593\u306e\u4f53\u306f\u30db\u30e1\u30aa\u30b9\u30bf\u30b7\u30b9\u3068\u3044\u3063\u3066\u3001\u5e38\u306b\u4e00\u5b9a\u306e\u72b6\u614b\u306b\u4fdd\u3068\u3046\u3068\u3044\u3046\u4ed5\u7d44\u307f\u304c\u3042\u308a\u307e\u3059\u3002\u4eba\u9593\u306b\u3068\u3063\u3066\u80c3\u9178\u304c\u51fa\u308b\u3053\u3068\u306f\u5f53\u305f\u308a\u524d\u306e\u73fe\u8c61\u3067\u3059\u3002\u305d\u308c\u3092\u85ac\u3067\u7121\u7406\u3084\u308a\u6b62\u3081\u3066\u3057\u307e\u3046\u3068\u3001\u4eba\u9593\u306e\u4f53\u306f\u300c\u80c3\u9178\u304c\u8db3\u308a\u306a\u3044\uff01\u3082\u3063\u3068\u4f5c\u3089\u306a\u304d\u3083\uff01\u300d\u3068\u3044\u3046\u53cd\u5fdc\u3092\u8d77\u3053\u3057\u3001\u4ee3\u511f\u6027\u306b\u30ac\u30b9\u30c8\u30ea\u30f3\u304c\u5897\u52a0\u3057\u3001\u80c3\u9178\u3092\u5206\u6ccc\u3059\u308b\u7d30\u80de\u3092\u904e\u5270\u306b\u5897\u52a0\u3055\u305b\u307e\u3059\u3002\u305d\u308c\u306b\u3088\u308a\u3001\u4e2d\u6b62\u5f8c\u306b\u80c3\u9178\u304c\u904e\u5270\u5206\u6ccc\u306b\u306a\u308b\u306e\u3067\u3059\u3002\uff08\u56f3\u306f<a href=\"http:\/\/www.gastrojournal.org\/article\/S0016-5085(09)00780-X\/abstract\" target=\"_blank\" rel=\"noopener\">\u3053\u306e\u8ad6\u6587<\/a>\u3088\u308a\u6539\u5909\uff09<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/12\/9430a654cd5d017ce3e82a80d9506c73.png\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"3169\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=3169\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/12\/9430a654cd5d017ce3e82a80d9506c73.png?fit=981%2C824&amp;ssl=1\" data-orig-size=\"981,824\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"PPI\u9ad8\u30ac\u30b9\u30c8\u30ea\u30f3\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/12\/9430a654cd5d017ce3e82a80d9506c73.png?fit=300%2C252&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2017\/12\/9430a654cd5d017ce3e82a80d9506c73.png?fit=640%2C538&amp;ssl=1\" class=\"alignnone size-medium wp-image-3169\" 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\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>to be continued\u2026<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5c11\u3057\u524d\u306e\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u6c5f\u90e8\u5148\u751f\u306e\u30d6\u30ed\u30b0\u3067\u9006\u6d41\u6027\u98df\u9053\u708e\u306e\u65b9\u304c\u8cea\u554f\u3057\u3001\u305d\u308c\u306b\u6a2a\u304b\u3089\u5931\u793c\u3057\u3066\u3001\u30a2\u30c9\u30d0\u30a4\u30b9\u3092\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002\uff08\u305d\u306e\u8a18\u4e8b\u3078\u306e\u30b3\u30e1\u30f3\u30c8\u306f\u3053\u3053\uff09 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