{"id":31718,"date":"2025-08-29T10:54:32","date_gmt":"2025-08-29T01:54:32","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=31718"},"modified":"2025-08-29T10:54:32","modified_gmt":"2025-08-29T01:54:32","slug":"%e5%bc%b7%e5%8c%96%e8%84%82%e8%b3%aa%e4%bd%8e%e4%b8%8b%e7%99%82%e6%b3%95%e3%81%a7ldl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e3%82%92%e5%a4%a7%e3%81%8d%e3%81%8f%e4%b8%8b","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=31718","title":{"rendered":"\u5f37\u5316\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5927\u304d\u304f\u4e0b\u3052\u3066\u3082\u52b9\u679c\u306f\u307b\u3068\u3093\u3069\u306a\u3044"},"content":{"rendered":"

\u591a\u304f\u306e\u7814\u7a76\u306f\u76f8\u5bfe\u30ea\u30b9\u30af\u3092\u793a\u3057\u3066\u3001\u904e\u5927\u8a55\u4fa1\u3092\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u5b9f\u969b\u306b\u306f\u76ee\u304f\u305d\u9f3b\u304f\u305d\u30ec\u30d9\u30eb\u306e\u52b9\u679c\u3057\u304b\u306a\u3044\u306e\u306b\u3001\u5927\u304d\u306a\u52b9\u679c\u304c\u3042\u308b\u3088\u3046\u306b\u898b\u305b\u3001\u305d\u308c\u3092\u771f\u306b\u53d7\u3051\u3066\u3057\u307e\u3046\u4eba\u3082\u591a\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n

LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u60aa\u7389\u3067\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u5c11\u306a\u3051\u308c\u3070\u5c11\u306a\u3044\u307b\u3069\u826f\u3044\u306e\u3067\u3042\u308c\u3070\u3001\u30b9\u30bf\u30c1\u30f3\u3084\u4ed6\u306e\u85ac\u3067\u30ac\u30c3\u30c4\u30ea\u3068\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4e0b\u3052\u308c\u3070\u3001\u3055\u305e\u304b\u3057\u591a\u304f\u306e\u4eba\u304c\u52a9\u304b\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u5f37\u5316\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3068\u6a19\u6e96\u7684\u306a\u85ac\u7269\u7642\u6cd5\u306e\u9055\u3044\u3092\u5206\u6790\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u5bfe\u8c61\u3068\u306a\u3063\u305f11\u4ef6\u306e\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u4ecb\u5165\u7fa4\u306f\u305d\u308c\u305e\u308c\u7570\u306a\u308b\u5f37\u5316\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u3066\u307e\u3057\u305f\u30024\u4ef6\u306e\u8a66\u9a13\u3067\u306f\u3088\u308a\u5f37\u529b\u307e\u305f\u306f\u9ad8\u7528\u91cf\u306e\u30b9\u30bf\u30c1\u30f3\u30011\u4ef6\u306e\u8a66\u9a13\u3067\u306f\u30a8\u30bc\u30c1\u30df\u30d6\u30016\u4ef6\u306e\u8a66\u9a13\u3067\u306fPCSK9\u963b\u5bb3\u85ac\u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\n
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u6210\u679c<\/th>\n\u6a19\u6e96\u7684\u306a\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306b\u3088\u308b1000\u4eba\u3042\u305f\u308a\u306e\u60f3\u5b9a\u30ea\u30b9\u30af<\/th>\n1000\u4eba\u3042\u305f\u308a\u306e\u5f37\u5316\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306b\u3088\u308b\u30ea\u30b9\u30af\uff0895% CI\uff09<\/th>\n\u6642\u9593\u306e\u7d4c\u904e\u306b\u4f34\u3046\u30ea\u30b9\u30af\u6bd4\uff08HR; 95% CI\uff09<\/th>\n\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u8005\u306e\u5272\u5408\u306e\u6e1b\u5c11 (95% CI)<\/th>\n\u30a4\u30d9\u30f3\u30c8\u307e\u3067\u306e\u5e73\u5747\u9045\u5ef6\u65e5\u6570\uff0895\uff05CI\uff09<\/th>\n<\/tr>\n<\/thead>\n
2\u5e74\u9593\u306e\u8ffd\u8de1\u8abf\u67fb<\/td>\n<\/tr>\n
MACE<\/td>\n104<\/td>\n91\uff0886\u304b\u308995\uff09<\/td>\n0.87 (0.82\u304b\u30890.91)<\/td>\n1.1\uff080.7\uff5e1.5\uff09<\/td>\n4.1\uff082.6\u304b\u30895.6\uff09<\/td>\n<\/tr>\n
\u5fc3\u7b4b\u6897\u585e<\/td>\n55<\/td>\n48\uff0844\u304b\u308951\uff09<\/td>\n0.86\uff080.80\u304b\u30890.93\uff09<\/td>\n0.7\uff080.4\u304b\u30890.9\uff09<\/td>\n2.5\uff081.6\uff5e3.3\uff09<\/td>\n<\/tr>\n
\u8133\u5352\u4e2d<\/td>\n14<\/td>\n12\uff0811\uff5e13\uff09<\/td>\n0.83 (0.76\u304b\u30890.90)<\/td>\n0.2\uff080.1\uff5e0.3\uff09<\/td>\n0.9\uff080.5\uff5e1.2\uff09<\/td>\n<\/tr>\n
\u5168\u6b7b\u4ea1\u7387<\/td>\n42<\/td>\n40\uff0838\uff5e42\uff09<\/td>\n0.97\uff080.92\u304b\u30891.02\uff09<\/td>\n0.2 (-0.1 \uff5e 0.4)<\/td>\n0.6\uff08\u22120.4\uff5e1.5\uff09<\/td>\n<\/tr>\n
5\u5e74\u9593\u306e\u8ffd\u8de1\u8abf\u67fb<\/td>\n<\/tr>\n
MACE<\/td>\n236<\/td>\n208\uff08198\u304b\u3089218\uff09<\/td>\n0.87 (0.82\u304b\u30890.91)<\/td>\n2.4\uff081.5\uff5e3.3\uff09<\/td>\n23.5\uff0814.9\u304b\u308932.0\uff09<\/td>\n<\/tr>\n
\u5fc3\u7b4b\u6897\u585e<\/td>\n132<\/td>\n115\uff08107\u304b\u3089123\uff09<\/td>\n0.86\uff080.80\u304b\u30890.93\uff09<\/td>\n1.5\uff081.0\u304b\u30892.1\uff09<\/td>\n14.6\uff089.3\u304b\u308920.0\uff09<\/td>\n<\/tr>\n
\u8133\u5352\u4e2d<\/td>\n36<\/td>\n30\uff0828\uff5e32\uff09<\/td>\n0.83 (0.76\u304b\u30890.90)<\/td>\n0.6\uff080.4\u304b\u30890.8\uff09<\/td>\n5.3\uff083.3\u304b\u30897.4\uff09<\/td>\n<\/tr>\n
\u5168\u6b7b\u4ea1\u7387<\/td>\n102<\/td>\n99\uff0895\u304b\u3089104\uff09<\/td>\n0.97\uff080.92\u304b\u30891.02\uff09<\/td>\n0.4\uff08-0.2\uff5e1.0\uff09<\/td>\n3.6 (-2.1\u304b\u30899.2)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n
MACE\uff1a\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8<\/div>\n

\u4e0a\u306e\u8868\u306e\u3088\u3046\u306b\u30012\u5e74\u9593\u306e\u5f37\u5316\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u7d4c\u904e\u4e2d\u306b\u6a19\u6e96\u7684\u306a\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u3001\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u3092\u767a\u75c7\u3057\u305f\u60a3\u8005\u6570\u304c1.1%\u5c11\u306a\u304f\u3001MACE\u304c\u8d77\u304d\u308b\u307e\u3067\u306e\u671f\u9593\u304c4.1\u65e5\u9045\u308c\u307e\u3057\u305f\u3002\u76f8\u5bfe\u30ea\u30b9\u30af\u3092\u898b\u308b\u306813\uff05\u306e\u4f4e\u4e0b\u3067\u3059\u3002\u76f8\u5bfe\u7684\u306b\u306f\u7d76\u5bfe\u7684\u306a\u30ea\u30b9\u30af\u3088\u308a10\u500d\u4ee5\u4e0a\u904e\u5927\u8a55\u4fa1\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u5fc3\u7b4b\u6897\u585e\u3067\u306f0.7%\u5c11\u306a\u304f\u30012.5\u65e5\u9045\u308c\u3001\u3001\u8133\u5352\u4e2d\u3067\u306f0.2%\u5c11\u306a\u304f\u30010.9\u65e5\u9045\u308c\u3001\u5168\u539f\u56e0\u6b7b\u4ea1\u306f0.2%\u5c11\u306a\u304f\u30010.6\u65e5\u9045\u308c\u308b\u3060\u3051\u3067\u3057\u305f\u3002\u79c1\u306b\u306f\u8aa4\u5dee\u7bc4\u56f2\u306b\u3057\u304b\u898b\u3048\u307e\u305b\u3093\u3002\u6b7b\u4ea1\u3059\u308b\u5272\u5408\u306f1000\u4eba\u4e2d2\u4eba\u3057\u304b\u9055\u3044\u304c\u306a\u3044\u306e\u3067\u3059\u304b\u3089\u3002<\/p>\n

\u5e73\u57475\u5e74\u9593\u306e\u5f37\u5316\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3067\u306f\u3001\u6a19\u6e96\u7684\u306a\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3068\u6bd4\u8f03\u3057\u3066MACE\u3092\u767a\u75c7\u3057\u305f\u60a3\u8005\u304c2.4%\u6e1b\u5c11\u3057\u3001MACE\u767a\u75c7\u307e\u3067\u306e\u671f\u9593\u306f23.5\u65e5\u9045\u5ef6\u3057\u307e\u3057\u305f\u3002\u5fc3\u7b4b\u6897\u585e\u3067\u306f1.5\uff05\u5c11\u306a\u304f\u300114.6\u65e5\u9045\u308c\u3001\u8133\u5352\u4e2d\u3067\u306f0.6\uff05\u5c11\u306a\u304f\u30015.3\u65e5\u9045\u308c\u3001\u5168\u539f\u56e0\u6b7b\u4ea1\u3067\u306f0.4\uff05\u5c11\u306a\u304f\u30013.6\u65e5\u9045\u308c\u3067\u3057\u305f\u3002\u307e\u3055\u306b\u76ee\u304f\u305d\u9f3b\u304f\u305d\u3067\u3059\u306d\u3002<\/p>\n

\u5f37\u529b\u306a\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u884c\u3063\u3066\u3082\u3001\u6b7b\u4ea1\u6570\u306e\u6e1b\u5c11\u3084\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u306b\u306f\u3064\u306a\u304c\u3089\u305a\u3001\u5fc3\u7b4b\u6897\u585e\u304a\u3088\u3073\u8133\u5352\u4e2d\u3078\u306e\u5f71\u97ff\u306f\u7121\u8996\u3067\u304d\u308b\u307b\u3069\u5c0f\u3055\u3044\u306e\u3067\u3059\u3002\u3053\u306e\u3053\u3068\u3092\u3061\u3083\u3093\u3068\u60a3\u8005\u306b\u4f1d\u3048\u308c\u3070\u3001\u3053\u306e\u3088\u3046\u306a\u6cbb\u7642\u3092\u9078\u629e\u3059\u308b\u60a3\u8005\u306f\u304b\u306a\u308a\u5c11\u306a\u304f\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u307e\u3042\u3001\u3082\u3068\u3082\u3068LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u539f\u56e0\u3067\u306f\u306a\u3044\u3067\u3059\u304b\u3089\u306d\u3002<\/p>\n

\u5f37\u529b\u306a\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u884c\u3048\u3070\u3001\u305d\u306e\u5206\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u3082\u5927\u304d\u304f\u306a\u308a\u307e\u3059\u3002\u533b\u7642\u5074\u304c\u305d\u308c\u304c\u72d9\u3044\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u300cTime Gained to Cardiovascular Disease by Intensive Lipid-Lowering Therapy: Results of Individual Placebo-Controlled Trials and Pooled Effects\u300d<\/span><\/p>\n

\u300c\u5f37\u5316\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u75be\u60a3\u767a\u75c7\u307e\u3067\u306e\u671f\u9593\u306e\u77ed\u7e2e\uff1a\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3068\u7d71\u5408\u52b9\u679c\u306e\u7d50\u679c\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u591a\u304f\u306e\u7814\u7a76\u306f\u76f8\u5bfe\u30ea\u30b9\u30af\u3092\u793a\u3057\u3066\u3001\u904e\u5927\u8a55\u4fa1\u3092\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u5b9f\u969b\u306b\u306f\u76ee\u304f\u305d\u9f3b\u304f\u305d\u30ec\u30d9\u30eb\u306e\u52b9\u679c\u3057\u304b\u306a\u3044\u306e\u306b\u3001\u5927\u304d\u306a\u52b9\u679c\u304c\u3042\u308b\u3088\u3046\u306b\u898b\u305b\u3001\u305d\u308c\u3092\u771f\u306b\u53d7\u3051\u3066\u3057\u307e\u3046\u4eba\u3082\u591a\u3044\u3067\u3057\u3087\u3046\u3002 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