{"id":32157,"date":"2025-09-04T08:30:50","date_gmt":"2025-09-03T23:30:50","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=32157"},"modified":"2025-09-04T08:30:50","modified_gmt":"2025-09-03T23:30:50","slug":"%e4%b8%ad%e6%80%a7%e8%84%82%e8%82%aa%e3%82%92%e4%b8%8b%e3%81%92%e3%82%8b%e8%96%ac%e3%82%aa%e3%83%ac%e3%82%b6%e3%83%ab%e3%82%bb%e3%83%b3%e3%81%ae%e5%8a%b9%e6%9e%9c","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=32157","title":{"rendered":"\u4e2d\u6027\u8102\u80aa\u3092\u4e0b\u3052\u308b\u85ac\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u306e\u52b9\u679c"},"content":{"rendered":"

LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4e0b\u3052\u308b\u85ac\u30b9\u30bf\u30c1\u30f3\u3060\u3051\u3067\u306f\u98fd\u304d\u8db3\u3089\u305a\u3001\u88fd\u85ac\u4f1a\u793e\u306fLp(a)\u3092\u4e0b\u3052\u308b\u85ac\u3092\u958b\u767a\u3057\u3001\u4eca\u5ea6\u306f\u4e2d\u6027\u8102\u80aa\u3092\u4e0b\u3052\u308b\u85ac\u3092\u51fa\u3057\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u78ba\u304b\u306b\u9ad8\u4e2d\u6027\u8102\u80aa\u306f\u826f\u3044\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u306e\u3067\u3001\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306f\u5fc5\u8981\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u7b2c3\u76f8\u56fd\u969b\u4e8c\u91cd\u76f2\u691c\u30e9\u30f3\u30c0\u30e0\u5316\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u306e\u7d50\u679c\u3067\u3059\u3002\u3053\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u4e2d\u7b49\u5ea6\u306e\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\uff08\u4e2d\u6027\u8102\u80aa\u5024150\uff5e499 mg\/dL\uff09\u3067\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u3001\u307e\u305f\u306f\u91cd\u5ea6\u306e\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\uff08\u4e2d\u6027\u8102\u80aa\u5024500 mg\/dL\u4ee5\u4e0a\uff09\u306e\u60a3\u8005\u3092\u767b\u9332\u3057\u3001\u67081\u56de\u306e\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u76ae\u4e0b\u6295\u4e0e\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u67081\u56de\u306e\u6295\u4e0e\u3067\u6e08\u3080\u3068\u3044\u3046\u3053\u3068\u306f\u5229\u4fbf\u6027\u306f\u826f\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u526f\u4f5c\u7528\u304c\u8d77\u304d\u308c\u3070\u30011\u304b\u6708\u526f\u4f5c\u7528\u304b\u3089\u9003\u308c\u3089\u308c\u306a\u3044\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u306d\u3002<\/p>\n

\u5408\u8a081349\u4eba\u306e\u60a3\u8005\uff08\u30aa\u30ec\u30b6\u30eb\u30bb\u30f350mg\u7fa4254\u4eba\u3001\u30aa\u30ec\u30b6\u30eb\u30bb\u30f380mg\u7fa4766\u4eba\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4329\u4eba\uff09\u304c\u5bfe\u8c61\u3067\u3001\u5e74\u9f62\u306e\u4e2d\u592e\u5024\u306f64\u6b73\u3001\u60a3\u8005\u306e40%\u304c\u5973\u6027\u3067\u3057\u305f\u3002<\/p>\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u4e2d\u6027\u8102\u80aa\u5024\u306e\u4e2d\u592e\u5024\u306f238.5mg\/dL\u3067\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306eA\u306f12\u304b\u6708\u9593\u306e\u4e2d\u6027\u8102\u80aa\u5024\u306e\u63a8\u79fb\u3067\u3059\u3002\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u7fa4\u306f\u3069\u3061\u3089\u308228\u65e5\u5f8c\u306b\u306f\u5927\u304d\u304f\u4e2d\u6027\u8102\u80aa\u5024\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u5f8c\u306f\u5c11\u3057\u4f4e\u4e0b\u3057\u307e\u3059\u304c\u3001\u6a2a\u3070\u3044\u3067\u3059\u3002<\/p>\n

B\u306b\u793a\u3059\u3088\u3046\u306b\u30016\u304b\u6708\u6642\u70b9\u306e\u30d7\u30e9\u30bb\u30dc\u8abf\u6574\u5f8c\u4e2d\u6027\u8102\u80aa\u5024\u306e\u5909\u5316\u5e73\u5747\u5024\u306f\u3001\u30aa\u30ec\u30b6\u30eb\u30bb\u30f350mg\u7fa4\u3067-58.4\u30d1\u30fc\u30bb\u30f3\u30c8\u30dd\u30a4\u30f3\u30c8\u3001\u30aa\u30ec\u30b6\u30eb\u30bb\u30f380mg\u7fa4\u3067-60.6\u30d1\u30fc\u30bb\u30f3\u30c8\u30dd\u30a4\u30f3\u30c8\u3067\u3057\u305f\u3002
\n\u305d\u308c\u4ee5\u5916\u306e\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001VLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306a\u3069\u3082\u5927\u304d\u304f\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5927\u304d\u304f\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u6b63\u76f4\u8a00\u3063\u3066\u7406\u60f3\u7684\u306a\u5909\u5316\u3067\u3059\u306d\u3002\u4e2d\u6027\u8102\u80aa\u304c\u4f4e\u4e0b\u3057\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u3082\u6e1b\u5c11\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5897\u52a0\u3068\u3044\u3046\u5909\u5316\u3067\u3059\u304b\u3089\u3002<\/p>\n

\u3053\u306e\u85ac\u3001\u4e2d\u6027\u8102\u80aa\u306e\u9664\u53bb\u3092\u963b\u5bb3\u3059\u308b\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaC-III\uff08ApoC\u2162\uff09\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u4e0a\u306e\u56f3\u3067\u3082ApoC\u2162\u306f\u5927\u304d\u304f\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u7814\u7a76\u8ad6\u6587\u306e\u8981\u65e8\u306e\u6700\u521d\u306e\u6587\u7ae0\u306f\u6b21\u306e\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u300cHighly effective therapies to reduce triglyceride levels are lacking. \u300d<\/span><\/p>\n

\u300c\u4e2d\u6027\u8102\u80aa\u5024\u3092\u4e0b\u3052\u308b\u305f\u3081\u306e\u975e\u5e38\u306b\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6cd5\u306f\u672a\u3060\u5b58\u5728\u3057\u306a\u3044\u300d<\/span><\/p>\n

\u307e\u3055\u306b\u3001\u3053\u308c\u304c\u4eca\u306e\u533b\u7642\u306e\u554f\u984c\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u4e2d\u6027\u8102\u80aa\u5024\u3092\u4e0b\u3052\u308b\u305f\u3081\u306e\u975e\u5e38\u306b\u52b9\u679c\u7684\u306a\u300c\u6cbb\u7642\u6cd5\u300d\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u4e2d\u6027\u8102\u80aa\u5024\u3092\u4e0b\u3052\u308b\u305f\u3081\u306e\u975e\u5e38\u306b\u52b9\u679c\u7684\u306a\u300c\u98df\u4e8b\u6cd5\u300d\u306f\u305a\u3063\u3068\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u98df\u4e8b\u6cd5\u306f\u7cd6\u8cea\u5236\u9650\u3067\u3059\u3002\u52b9\u679c\u7684\u306a\u98df\u4e8b\u6cd5\u306f\u7121\u8996\u3057\u3066\u3001\u85ac\u3092\u60a3\u8005\u306b\u98f2\u307e\u305b\u305f\u3044\u306e\u3067\u3057\u3087\u3046\u306d\u3002<\/p>\n

ApoC\u2162\u306fAPOC3\u306e\u907a\u4f1d\u5b50\u306b\u30b3\u30fc\u30c9\u3055\u308c\u3066\u3044\u3066\u3001APOC3\u306f\u7cd6\u8cea\u306b\u3088\u3063\u3066\u5897\u52a0\u3057\u307e\u3059\u3002\u300cApoC\u2162\u7523\u751f\u901f\u5ea6\u306e\u5897\u52a0\u304c\u4e2d\u6027\u8102\u80aa\u5024\u3092\u9ad8\u304f\u3057\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u306a\u3044<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u7cd6\u8cea\u6442\u53d6\u2192ChREBP\u6d3b\u6027\u5316\u2192ApoC\u2162\u5897\u52a0\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

ApoC\u2162\u306f\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u3001VLDL\u3084LDL\u306b\u304f\u3063\u3064\u304f\u3053\u3068\u306b\u3088\u308a\u3001LPL\u6d3b\u6027\u304c\u4e0b\u304c\u308b\u306e\u3067\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u3092\u4f5c\u308b\u539f\u56e0\u3068\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u307e\u305fHDL\u306b\u304f\u3063\u3064\u304f\u3068\u5f15\u304d\u629c\u304d\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u6a5f\u80fd\u4e0d\u5168\u306eHDL\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n

\u4ee5\u524d\u306e\u8a18\u4e8b\u300cApoC\u2162\u306e\u8abf\u7bc0\u3068\u5f79\u5272<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u73fe\u4ee3\u306e\u98df\u4e8b\u3001\u3064\u307e\u308a\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u98df\u3067\u306fApoC\u2162\u306f\u300c\u60aa\u7389\u300d\u3067\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u304cApoC\u2162\u306e\u7570\u5e38\u306a\u5897\u52a0\u3092\u751f\u3093\u3067\u3044\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u7279\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u3042\u307e\u308a\u523a\u6fc0\u3057\u306a\u3044\u679c\u7cd6\u306e\u6442\u53d6\u304cApoC\u2162\u3092\u5927\u304d\u304f\u5897\u52a0\u3055\u305b\u307e\u3059\u3002\uff08\u300c\u679c\u7cd6\u306f\u30d6\u30c9\u30a6\u7cd6\u3088\u308a\u3082ApoCIII\u3092\u5927\u5e45\u306b\u5897\u52a0\u3055\u305b\u308b<\/a>\u300d\u53c2\u7167\uff09<\/p>\n

\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u3001ApoC\u2162\u304c\u6b20\u640d\u3057\u3066\u3044\u308b\u3068\u8102\u80aa\u306e\u7570\u5e38\u306a\u84c4\u7a4d\u3001\u4f53\u91cd\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002ApoC\u2162\u3092\u963b\u5bb3\u3059\u308b\u3001\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u3092\u6295\u4e0e\u3067\u4eba\u9593\u304c\u3069\u3046\u306a\u308b\u306e\u304b\u306f\u307e\u3060\u308f\u304b\u308a\u307e\u305b\u3093\u3002\u4e00\u5fdc\u3001\u88fd\u85ac\u4f1a\u793e\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u73fe\u7387\u306f\u3001\u4e21\u8a66\u9a13\u7fa4\u3067\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3001\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u4e2d\u8eab\u306f\u79c1\u306f\u78ba\u8a8d\u3067\u304d\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u540c\u3058\u3067\u3001ApoC\u2162\u305d\u306e\u3082\u306e\u304c\u300c\u60aa\u7389\u300d\u3067\u306f\u306a\u304f\u3001\u6050\u3089\u304f\u4f53\u306b\u3068\u3063\u3066\u306f\u5fc5\u9808\u306e\u3082\u306e\u3067\u3059\u3002ApoC\u2162\u306b\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u306a\u3069\u3001\u305d\u306e\u4ed6\u306e\u91cd\u8981\u306a\u5f79\u5272\u3082\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u73fe\u4ee3\u306e\u98df\u751f\u6d3b\u3068\u30df\u30b9\u30de\u30c3\u30c1\u3092\u8d77\u3053\u3057\u3066\u3044\u308b\u304b\u3089\u3068\u8a00\u3063\u3066\u3001\u6291\u3048\u8fbc\u3081\u3070\u3059\u3079\u3066\u304c\u3046\u307e\u304f\u884c\u304f\u308f\u3051\u304c\u306a\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u304c\u3001\u6570\u5024\u5408\u308f\u305b\u304c\u4eca\u306e\u533b\u7642\u3067\u3059\u3002<\/p>\n

\u98df\u4e8b\u3067\u6539\u5584\u3059\u308b\u3082\u306e\u3092\u308f\u3056\u308f\u3056\u85ac\u3067\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u306e\u306f\u3001\u304a\u304b\u3057\u3044\u3068\u601d\u3044\u307e\u305b\u3093\u304b\uff1f\u305d\u308c\u304c\u4eca\u306e\u533b\u7642\u306e\u6b6a\u3093\u3060\u3084\u308a\u65b9\u3067\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3092\u63a8\u5968\u3057\u3001\u4e2d\u6027\u8102\u80aa\u5024\u3092\u4e0a\u3052\u3055\u305b\u3001\u4e2d\u6027\u8102\u80aa\u5024\u3092\u4e0b\u3052\u308b\u85ac\u3092\u6295\u4e0e\u3057\u3066\u3001\u6cbb\u7642\u3057\u305f\u6c17\u306b\u306a\u308b\u306e\u304c\u5c02\u9580\u5bb6\u3068\u547c\u3070\u308c\u307e\u3059\u3002<\/p>\n

\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u306f\u4eca\u5f8c\u3069\u3093\u306a\u85ac\u306b\u306a\u308b\u306e\u304b\uff1f\u7b2c2\u306e\u30b9\u30bf\u30c1\u30f3\u306b\u306a\u308b\u306e\u304b\uff1f\u305d\u308c\u3068\u3082\u672c\u5f53\u306b\u6709\u76ca\u306a\u85ac\u306b\u306a\u308b\u306e\u304b\uff1f<\/p>\n

\u300cTargeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia\u300d<\/span><\/p>\n

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