{"id":32180,"date":"2025-09-10T10:56:36","date_gmt":"2025-09-10T01:56:36","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=32180"},"modified":"2025-09-10T10:56:36","modified_gmt":"2025-09-10T01:56:36","slug":"%e7%b3%96%e5%b0%bf%e7%97%85%e8%96%ac%ef%bc%9f%e3%82%84%e3%81%9b%e8%96%ac%ef%bc%9fglp-1%e5%8f%97%e5%ae%b9%e4%bd%93%e4%bd%9c%e5%8b%95%e8%96%ac%e3%81%ae%e5%89%af%e4%bd%9c%e7%94%a8%e3%80%80%e3%81%9d-15","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=32180","title":{"rendered":"\u7cd6\u5c3f\u75c5\u85ac\uff1f\u3084\u305b\u85ac\uff1fGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u526f\u4f5c\u7528\u3000\u305d\u306e13\u3000\u80c6\u56a2\u708e\u304a\u3088\u3073\u80c6\u77f3\u75c7"},"content":{"rendered":"

\u3053\u306e\u30b7\u30ea\u30fc\u30ba\u306f\u306a\u304b\u306a\u304b\u5c3d\u304d\u307e\u305b\u3093\u3002\u3082\u3046\u300c\u305d\u306e13\u300d\u3067\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u3088\u308b\u80c6\u56a2\u708e\u3001\u80c6\u77f3\u75c7\u3067\u3059\u3002<\/p>\n

FDA\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\uff08FAERS\uff09\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u5831\u544a\u30aa\u30c3\u30ba\u6bd4\uff08ROR\uff09\u3001\u6bd4\u4f8b\u5831\u544a\u6bd4\uff08PRR\uff09\u3001Bayesian confidence propagation neural network (BCPNN)\u3092\u4f7f\u7528\u3057\u3066GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u80c6\u56a2\u708e\u304a\u3088\u3073\u80c6\u77f3\u75c7\u306e\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u3092\u62bd\u51fa\u3057\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u305d\u308c\u305e\u308c\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u3088\u308b\u80c6\u56a2\u708e\u304a\u3088\u3073\u80c6\u77f3\u75c7\u306eROR\u3001PRR\u3001BCPNN\u3067\u3059\u3002\u30a8\u30ad\u30bb\u30ca\u30c1\u30c9\u306fROR=1.88\u3001PRR=1.88\u3001IC = 0.90\u3001\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u306fROR=6.75\u3001PRR=6.71\u3001IC=2.74\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306fROR=5.74\u3001PRR=5.71\u3001IC=2.50\uff09\u3001 \u30c7\u30e5\u30e9\u30b0\u30eb\u30c1\u30c9\u306fROR=1.29\u3001PRR=1.29\u3001IC=0.37\u3001\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306fROR=1.98\u3001PRR=1.98\u3001IC=0.98\u3067\u3042\u308a\u3001\u3002\u30b7\u30b0\u30ca\u30eb\u691c\u51fa\u7d50\u679c\u306f\u3001GLP-1\u85ac\u304c3\u3064\u306e\u691c\u51fa\u6cd5\u3059\u3079\u3066\u3067\u967d\u6027\u30b7\u30b0\u30ca\u30eb\u3092\u793a\u3057\u307e\u3057\u305f\u3002GLP-1\u85ac\u7fa4\u5168\u4f53\u3067\u3082\u967d\u6027\u30b7\u30b0\u30ca\u30eb\u304c\u8a8d\u3081\u3089\u308c\u3001ROR=2.86\u3001PRR=2.86\u3001IC=1.48\u3067\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306ea\u306b\u793a\u3059\u3088\u3046\u306b\u3001GLP-1\u85ac\u8a98\u767a\u6027\u80c6\u56a2\u708e\u304a\u3088\u3073\u80c6\u77f3\u75c7\u306e\u767a\u73fe\u307e\u3067\u306e\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f182\u65e5\u3067\u3057\u305f\u3002\u56f3\u306eb\u306f\u305d\u308c\u305e\u308c\u306e\u85ac\u306e\u80c6\u56a2\u708e\u304a\u3088\u3073\u80c6\u77f3\u75c7\u306e\u767a\u73fe\u307e\u3067\u306e\u65e5\u6570\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u30a8\u30ad\u30bb\u30ca\u30c1\u30c9\u3001\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3067\u306f\u3001\u80c6\u56a2\u708e\u304a\u3088\u3073\u80c6\u77f3\u75c7\u306f\u901a\u5e38360\u65e5\u5f8c\u306b\u767a\u73fe\u3057\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u30a8\u30ad\u30bb\u30ca\u30c1\u30c9\u6295\u4e0e\u958b\u59cb\u5f8c7\u65e5\u4ee5\u5185\u306b\u3082\u76f8\u5f53\u6570\u306e\u3053\u308c\u3089\u306e\u75c7\u72b6\u3092\u767a\u73fe\u3057\u307e\u3057\u305f\u3002\u56f3\u306ec\u306b\u793a\u3059\u3088\u3046\u306b\u3001\u80c6\u56a2\u708e\u304a\u3088\u3073\u80c6\u77f3\u75c7\u306e\u767a\u73fe\u307e\u3067\u306e\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u3001\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u304c\u6700\u3082\u77ed\u304f80\u65e5\u3067\u3057\u305f\u304c\u3001\u30a8\u30ad\u30bb\u30ca\u30c1\u30c9\u306f\u6700\u3082\u9577\u304f230\u65e5\u3067\u3057\u305f\u3002\u5168\u4f53\u7684\u306b\u3001\u767a\u73fe\u307e\u3067\u306e\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u3001\u3055\u307e\u3056\u307e\u306aGLP-1\u85ac\u306e\u9593\u3067\u6709\u610f\u306b\u7570\u306a\u308a\u307e\u3057\u305f\u3002\u5973\u6027\u60a3\u8005\u3067\u306f\u3001\u30a8\u30ad\u30bb\u30ca\u30c1\u30c9\u304a\u3088\u3073\u30c7\u30e5\u30e9\u30b0\u30eb\u30c1\u30c9\u3092\u6295\u4e0e\u3055\u308c\u305f\u969b\u306b\u3001\u80c6\u56a2\u708e\u304a\u3088\u3073\u80c6\u77f3\u75c7\u306e\u767a\u73fe\u307e\u3067\u306e\u671f\u9593\u306e\u4e2d\u592e\u5024\u304c\u7537\u6027\u60a3\u8005\u3088\u308a\u9577\u304f\u3001\u305d\u308c\u305e\u308c280\u65e5\u304a\u3088\u3073248\u65e5\u3067\u3057\u305f\u3002\u4e00\u65b9\u3001\u7537\u6027\u60a3\u8005\u3067\u306f\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u304a\u3088\u3073\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u3092\u6295\u4e0e\u3055\u308c\u305f\u969b\u306b\u3001\u3053\u308c\u3089\u306e\u75c7\u72b6\u306e\u767a\u73fe\u307e\u3067\u306e\u671f\u9593\u306e\u4e2d\u592e\u5024\u304c\u5973\u6027\u60a3\u8005\u3088\u308a\u9577\u304f\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u60a3\u8005\u306e\u5e74\u9f62\u5c64\u5225\u306b\u898b\u3066\u3082\u3001\u767a\u73fe\u307e\u3067\u306e\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u3001GLP-1\u85ac\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u7570\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u7279\u306b\u3001\u30a8\u30ad\u30bb\u30ca\u30c1\u30c9\u306f18\u6b73\u672a\u6e80\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u80c6\u56a2\u708e\u304a\u3088\u3073\u80c6\u77f3\u75c7\u306e\u767a\u73fe\u307e\u3067\u306e\u671f\u9593\u306e\u4e2d\u592e\u5024\u304c451\u65e5\u3068\u6700\u3082\u9577\u304f\u3001\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f65\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005\u306b\u304a\u3044\u306655\u65e5\u3068\u6700\u3082\u77ed\u304b\u3063\u305f\u3067\u3059\u3002<\/p>\n

\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u3001GLP-1\u85ac\u306e\u4f7f\u7528\u306f\u80c6\u56a2\u708e\u304a\u3088\u3073\u80c6\u77f3\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u304f\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u3082\u3046\u4e00\u3064\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u300212\u304b\u6708\u9593GLP-1\u85ac\u3092\u7d99\u7d9a\u3057\u3066\u4f7f\u7528\u3057\u305f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005216\u4eba\u3068\u3001GLP-1\u85ac\u3092\u542b\u307e\u306a\u3044\u5f93\u6765\u306e\u6297\u7cd6\u5c3f\u75c5\u85ac\u3067\u6cbb\u7642\u3055\u308c\u305f\u5bfe\u7167\u7fa492\u4eba\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u75c7\u5019\u6027\u80c6\u77f3\u75c7\u306f\u81e8\u5e8a\u7684\u306b\u75c7\u72b6\u306e\u3042\u308b\u80c6\u77f3\u75c7\u3067\u3042\u308a\u3001\u6d3b\u52d5\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u533b\u5e2b\u306e\u8a3a\u5bdf\u3092\u53d7\u3051\u308b\u3053\u3068\u3092\u4f59\u5100\u306a\u304f\u3055\u305b\u305f\u75c7\u72b6\u306e\u3042\u308b\u80c6\u77f3\u3067\u3059\u3002\u7121\u75c7\u5019\u6027\u80c6\u77f3\u75c7\u306f\u81e8\u5e8a\u75c7\u72b6\u3092\u4f34\u308f\u306a\u3044\u80c6\u77f3\u75c7\u3067\u3059\u3002<\/p>\n

GLP-1\u85ac\u306e\u4f7f\u7528\u306f\u3001\u809d\u6a5f\u80fd\u969c\u5bb3\u3092\u793a\u3059AST\u304a\u3088\u3073ALT\u5024\u306e\u6709\u610f\u306a\u6539\u5584\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u4e00\u65b9\u3067\u80c6\u6c41\u3046\u3063\u6ede\u30de\u30fc\u30ab\u30fc\uff08ALP\u3001\u30d3\u30ea\u30eb\u30d3\u30f3\uff09\u306f\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u4e0a\u6607\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u81b5\u9175\u7d20\u3001\u8840\u6e05\u30a2\u30df\u30e9\u30fc\u30bc\u304a\u3088\u3073\u30ea\u30d1\u30fc\u30bc\u3082GLP-1\u85ac\u4f7f\u7528\u8005\u306e\u9593\u3067\u6709\u610f\u306a\u4e0a\u6607\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u53c2\u52a0\u8005\u306b\u304a\u3051\u308b\u80c6\u77f3\u75c7\u306e\u767a\u75c7\u983b\u5ea6\u306f31.2% (96\/308) \u3067\u3001\u80c6\u77f3\u75c7\u60a3\u8005\u306e\u307b\u3068\u3093\u3069 (58\/96\u300160.4%) \u306f\u75c7\u72b6\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u75c7\u5019\u6027\u80c6\u77f3\u75c7\u306e\u983b\u5ea6\u306f\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u4f7f\u7528\u8005\uff0881.8%\uff09\u3067\u6709\u610f\u306b\u9ad8\u304f\u3001\u6b21\u3044\u3067\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u4f7f\u7528\u8005\uff0868%\uff09\u3001\u30c7\u30e5\u30e9\u30b0\u30eb\u30c1\u30c9\u4f7f\u7528\u8005\uff0844%\uff09\u306e\u9806\u3067\u3057\u305f\u3002<\/p>\n

\n

\u4e0b\u306e\u8868\u306fGLP\u20101\u85ac\u7fa4\u3068\u5bfe\u7167\u7fa4\u306b\u304a\u3051\u308b\u80c6\u77f3\u75c7\u5168\u4f53\u304a\u3088\u3073\u75c7\u5019\u6027\u80c6\u77f3\u75c7\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u3068\u6709\u5bb3\u4e8b\u8c61\u767a\u751f\u5fc5\u8981\u6570NNT\u3067\u3059\u3002\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/span><\/p>\n<\/div>\n

\n\n\n\n\n\n\n\n
\u30a4\u30d9\u30f3\u30c8<\/span><\/th>\n\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9<\/span><\/th>\n\u30c7\u30e5\u30e9\u30b0\u30eb\u30c1\u30c9<\/span><\/th>\n\u30bb\u30de\u30b0\u30eb\u30c1\u30c9<\/span><\/th>\n<\/tr>\n
RR<\/span><\/th>\nNNT\uff08\u5bb3\uff09<\/span><\/th>\nRR<\/span><\/th>\nNNT\uff08\u5bb3\uff09<\/span><\/th>\nRR<\/span><\/th>\nNNT\uff08\u5bb3\uff09<\/span><\/th>\n<\/tr>\n<\/thead>\n
\u80c6\u77f3\u75c7<\/span><\/td>\n1.2<\/span><\/td>\n17.25<\/span><\/td>\n1.3<\/span><\/td>\n14.69<\/span><\/td>\n1.4<\/span><\/td>\n10.96<\/span><\/td>\n<\/tr>\n
\u75c7\u72b6\u6027\u80c6\u77f3\u75c7<\/span><\/td>\n1.6<\/span><\/td>\n3.14<\/span><\/td>\n0.9<\/span><\/td>\n16.67<\/span><\/td>\n1.4<\/span><\/td>\n5.56<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u8868\u306b\u793a\u3059\u3088\u3046\u306b\u3001\u80c6\u77f3\u75c7\u306e\u5168\u4f53\u7684\u306a\u76f8\u5bfe\u30ea\u30b9\u30af\u306f\u3001\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u3001\u30c7\u30e5\u30e9\u30b0\u30eb\u30c1\u30c9\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3067\u305d\u308c\u305e\u308c1.2\u30011.3\u30011.4\uff08\u6709\u610f\u5dee\u306a\u3057\uff09\u3067\u3042\u308a\u3001\u80c6\u77f3\u75c7\u60a3\u8005\u306b\u304a\u3051\u308b\u75c7\u5019\u6027\u80c6\u77f3\u75c7\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u306f\u3001\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u3001\u30c7\u30e5\u30e9\u30b0\u30eb\u30c1\u30c9\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3067\u305d\u308c\u305e\u308c1.6\u30010.9\u30011.4\u3067\u3001\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u306e\u307f\u6709\u610f\u3067\u3057\u305f\u3002<\/p>\n

\u80c6\u77f3\u75c7\u306e\u6709\u5bb3\u4e8b\u8c61\u767a\u751f\u5fc5\u8981\u6570\u306f\u305d\u308c\u305e\u308c17.25\u300114.69\u300110.96\u3067\u3042\u3063\u305f\u3002\u80c6\u77f3\u75c7\u60a3\u8005\u306b\u304a\u3051\u308b\u75c7\u5019\u6027\u80c6\u77f3\u75c7\u306e\u6709\u5bb3\u4e8b\u8c61\u767a\u751f\u5fc5\u8981\u6570\u306f\u305d\u308c\u305e\u308c3.14\u300116.67\u30015.56\u3067\u3057\u305f\u3002<\/p>\n

\u3064\u307e\u308a\u3001GLP\u20101\u85ac\u306f11\u4eba\u304b\u308917\u4eba\u306b1\u4eba\u306e\u5272\u5408\u3067\u3001\u75c7\u72b6\u306e\u6709\u7121\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u304c\u3001\u80c6\u77f3\u75c7\u3092\u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u3059\u3002\u304b\u306a\u308a\u591a\u3044\u3068\u601d\u3044\u307e\u305b\u3093\u304b\uff1f<\/span><\/p>\n

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\u300cGlucagon-like peptide-1 receptor agonist-induced cholecystitis and cholelithiasis: a real-world pharmacovigilance analysis using the FAERS database\u300d<\/span><\/p>\n

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