{"id":32204,"date":"2025-09-08T08:21:40","date_gmt":"2025-09-07T23:21:40","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=32204"},"modified":"2025-09-08T08:21:40","modified_gmt":"2025-09-07T23:21:40","slug":"%e7%94%b7%e6%80%a7%e5%9e%8b%e8%84%b1%e6%af%9b%e7%97%87%ef%bc%88aga%ef%bc%89%e3%81%8a%e3%82%88%e3%81%b3%e5%89%8d%e7%ab%8b%e8%85%ba%e8%82%a5%e5%a4%a7%e3%81%ae%e8%96%ac%e3%83%95%e3%82%a3%e3%83%8a","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=32204","title":{"rendered":"\u7537\u6027\u578b\u8131\u6bdb\u75c7\uff08AGA\uff09\u304a\u3088\u3073\u524d\u7acb\u817a\u80a5\u5927\u306e\u85ac\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u306e\u526f\u4f5c\u7528\u3000\u305d\u306e1\u3000\u81ea\u6bba\u304a\u3088\u3073\u5fc3\u7406\u7684\u6709\u5bb3\u4e8b\u8c61"},"content":{"rendered":"

\u7537\u6027\u578b\u8131\u6bdb\uff08AGA\uff09\u3067\u60a9\u3093\u3067\u3044\u308b\u4eba\u3082\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u30cd\u30c3\u30c8\u3067\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u3001\u7c21\u5358\u306b\u85ac\u304c\u51e6\u65b9\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u73fe\u72b6\u3067\u3057\u3087\u3046\u3002\u305d\u306e\u51e6\u65b9\u3055\u308c\u308b\u85ac\u306e\u4e00\u3064\u306b\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u3068\u3044\u3046\u85ac\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u306e\u526f\u4f5c\u7528\u306f\u6df1\u523b\u3067\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u4e16\u754c\u4fdd\u5065\u6a5f\u95a2\uff08WHO\uff09\u306e\u5b89\u5168\u6027\u5831\u544a\u306e\u56fd\u969b\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3067\u3042\u308bVigiBase\u3092\u7528\u3044\u3066\u3001\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u4f7f\u7528\u3068\u81ea\u6bba\u50be\u5411\uff08\u81ea\u6bba\u5ff5\u616e\u3001\u81ea\u6bba\u4f01\u56f3\u3001\u81ea\u6bba\u65e2\u9042\uff09\u304a\u3088\u3073\u5fc3\u7406\u7684\u6709\u5bb3\u4e8b\u8c61\uff08\u3046\u3064\u75c5\u304a\u3088\u3073\/\u307e\u305f\u306f\u4e0d\u5b89\uff09\u3068\u306e\u95a2\u9023\u6027\u3092\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u4f7f\u7528\u306b\u95a2\u9023\u3059\u308b\u81ea\u6bba\u50be\u5411\u75c7\u4f8b356\u4ef6\u3068\u5fc3\u7406\u7684\u6709\u5bb3\u4e8b\u8c612926\u4ef6\u3092\u7279\u5b9a\u3057\u3001\u5408\u8a083282\u4ef6\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u5831\u544a\u30aa\u30c3\u30ba\u6bd4 (ROR)\u306f\u6b21\u306e\u3088\u3046\u3067\u3059\u3002\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\n\n\n\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n
\u6709\u5bb3\u4e8b\u8c61<\/span><\/th>\nROR\uff0895%\u4fe1\u983c\u533a\u9593\uff09<\/span><\/th>\n<\/tr>\n<\/thead>\n
\u81ea\u6bba\u50be\u5411<\/span><\/td>\n1.63 (1.47-1.81)<\/span><\/td>\n<\/tr>\n
\u81ea\u6bba\u5ff5\u616e<\/span><\/td>\n4.39 (3.90-4.95)<\/span><\/td>\n<\/tr>\n
\u81ea\u6bba\u672a\u9042<\/span><\/td>\n\uff0d<\/span><\/td>\n<\/tr>\n
\u81ea\u6bba\u672a\u9042<\/span><\/td>\n\uff0d<\/span><\/td>\n<\/tr>\n
\u5fc3\u7406\u7684<\/span><\/td>\n4.33 (4.17-4.49)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u81ea\u6bba\u672a\u9042\u307e\u305f\u306f\u81ea\u6bba\u65e2\u9042\u306b\u3064\u3044\u3066\u306fROR\u306b\u3088\u308b\u30b7\u30b0\u30ca\u30eb\u306f\u78ba\u8a8d\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u81ea\u6bba\u50be\u5411\u306f1.63\u500d\u3001\u81ea\u6bba\u5ff5\u616e\u306f4.39\u500d\u3001\u5fc3\u7406\u7684\u6709\u5bb3\u4e8b\u8c61\u306f4.33\u500d\u3067\u3057\u305f\u3002<\/p>\n

\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u6295\u4e0e\u91cf\u5225\u306e\u81ea\u6bba\u50be\u5411\u306eROR\u306f\u6b21\u306e\u3088\u3046\u3067\u3057\u305f\u3002<\/p>\n

\n\n\n\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n
\u7528\u91cf<\/span><\/th>\nROR\uff0895%\u4fe1\u983c\u533a\u9593\uff09<\/span><\/th>\n<\/tr>\n<\/thead>\n
1mg<\/span><\/td>\n1.64 (1.41-1.91)<\/span><\/td>\n<\/tr>\n
5mg<\/span><\/td>\n\uff0d<\/span><\/td>\n<\/tr>\n
\u672a\u77e5<\/span><\/td>\n1.97 (1.68-2.30)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

5mg\u3067\u306f\u30b7\u30b0\u30ca\u30eb\u306f\u306a\u304f\u30011mg\u3067\u81ea\u6bba\u50be\u5411\u306eROR\u306f1.64\u500d\u3067\u3057\u305f\u3002<\/p>\n

\u307e\u305f\u3001\u9069\u5fdc\u75c7\u304a\u3088\u3073\u5e74\u9f62\u5225\u306e\u5206\u6790\u3067\u306f\u3001\u81ea\u6bba\u306b\u95a2\u3059\u308b\u6709\u610f\u306a\u4e0d\u5747\u8861\u30b7\u30b0\u30ca\u30eb\u306f\u3001\u82e5\u5e74\u60a3\u8005\u3067ROR3.47\u500d\u3001\u8131\u6bdb\u75c7\u60a3\u8005\u3067ROR2.06\u500d\u3067\u3057\u305f\u3002\u4e00\u65b9\u3001\u9ad8\u9f62\u60a3\u8005\u304a\u3088\u3073\u524d\u7acb\u817a\u80a5\u5927\u75c7\u60a3\u8005\u306b\u304a\u3044\u3066\u306f\u30b7\u30b0\u30ca\u30eb\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u3082\u3046\u4e00\u3064\u3001\u30a2\u30e1\u30ea\u30ab\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u306e\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\uff08FAERS\uff09\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u7814\u7a76\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u3044\u308f\u3086\u308b\u30dd\u30b9\u30c8\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u75c7\u5019\u7fa4\uff08PFS\uff09\uff08\u6b21\u56de\u4ee5\u964d\u3067\u53d6\u308a\u4e0a\u3052\u307e\u3059\uff09<\/p>\n

PFS\u304c\u300c\u6b63\u5f0f\u306b\u300d\u8a8d\u8b58\u3055\u308c\u308b\u958b\u59cb\u306e1\u5e74\u524d\u307e\u3067\u306e 6 \u5e74\u9593\uff082006 \u5e74\u301c 2011 \u5e74\uff09\u3001PFS\u8a8d\u8b58\u5f8c\u306e6\u5e74\u9593\u300cPFS \u5f8c\u7b2c 1 \u6642\u4ee3\uff082013 \u5e74\u301c 2018 \u5e74\uff09\u300d\u3001PFS \u304c\u8a8d\u8b58\u3055\u308c\u3066\u304b\u30897\u5e74\u5f8c\u306e5\u5e74\u9593\u300cPFS \u5f8c\u7b2c 2 \u6642\u4ee3\uff082019 \u5e74\u301c 2023 \u5e74\uff09\u300d\u306b\u95a2\u3057\u3066\u30015\u3064\u306e\u6709\u5bb3\u4e8b\u8c61\uff08AE\uff09\u300c\u81ea\u6bba\u65e2\u9042\u300d\u3001\u300c\u81ea\u6bba\u50be\u5411\u306b\u3042\u308b\u3046\u3064\u75c5\u300d\u3001\u300c\u81ea\u6bba\u884c\u70ba\u300d\u3001\u300c\u81ea\u6bba\u5ff5\u616e\u300d\u3001\u300c\u81ea\u6bba\u672a\u9042\u300d\u3092\u8abf\u67fb\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u3082\u30b7\u30b0\u30ca\u30eb\u306f\u5831\u544a\u30aa\u30c3\u30ba\u6bd4\uff08ROR\uff09\u3067\u3059\u3002<\/p>\n

2006\u5e74\u304b\u30892011\u5e74\u306b\u304b\u3051\u3066\u3001\u7d4c\u53e3\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u6295\u4e0e\u7fa4\u3067\u306f\u30015\u3064\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u3044\u305a\u308c\u306b\u304a\u3044\u3066\u3082\u6709\u610f\u306a\u6709\u5bb3\u4e8b\u8c61\u306e\u30b7\u30b0\u30ca\u30eb\u306f\u691c\u51fa\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u3055\u304b\u3001\u3053\u306e\u85ac\u3067\u3053\u306e\u3088\u3046\u306a\u6709\u5bb3\u4e8b\u8c61\u304c\u8d77\u304d\u308b\u3068\u306f\u307f\u3093\u306a\u601d\u308f\u306a\u304b\u3063\u305f\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001PFS\u304c\u8a8d\u8b58\u3055\u308c\u305f\u5f8c\u306f\u3069\u3046\u306a\u3063\u305f\u3067\u3057\u3087\u3046\u304b\uff1f\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n\n
\u6709\u5bb3\u4e8b\u8c61<\/span><\/th>\n2013\uff5e2018\u5e74<\/span><\/th>\n2013\uff5e2018\u5e74<\/span>\uff081 mg\uff09<\/span><\/th>\n2013\uff5e2018\u5e74<\/span>\uff085 mg\uff09<\/span><\/th>\n<\/tr>\n
ROR<\/span><\/th>\nROR<\/span><\/th>\nROR<\/span><\/th>\n<\/tr>\n<\/thead>\n
\u81ea\u6bba\u672a\u9042<\/span><\/td>\n0.96<\/span><\/td>\n3.963<\/span><\/strong><\/span><\/td>\n0.733<\/span><\/td>\n<\/tr>\n
\u3046\u3064\u75c5\u81ea\u6bba\u9858\u671b<\/span><\/td>\n4.614<\/span><\/strong><\/span><\/td>\n17.849<\/span><\/strong><\/span><\/td>\n2.163<\/span><\/td>\n<\/tr>\n
\u81ea\u6bba\u884c\u70ba<\/span><\/td>\n1.247<\/span><\/td>\n\u2014<\/span><\/td>\n0.543<\/span><\/td>\n<\/tr>\n
\u81ea\u6bba\u5ff5\u616e<\/span><\/td>\n2.827<\/span><\/strong><\/span><\/td>\n3.628<\/span><\/strong><\/span><\/td>\n1.847<\/span><\/strong><\/span><\/td>\n<\/tr>\n
\u81ea\u6bba\u672a\u9042<\/span><\/td>\n0.663<\/span><\/td>\n0.955<\/span><\/td>\n0.216<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
<\/div>\n
\u4e0a\u306e\u8868\u306f\u30012013\u5e74\u304b\u30892018\u5e74\u307e\u3067\u306ePFS\u306e\u516c\u8868\u5f8c\u306e\u7d4c\u53e3\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u306e\u4f7f\u7528\u3068\u5fc3\u7406\u7684\u5f71\u97ff\u3068\u306e\u95a2\u9023\u6027\u3067\u3059\u3002\u3046\u3064\u75c5\u306e\u81ea\u6bba\u9858\u671b\u306eROR\u306f\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u5168\u4f53\u30674.614\u500d\u30011mg\u3060\u3051\u3092\u898b\u308b\u306817.849\u500d\u306b\u3082\u306a\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u30011mg\u7fa4\u3067\u306f\u81ea\u6bba\u672a\u90423.963\u500d\u3001\u81ea\u6bba\u5ff5\u616e3.628\u500d\u3067\u3057\u305f\u3002<\/span><\/div>\n
<\/div>\n
\n
\n\n\n\n\n\n\n\n\n\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n\n
\u6709\u5bb3\u4e8b\u8c61<\/span><\/th>\n2019\uff5e2023\u5e74\uff08\u542b\u3080\uff09<\/span><\/th>\n2019\uff5e2023\u5e74<\/span>\uff081 mg\uff09<\/span><\/th>\n2019\uff5e2023\u5e74<\/span>\uff085 mg\uff09<\/span><\/th>\n<\/tr>\n
ROR<\/span><\/th>\nROR<\/span><\/th>\nROR<\/span><\/th>\n<\/tr>\n<\/thead>\n
\u81ea\u6bba\u672a\u9042<\/span><\/td>\n1.705<\/span><\/strong><\/span><\/td>\n8.967<\/span><\/strong><\/span><\/td>\n2.354<\/span><\/strong><\/span><\/td>\n<\/tr>\n
\u3046\u3064\u75c5\u81ea\u6bba\u9858\u671b<\/span><\/td>\n8.806<\/span><\/strong><\/span><\/td>\n49.567<\/span><\/strong><\/span><\/td>\n3.368<\/span><\/td>\n<\/tr>\n
\u81ea\u6bba\u884c\u70ba<\/span><\/td>\n3.225<\/span><\/strong><\/span><\/td>\n6.625<\/span><\/strong><\/span><\/td>\n1.212<\/span><\/td>\n<\/tr>\n
\u81ea\u6bba\u5ff5\u616e<\/span><\/td>\n4.956<\/span><\/strong><\/span><\/td>\n9.893<\/span><\/strong><\/span><\/td>\n2.37<\/span><\/strong><\/span><\/td>\n<\/tr>\n
\u81ea\u6bba\u672a\u9042<\/span><\/td>\n0.709<\/span><\/td>\n1.622<\/span><\/td>\n0.841<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n

\u4e0a\u306e\u8868\u306f\u30012019\u5e74\u304b\u30892023\u5e74\u307e\u3067\u306e\u7d4c\u53e3\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u306e\u4f7f\u7528\u3068\u5fc3\u7406\u7684\u5f71\u97ff\u3068\u306e\u95a2\u9023\u6027\u3067\u3059\u3002\u3046\u3064\u75c5\u306e\u81ea\u6bba\u9858\u671b\u306eROR\u306f\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u5168\u4f53\u30678.806\u500d\u30011mg\u3060\u3051\u3092\u898b\u308b\u3068\u306a\u3093\u306849.567\u500d\u306b\u3082\u306a\u308a\u307e\u3057\u305f\u30021mg\u306f\u4ed6\u306b\u3082\u3001\u81ea\u6bba\u672a\u90428.967\u500d\u3001\u81ea\u6bba\u884c\u70ba6.625\u500d\u3001\u81ea\u6bba\u5ff5\u616e9.893\u500d\u306e\u30b7\u30b0\u30ca\u30eb\u304c\u51fa\u3066\u3044\u307e\u3057\u305f\u3002<\/span><\/p>\n

\u6bdb\u3092\u5931\u308f\u306a\u304f\u306a\u3063\u305f\u3068\u3057\u3066\u3082\u3001\u547d\u3084\u5065\u5eb7\u306a\u5fc3\u3092\u5931\u3063\u3066\u3057\u307e\u3046\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u4eba\u9593\u306e\u672c\u6765\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u521d\u671f\u8a2d\u5b9a\u3092\u5909\u66f4\u3057\u305f\u308a\u3001\u505c\u6b62\u3057\u305f\u308a\u3001\u7121\u7406\u306b\u4fc3\u9032\u3057\u305f\u308a\u3001\u305d\u306e\u3088\u3046\u306a\u85ac\u304c\u591a\u3059\u304e\u307e\u3059\u3002GLP-1\u85ac\u3068\u540c\u69d8\u306b\u3001\u4eba\u9593\u3092\u81ea\u6bba\u306b\u307e\u3067\u8ffd\u3044\u8fbc\u3080\u3088\u3046\u306a\u526f\u4f5c\u7528\u304c\u3042\u308a\u306a\u304c\u3089\u3001\u5e73\u6c17\u3067\u30d3\u30b8\u30cd\u30b9\u306e\u305f\u3081\u306b\u85ac\u3092\u51e6\u65b9\u3057\u3066\u3044\u308b\u533b\u5e2b\u304c\u5897\u3048\u3066\u3044\u308b\u306e\u3082\u78ba\u304b\u3067\u3057\u3087\u3046\u3002\u81ea\u7531\u8a3a\u7642\u3067\u3042\u308c\u3070\u3055\u3089\u306b\u3001\u533b\u5e2b\u306e\u8cac\u4efb\u304c\u8efd\u304f\u306a\u308b\u3068\u3067\u3082\u601d\u3063\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u533b\u7642\u304c\u30b3\u30f3\u30d7\u30ec\u30c3\u30af\u30b9\u7523\u696d\u306b\u6210\u308a\u4e0b\u304c\u3063\u3066\u3057\u307e\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

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 <\/p>\n

\u300cInvestigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride\u300d<\/span><\/p>\n

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\u300cFinasteride Use: Evaluation of Depression and Suicide Risk\u300d<\/span><\/p>\n

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