{"id":32833,"date":"2025-11-10T08:48:32","date_gmt":"2025-11-09T23:48:32","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=32833"},"modified":"2025-11-10T08:48:32","modified_gmt":"2025-11-09T23:48:32","slug":"%e6%9c%ac%e5%bd%93%e3%81%abldl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e3%81%8c%e4%bd%8e%e3%81%84%e3%81%bb%e3%81%a9%e8%89%af%e3%81%84%e3%81%ae%e3%81%a7%e3%81%82%e3%82%8c","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=32833","title":{"rendered":"\u672c\u5f53\u306bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4f4e\u3044\u307b\u3069\u826f\u3044\u306e\u3067\u3042\u308c\u3070\u3001PCSK9\u963b\u5bb3\u5264\u306f\u306a\u305c\u3053\u3053\u307e\u3067\u52b9\u679c\u304c\u5c11\u306a\u3044\u306e\u3067\u3042\u308d\u3046\uff1f"},"content":{"rendered":"

LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u4f4e\u3051\u308c\u3070\u4f4e\u3044\u65b9\u304c\u672c\u5f53\u306b\u5065\u5eb7\u7684\u306a\u306e\u3067\u3042\u308c\u3070\u3001\u975e\u5e38\u306b\u5f37\u3044\u85ac\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5287\u7684\u306b\u4e0b\u3052\u308c\u3070\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u304c\u6fc0\u6e1b\u3057\u3001\u6b7b\u4ea1\u7387\u3082\u975e\u5e38\u306b\u4f4e\u4e0b\u3059\u308b\u306f\u305a\u3067\u3059\u3002<\/p>\n

LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4e0b\u3052\u308b\u85ac\u3067\u3088\u304f\u4f7f\u308f\u308c\u308b\u30b9\u30bf\u30c1\u30f3\u3088\u308a\u3082\u3001\u3082\u3063\u3068LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308bPCSK9\u963b\u5bb3\u85ac\u3068\u3044\u3046\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3092\u4f7f\u3063\u3066LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6975\u7aef\u306b\u4f4e\u4e0b\u3055\u305b\u308c\u3070\u3001\u3055\u305e\u304b\u3057\u5927\u304d\u306a\u52b9\u679c\u304c\u3042\u308a\u3001\u6b7b\u4ea1\u7387\u306f\u30bc\u30ed\u306b\u8fd1\u3065\u3044\u3066\u3082\u304a\u304b\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u52d5\u8108\u786c\u5316\u75c7\u307e\u305f\u306f\u7cd6\u5c3f\u75c5\u3092\u6709\u3057\u3001\u5fc3\u7b4b\u6897\u585e\u307e\u305f\u306f\u8133\u5352\u4e2d\u306e\u65e2\u5f80\u304c\u306a\u304f\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c90mg\/dL\u4ee5\u4e0a\u306e\u60a3\u800512,257\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u307e\u3059\u3002PCSK9\u963b\u5bb3\u85ac\u306e\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa46,129\u4eba\u3001\u30d7\u30e9\u30bb\u30dc\u7fa46,128\u4eba\u306b\u5206\u3051\u307e\u3057\u305f\u3002\u5e74\u9f62\u4e2d\u592e\u5024\u306f66\u6b73\u3067\u300143%\u304c\u5973\u6027\u3001\u8ffd\u8de1\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f4.6\u5e74\u3067\u3057\u305f\u3002\u30b9\u30bf\u30c1\u30f3\u306f87\uff05\u3067\u4f7f\u7528\u3055\u308c\u300168\uff05\u306f\u9ad8\u5f37\u5ea6\u306e\u30b9\u30bf\u30c1\u30f3\u3067\u3057\u305f\u3002\u30a8\u30bc\u30c1\u30df\u30d6\uff08\u30bc\u30c1\u30fc\u30a2\uff09\u306f19\uff5e20\uff05\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u300213%\u306e\u60a3\u8005\u306f\u30b9\u30bf\u30c1\u30f3\u3092\u670d\u7528\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u30013\u30dd\u30a4\u30f3\u30c8MACE\u3068\u3057\u3066\u51a0\u52d5\u8108\u75be\u60a3\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u307e\u305f\u306f\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u3088\u308b\u6b7b\u4ea1\u306e\u8907\u5408\u30014\u30dd\u30a4\u30f3\u30c8MACE\u3068\u3057\u30663\u30dd\u30a4\u30f3\u30c8MACE\u307e\u305f\u306f\u865a\u8840\u6027\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u306b\u3088\u308b\u6b7b\u4ea1\u306e\u8907\u5408\u3068\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e2d\u592e\u5024\u306f122mg\/dL\u3067\u3001\u7bc4\u56f2\u306f104\uff5e149 mg\/dL\u3067\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

\"\"<\/a>
\n\u4e0a\u306e\u56f3\u306e\u3088\u3046\u306b\u30013\u30dd\u30a4\u30f3\u30c8MACE\u30a4\u30d9\u30f3\u30c8\u306f\u3001\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u3067336\u4eba\uff086.2%\uff09\u306b\u767a\u751f\u3057\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f443\u4eba\uff088.0%\uff09\u306b\u767a\u751f\u3057\u307e\u3057\u305f\u3002\u3064\u307e\u308a5\u5e74\u9593\u30673\u30dd\u30a4\u30f3\u30c8MACE\u30a4\u30d9\u30f3\u30c8\u3092\u767a\u751f\u306f0.75\u500d\u300125\uff05\u4f4e\u4e0b\u3057\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u30024\u30dd\u30a4\u30f3\u30c8MACE\u30a4\u30d9\u30f3\u30c8\u306f\u3001\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u3067747\u4eba\uff0813.4%\uff09\u306b\u767a\u751f\u3057\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f907\u4eba\uff0816.2%\uff09\u306b\u767a\u751f\u3057\u305f\u306e\u3067\u3001\u767a\u751f\u30ea\u30b9\u30af\u306f0.81\u500d\u300119\uff05\u6e1b\u5c11\u3057\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u3067\u306f\u3001\u5b9f\u969b\u306b\u53c2\u52a0\u8005\u306e\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3069\u308c\u304f\u3089\u3044\u4f4e\u4e0b\u3057\u305f\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\"\"<\/a>
\n\u4e0a\u306e\u56f3\u306e\u3088\u3046\u306b\u3001\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u306e48\u9031\u6642\u70b9\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e2d\u592e\u5024\u306f45mg\/dL\uff08\u7bc4\u56f226\uff5e73mg\/dL\uff09\u3067\u3057\u305f\u3002\u305d\u306e\u5f8c\u306f\u6a2a\u3070\u3044\u3067\u3059\u3002\u3082\u306e\u3059\u3054\u3044\u4f4e\u5024\u3067\u3059\u3002\u305d\u308c\u306a\u306e\u306b\u3001MACE\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u30ea\u30b9\u30af\u4f4e\u4e0b\u306f\u3042\u307e\u308a\u306b\u3082\u30b7\u30e7\u30dc\u3044\u3067\u3059\u306d\u3002NNT\uff08\u6cbb\u7642\u5fc5\u8981\u6570\uff09\u3067\u898b\u308b\u3068\u30015\u5e74\u9593\u30673\u30dd\u30a4\u30f3\u30c8MACE\u30a4\u30d9\u30f3\u30c8\u306f55.6\u30014\u30dd\u30a4\u30f3\u30c8MACE\u30a4\u30d9\u30f3\u30c8\u306f35.7\u3067\u3059\u30025\u5e74\u9593\u3053\u3093\u306a\u9ad8\u984d\u306a\u85ac\u3092\u4f7f\u3063\u3066\u3001\u7570\u5e38\u306a\u307b\u3069\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u3092\u3057\u305f\u306e\u306b\u3001\u305d\u306e\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u4eba\u306f35\uff5e55\u4eba\u306b1\u4eba\u3057\u304b\u3044\u307e\u305b\u3093\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u307e\u305f\u3001\u4e0a\u306e\u56f3\u306e\u3088\u3046\u306b\u30013\u30dd\u30a4\u30f3\u30c8MACE\u3067\u306f\u6700\u521d\u306e1\u5e74\u9593\u3067\u306f\u6709\u610f\u5dee\u304c\u51fa\u306a\u304f\u3001\u5206\u6790\u306b\u82e6\u52b4\u3057\u3066\u3044\u308b\u306e\u304c\u57a3\u9593\u898b\u3048\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306eA\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u6b7b\u3001\u4e0b\u306eB\u304c\u5168\u539f\u56e0\u6b7b\u4ea1\u3067\u3059\u3002\u6700\u521d\u306e1.5\u5e74\u306f\u5168\u304f\u5dee\u304c\u3042\u308a\u307e\u305b\u3093\u30025\u5e74\u9593\u3067\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u6b7b0.79\u500d\u3067\u3059\u304c\u3001NNT\u306f125\u3067\u3059\u3002125\u4eba\u306b\u9ad8\u4fa1\u306aPCSK9\u963b\u5bb3\u85ac\u30925\u5e74\u9593\u4f7f\u3063\u3066\u3084\u3063\u30681\u4eba\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u6b7b\u3092\u9632\u3052\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u5168\u539f\u56e0\u6b7b\u4ea1\u306f\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u30670.8\u500d\u3067\u3001NNT\u306f55.6\u3067\u3059\u3002\u3084\u306f\u308a5\u5e74\u9593\u306755.6\u4eba\u306b1\u4eba\u306e\u6b7b\u4ea1\u3092\u9632\u3052\u308b\u3060\u3051\u3067\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\u5f53\u7136\u306a\u304c\u3089\u3001\u3053\u306e\u7814\u7a76\u306f\u5229\u76ca\u76f8\u53cd\u30d0\u30ea\u30d0\u30ea\u3067\u3057\u3087\u3046\u3002\u305d\u306e\u3088\u3046\u306a\u7814\u7a76\u3067\u3055\u3048\u3001\u3053\u306e\u7a0b\u5ea6\u306e\u7d50\u679c\u3057\u304b\u51fa\u306a\u3044\u85ac\u3092\u4f7f\u3046\u610f\u5473\u304c\u3042\u308b\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u4ee5\u524d\u306e\u8a18\u4e8b\u300cLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5f37\u529b\u306b\u4f4e\u4e0b\u3055\u305b\u308bPCSK9\u963b\u5bb3\u85ac\u306e\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u3068\u6b7b\u4ea1<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001PCSK9\u963b\u5bb3\u85ac\u306e\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u3001\u8102\u8cea\u4f4e\u4e0b\u8a66\u9a13\u3067\u306e\u6b7b\u4ea1\u306e\u53ef\u80fd\u6027\u306f1.18\u500d\u3001\u81e8\u5e8a\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u3067\u306f1.12\u500d\uff08\u30ae\u30ea\u6709\u610f\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\uff09\u3067\u3057\u305f\u3002\u81e8\u5e8a\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u306fFOURIER\u8a66\u9a13\u3068\u3044\u3046\u3082\u306e\u3067\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u6b7b\u4ea1\u3057\u305f\u53c2\u52a0\u8005\u306e\u5272\u5408\u306f4.3%\u3001\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u7fa4\u3067\u306f4.8%\u3067\u3057\u305f\u3002\u305d\u3057\u3066\u3053\u306eFOURIER\u8a66\u9a13\u306f\u3001\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024\u306f\u5f53\u521d\u7d044\u5e74\u3068\u8a08\u753b\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u30ba\u30eb\u3092\u3057\u3066\u7d04\u534a\u5206\u306e2.2\u5e74\u306b\u8ffd\u8de1\u671f\u9593\u304c\u77ed\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u90fd\u5408\u304c\u60aa\u304b\u3063\u305f\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u81e8\u5e8a\u8ee2\u5e30\u3082\u5168\u7136\u6539\u5584\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u539f\u56e0\u3067\u3042\u308b\u3068\u8a00\u3044\u7d9a\u3051\u308b\u3053\u3068\u306f\u3001\u533b\u7642\u696d\u754c\u306e\u6700\u5927\u306e\u8a50\u6b3a\u306e1\u3064\u3067\u3059\u3002<\/p>\n

\u300cEvolocumab in Patients without a Previous Myocardial Infarction or Stroke\u300d<\/span><\/p>\n

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