{"id":33044,"date":"2025-12-04T09:03:52","date_gmt":"2025-12-04T00:03:52","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=33044"},"modified":"2025-12-04T09:03:52","modified_gmt":"2025-12-04T00:03:52","slug":"%e3%83%91%e3%83%a9%e3%83%99%e3%83%b3%e3%81%a8%e3%83%95%e3%82%bf%e3%83%ab%e9%85%b8%e3%82%a8%e3%82%b9%e3%83%86%e3%83%ab%e3%82%92%e5%90%ab%e3%82%80%e3%83%91%e3%83%bc%e3%82%bd%e3%83%8a%e3%83%ab%e3%82%b1","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=33044","title":{"rendered":"\u30d1\u30e9\u30d9\u30f3\u3068\u30d5\u30bf\u30eb\u9178\u30a8\u30b9\u30c6\u30eb\u3092\u542b\u3080\u30d1\u30fc\u30bd\u30ca\u30eb\u30b1\u30a2\u88fd\u54c1\u3084\u3081\u308b\u3068\u4e73\u304c\u3093\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b"},"content":{"rendered":"

\u5316\u7ca7\u54c1\u3084\u30b7\u30e3\u30f3\u30d7\u30fc\u3001\u30b9\u30ad\u30f3\u30b1\u30a2\u3001\u30dc\u30c7\u30a3\u30b1\u30a2\u306a\u3069\u306e\u65e5\u5e38\u7684\u306a\u30d1\u30fc\u30bd\u30ca\u30eb\u30b1\u30a2\u88fd\u54c1\u306b\u306f\u3001\u30d1\u30e9\u30d9\u30f3\u3084\u30d5\u30bf\u30eb\u9178\u30a8\u30b9\u30c6\u30eb\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u591a\u3005\u3042\u308a\u307e\u3059\u3002\u30d5\u30bf\u30eb\u9178\u30a8\u30b9\u30c6\u30eb\u3068\u66f8\u304b\u308c\u3066\u3044\u306a\u304f\u3066\u3082\u3001\u9999\u6599\u306e\u4e2d\u306b\u6f5c\u3093\u3067\u3044\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u30d1\u30e9\u30d9\u30f3\u3068\u30d5\u30bf\u30eb\u9178\u30a8\u30b9\u30c6\u30eb\u306f\u4f53\u5185\u3067\u5f31\u3044\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u3088\u3046\u306a\u4f5c\u7528\u3092\u793a\u3059\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u30b7\u30b0\u30ca\u30eb\u306e\u904e\u5270\u306f\u9577\u5e74\u3001\u4e73\u304c\u3093\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u95a2\u9023\u3065\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u5b9a\u671f\u7684\u306b\u30d1\u30fc\u30bd\u30ca\u30eb\u30b1\u30a2\u88fd\u54c1\u3092\u4f7f\u7528\u3057\u3001\u304c\u3093\u306e\u8a3a\u65ad\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u5065\u5eb7\u306a\u5973\u602736\u4eba\u306b\u3001\u3059\u3079\u3066\u306e\u30d1\u30fc\u30bd\u30ca\u30eb\u30b1\u30a2\u88fd\u54c1\u3092\u30d1\u30e9\u30d9\u30f3\u3084\u30d5\u30bf\u30eb\u9178\u30a8\u30b9\u30c6\u30eb\u3092\u542b\u307e\u306a\u3044\u3082\u306e\u306b28\u65e5\u9593\u5207\u308a\u66ff\u3048\u308b\u3088\u3046\u4f9d\u983c\u3057\u307e\u3057\u305f\u3002\u85ac\u306f\u306a\u3057\u3001\u98df\u4e8b\u5236\u9650\u306f\u306a\u3057\u3002\u305f\u3060\u88fd\u54c1\u3092\u5909\u3048\u308b\u3060\u3051\u3067\u3059\u3002<\/p>\n

\u53c2\u52a0\u8005\u306f\u30d1\u30e9\u30d9\u30f3\u542b\u6709\u30d1\u30fc\u30bd\u30ca\u30eb\u30b1\u30a2\u88fd\u54c1\u3092\u90317\u65e5\u9593\u3001\u5c11\u306a\u304f\u3068\u30821\u7a2e\u985e\u4ee5\u4e0a\u4f7f\u7528\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u4eba\u5de5\u9999\u6599\u306e\u672a\u516c\u958b\u6210\u5206\u3067\u3042\u308b\u30d5\u30bf\u30eb\u9178\u30a8\u30b9\u30c6\u30eb\u306f\u3001\u53c2\u52a0\u8005\u304c\u4f7f\u7528\u3059\u308b\u30d1\u30fc\u30bd\u30ca\u30eb\u30b1\u30a2\u88fd\u54c1\u306e\u4e00\u822c\u7684\u306a\u6210\u5206\u3067\u3057\u305f\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u5206\u6790\u5bfe\u8c61\u7269<\/span><\/th>\n\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6fc3\u5ea6\u7bc4\u56f2<\/span><\/th>\n\u5168\u3066\u306e\u7814\u7a76\u53c2\u52a0\u8005<\/span><\/th>\n\u907a\u4f1d\u5b50\u767a\u73fe\u7814\u7a76\u5bfe\u8c61<\/span><\/th>\n<\/tr>\n
<\/td>\n\u4e8b\u5f8c<\u4e8b\u524d\/\u5408\u8a08<\/span><\/th>\n\u4e8b\u5f8c<\u4e8b\u524d\/\u5408\u8a08<\/span><\/th>\n<\/tr>\n<\/thead>\n
\u5c3f\u691c\u67fb<\/span><\/u><\/th>\n<\/tr>\n
\u30d1\u30e9\u30d9\u30f3\uff08\u03bcg\/g\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\uff09<\/span><\/strong><\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
MP<\/td>\n0.00 \u2013 648.35<\/span><\/td>\n29\/36<\/span><\/td>\n12\/12<\/span><\/td>\n<\/tr>\n
EP<\/span><\/td>\n0.00 \u2013 220.73<\/span><\/td>\n26\/36<\/span><\/td>\n10\/12<\/span><\/td>\n<\/tr>\n
PP<\/span><\/td>\n0.09 \u2013 361.97<\/span><\/td>\n32\/36<\/span><\/td>\n12\/12<\/span><\/td>\n<\/tr>\n
BP<\/span><\/td>\n0.00 \u2013 55.21<\/span><\/td>\n27\/36<\/span><\/td>\n9\/12<\/span><\/td>\n<\/tr>\n
\u30d5\u30bf\u30eb\u9178\u30a8\u30b9\u30c6\u30eb\uff08\u03bcg\/g\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\uff09<\/span><\/strong><\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
MEHHP<\/td>\n1.40\uff5e39.00<\/span><\/td>\n20\/36<\/span><\/td>\n6\/12<\/span><\/td>\n<\/tr>\n
MEHP<\/span><\/td>\n0.00 \u2013 14.87<\/span><\/td>\n17\/36<\/span><\/td>\n4\/12<\/span><\/td>\n<\/tr>\n
MEOHP<\/span><\/td>\n1.13 \u2013 17.00<\/span><\/td>\n10\/22<\/span><\/td>\n1\/12<\/span><\/td>\n<\/tr>\n
MEP<\/td>\n6.93 \u2013 385.00<\/span><\/td>\n26\/36<\/span><\/td>\n8\/12<\/span><\/td>\n<\/tr>\n
\u8840\u6e05\u5206\u6790<\/span><\/u><\/th>\n<\/tr>\n
\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\uff08pg\/ml\uff09<\/span><\/td>\n6.50 \u2013 357.00<\/span><\/td>\n23\/36<\/span><\/td>\n9\/12<\/span><\/td>\n<\/tr>\n
\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\uff08ng\/ml\uff09<\/span><\/td>\n0.10 \u2013 19.70<\/span><\/td>\n9\/36<\/span><\/td>\n2\/12<\/span><\/td>\n<\/tr>\n
SHBG (nM\/L)<\/span><\/td>\n25.70 \u2013 247.10<\/span><\/td>\n20\/35<\/span><\/td>\n8\/12<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e0a\u306e\u8868\u306f\u3001\u3053\u306e\u8a66\u9a13\u524d\u5f8c\u306e\u5c3f\u691c\u67fb\u3084\u8840\u6db2\u691c\u67fb\u3067\u3001\u8a66\u9a13\u524d\u3088\u308a\u3082\u8a66\u9a13\u5f8c\u306b\u6e1b\u5c11\u3057\u305f\u69d8\u3005\u306a\u7269\u8cea\u3092\u8a8d\u3081\u305f\u4eba\u6570\u3067\u3059\u3002\u3059\u3079\u3066\u306e\u30d1\u30e9\u30d9\u30f3\u3001MP (\u30e1\u30c1\u30eb\u30d1\u30e9\u30d9\u30f3)\u3001EP (\u30a8\u30c1\u30eb\u30d1\u30e9\u30d9\u30f3)\u3001PP (\u30d7\u30ed\u30d4\u30eb\u30d1\u30e9\u30d9\u30f3)\u3001 BP (\u30d6\u30c1\u30eb\u30d1\u30e9\u30d9\u30f3) \u3001\u304a\u3088\u3073\u30b8\u30a8\u30c1\u30eb\u30d5\u30bf\u30eb\u9178\u30a8\u30b9\u30c6\u30eb\u4ee3\u8b1d\u7269 MEP (\u30e2\u30ce\u30a8\u30c1\u30eb\u30d5\u30bf\u30eb\u9178)\u306b\u3064\u3044\u3066\u3001 \u8a66\u9a13\u5f8c\u306e\u30b5\u30f3\u30d7\u30eb\u3067\u6709\u610f\u306a\u6e1b\u5c11\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u8840\u6e05\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\uff08\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb<\/span>\uff09\u3001\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u3001\u304a\u3088\u3073\u6027\u30db\u30eb\u30e2\u30f3\u7d50\u5408\u30b0\u30ed\u30d6\u30ea\u30f3\uff08SHBG\uff09\u306e\u5024\u306f\u6bd4\u8f03\u7684\u5909\u5316\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u767a\u73fe\u5909\u52d5\u907a\u4f1d\u5b50\uff08DEG\uff09\u306f\u3001\u7570\u306a\u308b\u6761\u4ef6\u306e\u9593\u306e\u6bd4\u8f03\u306b\u304a\u3044\u3066\u3001\u767a\u73fe\u91cf\u304c\u5927\u304d\u304f\u4e0a\u6607\u307e\u305f\u306f\u6e1b\u5c11\u3057\u305f\u907a\u4f1d\u5b50\u3067\u3059\u304c\u3001\u4eca\u56de\u306e\u7814\u7a76\u3067\u3001\u30d1\u30e9\u30d9\u30f3\u304a\u3088\u3073\u30d5\u30bf\u30eb\u9178\u30a8\u30b9\u30c6\u30eb\u3092\u542b\u307e\u306a\u3044\u30d1\u30fc\u30bd\u30ca\u30eb\u30b1\u30a2\u88fd\u54c1\u306e\u4f7f\u7528\u306b\u3088\u3063\u3066\u3001\u4e3b\u306b\u4e73\u623f\u7d44\u7e54\u5185\u3067\u8a98\u767a\u3055\u308c\u305f\u91cd\u8981\u306a\u5206\u5b50\u5909\u5316\u306b\u306f\u300126\u306eDEG\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u8a66\u9a13\u524d\u5f8c\u3067\u767a\u73fe\u6bd4\u304c30%\uff5e90%\u4f4e\u4e0b\u3057\u305f\u907a\u4f1d\u5b50\u304c\u591a\u6570\u3042\u308a\u3001\u767a\u73fe\u7387\u304c26%\uff5e334%\u5897\u52a0\u3057\u305f\u907a\u4f1d\u5b50\u3082\u591a\u6570\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u7279\u306b\u3001\u304c\u3093\u95a2\u9023\u907a\u4f1d\u5b5026\u500b\u4e2d19\u500b\uff0873%\uff09\u306e\u767a\u73fe\u306f\u3001\u6bd4\u8f03\u7684\u300c\u6b63\u5e38\u306a\u300d\u3078\u306e\u30b7\u30d5\u30c8\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u30bc\u30ce\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\uff08\u5206\u5b50\u69cb\u9020\u304c\u5929\u7136\u306e\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306b\u4f3c\u3066\u3044\u308b\u5408\u6210\u5316\u5b66\u7269\u8cea\uff09\u30ec\u30d9\u30eb\u306f\u3001\u30d1\u30e9\u30d9\u30f3\u304a\u3088\u3073\u30d5\u30bf\u30eb\u9178\u30a8\u30b9\u30c6\u30eb\u3092\u542b\u3080\u30d1\u30fc\u30bd\u30ca\u30eb\u30b1\u30a2\u88fd\u54c1\u306e\u4f7f\u7528\u306b\u3088\u3063\u3066\u4fc3\u9032\u3055\u308c\u3001\u9ad8\u304c\u3093\u30ea\u30b9\u30af\u8868\u73fe\u578b\u3092\u793a\u3057\u3001\u30d1\u30e9\u30d9\u30f3\u304a\u3088\u3073\u30d5\u30bf\u30eb\u9178\u30a8\u30b9\u30c6\u30eb\u3092\u542b\u307e\u306a\u3044\u30d1\u30fc\u30bd\u30ca\u30eb\u30b1\u30a2\u88fd\u54c1\u306e\u4f7f\u7528\u306b\u3088\u308a\u9006\u8ee2\u3055\u305b\u3001\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30d1\u30e9\u30d9\u30f3\u304a\u3088\u3073\u30d5\u30bf\u30eb\u9178\u30a8\u30b9\u30c6\u30eb\u3092\u542b\u307e\u306a\u3044\u30d1\u30fc\u30bd\u30ca\u30eb\u30b1\u30a2\u88fd\u54c1\u306e\u4f7f\u7528\u306b\u3088\u3063\u3066\u7d30\u80de\u7d4c\u8def\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u6b63\u5e38\u30ec\u30d9\u30eb\u306b\u30b7\u30d5\u30c8\u3059\u308b\u3053\u3068\u3067\u3001\u30db\u30eb\u30e2\u30f3\u611f\u53d7\u6027\u4e73\u623f\u7d30\u80de\u306e\u5929\u7136\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u306b\u5bfe\u3059\u308b\u5fdc\u7b54\u6027\u304c\u518d\u8abf\u6574\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

PI3K-AKT\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306f\u3001\u4e73\u304c\u3093\u306b\u304a\u3044\u3066\u983b\u7e41\u306b\u6d3b\u6027\u5316\u3055\u308c\u3001\u7d30\u80de\u306e\u751f\u5b58\u3001\u5897\u6b96\u3001\u4ee3\u8b1d\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u56de\u907f\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u305d\u306ePI3K-AKT\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u304c\u3001\u8a66\u9a13\u5f8c\u306e\u7d30\u80de\u3067\u6700\u3082\u6709\u610f\u306a\u6e1b\u5c11\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n

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\u6bd4\u8f03\u7684\u300c\u5b89\u5168\u300d\u3068\u601d\u308f\u3055\u308c\u3066\u3044\u308b\u5316\u5b66\u7269\u8cea\u66dd\u9732\u3067\u3001\u5065\u5eb7\u306a\u4e73\u623f\u7d30\u80de\u304c\u304c\u3093\u8a98\u767a\u6027\u306b\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

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