{"id":33078,"date":"2026-01-13T08:54:22","date_gmt":"2026-01-12T23:54:22","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=33078"},"modified":"2026-01-13T08:54:22","modified_gmt":"2026-01-12T23:54:22","slug":"%e3%82%b9%e3%82%bf%e3%83%81%e3%83%b3%e3%81%ae%e8%87%a8%e5%ba%8a%e5%8a%b9%e6%9e%9c%e3%81%afldl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e3%82%84%e9%9d%9ehdl%e3%82%b3%e3%83%ac","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=33078","title":{"rendered":"\u30b9\u30bf\u30c1\u30f3\u306e\u81e8\u5e8a\u52b9\u679c\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3084\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\u3067\u306f\u8aac\u660e\u3067\u304d\u306a\u3044"},"content":{"rendered":"

LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3082\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-c\uff09\u3082\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3059\u308b\u56e0\u5b50\u3060\u3068\u4fe1\u3058\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3084\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u672c\u5f53\u306b\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u30a6\u30bd\u3067\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u300120\u4ef6\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u3059\u3002\u6cbb\u7642\u306e\u52b9\u679c\u3092\u63a8\u5b9a\u3059\u308b\u305f\u3081\u306e\u81e8\u5e8a\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u4ee3\u308f\u308b\u4ee3\u66ff\u6307\u6a19\u3068\u3057\u3066\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3084\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u59a5\u5f53\u306a\u7269\u304b\u3069\u3046\u304b\u3092\u5206\u6790\u3057\u3066\u3044\u307e\u3059\u3002\u5408\u8a08194,686\u4eba\u306e\u53c2\u52a0\u8005\u304c\u542b\u307e\u308c\uff081\u8a66\u9a13\u3042\u305f\u308a\u306e\u4e2d\u592e\u5024\u306f4,614\u4eba\uff09\u3001\u8ffd\u8de1\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f4.85\u5e74\u3067\u3057\u305f\u3002\u8ffd\u8de1\u7d42\u4e86\u6642\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u7fa4\u9593\u5dee\u306e\u4e2d\u592e\u5024\u306f0.99 mmol\/L\uff08\u65e5\u672c\u306e\u5358\u4f4d\u306738.3mg\/dL\uff09\u3001\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3067\u306f1.21 mmol\/L\uff0846.8mg\/dL\uff09\u3067\u3057\u305f\u3002\u307b\u3068\u3093\u3069\uff0815\u4ef6\uff09\u306e\u8a66\u9a13\u3067\u306f\u30d7\u30e9\u30bb\u30dc\u304c\u6bd4\u8f03\u5bfe\u7167\u85ac\u3068\u3055\u308c\u3001\u30b9\u30bf\u30c1\u30f3\u306f\u4e00\u6b21\u4e88\u9632\u304c8\u4ef6\u3001\u4e8c\u6b21\u4e88\u9632\u304c8\u4ef6\u3001\u307e\u305f\u306f\u305d\u306e\u4e21\u65b9\u304c4\u4ef6\u306b\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u6c7a\u5b9a\u4fc2\u6570\uff08R\u00b2\uff09\u3092\u4f7f\u3063\u3066\u3044\u308b\u306e\u3067\u3001\u3061\u3087\u3063\u3068\u3060\u3051\u8aac\u660e\u3057\u307e\u3059\u3002R\u00b2\u306f\u69cb\u7bc9\u3057\u305f\u4e88\u6e2c\u30e2\u30c7\u30eb\u304c\u3001\u76ee\u7684\u5909\u6570\u306e\u5024\u306e\u5909\u52d5\u3092\u3069\u308c\u304f\u3089\u3044\u8aac\u660e\u3067\u304d\u3066\u3044\u308b\u304b\u3092\u793a\u3059\u6307\u6a19\u3067\u3059\u3002\u5024\u306e\u7bc4\u56f2\u306f0\u304b\u30891\u307e\u3067\u306e\u5024\uff08\u307e\u305f\u306f0%\u304b\u3089100%\uff09\u3067\u3059\u3002\u89e3\u91c8\u3068\u3057\u3066\u306f\u30011\u306b\u8fd1\u3044\u307b\u3069\u3001\u30e2\u30c7\u30eb\u306e\u5f53\u3066\u306f\u307e\u308a\u304c\u826f\u304f\u3001\u8aac\u660e\u5909\u6570\u304c\u76ee\u7684\u5909\u6570\u306e\u5909\u52d5\u3092\u3088\u304f\u8aac\u660e\u3067\u304d\u3066\u3044\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u30020\u306b\u8fd1\u3044\u307b\u3069\u3001\u30e2\u30c7\u30eb\u306e\u5f53\u3066\u306f\u307e\u308a\u304c\u60aa\u304f\u3001\u8aac\u660e\u5909\u6570\u304c\u76ee\u7684\u5909\u6570\u306e\u5909\u52d5\u3092\u307b\u3068\u3093\u3069\u8aac\u660e\u3067\u304d\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u3067\u8a00\u3048\u3070\u3001R\u00b2\u306f\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u307e\u305f\u306f\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u3069\u308c\u3060\u3051\u4f4e\u4e0b\u3057\u305f\u304b\u306b\u3088\u3063\u3066\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u7d50\u679c\u306e\u9055\u3044\u3092\u3069\u306e\u7a0b\u5ea6\u8aac\u660e\u3067\u304d\u308b\u304b\u3092\u793a\u3057\u307e\u3059\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306f\u3001\u6a2a\u8ef8\u304c\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u307e\u305f\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5e73\u5747\u5909\u5316\u91cf\u3092\u793a\u3057\u3001\u7e26\u8ef8\u306f\u3001\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u3001\u5168\u6b7b\u4ea1\u7387\u3001\u5fc3\u8840\u7ba1\uff08CV\uff09\u6b7b\u4ea1\u7387\u3001\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u3001\u304a\u3088\u3073\u8133\u5352\u4e2d\u306e\u5bfe\u6570\u30ea\u30b9\u30af\u6bd4\uff08RR\uff09\u3067\u3059\u3002\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u307e\u305f\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6e1b\u5c11\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u52b9\u679c\u3068\u81e8\u5e8a\u8ee2\u5e30\u306e\u76f8\u5bfe\u7684\u6e1b\u5c11\u3068\u306e\u95a2\u9023\u304c\u3042\u308b\u3088\u3046\u306b\u306f\u898b\u3048\u307e\u305b\u3093\u3002\u95a2\u9023\u304c\u3042\u308b\u306e\u3067\u3042\u308c\u3070\u3001\u53f3\u80a9\u4e0b\u304c\u308a\u306e\u30b0\u30e9\u30d5\u306b\u306a\u308b\u306f\u305a\u3067\u3059\u3002<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n
<\/td>\nLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/th>\n\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/th>\n<\/tr>\n
\u7d50\u679c<\/span><\/th>\n\u50be\u304d\uff0895%\u4fe1\u983c\u533a\u9593\uff09<\/span><\/th>\nR\u00b2\uff0895\uff05CI\uff09<\/span><\/th>\n\u50be\u304d\uff0895%\u4fe1\u983c\u533a\u9593\uff09<\/span><\/th>\nR\u00b2\uff0895\uff05CI\uff09<\/span><\/th>\n<\/tr>\n<\/thead>\n
MACE<\/td>\n\u22120.12 (\u22120.31, 0.07)<\/span><\/td>\n0.1 (0, 0.5)<\/span><\/td>\n\u22120.04 (\u22120.21, 0.12)<\/span><\/td>\n0.02 (0, 0.36)<\/span><\/td>\n<\/tr>\n
\u5168\u6b7b\u4ea1\u7387<\/span><\/td>\n\u22120.1 (\u22120.28, 0.07)<\/span><\/td>\n0.08 (0, 0.56)<\/span><\/td>\n\u22120.06 (\u22120.22, 0.1)<\/span><\/td>\n0.04 (0, 0.45)<\/span><\/td>\n<\/tr>\n
\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387<\/span><\/td>\n\u22120.02 (\u22120.29, 0.2)<\/span><\/td>\n0 (0, 0.22)<\/span><\/td>\n\u22120.05 (\u22120.25, 0.15)<\/span><\/td>\n0.02 (0, 0.23)<\/span><\/td>\n<\/tr>\n
\u5fc3\u7b4b\u6897\u585e<\/span><\/td>\n\u22120.09 (\u22120.38, 0.2)<\/span><\/td>\n0.03 (0, 0.49)<\/span><\/td>\n\u22120.03 (\u22120.28, 0.22)<\/span><\/td>\n0.0 (0, 0.44)<\/span><\/td>\n<\/tr>\n
\u8133\u5352\u4e2d<\/span><\/td>\n\u22120.12 (\u22120.44, 0.19)<\/span><\/td>\n0.04 (0, 0.39)<\/span><\/td>\n\u22120.01 (\u22120.29, 0.27)<\/span><\/td>\n0.0 (0, 0.34)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u5148\u307b\u3069\u8aac\u660e\u3057\u305fR\u00b2\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u6700\u5927\u3067\u30820.1\u3067\u3059\u3002\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u304c0\u306b\u8fd1\u3044\u5024\u3067\u3059\u3002\u5b9f\u969b\u306b\u306f\u300195%CI\u306e\u4e0b\u9650\u304c \u2265 0.65 \u306e\u5834\u5408\u306b\u3001\u8a66\u9a13\u30ec\u30d9\u30eb\u306e\u4ee3\u66ff\u6307\u6a19\u304c\u9054\u6210\u3055\u308c\u308b\u3068\u4e00\u822c\u7684\u306b\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\u305d\u3046\u3067\u3059\u3002\u4eca\u56de\u306e\u5206\u6790\u3067\u306f95%CI\u306e\u4e0b\u9650\u306f\u30bc\u30ed\u3067\u3059\u3002<\/span><\/p>\n

\u3064\u307e\u308a\u3001\u307b\u3068\u3093\u3069\u307e\u305f\u306f\u5168\u304f\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3082LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3082\u3001\u3069\u3061\u3089\u3082\u30b9\u30bf\u30c1\u30f3\u306e\u8a66\u9a13\u306b\u304a\u3051\u308b\u81e8\u5e8a\u7d50\u679c\u306e\u4ee3\u66ff\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u306e\u6295\u4e0e\u306b\u3088\u3063\u3066\u30b9\u30bf\u30c1\u30f3\u304c\u52b9\u679c\u3092\u793a\u3057\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u4f4e\u4e0b\u3059\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u305d\u306e\u4f4e\u4e0b\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3092\u610f\u5473\u3059\u308b\u3082\u306e\u3067\u306f\u5168\u304f\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/span>\u30b9\u30bf\u30c1\u30f3\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4f4e\u4e0b\u3057\u305f\u3002\u3081\u3067\u305f\u3057\u3081\u3067\u305f\u3057\u3001\u3067\u306f\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n

LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3084\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4f4e\u4e0b\u3057\u305f\u3089\u3001\u5065\u5eb7\u306b\u306a\u308c\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u672c\u5f53\u306e\u52b9\u679c\u3092\u8aac\u660e\u3067\u304d\u306a\u3044\u691c\u67fb\u5024\u3067\u533b\u5e2b\u306f\u7d0d\u5f97\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4e0b\u304c\u3063\u305f\u306e\u306b\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u767a\u75c7\u3059\u308c\u3070\u3001\u305d\u308c\u306f\u60a3\u8005\u306e\u4f53\u304c\u554f\u984c\u3060\u3068\u8003\u3048\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u5fc3\u8840\u7ba1\u75be\u60a3\u306f\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4\u3067\u3059\u3002\u307e\u305a\u306f\u7cd6\u8cea\u5236\u9650\u3067\u4ee3\u8b1d\u7570\u5e38\u3092\u6539\u5584\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n

\u300cTrial-level surrogacy of non-high-density and low-density lipoprotein cholesterol reduction on the clinical efficacy of statins\u300d<\/span><\/p>\n

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