{"id":33086,"date":"2026-01-21T16:42:32","date_gmt":"2026-01-21T07:42:32","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=33086"},"modified":"2026-01-21T20:42:48","modified_gmt":"2026-01-21T11:42:48","slug":"%e7%b3%96%e5%b0%bf%e7%97%85%e8%96%ac%e3%81%aesglt-2%e9%98%bb%e5%ae%b3%e8%96%ac%e3%81%ae%e5%8a%b9%e6%9e%9c%e3%81%af%e9%81%8e%e5%a4%a7%e5%ba%83%e5%91%8a","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=33086","title":{"rendered":"\u7cd6\u5c3f\u75c5\u85ac\u306eSGLT-2\u963b\u5bb3\u85ac\u306e\u52b9\u679c\u306f\u8a87\u5927\u5e83\u544a"},"content":{"rendered":"

\u7cd6\u5c3f\u75c5\u306eSGLT-2\u963b\u5bb3\u85ac\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u672c\u5f53\u306b\u4f7f\u7528\u304c\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u306d\u3002\u3069\u3093\u3069\u3093\u3001\u3053\u308c\u3089\u306e\u6709\u76ca\u306a\u52b9\u679c\u306e\u5ba3\u4f1d\u3068\u306a\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u51fa\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u6c17\u6301\u3061\u304c\u60aa\u3044\u304f\u3089\u3044\u3067\u3059\u3002<\/p>\n

\u6628\u5e74\u306e\u8b1b\u6f14\u3067\u3082\u8a71\u3057\u305f\u3088\u3046\u306b\u3001\u5b9f\u969b\u306b\u306f\u3053\u308c\u307e\u3067\u306e\u7cd6\u5c3f\u75c5\u85ac\u306e\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3068\u6bd4\u8f03\u3057\u3066\u3082\u5927\u5dee\u304c\u306a\u3044\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u88fd\u85ac\u4f1a\u793e\u306f\u8a87\u5927\u5e83\u544a\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u305d\u306eSGLT-2\u963b\u5bb3\u85ac\u3068\u30e1\u30c8\u30db\u30eb\u30df\u30f3\uff08\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\uff09\u3092\u6bd4\u8f03\u3057\u3066\u3044\u307e\u3059\u3002\u4eba\u53e3\u7d71\u8a08\u5b66\u7684\u3001\u81e8\u5e8a\u7684\u3001\u81e8\u5e8a\u691c\u67fb\u5024\u3001\u304a\u3088\u3073\u751f\u6d3b\u7fd2\u6163\u5909\u6570\u306b\u3064\u3044\u30661:1\u306e\u50be\u5411\u30b9\u30b3\u30a2\u30de\u30c3\u30c1\u30f3\u30b0\u3092\u884c\u3063\u305f\u5f8c\u30011,246\u4eba\uff08\u5404\u7fa4623\u4eba\uff09\u3092\u4e2d\u592e\u50242.9\u5e74\uff08\u6700\u95777.2\u5e74\uff09\u8ffd\u8de1\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002\u8133\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u5fc3\u81d3\u30a4\u30d9\u30f3\u30c8\u3001\u307e\u305f\u306f\u5168\u6b7b\u4ea1\u7387\u304b\u3089\u306a\u308b\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u6700\u521d\u306e\u30a4\u30d9\u30f3\u30c8\u307e\u3067\u306e\u6642\u9593\u3092\u6bd4\u8f03\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\n\n\n\n\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u7d50\u679c<\/span><\/th>\n\u66b4\u9732<\/span><\/th>\n3\u5e74\u5f8c\u306e\u7d2f\u7a4d\u767a\u751f\u7387<\/span><\/th>\n<\/tr>\n<\/thead>\n
\u8907\u5408\u30a4\u30d9\u30f3\u30c8<\/span><\/td>\n\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\uff08n = 623\uff09<\/span><\/td>\n5.9<\/span><\/td>\n<\/tr>\n
<\/td>\nSGLT2\u963b\u5bb3\u85ac\uff08n = 623\uff09<\/span><\/td>\n5.5<\/span><\/td>\n<\/tr>\n
\u5fc3\u81d3\u767a\u4f5c<\/span><\/td>\n\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\uff08n = 623\uff09<\/span><\/td>\n3.1<\/span><\/td>\n<\/tr>\n
<\/td>\nSGLT2\u963b\u5bb3\u85ac\uff08n = 623\uff09<\/span><\/td>\n2.6<\/span><\/td>\n<\/tr>\n
\u8133\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8<\/span><\/td>\n\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\uff08n = 623\uff09<\/span><\/td>\n1.4<\/span><\/td>\n<\/tr>\n
<\/td>\nSGLT2\u963b\u5bb3\u85ac\uff08n = 623\uff09<\/span><\/td>\n1.9<\/span><\/td>\n<\/tr>\n
\u6b7b\u4ea1<\/span><\/td>\n\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\uff08n = 623\uff09<\/span><\/td>\n2.1<\/span><\/td>\n<\/tr>\n
<\/td>\nSGLT2\u963b\u5bb3\u85ac\uff08n = 623\uff09<\/span><\/td>\n1.2<\/span><\/td>\n<\/tr>\n
\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7<\/span><\/td>\n\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\uff08n = 623\uff09<\/span><\/td>\n16.8<\/span><\/td>\n<\/tr>\n
SGLT2\u963b\u5bb3\u85ac\uff08n = 623\uff09<\/span><\/td>\n12.9<\/span><\/td>\n<\/tr>\n
\u7cd6\u5c3f\u75c5\u7db2\u819c\u75c7<\/span><\/td>\n\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\uff08n = 623\uff09<\/span><\/td>\n13.2<\/span><\/td>\n<\/tr>\n
<\/td>\nSGLT2\u963b\u5bb3\u85ac\uff08n = 623\uff09<\/span><\/td>\n10.6<\/span><\/td>\n<\/tr>\n
\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7<\/span><\/td>\n\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\uff08n = 623\uff09<\/span><\/td>\n3.9<\/span><\/td>\n<\/tr>\n
<\/td>\nSGLT2\u963b\u5bb3\u85ac\uff08n = 623\uff09<\/span><\/td>\n2.4<\/span><\/td>\n<\/tr>\n
\u7cd6\u5c3f\u75c5\u6027\u795e\u7d4c\u969c\u5bb3<\/span><\/td>\n\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\uff08n = 623\uff09<\/span><\/td>\n0.8<\/span><\/td>\n<\/tr>\n
<\/td>\nSGLT2\u963b\u5bb3\u85ac\uff08n = 623\uff09<\/span><\/td>\n0.4<\/span><\/td>\n<\/tr>\n
\u305d\u306e\u4ed6\u306e\u6761\u4ef6<\/span>*<\/span><\/sup><\/td>\n\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\uff08n = 623\uff09<\/span><\/td>\n1.9<\/span><\/td>\n<\/tr>\n
<\/td>\nSGLT2\u963b\u5bb3\u85ac\uff08n = 623\uff09<\/span><\/td>\n1.0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u4e0a\u306e\u8868\u306e\u3088\u3046\u306b\u3001\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\u3068\u6bd4\u8f03\u3059\u308b\u3068SGLT-2\u963b\u5bb3\u85ac\u306e\u65b9\u306f\u767a\u751f\u7387\u306f\u4f4e\u304f\u306a\u3063\u3066\u3044\u308b\u3088\u3046\u306b\u898b\u3048\u307e\u3059\u304c\u3001\u6b8b\u5ff5\u306a\u304c\u3089\u3069\u306e\u7d50\u679c\u3082\u6709\u610f\u306a\u5dee\u304c\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u4e0b\u306e\u56f3\u306f\u3001a\u306f\u5fc3\u81d3\u307e\u305f\u306f\u8133\u8840\u7ba1\u75be\u60a3\u307e\u305f\u306f\u6b7b\u4ea1\u7387\u306e\u8907\u5408\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u3001b\u306f\u7cd6\u5c3f\u75c5\u6027\u7db2\u819c\u75c7\u3001\u814e\u75c7\u3001\u795e\u7d4c\u969c\u5bb3\u3001\u305d\u306e\u4ed6\u306e\u75c5\u72b6\u3092\u542b\u3080\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u306e\u7d2f\u7a4d\u767a\u751f\u7387\u3067\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u3069\u3061\u3089\u3082\u6709\u610f\u306a\u5dee\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\u3068SGLT-2\u963b\u5bb3\u85ac\u306e\u4f7f\u7528\u3092\u6bd4\u8f03\u3057\u305f\u5834\u5408\u3001\u6709\u610f\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u3042\u3089\u3086\u308b\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u306f0.88\u500d\u3067\u3001\u500b\u3005\u306e\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u306f\u3001\u7db2\u819c\u75c7\u304c0.93\u500d\u3001\u814e\u75c7\u304c0.97\u500d\u3001\u795e\u7d4c\u969c\u5bb3\u304c0.76\u500d\u3001\u305d\u306e\u4ed6\u306e\u75be\u60a3\u304c1.04\u500d\u3067\u3057\u305f\u3002<\/p>\n

\u305f\u3060\u3001\u8907\u5408\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u3064\u3044\u3066\u306fBMI25\u4ee5\u4e0a\u306e\u4eba\uff080.38\u500d\uff09\u3068\u3001HbA1c7%\uff5e8%\u672a\u6e80\u306e\u4eba\uff080.24\u500d\uff09\u3060\u3051\u306f\u6709\u610f\u306bSGLT-2\u963b\u5bb3\u85ac\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u3055\u3089\u306b\u5225\u306e14\u4ef6\u306e\u7814\u7a76\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u304a\u3088\u3073SGLT-2\u963b\u5bb3\u85ac\u306e\u6bd4\u8f03\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\u3055\u3089\u306b\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u30d7\u30e9\u30bb\u30dc\u306b\u3055\u3048SGLT-2\u963b\u5bb3\u85ac\u306f\u52dd\u3066\u306a\u304b\u3063\u305f\u3068\u3044\u3046\u9ed2\u6b74\u53f2\u304c\u3042\u308a\u307e\u3059\u3002SGLT-2\u963b\u5bb3\u85ac\u306e\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\uff08\u5546\u54c1\u540d\u30b8\u30e3\u30c7\u30a3\u30a2\u30f3\u30b9\uff09\u306e\u5b89\u5168\u6027\u3092\u8a55\u4fa1\u3059\u308b\u8a66\u9a13\u306e\u7d50\u679c\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n

\u85ac\u7269\u6cbb\u7642\u672a\u7d4c\u9a13\uff08HbA 1c \u2265 7.0%\u3001\u2264 9.0%\uff09\u307e\u305f\u306f\u8840\u7cd6\u964d\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\uff08HbA 1c \u2265 7.0%\u3001\u2264 10.0%\uff09\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u9ad8\u30ea\u30b9\u30af\u60a3\u80057020\u4eba\u3092\u7121\u4f5c\u70ba\u5316\u3057\u3001\u6a19\u6e96\u6cbb\u7642\u306b\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f310mg\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f325mg\u3001\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u3092\u4f75\u7528\u6295\u4e0e\u3057\u307e\u3057\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u7b4b\u6897\u585e\u3001\u307e\u305f\u306f\u975e\u81f4\u6b7b\u6027\u8133\u5352\u4e2d\u306e\u521d\u56de\u767a\u73fe\u307e\u3067\u306e\u6642\u9593\u3067\u3059\u3002<\/p>\n

\u78ba\u304b\u306b\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u7fa410.5%\u3067\u3001\u30d7\u30e9\u30bb\u30dc\u7fa412.1%\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u4f4e\u3044\u5272\u5408\u3067\u767a\u73fe\u3057\u3001\u30ea\u30b9\u30af\u306f0.86\u500d\u3067\u3057\u305f\u3002\u305f\u3060\u3001\u554f\u984c\u3042\u308a\u3042\u308a\u3067\u3059\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

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\u3055\u3089\u306b\u3001\u3053\u306e\u8a66\u9a13\u306e\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306f10mg\u306825mg\u304c\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u4e21\u65b9\u306e\u91cf\u3092\u5408\u308f\u305b\u305f\u3082\u306e\u304c\u7d71\u8a08\u7684\u306b\u6709\u610f\u306b\u52b9\u679c\u304c\u3042\u3063\u305f\u3068\u3057\u3066\u3044\u307e\u3059\u304c\u300110mg\u306825mg\u3092\u5206\u3051\u305f\u3068\u304d\u3069\u3046\u306a\u3063\u3066\u3044\u308b\u304b\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

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SGLT-2\u963b\u5bb3\u85ac\u306b\u305f\u3068\u3048\u3001\u5fc3\u4fdd\u8b77\u4f5c\u7528\u304c\u3042\u3063\u305f\u3068\u3057\u3066\u3082\u3001\u305d\u306e\u30c8\u30ec\u30fc\u30c9\u30aa\u30d5\u3068\u3057\u3066\u8133\u5352\u4e2d\u304c\u9ad8\u304f\u306a\u308b\u3053\u3068\u306f\u8a31\u5bb9\u3067\u304d\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

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\u300cComparative effectiveness of biguanides versus SGLT2 inhibitors on cardiovascular and cerebrovascular events, diabetic nephropathy, retinopathy, neuropathy, and treatment expenditures in patients with type 2 diabetes\u300d<\/span><\/p>\n

\u300c2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u8133\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u3001\u7db2\u819c\u75c7\u3001\u795e\u7d4c\u969c\u5bb3\u3001\u304a\u3088\u3073\u6cbb\u7642\u8cbb\u306b\u5bfe\u3059\u308b\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\u85ac\u3068SGLT2\u963b\u5bb3\u85ac\u306e\u6709\u52b9\u6027\u306e\u6bd4\u8f03\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n

\u300cEvaluation of the Lifetime Benefits of Metformin and SGLT2 Inhibitors in Type 2 Diabetes Mellitus Patients with Cardiovascular Disease: A Systematic Review and Two-Stage Meta-Analysis\u300d<\/span><\/p>\n

\u300c\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u304a\u3088\u3073SGLT2\u963b\u5bb3\u85ac\u306e\u751f\u6daf\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306e\u8a55\u4fa1\uff1a\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u304a\u3088\u30732\u6bb5\u968e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n

\u300cRationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME™)\u300d<\/span><\/p>\n

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