{"id":34757,"date":"2026-07-13T08:49:23","date_gmt":"2026-07-12T23:49:23","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=34757"},"modified":"2026-07-13T08:49:23","modified_gmt":"2026-07-12T23:49:23","slug":"%e3%83%97%e3%83%ad%e3%83%88%e3%83%b3%e3%83%9d%e3%83%b3%e3%83%97%e9%98%bb%e5%ae%b3%e8%96%ac%ef%bc%88ppi%ef%bc%89%e3%81%a8%e3%81%8c%e3%82%93%e6%82%a3%e8%80%85%e3%81%ae%e6%ad%bb%e4%ba%a1%e3%83%aa","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=34757","title":{"rendered":"\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff08PPI\uff09\u3068\u304c\u3093\u60a3\u8005\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af"},"content":{"rendered":"

\u30de\u30c3\u30c1\u30dd\u30f3\u30d7\u85ac\u306e\u4ee3\u8868\u3001\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\uff08PPI\uff09\u306f\u69d8\u3005\u306a\u304c\u3093\u306e\u30ea\u30b9\u30af\u3092\u4e0a\u3052\u308b\u3053\u3068\u3092\u77e5\u3063\u3066\u3044\u308b\u4eba\u3082\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u3067\u306f\u3001\u304c\u3093\u60a3\u8005\u304cPPI\u3092\u4f7f\u7528\u3057\u305f\u3089\u3069\u3046\u306a\u308b\u3067\u3057\u3087\u3046\uff1f<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u6210\u4eba\u306e\u304c\u3093\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u65b0\u898f\u306bPPI\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u3068\u975e\u4f7f\u7528\u8005\u304a\u3088\u3073\u65b0\u898f\u306b\u30d2\u30b9\u30bf\u30df\u30f3H2\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\uff08H2RA\uff09\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u50be\u5411\u30b9\u30b3\u30a2\u30de\u30c3\u30c1\u30f3\u30b0\u5f8c\u306bPPI\u4f7f\u7528\u7fa4\u3001\u975e\u4f7f\u7528\u7fa448452\u4eba\u305a\u3064\u3067\u8a55\u4fa1\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\n

\u4e0b\u306e\u8868\u306f\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\u306e\u65b0\u898f\u4f7f\u7528\u8005\u3068\u975e\u4f7f\u7528\u8005\u306b\u304a\u3051\u308b\u5168\u539f\u56e0\u6b7b\u4ea1\u30ea\u30b9\u30af\u3067\u3059\u3002\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/span><\/p>\n<\/div>\n

\n\n\n\n\n\n\n\n
\u7d50\u679c<\/span><\/strong><\/td>\nPPI\u4f7f\u7528\u8005<\/span><\/strong><\/td>\n\u975e\u5229\u7528\u8005<\/span><\/strong><\/td>\nHR\uff0895%\u4fe1\u983c\u533a\u9593\uff09<\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n
1\u5e74<\/span><\/td>\n8888<\/span><\/td>\n3272<\/span><\/td>\n2.72 (2.61-2.83)<\/span><\/td>\n<\/tr>\n
2\u5e74<\/span><\/td>\n13719<\/span><\/td>\n5276<\/span><\/td>\n2.66 (2.58-2.74)<\/span><\/td>\n<\/tr>\n
\u8ffd\u8de1\u8abf\u67fb\u4e2d\u306e\u5168\u4f53\u7684\u306a\u7d50\u679c<\/span><\/td>\n23421<\/span><\/td>\n11656<\/span><\/td>\n2.34 (2.29-2.42)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

1\u5e74\u5f8c\u3001PPI\u4f7f\u7528\u8005\u306e\u6b7b\u4ea1\u7387\u306f\u975e\u4f7f\u7528\u8005\u3088\u308a\u3082\u5927\u5e45\u306b\u9ad8\u304f\u3001PPI\u7fa4\u3067\u306f8888\u4ef6\u3001\u975ePPI\u7fa4\u3067\u306f3272\u4ef6\u3067\u3057\u305f\u3002PPI\u4f7f\u7528\u8005\u306f2.72\u500d\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u306e\u3067\u3059\u30022\u5e74\u5f8c\u306b\u306f\u3001PPI\u4f7f\u7528\u8005\u3067\u306f13719\u4ef6\u3001\u975e\u4f7f\u7528\u8005\u3067\u306f5276\u4ef6\u3067\u3001PPI\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u306f2.66\u500d\u3067\u3057\u305f\u3002<\/p>\n

\u8ffd\u8de1\u671f\u9593\u5168\u4f53\uff08PPI\u4f7f\u7528\u8005\u3067\u306f\u5e73\u57475.4\u5e74\u3001\u975e\u4f7f\u7528\u8005\u3067\u306f\u5e73\u57476.5\u5e74\uff09\u306b\u304a\u3044\u3066\u3001\u7d2f\u7a4d\u6b7b\u4ea1\u767a\u751f\u6570\u306fPPI\u4f7f\u7528\u8005\u306723421\u4eba\u3001\u975e\u4f7f\u7528\u8005\u306711656\u4eba\u3067\u3001\u6b7b\u4ea1\u30ea\u30b9\u30af\u306f2.34\u500d\u3067\u3059\u3002<\/p>\n

\n

\u4e0b\u306e\u8868\u306f\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u85ac\u306e\u65b0\u898f\u4f7f\u7528\u8005\u3068\u30d2\u30b9\u30bf\u30df\u30f32\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\uff08H2RA\uff09\u306e\u65b0\u898f\u4f7f\u7528\u8005\u9593\u306e\u5168\u539f\u56e0\u6b7b\u4ea1\u30ea\u30b9\u30af\u3067\u3059\u3002<\/span><\/p>\n<\/div>\n

\n\n\n\n\n\n\n\n
\u7d50\u679c<\/span><\/strong><\/td>\nPPI\u4f7f\u7528\u8005<\/span><\/strong><\/td>\nH2RA\u4f7f\u7528\u8005<\/span><\/strong><\/td>\nHR\uff0895%\u4fe1\u983c\u533a\u9593\uff09<\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n
1\u5e74<\/span><\/td>\n8393<\/span><\/td>\n7980<\/span><\/td>\n1.51 (1.41-1.69)<\/span><\/td>\n<\/tr>\n
2\u5e74<\/span><\/td>\n12950<\/span><\/td>\n11989<\/span><\/td>\n1.16 (1.04-1.39)<\/span><\/td>\n<\/tr>\n
\u8ffd\u8de1\u8abf\u67fb\u4e2d\u306e\u5168\u4f53\u7684\u306a\u7d50\u679c<\/span><\/td>\n18304<\/span><\/td>\n17146<\/span><\/td>\n1.17 (1.05-2.16)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

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PPI\u81ea\u4f53\u304c\u3001\u304c\u3093\u60a3\u8005\u3092\u6b7b\u4ea1\u3055\u305b\u3066\u3044\u308b\u306e\u304b\u3069\u3046\u304b\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u304c\u3001\u30de\u30c3\u30c1\u30dd\u30f3\u30d7\u85ac\u306e\u4ee3\u8868\u7684\u306a\u85ac\u306a\u306e\u3067\u3001\u69d8\u3005\u306a\u526f\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u814e\u6a5f\u80fd\u3082\u4f4e\u4e0b\u3055\u305b\u305f\u308a\u3001\u611f\u67d3\u30ea\u30b9\u30af\u3082\u591a\u304f\u306a\u308c\u3070\u3001\u6b7b\u4ea1\u7387\u3082\u4e0a\u304c\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n

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\u300cProton pump inhibitors and all-cause mortality risk among cancer patients\u300d<\/span><\/p>\n

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