{"id":35266,"date":"2026-09-28T15:20:33","date_gmt":"2026-09-28T06:20:33","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=35266"},"modified":"2026-09-28T15:20:33","modified_gmt":"2026-09-28T06:20:33","slug":"glp-1%e5%8f%97%e5%ae%b9%e4%bd%93%e4%bd%9c%e5%8b%95%e8%96%ac%e3%81%ae%e5%bf%83%e4%bf%9d%e8%ad%b7%e5%8a%b9%e6%9e%9c%e3%81%af%e8%aa%87%e5%a4%a7%e5%ba%83%e5%91%8a%e3%81%ae%e5%8f%af%e8%83%bd%e6%80%a7","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=35266","title":{"rendered":"GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u5fc3\u4fdd\u8b77\u52b9\u679c\u306f\u8a87\u5927\u5e83\u544a\u306e\u53ef\u80fd\u6027"},"content":{"rendered":"

\u533b\u7642\u696d\u754c\u3067\u306fGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3084SGLT-2\u963b\u5bb3\u85ac\u3078\u306e\u79f0\u8cdb\u304c\u6b62\u307e\u308a\u307e\u305b\u3093\u3002\u5fc3\u4fdd\u8b77\u52b9\u679c\u3001\u814e\u4fdd\u8b77\u52b9\u679c\u2026\u2026\u3002\u672c\u5f53\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u7279\u306b\u6700\u8fd1\u306fGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u52b9\u679c\u304c\u6d3e\u624b\u306b\u5ba3\u4f1d\u3055\u308c\u3066\u3044\u307e\u3059\u3002GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6291\u5236\u52b9\u679c\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\uff08\u5546\u54c1\u540d\uff1a\u30de\u30f3\u30b8\u30e3\u30ed\uff09\u304c\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u306e\u6e1b\u5c11\u306e\u7a0b\u5ea6\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\"\"<\/a><\/p>\n

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\u3053\u308c\u3060\u3051\u3092\u898b\u308c\u3070\u3001\u3084\u3063\u3071\u308aGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u3059\u3054\u3044\u85ac\u306a\u3093\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u3067\u306f\u3001\u3082\u3046\u5c11\u3057\u7d30\u304b\u3044\u3068\u3053\u308d\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u5bfe\u8c61\u3068\u306a\u3063\u305f\u306e\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u304a\u3088\u3073\u78ba\u7acb\u3055\u308c\u305f\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b40\u6b73\u4ee5\u4e0a\u306e52,971\u4eba\u3067\u300135,353\u4eba\u304cGLP-1\u85ac\u306b\u5272\u308a\u632f\u3089\u308c\u3001\u6b8b\u308a\u306e\u4eba\u306b\u306f\u30b7\u30bf\u30b0\u30ea\u30d7\u30c1\u30f3\u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u30b7\u30bf\u30b0\u30ea\u30d7\u30c1\u30f3\u3068\u3044\u3046\u306e\u306f\u3001\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u7cd6\u5c3f\u75c5\u85acDPP-4\u963b\u5bb3\u85ac\u306e\u30b7\u30e7\u30dc\u3044\u52b9\u679c<\/a>\u300d\u3067\u3082\u66f8\u3044\u305f\u3001\u5546\u54c1\u540d\uff1a\u30b8\u30e3\u30cc\u30d3\u30a2\u3001\u30b0\u30e9\u30af\u30c6\u30a3\u30d6\u306a\u3069\u306eDPP-4\u963b\u5bb3\u85ac\u3067\u3059\u3002DPP-4\u963b\u5bb3\u85ac\u306f\u30d7\u30e9\u30bb\u30dc\u306b\u3082\u52dd\u3066\u305a\u3001DPP-4\u963b\u5bb3\u85ac\u304c\u52dd\u3066\u308b\u85ac\u306f\u30b9\u30eb\u30db\u30cb\u30eb\u5c3f\u7d20\u304f\u3089\u3044\u3057\u304b\u306a\u3044\u306e\u3067\u3059\u3002\u305d\u3093\u306a\u307b\u3068\u3093\u3069\u52b9\u679c\u3092\u793a\u3059\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u85ac\u3068\u6bd4\u8f03\u3057\u3066\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306fMACE\u30ea\u30b9\u30af\u306a\u3069\u3092\u5927\u304d\u304f\u6e1b\u5c11\u3055\u305b\u305f\u3068\u8a00\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n

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\u3055\u3089\u306b\u3001MACE\u306e1\u5e74\u30ea\u30b9\u30af\u306f\u3001DPP-4\u963b\u5bb3\u85ac\u306e\u30b7\u30bf\u30b0\u30ea\u30d7\u30c1\u30f3\u7fa4\u304c4.4\uff05\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001GLP-1\u85ac\u306e\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u7fa4\u306f2.9\uff05\u3067\u30011\u5e74\u5f8c\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u5dee\u306f-1.4\uff05\u3057\u304b\u306a\u304f\u3001\u6cbb\u7642\u5fc5\u8981\u6570\uff08NNT\uff09\u306f70\u3067\u3057\u305f\u3002NNT\uff1d70\u3068\u3044\u3046\u3053\u3068\u306f\u300170\u4eba\u306b\u4e00\u4eba\u3057\u304bGLP-1\u85ac\u306e\u6069\u6075\u306f\u53d7\u3051\u3089\u308c\u306a\u3044\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\uff08\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n\n\n\n\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n\n\n
\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8<\/span><\/strong><\/td>\n1\u5e74\u9593\u306e\u30ea\u30b9\u30af<\/span><\/strong><\/td>\n\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895%\u4fe1\u983c\u533a\u9593\uff09<\/span><\/strong><\/td>\nNNT<\/span><\/strong><\/td>\n<\/tr>\n
GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac<\/td>\nDPP-4\u963b\u5bb3\u85ac<\/td>\n\u7d76\u5bfe\u30ea\u30b9\u30af\u5dee<\/span><\/strong><\/td>\n<\/tr>\n
MACE<\/td>\n2.9\uff082.5\uff5e3.4\uff09<\/span><\/td>\n4.4\uff083.8\uff5e4.9\uff09<\/span><\/td>\n-1.4\uff08-2.1\uff5e-0.7\uff09<\/span><\/td>\n0.68\uff080.58\uff5e0.80\uff09<\/span><\/td>\n70<\/span><\/td>\n<\/tr>\n
\u5fc3\u7b4b\u6897\u585e\u307e\u305f\u306f\u8133\u5352\u4e2d<\/span><\/td>\n1.8\uff081.5\uff5e2.1\uff09<\/span><\/td>\n2.6\uff082.2\uff5e3.0\uff09<\/span><\/td>\n-0.8\uff08-1.4\uff5e-0.3\uff09<\/span><\/td>\n0.74\uff080.61\uff5e0.91\uff09<\/span><\/td>\n124<\/span><\/td>\n<\/tr>\n
\u5fc3\u7b4b\u6897\u585e<\/span><\/td>\n1.1\uff080.9\uff5e1.4\uff09<\/span><\/td>\n1.9\uff081.5\uff5e2.3\uff09<\/span><\/td>\n-0.8\uff08-1.2\uff5e-0.3\uff09<\/span><\/td>\n0.67\uff080.52\uff5e0.87\uff09<\/span><\/td>\n130<\/span><\/td>\n<\/tr>\n
\u8133\u5352\u4e2d<\/span><\/td>\n0.7\uff080.5\uff5e0.9\uff09<\/span><\/td>\n0.7\uff080.5\uff5e1.0\uff09<\/span><\/td>\n-0.0 (-0.4\uff5e0.3)<\/span><\/td>\n0.91\uff080.64\uff5e1.28\uff09<\/span><\/td>\n2500<\/span><\/td>\n<\/tr>\n
\u5168\u539f\u56e0\u6b7b\u4ea1\u7387<\/span><\/td>\n1.3\uff081.0\uff5e1.5\uff09<\/span><\/td>\n2.1\uff081.7\uff5e2.5\uff09<\/span><\/td>\n-0.8\uff08-1.3\uff5e-0.3\uff09<\/span><\/td>\n0.55\uff080.42\uff5e0.72\uff09<\/span><\/td>\n122<\/span><\/td>\n<\/tr>\n
\u611f\u67d3\u95a2\u9023\u6b7b\u4ea1\u7387<\/span><\/td>\n0.5\uff080.3\uff5e0.7\uff09<\/span><\/td>\n1.0\uff080.7\uff5e1.2\uff09<\/span><\/td>\n-0.5\uff08-0.8\uff5e0.2\uff09<\/span><\/td>\n0.40\uff080.26\uff5e0.61\uff09<\/span><\/td>\n200<\/span><\/td>\n<\/tr>\n
\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7<\/span><\/td>\n13.1\uff0812.3\uff5e13.9\uff09<\/span><\/td>\n14.5\uff0813.6\uff5e15.4\uff09<\/span><\/td>\n-1.4\uff08-2.6\uff5e-0.2\uff09<\/span><\/td>\n0.92\uff080.85\uff5e0.99\uff09<\/span><\/td>\n72<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u3055\u3089\u306b\u3055\u3089\u306b\u3001\u4e0a\u306e\u8868\u306e\u3088\u3046\u306b\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3057\u305f\u3068\u66f8\u304d\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u5dee\u306f-0.8\uff05\u3057\u304b\u306a\u304f\u3001NNT\u3082130\u3067\u3059\u3002\u5168\u539f\u56e0\u6b7b\u4ea1\u3082\u305d\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u5dee\u306f-0.8\uff05\u3067\u3001NNT\u306f122\u3067\u3059\u3002\u611f\u67d3\u95a2\u9023\u6b7b\u4ea1\u7387\u306a\u3093\u306660\uff05\u3082\u6e1b\u5c11\u3068\u8a00\u3044\u307e\u3059\u304c\u3001\u7d76\u5bfe\u30ea\u30b9\u30af\u5dee\u306f-0.5\uff05\u3067\u3057\u304b\u306a\u304f\u3001NNT\u3082200\u3067\u3059\u3002<\/span><\/p>\n

\u6700\u521d\u306e\u30b0\u30e9\u30d5\u306e\u7e26\u8ef8\u306f0\uff5e5\uff05\u307e\u3067\u3057\u304b\u306a\u304f\u3001\u5dee\u304c\u5927\u304d\u304f\u898b\u3048\u308b\u3088\u3046\u306b\u3057\u3066\u3044\u307e\u3059\u304c\u30010\uff5e100\uff05\u306b\u3057\u3066\u3001\u68d2\u30b0\u30e9\u30d5\u306b\u3059\u308b\u3068\u6b21\u306e\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\u300cTirzepatide and the risk of atherosclerotic cardiovascular events: population based cohort study\u300d<\/span><\/p>\n

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\u300cSemaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes\u300d<\/span><\/p>\n

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