{"id":3546,"date":"2018-03-27T00:09:04","date_gmt":"2018-03-26T15:09:04","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=3546"},"modified":"2020-01-10T08:41:25","modified_gmt":"2020-01-09T23:41:25","slug":"post-3546","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=3546","title":{"rendered":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u672c\u5f53\u306b\u52d5\u8108\u306e\u8840\u7ba1\u5185\u8154\u304b\u3089\u8840\u7ba1\u5185\u76ae\u3092\u901a\u3063\u3066\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u8d77\u3053\u3059\u306e\u304b\uff1f\u3000\u305d\u306e5"},"content":{"rendered":"<p><a href=\"http:\/\/promea2014.com\/blog\/?p=3535\" target=\"_blank\" rel=\"noopener noreferrer\">\u524d\u56de\u306e\u8a18\u4e8b\u300c\u305d\u306e4\u300d<\/a>\u3067\u306f\u3001\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306b\u3088\u308a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u969c\u5bb3\u304c\u8d77\u3053\u308a\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u5185\u819c\u304c\u80a5\u539a\u3059\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u4eee\u8aac\u3092\u66f8\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u3067\u306f\u3001\u306a\u305c\u8102\u8cea\u304c\u5185\u819c\u306b\u84c4\u7a4d\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u305d\u308c\u3092\u8aac\u660e\u3059\u308b\u306e\u306b\u3001\u5927\u304d\u306a\u6d77\u306b\u51fa\u305f\u611f\u3058\u3067\u3001\u307b\u3068\u3093\u3069\u6eba\u308c\u3066\u3044\u307e\u3059\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u539f\u56e0\u3092\u7a81\u304d\u6b62\u3081\u3088\u3046\u3068\u51fa\u305f\u6d77\u306f\u975e\u5e38\u306b\u5e83\u304f\u3001\u305d\u3057\u3066\u6df1\u304f\u3001\u3055\u3063\u3071\u308a\u3069\u3053\u3092\u6cf3\u3044\u3060\u3089\u3044\u3044\u306e\u304b\u3001\u3069\u3061\u3089\u306e\u65b9\u5411\u3078\u6cf3\u3044\u3060\u3089\u3044\u3044\u306e\u304b\u308f\u304b\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u8208\u5473\u306f\u9014\u5207\u308c\u3066\u3044\u306a\u3044\u306e\u3067\u3001\u4f55\u3068\u304b\u8003\u3048\u3066\u3044\u304f\u3064\u3082\u308a\u3067\u3059\u3002<\/p>\n<p>\u3055\u3066\u3001\u57fa\u672c\u7684\u306a\u8003\u3048\u306fresponse-to-retention hypothesis\uff08\u8caf\u7559\u53cd\u5fdc\u4eee\u8aac\uff09\u3067\u3059\u3002\u3053\u3053\u3067\u30ab\u30ae\u3068\u306a\u308b\u306e\u304c\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002\u7cd6\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8907\u5408\u4f53\u3067\u3001\u4f53\u306e\u7d44\u7e54\u4e2d\u306e\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u3084\u7d30\u80de\u8868\u9762\u306a\u3069\u306b\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u8840\u7ba1\u306e\u5185\u819c\u306b\u3082\u5b58\u5728\u3057\u3066\u304a\u308a\u3001\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306e\u4e3b\u8981\u69cb\u6210\u6210\u5206\u306e\u4e00\u3064\u3067\u3059\u3002<\/p>\n<p>\u8102\u8cea\u304c\u6c88\u7740\u3059\u308b\u524d\u306e\u72b6\u614b\u3067\u3042\u308b\u3073\u307e\u3093\u6027\u5185\u819c\u80a5\u539a\u306e\u6df1\u3044\u90e8\u5206\u306b\u306f\u30d3\u30b0\u30ea\u30ab\u30f3\u3084\u30c7\u30b3\u30ea\u30f3\u3068\u3044\u3046\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306e\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u304c\u521d\u671f\u306e\u8102\u8cea\u306e\u6c88\u7740\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u5f37\u304f\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u30a2\u30c6\u30ed\u30fc\u30e0\u767a\u751f\u6027\u306e\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7d30\u80de\u5916\u306e\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5185\u819c\u5185\u306b\u4fdd\u6301\u3055\u308c\u308b\u3068\u8ff0\u3079\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u30011995\u5e74\u306b\u8caf\u7559\u53cd\u5fdc\u4eee\u8aac\u3068\u3057\u3066\u63d0\u6848\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u8907\u5408\u4f53\u304c\u3001\u9178\u5316\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u306e\u5897\u52a0\u3092\u793a\u3057\u3001\u6ce1\u6cab\u7d30\u80de\u3092\u5f62\u6210\u3059\u308b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308b\u53d6\u308a\u8fbc\u307f\u3092\u3082\u305f\u3089\u3059\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u5168\u3066\u306e\u4eba\u3067\u306f\u306a\u3044\u3067\u3059\u304c\u3001\u30d3\u30b0\u30ea\u30ab\u30f3\u306e\u5206\u5e03\u3092\u8102\u8cea\u6c88\u7740\u306e\u306a\u3044\u9818\u57df\u3067\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u30d3\u30b0\u30ea\u30ab\u30f3\u304c\u80a5\u539a\u3057\u305f\u5185\u819c\u306e\u5916\u5c64\u306b\u4e3b\u306b\u540c\u5fc3\u5186\u72b6\u304b\u3064\u7d30\u80de\u5916\u306b\u5c40\u5728\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u5185\u819c\u306b\u306f\u8102\u8cea\u304c\u84c4\u7a4d\u3055\u308c\u308b\u524d\u304b\u3089\u30d3\u30b0\u30ea\u30ab\u30f3\u306f\u5b58\u5728\u3059\u308b\u306e\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u5c40\u5728\u306f\u975e\u5e38\u306b\u8840\u7ba1\u306e\u5185\u8154\u304b\u3089\u898b\u308c\u3070\u6df1\u3044\u5834\u6240\u3067\u3059\u3002\u305d\u3053\u306b\u8840\u7ba1\u306e\u5185\u8154\u304b\u3089\u5165\u3063\u3066\u304d\u305f\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6700\u521d\u306b\u84c4\u7a4d\u3057\u3066\u304f\u308b\u3068\u306f\u975e\u5e38\u306b\u8003\u3048\u306b\u304f\u3044\u3053\u3068\u3067\u3059\u3002\u305d\u3057\u3066\u300c<a href=\"http:\/\/promea2014.com\/blog\/?p=3492&amp;\" target=\"_blank\" rel=\"noopener noreferrer\">\u305d\u306e3<\/a>\u300d\u3067\u3082\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u8840\u7ba1\u306e\u5185\u819c\u306b\u306f\u8840\u7ba1\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u3057\u3066\u3001\u80a5\u539a\u3057\u3066\u304d\u305f\u5185\u819c\u306e\u6df1\u3044\u90e8\u5206\u306f\u9178\u7d20\u4e0d\u8db3\u306b\u306a\u3063\u3066\u304f\u308b\u306e\u3067\u3001\u5916\u819c\u304b\u3089\u8840\u7ba1\u304c\u4f38\u3073\u3066\u304d\u307e\u3059\u3002<\/p>\n<p>\u305d\u3046\u3059\u308b\u3068\u3001\u5916\u819c\u304b\u3089\u4f38\u3073\u3066\u304d\u305f\u65b0\u751f\u8840\u7ba1\u3092\u901a\u308b\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u30d3\u30b0\u30ea\u30ab\u30f3\u306b\u7c21\u5358\u306b\u63a5\u89e6\u3067\u304d\u308b\u308f\u3051\u3067\u3059\u3002<\/p>\n<p>\u6050\u3089\u304f\u30c7\u30b3\u30ea\u30f3\u306f\u6b63\u7fa9\u306e\u5473\u65b9\u3067\u3042\u308a\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3092\u6e1b\u5c11\u3055\u305b\u308b\u65b9\u306b\u50cd\u3044\u3066\u308b\u3088\u3046\u3067\u3059\u3002\u30c7\u30b3\u30ea\u30f3\u306b\u3064\u3044\u3066\u306f\u6539\u3081\u3066\u66f8\u304f\u3068\u3057\u3066\u3001\u4eca\u56de\u306f\u30d3\u30b0\u30ea\u30ab\u30f3\u306b\u3064\u3044\u3066\u3067\u3059\u3002\u30d3\u30b0\u30ea\u30ab\u30f3\u3068LDL\u306e\u7d50\u5408\u304c\u3069\u3046\u3084\u3089\u554f\u984c\u306b\u306a\u3063\u3066\u3044\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n<p>\u9ad8\u8840\u5727\u3084\u8840\u7ba1\u306e\u5206\u5c90\u306a\u3069\u306e\u6a5f\u68b0\u7684\u6b6a\u307f\u306f\u8840\u7ba1\u58c1\u306e\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u7d44\u6210\u306b\u76f4\u63a5\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3001\u30c7\u30b3\u30ea\u30f3\u306e\u5408\u6210\u306e\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3057\u3001\u4e00\u65b9\u3067\u30d3\u30b0\u30ea\u30ab\u30f3\u306f\u8840\u7ba1\u5e73\u6ed1\u7b4b\u7d30\u80de\u306b\u3088\u308a\u5927\u91cf\u306b\u5408\u6210\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6a5f\u68b0\u7684\u6b6a\u307f\u306f\u3001\u57f9\u990a\u5e73\u6ed1\u7b4b\u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u30d3\u30b0\u30ea\u30ab\u30f3\u306emRNA\u306e\u767a\u73fe\u3092\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30c8\u3059\u308b\u305d\u3046\u3067\u3059\u3002\u305d\u308c\u306b\u3088\u308a\u30d3\u30b0\u30ea\u30ab\u30f3\u306e\u8cea\u304a\u3088\u3073\u91cf\u306b\u304a\u3051\u308b\u5c40\u6240\u7684\u306a\u5dee\u304c\u5185\u819c\u5185\u306b\u5b58\u5728\u3057\u3001\u304a\u305d\u3089\u304f\u8102\u8cea\u6c88\u7740\u91cf\u306e\u90e8\u4f4d\u306b\u3088\u308b\u5dee\u304c\u3067\u304d\u308b\u306e\u3067\u306f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u305d\u3057\u3066\u3001\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306eapoC\u2162\u304c\u91cd\u8981\u306a\u30ab\u30ae\u3092\u63e1\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u30022\u578b\u7cd6\u5c3f\u75c5\u306e\u9ad8apoC\u2162\u3092\u6709\u3059\u308bLDL\u306f\u3001\u4f4eapoC\u2162\u3092\u6709\u3059\u308bLDL\u3088\u308a\u3082\u30d3\u30b0\u30ea\u30ab\u30f3\u3078\u306e\u3088\u308a\u9ad8\u3044\u7d50\u5408\u3092\u793a\u3059\u305d\u3046\u3067\u3059\u3002\u3055\u3089\u306b\u3001apoC\u2162\u542b\u91cf\u304c\u9ad8\u3044\u307b\u3069\u3001\u30a4\u30f3\u30d3\u30c8\u30ed\u3067\u306e\u7d30\u80de\u5916\u52d5\u8108\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306e\u30d0\u30a4\u30b0\u30ea\u30ab\u30f3\u306b\u7d50\u5408\u3059\u308b\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u80fd\u529b\u304c\u3088\u308a\u5927\u304d\u304f\u306a\u308a\u3001LDL\u7c92\u5b50\u30b5\u30a4\u30ba\u306fapoC\u2162\u542b\u6709\u91cf\u3068\u9006\u76f8\u95a2\u3057\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u3088\u308a\u5c0f\u3055\u3044\u3001\u3088\u308a\u5bc6\u5ea6\u306e\u9ad8\u3044LDL\u7c92\u5b50\u306f\u30011\u7c92\u5b50\u3042\u305f\u308a\u3088\u308a\u591a\u304f\u306e\u91cf\u306eapoC\u2162\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>LDL\u306f\u30d3\u30b0\u30ea\u30ab\u30f3\u7d50\u5408\u306b\u5bfe\u3059\u308b\u7c92\u5b50\u30b5\u30a4\u30ba\u306e\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u308b\u306e\u3067\u3059\u3002\u3088\u308a\u5c0f\u3055\u3044\u9ad8\u5bc6\u5ea6\u306eLDL\u306f\u3001\u5927\u304d\u3044\u30d5\u30ef\u30d5\u30ef\u306eLDL\u3088\u308a\u3082\u7d50\u5408\u80fd\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u9ad8\u3044apoC\u2162\u30ec\u30d9\u30eb\u3092\u6709\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u9ad8\u4e2d\u6027\u8102\u80aa\u3092\u6709\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u3088\u308a\u5c0f\u3055\u3044\u3001\u9ad8\u5bc6\u5ea6\u306eLDL\u3068apoC\u2162\u306b\u5bcc\u3080\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u3088\u308a\u591a\u304f\u3092\u6709\u3059\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>\u305d\u3046\u3059\u308b\u3068\u3001LDL\u304c\u5c0f\u3055\u3044\u9ad8\u5bc6\u5ea6\u306esdLDL\u306f\u975e\u5e38\u306b\u30d3\u30b0\u30ea\u30ab\u30f3\u306b\u304f\u3063\u4ed8\u304d\u3084\u3059\u3044\u306e\u3067\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3092\u304a\u3053\u3057\u3084\u3059\u3044\u3068\u3044\u3046\u306e\u306f\u7d0d\u5f97\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u3082\u3046\u4e00\u5ea6\u304a\u3055\u3089\u3044\u3057\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>1\uff0e\u52d5\u8108\u306e\u5185\u819c\u306f\u8840\u7ba1\u304c\u306a\u304f\u3001\u8840\u7ba1\u306e\u5185\u8154\u304b\u3089\u672c\u6765\u306f\u8840\u6db2\u6210\u5206\u3084\u6804\u990a\u3092\u53d7\u3051\u53d6\u308b\u3002<\/p>\n<p>2\uff0e\u7cd6\u8cea\u904e\u5270\u72b6\u614b\u304c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u751f\u307f\u3001\u5185\u819c\u306e\u7d30\u80de\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u306b\u306a\u308a\u3001\u305d\u308c\u306b\u3088\u308bMfn-2\u306e\u6e1b\u5c11\u306f\u8840\u7ba1\u5e73\u6ed1\u7b4b\u7d30\u80de\u306e\u5897\u6b96\u3092\u62db\u304f\u3002<\/p>\n<p>3\uff0e\u3055\u3089\u306b\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u305d\u306e\u3082\u306e\u3084\u305d\u308c\u306b\u3088\u3063\u3066\u4fc3\u9032\u3055\u308c\u308bTGF-\u03b21\u3001\u305d\u306e\u4ed6\u306e\u6210\u9577\u56e0\u5b50\u306b\u3088\u308a\u3001\u3055\u3089\u306b\u8840\u7ba1\u5e73\u6ed1\u7b4b\u7d30\u80de\u306e\u5897\u6b96\u80fd\u529b\u304c\u5f37\u5316\u3055\u308c\u3001\u5185\u819c\u304c\u3069\u3093\u3069\u3093\u80a5\u539a\u3059\u308b\u3002<\/p>\n<p>4\uff0e\u5185\u819c\u304c\u539a\u304f\u306a\u308b\u3053\u3068\u306b\u3088\u308a\u5185\u819c\u306e\u6df1\u5c64\u3067\u306f\u4f4e\u9178\u7d20\u72b6\u614b\u306b\u306a\u308b\u3002<\/p>\n<p>5\uff0e\u80a5\u539a\u3057\u305f\u5185\u819c\u306e\u6df1\u5c64\u90e8\u5206\u306b\u5916\u819c\u304b\u3089\u65b0\u751f\u8840\u7ba1\u304c\u4f38\u3073\u3066\u304f\u308b\u3002<\/p>\n<p>6\uff0e\u4f38\u3073\u305f\u8840\u7ba1\u3092\u901a\u308b\u8840\u6db2\u306e\u4e2d\u306e\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u5185\u819c\u306e\u6df1\u5c64\u90e8\u5206\u306b\u5b58\u5728\u3059\u308b\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306e\u30d3\u30b0\u30ea\u30ab\u30f3\u306b\u63a5\u89e6\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u7d50\u5408\u3059\u308b\u3002<\/p>\n<p>7\uff0e\u4e00\u65b9\u3067\u3001\u5185\u819c\u306e\u5897\u6b96\u3057\u305f\u8840\u7ba1\u5e73\u6ed1\u7b4b\u7d30\u80de\u306f\u6a5f\u68b0\u7684\u306a\u6b6a\u307f\u306a\u3069\u4f55\u3089\u304b\u306e\u30b9\u30c8\u30ec\u30b9\u3067\u30d3\u30b0\u30ea\u30ab\u30f3\u3092\u5897\u52a0\u3055\u305b\u308b\u3002<\/p>\n<p>8\uff0e\u3082\u3068\u3082\u3068\u306e\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306e\u751f\u6d3b\u3067\u3042\u308c\u3070\u3001\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u304f\u3001LDL\u306f\u5c0f\u3055\u304f\u5bc6\u5ea6\u304c\u9ad8\u3044\u3082\u306e\u304c\u591a\u304f\u306a\u308a\u3001\u3055\u3089\u306bapoC\u2162\u3092\u6709\u3059\u308bLDL\u304c\u5897\u52a0\u3059\u308b\u3002<\/p>\n<p>9\uff0e\u305d\u306eLDL\u306f\u30d3\u30b0\u30ea\u30ab\u30f3\u306b\u7d50\u5408\u3057\u3084\u3059\u304f\u306a\u308a\u3001\u8102\u8cea\u304c\u84c4\u7a4d\u3059\u308b\u3053\u3068\u306b\u306a\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3068\u3044\u3063\u305f\u6d41\u308c\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u304b\u306a\u308a\u3001\u77db\u76fe\u304c\u5c11\u306a\u304f\u306a\u308a\u307e\u3057\u305f\u3002LDL\u306e\u8cea\u304c\u4e00\u756a\u554f\u984c\u306b\u306a\u308b\u306e\u3067\u306f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u3057\u304b\u3057\u3001LDL\u306f\u5c0f\u3055\u306asdLDL\u3067\u306f\u306a\u304f\u3066\u3082\u3001\u30d3\u30b0\u30ea\u30ab\u30f3\u3068\u7d50\u5408\u3057\u307e\u3059\u3057\u3001LDL\u306e\u6570\u306f\u554f\u984c\u306b\u306a\u308b\u306e\u304b\u306a\u3089\u306a\u3044\u306e\u304b\u304c\u306f\u3063\u304d\u308a\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u3053\u3092\u7a81\u304d\u6b62\u3081\u308b\u305f\u3081\u306b\u307e\u305f\u5e83\u3044\u6d77\u3092\u6cf3\u3044\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3001apoC\u2162\u306f\u304b\u306a\u308a\u554f\u984c\u304c\u3042\u308a\u305d\u3046\u306a\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u306d\u3002\u305d\u306e\u8fba\u3082\u4eca\u5ea6\u8a18\u4e8b\u306b\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u524d\u56de\u306e\u8a18\u4e8b\u300c\u305d\u306e4\u300d\u3067\u306f\u3001\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306b\u3088\u308a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u969c\u5bb3\u304c\u8d77\u3053\u308a\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u5185\u819c\u304c\u80a5\u539a\u3059\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u4eee\u8aac\u3092\u66f8\u304d\u307e\u3057\u305f\u3002 \u3067\u306f\u3001\u306a\u305c\u8102\u8cea\u304c\u5185\u819c\u306b\u84c4\u7a4d\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u305d\u308c\u3092\u8aac\u660e\u3059\u308b\u306e\u306b\u3001\u5927\u304d\u306a\u6d77\u306b\u51fa\u305f<\/p>\n","protected":false},"author":1,"featured_media":3947,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[150,13],"tags":[],"class_list":["post-3546","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diabetes","category-13","two-columns"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/03\/7de9d34129cf2d63ce5ced18cd0cc440_s.jpg?fit=640%2C427&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p9cBot-Vc","jetpack-related-posts":[{"id":5073,"url":"https:\/\/promea2014.com\/blog\/?p=5073","url_meta":{"origin":3546,"position":0},"title":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u672c\u5f53\u306b\u52d5\u8108\u306e\u8840\u7ba1\u5185\u8154\u304b\u3089\u8840\u7ba1\u5185\u76ae\u3092\u901a\u3063\u3066\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u8d77\u3053\u3059\u306e\u304b\uff1f\u3000\u305d\u306e10\u3000\u8d64\u8840\u7403\u305d\u3057\u3066\u9244","author":"Dr.Shimizu","date":"2018\u5e747\u670830\u65e5","format":false,"excerpt":"\u3053\u306e\u30b7\u30ea\u30fc\u30ba\u3082\u305d\u306e10\u307e\u3067\u6765\u307e\u3057\u305f\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u306e\u4e2d\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001LDL\u304c\u8840\u7ba1\u306e\u5185\u8154\u304b\u3089\u5185\u76ae\u7d30\u80de\u2026","rel":"","context":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb","block_context":{"text":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb","link":"https:\/\/promea2014.com\/blog\/?cat=145"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/07\/ea708496f0e21899ee0ad3e735588152_s.jpg?fit=640%2C480&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/07\/ea708496f0e21899ee0ad3e735588152_s.jpg?fit=640%2C480&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/07\/ea708496f0e21899ee0ad3e735588152_s.jpg?fit=640%2C480&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":4444,"url":"https:\/\/promea2014.com\/blog\/?p=4444","url_meta":{"origin":3546,"position":1},"title":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u672c\u5f53\u306b\u52d5\u8108\u306e\u8840\u7ba1\u5185\u8154\u304b\u3089\u8840\u7ba1\u5185\u76ae\u3092\u901a\u3063\u3066\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u8d77\u3053\u3059\u306e\u304b\uff1f\u3000\u305d\u306e7\u3000\u9178\u5316LDL\u3092\u72af\u4eba\u3068\u8003\u3048\u308b\u524d\u306b","author":"Dr.Shimizu","date":"2018\u5e746\u67085\u65e5","format":false,"excerpt":"\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u5c3f\u9178\u5024\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3000\u672c\u5f53\u3060\u308d\u3046\u304b\uff1f\u300d\u3067\u3001\u6297\u9178\u5316\u7269\u8cea\u306e\u5c3f\u9178\u304c\u305f\u304f\u3055\u3093\u3042\u308b\u306e\u306b\u3001\u3069\u3046\u2026","rel":"","context":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb","block_context":{"text":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb","link":"https:\/\/promea2014.com\/blog\/?cat=145"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/06\/bcdfaee953603f129b0592c2e2595714_s.jpg?fit=640%2C480&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/06\/bcdfaee953603f129b0592c2e2595714_s.jpg?fit=640%2C480&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/06\/bcdfaee953603f129b0592c2e2595714_s.jpg?fit=640%2C480&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":3387,"url":"https:\/\/promea2014.com\/blog\/?p=3387","url_meta":{"origin":3546,"position":2},"title":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u672c\u5f53\u306b\u52d5\u8108\u306e\u8840\u7ba1\u5185\u8154\u304b\u3089\u8840\u7ba1\u5185\u76ae\u3092\u901a\u3063\u3066\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u8d77\u3053\u3059\u306e\u304b\uff1f\u3000\u305d\u306e1","author":"Dr.Shimizu","date":"2018\u5e741\u67089\u65e5","format":false,"excerpt":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u3068\u95a2\u9023\u6027\u304c\u4e4f\u3057\u3044\u3068\u8003\u3048\u3089\u3066\u3044\u307e\u3059\u3002\u91cd\u8981\u306a\u306e\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u2026","rel":"","context":"\u7cd6\u8cea\u5236\u9650","block_context":{"text":"\u7cd6\u8cea\u5236\u9650","link":"https:\/\/promea2014.com\/blog\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/01\/84cda44087137601f7e43e3f5ee2b762_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/01\/84cda44087137601f7e43e3f5ee2b762_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/01\/84cda44087137601f7e43e3f5ee2b762_s.jpg?fit=640%2C427&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":3535,"url":"https:\/\/promea2014.com\/blog\/?p=3535","url_meta":{"origin":3546,"position":3},"title":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u672c\u5f53\u306b\u52d5\u8108\u306e\u8840\u7ba1\u5185\u8154\u304b\u3089\u8840\u7ba1\u5185\u76ae\u3092\u901a\u3063\u3066\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u8d77\u3053\u3059\u306e\u304b\uff1f\u3000\u305d\u306e4","author":"Dr.Shimizu","date":"2018\u5e741\u670824\u65e5","format":false,"excerpt":"\u524d\u56de\u306e\u8a18\u4e8b\u300c\u305d\u306e3\u300d\u3067\u306f\u5185\u819c\u306e\u80a5\u539a\u304c\u306a\u305c\u8d77\u3053\u308b\u306e\u304b\u3001\u7591\u554f\u3092\u5448\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u2026","rel":"","context":"\u7cd6\u5c3f\u75c5","block_context":{"text":"\u7cd6\u5c3f\u75c5","link":"https:\/\/promea2014.com\/blog\/?cat=150"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/01\/56cf8164f63b7fab60324276040d6587_s.jpg?fit=427%2C640&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":32636,"url":"https:\/\/promea2014.com\/blog\/?p=32636","url_meta":{"origin":3546,"position":4},"title":"\u30d7\u30e9\u30fc\u30af\u5185\u51fa\u8840\u306b\u3088\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u30d7\u30e9\u30fc\u30af\u306e\u9032\u884c\u3068\u7834\u88c2\u3000\u305d\u306e1","author":"Dr.Shimizu","date":"2026\u5e741\u67086\u65e5","format":false,"excerpt":"\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u51a0\u52d5\u8108\u9020\u5f71\u306f\u5c06\u6765\u306e\u5fc3\u7b4b\u6897\u585e\u3092\u4e88\u6e2c\u3057\u306a\u3044\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u51a0\u52d5\u8108\u9020\u5f71\u3067\u78ba\u8a8d\u3057\u3001\u305d\u306e\u5f8c\u9589\u585e\u3057\u2026","rel":"","context":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb","block_context":{"text":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb","link":"https:\/\/promea2014.com\/blog\/?cat=145"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/12\/33365355_s.jpg?fit=640%2C482&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/12\/33365355_s.jpg?fit=640%2C482&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2025\/12\/33365355_s.jpg?fit=640%2C482&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":3492,"url":"https:\/\/promea2014.com\/blog\/?p=3492","url_meta":{"origin":3546,"position":5},"title":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u672c\u5f53\u306b\u52d5\u8108\u306e\u8840\u7ba1\u5185\u8154\u304b\u3089\u8840\u7ba1\u5185\u76ae\u3092\u901a\u3063\u3066\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u8d77\u3053\u3059\u306e\u304b\uff1f\u3000\u305d\u306e3","author":"Dr.Shimizu","date":"2018\u5e741\u670820\u65e5","format":false,"excerpt":"\u5185\u819c\u306e\u69cb\u9020\u306f\u3001\u305f\u3063\u305f\u4e00\u5c64\u306e\u7d30\u80de\u3068\u3001\u305d\u306e\u4e0b\u306b\u3042\u308b\u307b\u3068\u3093\u3069\u7d30\u80de\u306e\u5b58\u5728\u3057\u306a\u3044\u7d44\u7e54\u3067\u3067\u304d\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u2026","rel":"","context":"\u85ac\u5264","block_context":{"text":"\u85ac\u5264","link":"https:\/\/promea2014.com\/blog\/?cat=4"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/01\/da3f7414c735f853710d1ff53b31981a_s.jpg?fit=640%2C428&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/01\/da3f7414c735f853710d1ff53b31981a_s.jpg?fit=640%2C428&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/01\/da3f7414c735f853710d1ff53b31981a_s.jpg?fit=640%2C428&ssl=1&resize=525%2C300 1.5x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/3546","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3546"}],"version-history":[{"count":10,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/3546\/revisions"}],"predecessor-version":[{"id":10990,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/3546\/revisions\/10990"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=\/wp\/v2\/media\/3947"}],"wp:attachment":[{"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3546"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3546"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/promea2014.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}