{"id":36119,"date":"2026-10-02T08:52:55","date_gmt":"2026-10-01T23:52:55","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=36119"},"modified":"2026-10-02T08:52:55","modified_gmt":"2026-10-01T23:52:55","slug":"%e8%82%a5%e6%ba%80%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e3%83%88%e3%83%aa%e3%83%97%e3%83%ab%e3%83%9b%e3%83%ab%e3%83%a2%e3%83%b3%e5%8f%97%e5%ae%b9%e4%bd%93%e4%bd%9c%e5%8b%95%e8%96%ac%e3%83%ac%e3%82%bf","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=36119","title":{"rendered":"\u80a5\u6e80\u306b\u5bfe\u3059\u308b\u30c8\u30ea\u30d7\u30eb\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u306e\u52b9\u679c\u306f\u3082\u306e\u3059\u3054\u3044\u304c\u2026\u2026"},"content":{"rendered":"

GIP\u53d7\u5bb9\u4f53\u3001GLP-1\u53d7\u5bb9\u4f53\u3001\u30b0\u30eb\u30ab\u30b4\u30f3\u53d7\u5bb9\u4f53\u306e3\u3064\u306e\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\u306b\u540c\u6642\u306b\u4f5c\u7528\u3059\u308b\u4e16\u754c\u521d\u306e\u85ac\u3001\u30c8\u30ea\u30d7\u30eb\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u304c\u3082\u306e\u3059\u3054\u3044\u7d50\u679c\u3092\u51fa\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u306e\u6b21\u4e16\u4ee3\u80a5\u6e80\u75c7\u6cbb\u7642\u85ac\u306f\u624b\u8853\u4e26\u307f\u306e\u6e1b\u91cf\u52b9\u679c\u3092\u793a\u3057\u305f\u304c\u2026<\/a>\u300d\u3067\u3082\u7d39\u4ecb\u3057\u307e\u3057\u305f\u304c\u3001\u305d\u308c\u304c\u8ad6\u6587\u5316\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u3082\u3061\u308d\u3093\u3001\u958b\u767a\u4f01\u696d\u306e\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u793e\u306b\u3088\u308b\u8cc7\u91d1\u63d0\u4f9b\u3092\u53d7\u3051\u3066\u3044\u308b\u8a66\u9a13\u3067\u3059\u304c\u3001\u305d\u308c\u3092\u5dee\u3057\u5f15\u3044\u3066\u3082\u80a5\u6e80\u60a3\u8005\u306e\u4e2d\u306b\u306f\u5927\u559c\u3073\u306e\u4eba\u3082\u3044\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u3053\u306e\u7b2c3\u76f8\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u3067\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u306a\u3044\u80a5\u6e80\u6210\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\uff084mg\u30019mg\u3001\u307e\u305f\u306f12mg\uff09\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u3092\u90311\u56de\u76ae\u4e0b\u6ce8\u5c04\u306780\u9031\u9593\u6295\u4e0e\u3057\u307e\u3057\u305f\u30022339\u4eba\u306e\u53c2\u52a0\u8005\u304c\u30e9\u30f3\u30c0\u30e0\u5316\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u53c2\u52a0\u8005\u306e\u5e73\u5747\u306e\u4f53\u91cd\u306f112.7kg\u3067\u3001BMI\u3082\u7d0440\u3067\u3059\u3002\u3067\u306f\u3001\u7d50\u679c\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306e\u3088\u3046\u306b\u3001\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u7fa4\u3067\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308980\u9031\u76ee\u307e\u3067\u306e\u4f53\u91cd\u306e\u5e73\u5747\u5909\u5316\u7387\u306f\u30014mg\u6295\u4e0e\u7fa4\u3067-17.6%\u30019mg\u6295\u4e0e\u7fa4\u3067-23.7%\u300112mg\u6295\u4e0e\u7fa4\u3067-25.0%\u3067\u3042\u308a\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e-3.9%\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u5927\u304d\u304f\u6e1b\u5c11\u3057\u307e\u3057\u305f\u300225%\u6e1b\u3068\u3044\u3046\u3053\u3068\u306f113kg\u306e\u4eba\u304c80kg\u53f0\u306b\u306a\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u5ef6\u9577\u30d5\u30a7\u30fc\u30ba\u3067\u306f\u3001104\u9031\u6642\u70b9\u3067\u5e73\u5747\u4f53\u91cd\u304c\u6700\u592729.9%\u306e\u6e1b\u5c11\u3067\u3057\u305f\u3002<\/p>\n

\u56f3\u306eB\u306b\u793a\u3059\u3088\u3046\u306b\u3001\u8179\u56f2\u308215%\u4ee5\u4e0a\u6e1b\u5c11\u3059\u308b\u306e\u306f\u300112mg\u6295\u4e0e\u7fa4\u306780%\u8fd1\u304f\u306b\u306a\u308a\u307e\u3059\u3002BMI\u304c30\u672a\u6e80\u306b\u306a\u3063\u305f\u306e\u306f9mg\u6295\u4e0e\u7fa4\u306812mg\u6295\u4e0e\u7fa4\u306750%\u3092\u8d85\u3048\u3066\u3044\u307e\u3059\u300212mg\u6295\u4e0e\u7fa4\u3067\u306f4\u5206\u306e1\u4ee5\u4e0a\u306e\u4eba\u304cBMI25\u672a\u6e80\u306e\u6b63\u5e38\u4f53\u91cd\u306b\u306a\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u5909\u5316\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u56f3\u306e\u3088\u3046\u306b\u3001\u4e2d\u6027\u8102\u80aa\u5024\u306f\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u7fa4\u306730%\u4ee5\u4e0a\u306e\u6e1b\u5c11\u3067\u3059\u3002\u3064\u307e\u308a\u300180mg\/dL\u7a0b\u5ea6\u307e\u3067\u4f4e\u4e0b\u3059\u308b\u3088\u3046\u3067\u3059\u3002\u3053\u308c\u306f\u3069\u3046\u3067\u3082\u826f\u3044\u3067\u3059\u304cLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3082\u4f4e\u4e0b\u3057\u307e\u3059\u3002<\/p>\n

HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3082\u308f\u305a\u304b\u306b\u5897\u52a0\u3057\u307e\u3059\u3002<\/p>\n

\u708e\u75c7\u3092\u793a\u3059CRP\u306f\u5927\u304d\u304f\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u53ce\u7e2e\u671f\u8840\u5727\u306f\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u7fa4\u306710mmHg\u524d\u5f8c\u306e\u4f4e\u4e0b\u3067\u3059\u3002<\/p>\n

\u56f3\u306eB\u306b\u793a\u3059\u3088\u3046\u306b\u3001\u8010\u7cd6\u80fd\u306b\u95a2\u3057\u3066\u3082\u3001\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u7fa4\u306e90%\u524d\u5f8c\u306e\u4eba\u304c\u6b63\u5e38\u8840\u7cd6\u3067\u3057\u305f\u3002\u7a7a\u8179\u6642\u30a4\u30f3\u30b9\u30ea\u30f3\u308250%\u524d\u5f8c\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u3002\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306f\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u819d\u306e\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u306e\u75bc\u75db\u30b9\u30b3\u30a2\uff0860%\u4ee5\u4e0a\uff09\u3001\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\u7fa4\u306eAHI\u30a4\u30d9\u30f3\u30c8\uff0850%\u4ee5\u4e0a\uff09\u3082\u6539\u5584\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u6c17\u306b\u306a\u308b\u5b89\u5168\u6027\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u6709\u5bb3\u4e8b\u8c61<\/span><\/th>\n\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9<\/th>\n\u30d7\u30e9\u30bb\u30dc\u7fa4<\/span>
\n\uff08N=586\uff09<\/span><\/th>\n<\/tr>\n
<\/td>\n4 mg<\/span>
\n(N=584)<\/span><\/th>\n		9 mg<\/span>
\n(N=583)<\/span><\/th>\n		12 mg<\/span>
\n(N=582)<\/span><\/th>\n		<\/td>\n<\/tr>\n
<\/td>\n\u53c2\u52a0\u8005\u6570\uff08\u30d1\u30fc\u30bb\u30f3\u30c8\uff09<\/span><\/th>\n<\/tr>\n<\/thead>\n
\u6cbb\u7642\u958b\u59cb\u5f8c\u306b\u767a\u751f\u3057\u305f\u3042\u3089\u3086\u308b\u6709\u5bb3\u4e8b\u8c61<\/span><\/td>\n508 (87.0)<\/span><\/td>\n519 (89.0)<\/span><\/td>\n519 (89.2)<\/span><\/td>\n473 (80.7)<\/span><\/td>\n<\/tr>\n
\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61<\/span><\/td>\n45 (7.7)<\/span><\/td>\n45 (7.7)<\/span><\/td>\n61 (10.5)<\/span><\/td>\n32 (5.5)<\/span><\/td>\n<\/tr>\n
\u6b7b<\/span><\/td>\n0<\/span><\/td>\n3 (0.5)<\/span><\/td>\n1 (0.2)<\/span><\/td>\n2 (0.3)<\/span><\/td>\n<\/tr>\n
\u6cbb\u9a13\u4e2d\u6b62\u306b\u3064\u306a\u304c\u308b\u4e8b\u8c61<\/span><\/td>\n6 (1.0)<\/span><\/td>\n8 (1.4)<\/span><\/td>\n16 (2.7)<\/span><\/td>\n10 (1.7)<\/span><\/td>\n<\/tr>\n
\u53c2\u52a0\u8005\u306e10%\u4ee5\u4e0a\u306b\u6709\u5bb3\u4e8b\u8c61\u304c\u8a8d\u3081\u3089\u308c\u305f\u4e8b\u8c61<\/span><\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u5410\u304d\u6c17<\/span><\/td>\n167 (28.6)<\/span><\/td>\n224 (38.4)<\/span><\/td>\n247 (42.4)<\/span><\/td>\n87 (14.8)<\/span><\/td>\n<\/tr>\n
\u4e0b\u75e2<\/span><\/td>\n147 (25.2)<\/span><\/td>\n199 (34.1)<\/span><\/td>\n186 (32.0)<\/span><\/td>\n79 (13.5)<\/span><\/td>\n<\/tr>\n
\u4fbf\u79d8<\/span><\/td>\n139 (23.8)<\/span><\/td>\n151 (25.9)<\/span><\/td>\n152 (26.1)<\/span><\/td>\n64 (10.9)<\/span><\/td>\n<\/tr>\n
\u5614\u5410<\/span><\/td>\n62 (10.6)<\/span><\/td>\n133 (22.8)<\/span><\/td>\n147 (25.3)<\/span><\/td>\n28 (4.8)<\/span><\/td>\n<\/tr>\n
\u98df\u6b32\u4e0d\u632f<\/span><\/td>\n75 (12.8)<\/span><\/td>\n78 (13.4)<\/span><\/td>\n96 (16.5)<\/span><\/td>\n34 (5.8)<\/span><\/td>\n<\/tr>\n
\u4e0a\u6c17\u9053\u611f\u67d3\u75c7<\/span><\/td>\n83 (14.2)<\/span><\/td>\n71 (12.2)<\/span><\/td>\n76 (13.1)<\/span><\/td>\n68 (11.6)<\/span><\/td>\n<\/tr>\n
\u3081\u307e\u3044<\/span><\/td>\n29 (5.0)<\/span><\/td>\n52 (8.9)<\/span><\/td>\n70 (12.0)<\/span><\/td>\n18 (3.1)<\/span><\/td>\n<\/tr>\n
\u6d88\u5316\u4e0d\u826f<\/span><\/td>\n46 (7.9)<\/span><\/td>\n52 (8.9)<\/span><\/td>\n63 (10.8)<\/span><\/td>\n22 (3.8)<\/span><\/td>\n<\/tr>\n
\u8179\u75db<\/span><\/td>\n41 (7.0)<\/span><\/td>\n34 (5.8)<\/span><\/td>\n60 (10.3)<\/span><\/td>\n11 (1.9)<\/span><\/td>\n<\/tr>\n
\u5026\u6020\u611f<\/span><\/td>\n43 (7.4)<\/span><\/td>\n62 (10.6)<\/span><\/td>\n59 (10.1)<\/span><\/td>\n21 (3.6)<\/span><\/td>\n<\/tr>\n
\u7279\u306b\u95a2\u5fc3\u306e\u3042\u308b\u6709\u5bb3\u4e8b\u8c61\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u30c8\u30d4\u30c3\u30af<\/span><\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u611f\u899a\u7570\u5e38\uff1a\u76ae\u819a\u306e\u707c\u71b1\u611f\u304a\u3088\u3073\u95a2\u9023\u3059\u308b\u6709\u5bb3\u4e8b\u8c61<\/span><\/td>\n30 (5.1)<\/span><\/td>\n72 (12.3)<\/span><\/td>\n73 (12.5)<\/span><\/td>\n5 (0.9)<\/span><\/td>\n<\/tr>\n
\u6ce8\u5c04\u90e8\u4f4d\u53cd\u5fdc<\/span><\/td>\n32 (5.5)<\/span><\/td>\n52 (8.9)<\/span><\/td>\n71 (12.2)<\/span><\/td>\n22 (3.8)<\/span><\/td>\n<\/tr>\n
\u4f4e\u8840\u5727\u3001\u8d77\u7acb\u6027\u4f4e\u8840\u5727\u3001\u8840\u5727\u4f4e\u4e0b<\/span><\/td>\n16 (2.7)<\/span><\/td>\n31 (5.3)<\/span><\/td>\n51 (8.8)<\/span><\/td>\n5 (0.9)<\/span><\/td>\n<\/tr>\n
\u91cd\u5ea6\u307e\u305f\u306f\u6df1\u523b\u306a\u80c3\u8178\u7cfb\u306e\u6709\u5bb3\u4e8b\u8c61<\/span><\/td>\n15 (2.6)<\/span><\/td>\n35 (6.0)<\/span><\/td>\n30 (5.2)<\/span><\/td>\n8 (1.4)<\/span><\/td>\n<\/tr>\n
\u304c\u3093<\/span><\/td>\n12 (2.1)<\/span><\/td>\n5 (0.9)<\/span><\/td>\n11 (1.9)<\/span><\/td>\n6 (1.0)<\/span><\/td>\n<\/tr>\n
\u91cd\u5ea6\u307e\u305f\u306f\u6df1\u523b\u306a\u4e0d\u6574\u8108\u307e\u305f\u306f\u5fc3\u81d3\u4f1d\u5c0e\u969c\u5bb3<\/span><\/td>\n1 (0.2)<\/span><\/td>\n4 (0.7)<\/span><\/td>\n5 (0.9)<\/span><\/td>\n5 (0.9)<\/span><\/td>\n<\/tr>\n
\u91cd\u5ea6\u307e\u305f\u306f\u6df1\u523b\u306a\u80c6\u56a2\u307e\u305f\u306f\u80c6\u9053\u75be\u60a3<\/span><\/td>\n10 (1.7)<\/span><\/td>\n5 (0.9)<\/span><\/td>\n4 (0.7)<\/span><\/td>\n4 (0.7)<\/span><\/td>\n<\/tr>\n
\u5be9\u67fb\u3067\u78ba\u8a8d\u3055\u308c\u305f\u81b5\u708e<\/span><\/td>\n1 (0.2)<\/span><\/td>\n3 (0.5)<\/span><\/td>\n4 (0.7)<\/span><\/td>\n2 (0.3)<\/span><\/td>\n<\/tr>\n
\u5be9\u67fb\u3067\u78ba\u8a8d\u3055\u308c\u305f\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u7cfb\u6709\u5bb3\u4e8b\u8c61<\/span><\/td>\n1 (0.2)<\/span><\/td>\n5 (0.9)<\/span><\/td>\n3 (0.5)<\/span><\/td>\n1 (0.2)<\/span><\/td>\n<\/tr>\n
\u91cd\u5ea6\u307e\u305f\u306f\u6df1\u523b\u306a\u6804\u990a\u5931\u8abf<\/span><\/td>\n1 (0.2)<\/span><\/td>\n2 (0.3)<\/span><\/td>\n0<\/span><\/td>\n0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u7fa4\u306e\u53c2\u52a0\u8005\u306e 7.7 \uff5e 10.5%\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u53c2\u52a0\u8005\u306e 5.5% \u3067\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u7fa4\u3067\u306e\u6b7b\u4ea1\u306f4\u4eba\u3001\u30d7\u30e9\u30bb\u30dc\u3067\u306f2\u4eba\u3067\u3057\u305f\u3002<\/p>\n

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\u304c\u3093\u306f\u30ec\u30bf\u30c8\u30eb\u30c1\u30c9\u7fa4\u306e4mg\u306712\u4eba (2.1%)\u30019mg\u30675\u4eba (0.9%)\u300112mg\u306711\u4eba (1.9%)\u3068\u3001\u30d7\u30e9\u30bb\u30dc\u306e6\u4eba (1.0%)\u3088\u308a\u3082\u591a\u3044\u6c17\u304c\u3057\u307e\u3059\u304c\u3001\u3069\u3046\u306a\u3093\u3067\u3057\u3087\u3046\u304b\uff1f<\/span><\/p>\n

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\"\"<\/a><\/p>\n

20\u9031\u307e\u3067\u306f9 mg\u7fa4\u306812 mg\u7fa4\u3067\u5fc3\u62cd\u6570\u304c\u5897\u52a0\u3057\u7d9a\u3051\u3001\u305d\u306e\u5f8c\u4f4e\u4e0b\u3057\u3066\u3044\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30d4\u30fc\u30af\u3067\u306f8\uff5e9\u306e\u5897\u52a0\u3092\u793a\u3057\u3001\u5b89\u9759\u6642\u5fc3\u62cd\u657080\u4ee5\u4e0a\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b80\u9031\u3067\u3082\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306b\u306f\u623b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u4f53\u91cd\u304c\u5927\u304d\u304f\u6e1b\u3063\u305f\u306e\u306b\u3001\u5fc3\u62cd\u6570\u306f\u5897\u52a0\u3001\u4f55\u3067\u3057\u3087\u3046\uff1f<\/p>\n

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\u300cRetatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity\u300d<\/span><\/p>\n

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