{"id":36573,"date":"2026-11-09T08:46:33","date_gmt":"2026-11-08T23:46:33","guid":{"rendered":"https:\/\/promea2014.com\/blog\/?p=36573"},"modified":"2026-11-09T08:46:33","modified_gmt":"2026-11-08T23:46:33","slug":"%e4%b8%ad%e5%b9%b4%e6%9c%9f%e3%81%ae%e3%82%a4%e3%83%b3%e3%82%b9%e3%83%aa%e3%83%b3%e6%8a%b5%e6%8a%97%e6%80%a7%e3%81%af%e8%80%81%e5%b9%b4%e6%9c%9f%e3%81%ae%e8%aa%8d%e7%9f%a5%e6%a9%9f%e8%83%bd%e4%bd%8e","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=36573","title":{"rendered":"\u4e2d\u5e74\u671f\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306f\u8001\u5e74\u671f\u306e\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u3092\u4e88\u6e2c\u3059\u308b"},"content":{"rendered":"<p>\u8a8d\u77e5\u75c7\u306b\u306a\u308a\u305f\u304f\u306a\u3044\u3068\u3044\u3046\u4eba\u306f\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u307b\u3068\u3093\u3069\u306e\u4eba\u306f\u305d\u3046\u3067\u3057\u3087\u3046\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u8a8d\u77e5\u75c7\u3092\u4e88\u9632\u3057\u3088\u3046\u3068\u601d\u3044\u59cb\u3081\u308b\u306e\u306f\u3001\u9ad8\u9f62\u306b\u306a\u3063\u3066\u304b\u3089\u306a\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u4e2d\u5e74\u671f\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3068\u8a8d\u77e5\u6a5f\u80fd\u306e\u95a2\u9023\u3092\u8abf\u3079\u3066\u3044\u307e\u3059\u3002\u30d5\u30a3\u30f3\u30e9\u30f3\u30c9\u5065\u5eb72000\u7814\u7a76\u306e\u53c2\u52a0\u800543\u4eba\u304c\u5bfe\u8c61\u3067\u3001\u4e2d\u5e74\u671f\uff08\u4e2d\u5e74\u671f\u306e\u5e73\u5747\u5e74\u9f6255.1\u6b73\uff09\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306eHOMA-IR\u304c\u6e2c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002HOMA-IR\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u30b0\u30eb\u30fc\u30d7\uff08IR+\u3001HOMA-IR &gt; 2.17\u300119\u4eba\uff09\u3068\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u30b0\u30eb\u30fc\u30d7\uff08IR\u2212\u3001HOMA-IR &lt; 1.25\u300124\u4eba\uff09\u3067\u3057\u305f\u3002<\/p>\n<p>2014\uff5e2016\u5e74\u306e\u8001\u5e74\u671f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3068\u30012019\uff5e2021\u5e74\u306e5\u5e74\u9593\u306e\u8ffd\u8de1\u8abf\u67fb\u5f8c\u306b\u3001\u8133\u306ePET\u3084\u795e\u7d4c\u8a8d\u77e5\u30c6\u30b9\u30c8\u304c\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002\u8ffd\u8de1\u8abf\u67fb\u6642\u306e\u5e73\u5747\u5e74\u9f62\u306f74.8\u6b73\u3067\u3057\u305f\u3002<\/p>\n<p><a href=\"http:\/\/promea2014.com\/blog\/wp-content\/uploads\/2026\/11\/332a1ed7d9802b4c9c11aee3ef4b3655.jpg\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"36605\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=36605\" data-orig-file=\"https:\/\/promea2014.com\/blog\/wp-content\/uploads\/2026\/11\/332a1ed7d9802b4c9c11aee3ef4b3655.jpg\" data-orig-size=\"558,995\" data-comments-opened=\"1\" data-image-title=\"\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u8a8d\u77e5\u75c71-s2.0-S0197458026001132-gr2\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/promea2014.com\/blog\/wp-content\/uploads\/2026\/11\/332a1ed7d9802b4c9c11aee3ef4b3655.jpg\" class=\"alignnone size-full wp-image-36605\" src=\"http:\/\/promea2014.com\/blog\/wp-content\/uploads\/2026\/11\/332a1ed7d9802b4c9c11aee3ef4b3655.jpg\" alt=\"\" width=\"558\" height=\"995\" srcset=\"https:\/\/promea2014.com\/blog\/wp-content\/uploads\/2026\/11\/332a1ed7d9802b4c9c11aee3ef4b3655.jpg 558w, https:\/\/promea2014.com\/blog\/wp-content\/uploads\/2026\/11\/332a1ed7d9802b4c9c11aee3ef4b3655-168x300.jpg 168w\" sizes=\"auto, (max-width: 558px) 100vw, 558px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u56f3\u306f\u3001A\u304c\u4e2d\u5e74\u671f\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u30b0\u30eb\u30fc\u30d7\u5225\u306e\u3001\u8001\u5e74\u671f\u306e\u8ffd\u8de1\u8abf\u67fb\u306b\u304a\u3051\u308b\u9818\u57df\u5225\uff08\u5b9f\u884c\u6a5f\u80fd\u3001\u51e6\u7406\u901f\u5ea6\u3001\u30a8\u30d4\u30bd\u30fc\u30c9\u8a18\u61b6\u3001\u8a00\u8a9e\uff09\u8a8d\u77e5\u30c6\u30b9\u30c8\u306e\u30b9\u30b3\u30a2\u3002B\u304c\u4e2d\u5e74\u671f\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u30b0\u30eb\u30fc\u30d7\u5225\u306e\u3001\u8001\u5e74\u671f\u306e\u8ffd\u8de1\u8abf\u67fb\u306b\u304a\u3051\u308b\u9818\u57df\u5225\u8a8d\u77e5\u30c6\u30b9\u30c8\u306e\u30b9\u30b3\u30a2\u306e 5 \u5e74\u9593\u306e\u5909\u5316\u3067\u3059\u3002 IR+ \u7fa4\u306f\u3001\u8abf\u67fb\u3057\u305f\u3059\u3079\u3066\u306e\u8a8d\u77e5\u9818\u57df\u306e\u5b9f\u884c\u6a5f\u80fd\u3001\u51e6\u7406\u901f\u5ea6\u3001\u30a8\u30d4\u30bd\u30fc\u30c9\u8a18\u61b6 \u3001\u8a00\u8a9e\u306b\u304a\u3044\u3066\u30012019 &#8211; 2021 \u5e74\u306e\u8001\u5e74\u671f\u8ffd\u8de1\u8abf\u67fb\u3067 IR- \u7fa4\u3088\u308a\u3082\u8a8d\u77e5\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304c\u52a3\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u56f3\u306eB\u306b\u793a\u3059\u3088\u3046\u306b\u3001 5\u5e74\u9593\u306e\u5909\u5316\u306f\u3001\u8001\u5e74\u671f\u306e\u30a8\u30d4\u30bd\u30fc\u30c9\u8a18\u61b6\u306e\u4f4e\u4e0b\u306fIR+\u7fa4\u306e\u65b9\u304cIR\u2013\u7fa4\u3088\u308a\u3082\u6025\u6fc0\u3067\u3057\u305f\u3002\u305d\u308c\u4ee5\u5916\u306f\u6709\u610f\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u307e\u305fIR+\u7fa4\u306fIR\u2212\u7fa4\u306b\u6bd4\u3079\u3066CERAD\u7dcf\u30b9\u30b3\u30a2\uff08\u8a8d\u77e5\u75c7\u306e\u30b9\u30b3\u30a2\uff09\u304c\u4f4e\u304f\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u84c4\u7a4d\u91cf\u304c\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u8133\u5185\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u8ca0\u8377\u306f\u3001\u30a8\u30d4\u30bd\u30fc\u30c9\u8a18\u61b6\u306e\u3088\u308a\u5927\u304d\u306a\u4f4e\u4e0b\u3092\u4e88\u6e2c\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>50\u4ee3\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u300170\u4ee3\u306e\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u306e\u60aa\u5316\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u306e\u3067\u3059\u3002\u4e2d\u5e74\u671f\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u3042\u3063\u305f\u4eba\u306f\u3001\u8001\u5e74\u671f\u306e5\u5e74\u9593\u3067\u8a18\u61b6\u529b\u30b9\u30b3\u30a2\u30922\u500d\u4ee5\u4e0a\u5931\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306f\u307b\u3068\u3093\u3069\u306e\u533b\u5e2b\u306f\u7121\u8996\u3057\u3066\u3044\u307e\u3059\u3002\u300c\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u300d\u3068\u3044\u3046\u8a00\u8449\u3055\u3048\u4f7f\u308f\u306a\u3044\u533b\u5e2b\u304c\u307b\u3068\u3093\u3069\u3067\u3057\u3087\u3046\u3002\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u306f\u6e2c\u5b9a\u3057\u3066\u3082\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5024\u306f\u6e2c\u5b9a\u3057\u3088\u3046\u3068\u306f\u3057\u307e\u305b\u3093\u3002\u3058\u3063\u3068\u305d\u308c\u306b\u306f\u89e6\u308c\u305a\u3001\u5f85\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u3084HbA1c\u304c\u4e0a\u6607\u3057\u3066\u304d\u305f\u3089\u3001\u7cd6\u5c3f\u75c5\u306b\u95a2\u3057\u3066\u306f\u7a4d\u6975\u7684\u306b\u85ac\u3092\u51fa\u305d\u3046\u3068\u3057\u307e\u3059\u304c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u307e\u3060\u4f55\u3082\u8a00\u3044\u307e\u305b\u3093\u3002\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u3084HbA1c\u304c\u6b63\u5e38\u3067\u3082\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u4eba\u306f\u3044\u307e\u3059\u3002<\/p>\n<p>\u533b\u5e2b\u306e\u8a3a\u65ad\u3092\u5f85\u305f\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u7406\u89e3\u304c\u5f97\u3089\u308c\u308b\u533b\u5e2b\u3067\u3042\u308c\u3070\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u3068\u7a7a\u8179\u6642\u30a4\u30f3\u30b9\u30ea\u30f3\u691c\u67fb\u3092\u4f9d\u983c\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u533b\u5e2b\u306f\u4f9d\u983c\u3057\u306a\u3044\u9650\u308a\u30a4\u30f3\u30b9\u30ea\u30f3\u691c\u67fb\u3092\u3059\u308b\u3053\u3068\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002\u3082\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5024\u3092\u6e2c\u5b9a\u3057\u3066\u304f\u308c\u306a\u3044\u5834\u5408\u3001\u307e\u305f\u306f\u4f9d\u983c\u3057\u306b\u304f\u3044\u5834\u5408\u306f\u3001\u4ed6\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u6307\u6570\uff08TyG\u30a4\u30f3\u30c7\u30c3\u30af\u30b9\u3084\u4e2d\u6027\u8102\u80aa\/HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6bd4\uff09\u306a\u3069\u3092\u8a08\u7b97\u3057\u3066\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u306a\u3044\u304b\u3069\u3046\u304b\u3092\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002TyG\u30a4\u30f3\u30c7\u30c3\u30af\u30b9\u306f\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=8733\" target=\"_blank\" rel=\"noopener\">\u4e2d\u6027\u8102\u80aa\u5024\u3068\u8840\u7cd6\u5024\u3060\u3051\u3067\u69d8\u3005\u306a\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3067\u304d\u308b<\/a>\u300d\u3067\u8a08\u7b97\u3067\u304d\u307e\u3059\u3002\uff08\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=24846\" target=\"_blank\" rel=\"noopener\">TyG\u30a4\u30f3\u30c7\u30c3\u30af\u30b9\u3068\u8a8d\u77e5\u75c7\u3068\u306e\u95a2\u9023\u6027<\/a>\u300d\u3082\u53c2\u7167\uff09<\/p>\n<p>\u8a8d\u77e5\u75c7\u306f\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4\u3067\u3059\u3002\u305d\u3057\u3066\u3001\u8a8d\u77e5\u75c7\u306f\u9ad8\u9f62\u306b\u306a\u3063\u3066\u304b\u3089\u59cb\u307e\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u305d\u306e20\u5e74\u4ee5\u4e0a\u3082\u524d\u304b\u3089\u59cb\u307e\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\uff08\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=30074\" target=\"_blank\" rel=\"noopener\">\u8133\u306e\u8001\u5316\u306f\u4e2d\u5e74\u671f\u304b\u3089\u306e\u8133\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3067\u8d77\u304d\u308b\u3000\u4e88\u9632\u306f60\u4ee3\u3067\u306f\u624b\u9045\u308c\u304b\u3082<\/a>\u300d\uff0940\u4ee3\u524d\u534a\u306b\u306f\u8133\u304c\u4e0d\u5b89\u5b9a\u306b\u306a\u308a\u59cb\u3081\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u3060\u304b\u3089\u3001\u9ad8\u9f62\u306b\u306a\u3063\u3066\u304b\u3089\u614c\u3066\u3066\u3082\u3082\u3046\u9045\u3044\u306e\u3067\u3059\u3002<\/p>\n<p>\u9ad8\u304f\u3066\uff08<a href=\"https:\/\/news.yahoo.co.jp\/articles\/6a07f5103c6160145bb02136747208d75d76e57f\" target=\"_blank\" rel=\"noopener\">\u3053\u3053<\/a>\u53c2\u7167\u3001\u60a3\u80051\u4eba\u5f53\u305f\u308a\u5e74\u7d04282\u4e07\u5186\uff09\u3001\u307b\u3068\u3093\u3069\u52b9\u679c\u3082\u306a\u304f\uff08\u300c<a href=\"https:\/\/promea2014.com\/blog\/?p=34180\" target=\"_blank\" rel=\"noopener\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u5bfe\u3059\u308b\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u3092\u6a19\u7684\u306b\u3057\u305f\u9ad8\u4fa1\u306a\u85ac\u306e\u52b9\u679c\u306f\u307b\u3068\u3093\u3069\u306a\u3044<\/a>\u300d\u306a\u3069\u53c2\u7167\uff09\u3001\u5371\u967a\u306a\u526f\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u3082\u3042\u308b\u85ac\u3092\u51e6\u65b9\u3055\u308c\u3066\u3082\u3001\u8a8d\u77e5\u6a5f\u80fd\u306f\u6539\u5584\u3057\u307e\u305b\u3093\u3002\u4e88\u9632\u3042\u308b\u306e\u307f\u3067\u3059\u3002\u305d\u308c\u306b\u306f\u7cd6\u8cea\u5236\u9650\u3067\u3059\u3002<\/p>\n<p><span style=\"color: #3366ff;\">\u300cMidlife insulin resistance and brain beta-amyloid accumulation as predictors of change in late-life cognitive function &#8211; A 20-year follow-up study\u300d<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u300c\u4e2d\u5e74\u671f\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3068\u8133\u5185\u03b2\u30a2\u30df\u30ed\u30a4\u30c9\u84c4\u7a4d\u304c\u6669\u5e74\u306e\u8a8d\u77e5\u6a5f\u80fd\u5909\u5316\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u306a\u308b\u304b \u2015 20\u5e74\u9593\u306e\u8ffd\u8de1\u8abf\u67fb\u300d\uff08\u539f\u6587\u306f<a style=\"color: #3366ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42302540\/\" target=\"_blank\" 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