{"id":3756,"date":"2018-02-26T11:18:14","date_gmt":"2018-02-26T02:18:14","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=3756"},"modified":"2018-02-26T11:18:14","modified_gmt":"2018-02-26T02:18:14","slug":"post-3756","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=3756","title":{"rendered":"\u307b\u3093\u306e\u308f\u305a\u304b\u306a\u7a7a\u8179\u6642\u8840\u7cd6\u306e\u5897\u52a0\u3067\u3055\u3048\u3001\u8133\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u69d8\u306e\u30d1\u30bf\u30fc\u30f3\u306e\u53cd\u5fdc\u306b\u306a\u308b"},"content":{"rendered":"

\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u3068\u8133\u306e\u6a5f\u80fd\u4f4e\u4e0b\u306f\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u3084\u8010\u7cd6\u80fd\u969c\u5bb3\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u306e\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

18<\/sup>F-FDG\u3068\u3044\u3046\u3082\u306e\u3092\u4f7f\u3063\u3066PET\u306e\u691c\u67fb\u3092\u884c\u3046\u3068\u3001\u8133\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u5229\u7528\u306e\u4ee3\u8b1d\u7387\u3092\u63a8\u5b9a\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u300218<\/sup>F-FDG\u306e\u53d6\u8fbc\u307f\u306e\u4f4e\u4e0b\u306f\u3001\u8133\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u5229\u7528\u304c\u4f4e\u4e0b\u3057\u3001\u8133\u306e\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u8868\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u795e\u7d4c\u306e\u7d30\u80de\u6570\u307e\u305f\u306f\u6d3b\u6027\u306e\u55aa\u5931\u3092\u53cd\u6620\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u306f\u3001\u9855\u8457\u306b\u8133\u306e\u6954\u524d\u90e8\u3068\u5f8c\u90e8\u5e2f\u72b6\u56de\u3068\u3044\u3046\u90e8\u5206\u306e18<\/sup>F-FDG\u306e\u53d6\u8fbc\u307f\u306e\u4f4e\u4e0b\u306e\u30d1\u30bf\u30fc\u30f3\u3092\u8a8d\u3081\u307e\u3059\u3002<\/p>\n

\u8840\u6f3f\u30b0\u30eb\u30b3\u30fc\u30b9\u304c\u4e0a\u6607\u3057\u305f\u8a8d\u77e5\u6a5f\u80fd\u306e\u6b63\u5e38\u306a\u4eba\u3067\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u540c\u69d8\u306a\u30d1\u30bf\u30fc\u30f3\u3001\u3064\u307e\u308a\u3001\u3068\u308a\u308f\u3051\u6954\u524d\u90e8\u3067\u306e18<\/sup>F-FDG\u306e\u53d6\u8fbc\u307f\u306e\u4f4e\u4e0b\u3092\u793a\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u9ad8\u8840\u7cd6\u72b6\u614b\u306e\u9593\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u69d8\u30d1\u30bf\u30fc\u30f3\u306f\u53ef\u9006\u7684\u3067\u3042\u308a\u3001\u30a2\u30df\u30ed\u30a4\u30c9-\u03b2\u6c88\u7740\u307e\u305f\u306f\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE\u03b54\u907a\u4f1d\u5b50\u578b\u3068\u306f\u72ec\u7acb\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u8840\u7cd6\u5024\u304c\u4e0a\u304c\u3063\u3066\u3044\u308b\u9593\u3001\u8133\u306f\u4e00\u6642\u7684\u306b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u306e\u3088\u3046\u306a\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u5229\u7528\u4f4e\u4e0b\u3092\u793a\u3059\u306e\u3067\u3059\u304c\u3001\u8840\u7cd6\u5024\u304c\u4f4e\u4e0b\u3059\u308c\u3070\u3001\u307e\u305f\u6b63\u5e38\u306a\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u4ee3\u8b1d\u304c\u56de\u5fa9\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n

2\u578b\u7cd6\u5c3f\u75c5\u521d\u671f\u3084\u7cd6\u5c3f\u75c5\u4e88\u5099\u8ecd\u3067\u8a8d\u77e5\u6a5f\u80fd\u304c\u6b63\u5e38\u306a\u4eba\u3067\u3042\u3063\u3066\u3082\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u9ad8\u307e\u308b\u3068\u6954\u524d\u90e8\u3067\u306e18<\/sup>F-FDG\u306e\u53d6\u8fbc\u307f\u306e\u4f4e\u4e0b\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u7a7a\u8179\u6642\u306e\u8840\u7cd6\u5024\u304c100\uff5e110mg\/dL\u3068\u3044\u3046\u306e\u8efd\u5ea6\u306e\u4e0a\u6607\u3067\u3042\u3063\u3066\u3082\u3001\u8133\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u3088\u3046\u306a\u30d1\u30bf\u30fc\u30f3\u3092\u793a\u3059\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u3093\u306a\u308f\u305a\u304b\u306a\u4e0a\u6607\u3067\u3042\u3063\u3066\u3082\u3001\u8133\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u4ee3\u8b1d\u304c\u4f4e\u4e0b\u3059\u308b\u306e\u3067\u3042\u308c\u3070\u3001\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3092\u3057\u3066\u3044\u308b\u4eba\u306f\u591a\u304f\u306e\u6642\u9593\u3001\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u3092\u8a8d\u3081\u308b\u306f\u305a\u306a\u306e\u3067\u3001\u975e\u5e38\u306b\u9577\u3044\u6642\u9593\u3001\u8133\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u4ee3\u8b1d\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u308c\u304c\u7a4d\u3082\u308a\u7a4d\u3082\u3063\u3066\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u767a\u75c7\u3059\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u5225\u306e\u7814\u7a76\u3067\u3082\u3001\u8a8d\u77e5\u6a5f\u80fd\u304c\u6b63\u5e38\u3067\u3042\u308b124\u540d\u3067\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u304c76\u301c126mg\/dL\u306e\u7bc4\u56f2\u306e\u4eba\u306e\u8133\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u306e\u4f4e\u4e0b\u3092\u8abf\u3079\u3066\u307f\u308b\u3068\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u95a2\u9023\u3057\u305f\u8133\u306e\u9818\u57df\u3067\u3001\u3088\u308a\u9ad8\u3044\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u3068\u306e\u9593\u306e\u95a2\u9023\u6027\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\uff08\u4e0b\u306e\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

\u3067\u304d\u308b\u9650\u308a\u3001\u8840\u7cd6\u5024\u3092\u4e0a\u3052\u306a\u3044\u98df\u751f\u6d3b\u3092\u9001\u308b\u3079\u304d\u3060\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f\u5b9f\u306f20\u4ee3\u3067\u3042\u3063\u3066\u3082\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u3042\u308b\u3068\u8133\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u5229\u7528\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u7814\u7a76\u3082\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u306f\u307e\u305f\u6b21\u306e\u8a18\u4e8b\u3067\u3002<\/p>\n

 <\/p>\n

\u300cRelationship between Alzheimer disease-like pattern of 18<\/sup>F-FDG and fasting plasma glucose levels in cognitively normal volunteers\u300d<\/span><\/p>\n

\u300c\u8a8d\u77e5\u7684\u306b\u6b63\u5e38\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u306b\u304a\u3051\u308b18<\/sup>F-FDG\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u69d8\u30d1\u30bf\u30fc\u30f3\u3068\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u3068\u306e\u95a2\u4fc2\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n

\u8981\u7d04<\/span><\/p>\n

\u5897\u52a0\u3057\u305f\u8840\u6f3f\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u30ec\u30d9\u30eb\u306f18<\/sup>F-FDG\u53d6\u8fbc\u307f\u306e\u8133\u306e\u3001\u7279\u306b\u6954\u524d\u90e8\u306e\u5206\u5e03\u30d1\u30bf\u30fc\u30f3\u3092\u5909\u5316\u3055\u305b\u300118<\/sup>F-FDG\u306e\u53d6\u8fbc\u307f\u3092\u6e1b\u3089\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u8a8d\u77e5\u6a5f\u80fd\u304c\u6b63\u5e38\u306a\u4eba\u3092\u5bfe\u8c61\u306b\u304a\u3051\u308b18<\/sup>F-FDG\u306e\u5206\u5e03\u30d1\u30bf\u30fc\u30f3\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u69d8\u30d1\u30bf\u30fc\u30f3\u3068\u3057\u3066\u793a\u3055\u308c\u308b\u3002\u3053\u306e\u7814\u7a76\u306e\u76ee\u7684\u306f\u3001\u6954\u524d\u90e8\u306b\u304a\u3051\u308b18<\/sup>F-FDG\u6442\u53d6\u3092\u6e1b\u5c11\u3055\u305b\u5f97\u308b\u7a7a\u8179\u6642\u8840\u6f3f\u30b0\u30eb\u30b3\u30fc\u30b9\u30ec\u30d9\u30eb\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u3067\u3042\u3063\u305f\u3002<\/span><\/p>\n

\u65b9\u6cd5\uff1a\u8a8d\u77e5\u6a5f\u80fd\u304c\u6b63\u5e38\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a251\u4eba\uff08\u5e73\u5747\u5e74\u9f62\u00b1SD\u300169.7\u00b15.9\u6b73\uff09\u304c18<\/sup>F-FDG PET\u30b9\u30ad\u30e3\u30f3\u3092\u53d7\u3051\u3001PET\u30b9\u30ad\u30e3\u30cb\u30f3\u30b0\u6642\u306e\u7a7a\u8179\u6642\u8840\u6f3f\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u30ec\u30d9\u30eb\u306b\u5fdc\u3058\u30662\u7fa4\u306b\u5206\u3051\u3089\u308c\u305f\uff1a\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff0831\u4eba\u300180mg\/dL\u2266\u7a7a\u8179\u6642\u8840\u7cd6\u5024<110mg\/dL\uff09\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u7570\u5e38\uff08IFG\uff09\uff08n = 20\u3001100mg\/dL\u2266\u7a7a\u8179\u6642PG<110mg\/dL\uff09\u300218<\/sup>F-FDG\u53d6\u8fbc\u307f\u3092\u30012\u3064\u306e\u7fa4\u9593\u3067\u6bd4\u8f03\u3057\u305f\u3002<\/span><\/p>\n

\u7d50\u679c\uff1a\u5168\u8133\u306evoxelwise\u5206\u6790\u306f\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u6954\u524d\u90e8\u306b\u304a\u3051\u308b18<\/sup>F-FDG\u53d6\u308a\u8fbc\u307f\u304cIFG\u7fa4\u3067\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f\u3053\u3068\u3092\u793a\u3057\u305f\u3002VOI\u5206\u6790\u3067\u306f\u3001IFG\u7fa4\u306e\u6954\u524d\u90e8\/\u8996\u899a\u91ce\u6bd4\u304a\u3088\u3073\u6954\u524d\u90e8\/\u5f8c\u90e8\u5e2f\u72b6\u56de\u6bd4\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3088\u308a\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f\u3002<\/span><\/p>\n

\u7d50\u8ad6\uff1a\u672c\u7814\u7a76\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u69d8\u30d1\u30bf\u30fc\u30f3\u306e\u3088\u3046\u306b\u3001\u7279\u306b\u6954\u524d\u90e8\u306b\u304a\u3044\u3066\u3001\u7a7a\u8179\u6642\u8840\u6f3f\u30b0\u30eb\u30b3\u30fc\u30b9\u30ec\u30d9\u30eb\u306e\u4e0a\u6607\u304c18<\/sup>F-FDG\u53d6\u8fbc\u307f\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u3053\u306e\u7814\u7a76\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u69d8\u30d1\u30bf\u30fc\u30f3\u304c\u3001\u7a7a\u8179\u6642\u8840\u6f3f\u30b0\u30eb\u30b3\u30fc\u30b9\u30ec\u30d9\u30eb\u306e\u8efd\u5ea6\u4e0a\u6607\uff08100\u301c110mg\/dL\uff09\u306e\u4eba\u3067\u3055\u3048\u73fe\u308c\u5f97\u308b\u3068\u3044\u3046\u6700\u521d\u306e\u8a3c\u62e0\u3092\u63d0\u4f9b\u3057\u305f\u3002<\/span><\/p>\n

 <\/p>\n

\u300cHigher serum glucose levels are associated with cerebral hypometabolism in Alzheimer regions\u300d<\/span><\/p>\n

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