{"id":3864,"date":"2018-03-19T00:03:52","date_gmt":"2018-03-18T15:03:52","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=3864"},"modified":"2020-01-10T08:44:54","modified_gmt":"2020-01-09T23:44:54","slug":"post-3864","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=3864","title":{"rendered":"HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u9ad8\u3051\u308c\u3070\u826f\u3044\u3063\u3066\u3082\u3093\u3058\u3083\u306a\u3044\uff1f\u3000\u305d\u306e2"},"content":{"rendered":"<p>\u524d\u56de\u306e\u8a18\u4e8b\u300c<a href=\"http:\/\/promea2014.com\/blog\/?p=3859\" target=\"_blank\" rel=\"noopener noreferrer\">HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u9ad8\u3051\u308c\u3070\u826f\u3044\u3063\u3066\u3082\u3093\u3058\u3083\u306a\u3044\uff1f<\/a>\u300d\u3067\u8d85\u9ad8\u5024\u306eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u3092\u66f8\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3082\u8cea\u306e\u554f\u984c\u304c\u3042\u308a\u307e\u3059\u3002HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u983b\u5ea6\u304c\u9006\u76f8\u95a2\u3059\u308b\u3053\u3068\u304b\u3089\u3001HDL\u3092\u4e0a\u6607\u3055\u305b\u308b\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u6e1b\u5c11\u3059\u308b\u306e\u3067\u306f\u3001\u3068\u3044\u3046\u300cHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4eee\u8aac\u300d\u304c\u9577\u3044\u9593\u4fe1\u3058\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3082\u3061\u308d\u3093\u4e00\u822c\u8ad6\u3068\u3057\u3066\u306fHDL\u306f\u591a\u3044\u65b9\u304c\u826f\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u304c\u3001\u5fc5\u305a\u3057\u3082HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u300c\u5584\u7389\u300d\u3067\u3042\u308b\u3068\u306f\u8a00\u3044\u5207\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u3054\u5b58\u77e5\u306e\u65b9\u3082\u3044\u308b\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u307e\u3067\u69d8\u3005\u306aHDL\u3092\u5897\u52a0\u3055\u305b\u308b\u85ac\u5264\u306e\u7814\u7a76\u304c\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u4f8b\u3048\u3070\u30d3\u30bf\u30df\u30f3B\u7fa4\u306e\u300c\u30ca\u30a4\u30a2\u30b7\u30f3\u300d\u3002\u4ee5\u524d\u304b\u3089\u30ca\u30a4\u30a2\u30b7\u30f3\u306fHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u3092\u7528\u3044\u305fAIM-HIGH\u7814\u7a76\u3067\u3001\u30b9\u30bf\u30c1\u30f3\uff0b\u30d7\u30e9\u30bb\u30dc\u3068\u30b9\u30bf\u30c1\u30f3\uff0b\u30ca\u30a4\u30a2\u30b7\u30f3\u3068\u306e\u6bd4\u8f03\u3067\u306f\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u7fa4\u306fHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u5897\u52a0\u3057\u3001\u4e2d\u6027\u8102\u80aa\u304c\u6e1b\u5c11\u3059\u308b\u3068\u3044\u3046\u975e\u5e38\u306b\u597d\u307e\u3057\u3044\u5909\u5316\u304c\u8a8d\u3081\u3089\u308c\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u7387\u3067\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u4f55\u3089\u7d50\u679c\u304c\u5909\u308f\u3089\u306a\u304b\u3063\u305f\u306e\u3067\u3059\u3002\uff08\u539f\u6587\u306f<a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1107579\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/p>\n<p>\u307e\u305f\u30d5\u30a1\u30a4\u30b6\u30fc\u304c\u958b\u767a\u3057\u305fCETP\u963b\u5bb3\u85ac\u306e\u30c8\u30eb\u30bb\u30c8\u30e9\u30d4\u30d6\u3068\u3044\u3046\u85ac\u306f\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5927\u5e45\u306b\u5897\u52a0\u3055\u305b\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u3057\u305f\u304c\u3001\u81e8\u5e8a\u8a66\u9a13\u3067\u5168\u6b7b\u4ea1\u30fb\u5fc3\u8840\u7ba1\u75be\u60a3\u304c\u5897\u52a0\u3057\u305f\u305f\u3081\u306b2006\u5e7412\u6708\u306b\u958b\u767a\u304c\u4e2d\u6b62\u3055\u308c\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5897\u52a0\u3057\u3066\u3082\u3001\u7d50\u679c\u3068\u3057\u3066\u306f\u6709\u5bb3\u3060\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n<p>HDL\u306f\u3001\u809d\u81d3\u304b\u3089\u307b\u3068\u3093\u3069\u8102\u8cea\u3092\u542b\u307e\u306a\u3044apoA-I\u3068\u3057\u3066\u5206\u6ccc\u3055\u308c\u3001\u3053\u308c\u3092\u65b0\u751fHDL\uff08pre-\u03b2 apoA-I\uff09\u3068\u547c\u3073\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5927\u91cf\u306b\u542b\u3093\u3060\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304b\u3089\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u53d7\u3051\u53d6\u308a\u3001\u539f\u59cbHDL\uff08nascent HDL\uff09\u3068\u306a\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304b\u3089\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u53d7\u3051\u53d6\u308a\u3001\u6210\u719fHDL\uff08mature HDL\uff09\u3068\u306a\u308b\u306e\u3067\u3059\u3002\u305d\u3057\u3066\u3001\u6210\u719fHDL\u306fCETP\u306b\u3088\u3063\u3066LDL\u306b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30a8\u30b9\u30c6\u30eb\u3092\u8f38\u9001\u3057\u3066\u3001LDL\u304b\u3089\u4e2d\u6027\u8102\u80aa\uff08\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff09\u3092\u53d7\u3051\u53d6\u3063\u3066TG\u30ea\u30c3\u30c1HDL\u3068\u306a\u308a\u307e\u3059\u3002\u305d\u308c\u305e\u308c\u306e\u9593\u306b\u3082\u9023\u7d9a\u7684\u306a\u7c92\u5b50\u306e\u5927\u304d\u3055\u306e\u5909\u5316\u304c\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u65b0\u751fHDL\u3001\u539f\u59cbHDL\u3001\u6210\u719fHDL\u3001TG\u30ea\u30c3\u30c1HDL\u3059\u3079\u3066\u3092\u5408\u308f\u305b\u3066\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u3057\u3066\u6e2c\u5b9a\u3055\u308c\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n<p>\u5c0f\u3055\u306a\u7c92\u5b50\u306e\u65b0\u751fHDL\u3001\u539f\u59cbHDL\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u9006\u8f38\u9001\u3092\u62c5\u3063\u3066\u3044\u308b\u306e\u3067\u3001\u3044\u308f\u3086\u308b\u300c\u5584\u7389\u300d\u3068\u8a00\u3048\u307e\u3059\u304c\u3001\u5927\u304d\u306a\u7c92\u5b50\u306e\u6210\u719fHDL\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9006\u8f38\u9001\u306b\u307b\u3068\u3093\u3069\u95a2\u4fc2\u3057\u306a\u3044\u306e\u3067\u3001\u6210\u719fHDL\u304c\u3044\u304f\u3089\u5897\u52a0\u3057\u3066\u3082\u5229\u76ca\u306f\u5f97\u3089\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u5927\u304d\u306aHDL\u7c92\u5b50\u306f\u3001\u9632\u5fa1\u6027\u304c\u4f4e\u304f\u3001\u6a5f\u80fd\u4e0d\u5168\u3067\u3055\u3048\u3042\u308a\u5f97\u308b\u306e\u3067\u3059\u304c\u3001\u4e2d\u5c0f\u30b5\u30a4\u30ba\u306eHDL\u7c92\u5b50\u306f\u3001\u3088\u308a\u5927\u304d\u306a\u6297\u9178\u5316\u6d3b\u6027\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6d41\u51fa\u80fd\u529b\u3001\u6297\u8840\u6813\u4f5c\u7528\u304c\u3042\u308b\u3068\u3044\u308f\u308c\u3066\u3044\u3066\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u3088\u308a\u5927\u304d\u306a\u4fdd\u8b77\u4f5c\u7528\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3064\u307e\u308a\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5c0f\u3055\u306a\u7c92\u5b50\u304c\u5897\u52a0\u3059\u308b\u307b\u3069\u826f\u3044\u306e\u3067\u3059\u3002\u30ca\u30a4\u30a2\u30b7\u30f3\u3084CETP\u963b\u5bb3\u85ac\u306f\u6050\u3089\u304f\u3001\u5927\u304d\u306aHDL\u7c92\u5b50\u3092\u5897\u52a0\u3055\u305b\u3066\u3044\u308b\u3060\u3051\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\u3057\u304b\u3057\u3001\u305d\u308c\u3060\u3051\u3067\u306f\u8d85\u9ad8\u5024\u306eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3067\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u7406\u7531\u3068\u306f\u306a\u308a\u307e\u305b\u3093\u304c\u3001\u305d\u306e\u7406\u7531\u306e\u4e00\u3064\u3068\u3057\u3066\u306f\u300c\u60aa\u7389\uff1f\u300dHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u3057\u3066\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u306f\u4eca\u5ea6\u306e\u8a18\u4e8b\u3067\u66f8\u304d\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u524d\u56de\u306e\u8a18\u4e8b\u300cHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u9ad8\u3051\u308c\u3070\u826f\u3044\u3063\u3066\u3082\u3093\u3058\u3083\u306a\u3044\uff1f\u300d\u3067\u8d85\u9ad8\u5024\u306eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u3092\u66f8\u304d\u307e\u3057\u305f\u3002 HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3082\u8cea\u306e\u554f\u984c\u304c\u3042\u308a\u307e\u3059\u3002HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3068<\/p>\n","protected":false},"author":1,"featured_media":3888,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[145,149,146,155,144,4],"tags":[],"class_list":["post-3864","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ldl","category-statin","category-hdl","category-cvd","category-cholesterol","category-4","two-columns"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/03\/c5516f1e1b54a949c4522b97547278c7_s.jpg?fit=640%2C412&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p9cBot-10k","jetpack-related-posts":[{"id":3898,"url":"https:\/\/promea2014.com\/blog\/?p=3898","url_meta":{"origin":3864,"position":0},"title":"HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u9ad8\u3051\u308c\u3070\u826f\u3044\u3063\u3066\u3082\u3093\u3058\u3083\u306a\u3044\uff1f\u3000\u305d\u306e3","author":"Dr.Shimizu","date":"2018\u5e743\u670821\u65e5","format":false,"excerpt":"\u4ee5\u524d\u306e\u8a18\u4e8b\u300cHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u9ad8\u3051\u308c\u3070\u826f\u3044\u3063\u3066\u3082\u3093\u3058\u3083\u306a\u3044\uff1f\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u2026","rel":"","context":"\u7cd6\u8cea\u5236\u9650","block_context":{"text":"\u7cd6\u8cea\u5236\u9650","link":"https:\/\/promea2014.com\/blog\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/03\/6b73957354cbc79ba323920d60ff6f3b_s.jpg?fit=640%2C409&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/03\/6b73957354cbc79ba323920d60ff6f3b_s.jpg?fit=640%2C409&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/03\/6b73957354cbc79ba323920d60ff6f3b_s.jpg?fit=640%2C409&ssl=1&resize=525%2C300 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