{"id":4012,"date":"2018-06-04T07:43:48","date_gmt":"2018-06-03T22:43:48","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=4012"},"modified":"2020-01-10T08:44:17","modified_gmt":"2020-01-09T23:44:17","slug":"post-4012","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=4012","title":{"rendered":"ApoC\u2162\u306e\u8abf\u7bc0\u3068\u5f79\u5272"},"content":{"rendered":"

\u4f55\u5ea6\u3082\u8a18\u4e8b\u306b\u767b\u5834\u3057\u3066\u3044\u308bApoC\u2162\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u3082\u3046\u4e00\u5ea6\u307e\u3068\u3081\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n

ApoC\u2162\u306f\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u69cb\u6210\u3057\u3066\u3044\u308b\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u3064\u3067\u3059\u3002<\/p>\n

\u30fbApoC\u2162\u306f\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30d1\u30fc\u30bc\uff08LPL\uff09\u3068\u3044\u3046\u9175\u7d20\u306e\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u3002\uff08LPL\u306f\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e2d\u6027\u8102\u80aa\u3092\u8102\u80aa\u7d44\u7e54\u306b\u53d6\u8fbc\u3080\u4f5c\u7528\u3092\u793a\u3059\u3002\uff09ApoC\u2162\u306fLPL\u306e\u4f5c\u7528\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3002\u4e00\u65b9ApoC\u2161\u306e\u65b9\u306fLPL\u3092\u6d3b\u6027\u5316\u3059\u308b\u3002\u3064\u307e\u308aApoC\u2162\u3068ApoC\u2161\u306f\u9006\u306e\u4f5c\u7528\u3092\u793a\u3059\u306e\u3067\u3059\u3002<\/p>\n

\u30fbApoC\u2162\u306f\u809d\u81d3\u304b\u3089\u306eVLDL\u5206\u6ccc\u3092\u5897\u52a0\u3055\u305b\u308b\u3002<\/p>\n

ApoC\u2162\u306e\u8abf\u7bc0\u306f\u3069\u306e\u3088\u3046\u306b\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1fApoC\u2162\u306fAPOC3\u306e\u907a\u4f1d\u5b50\u306b\u30b3\u30fc\u30c9\u3055\u308c\u3066\u3044\u3066\u3001APOC3\u306f\u7cd6\u8cea\u306b\u3088\u3063\u3066\u5897\u52a0\u3057\u307e\u3059\u3002\u300cApoC\u2162\u7523\u751f\u901f\u5ea6\u306e\u5897\u52a0\u304c\u4e2d\u6027\u8102\u80aa\u5024\u3092\u9ad8\u304f\u3057\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u306a\u3044<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u7cd6\u8cea\u6442\u53d6\u2192ChREBP\u6d3b\u6027\u5316\u2192ApoC\u2162\u5897\u52a0\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001APOC3\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u3063\u3066\u4f4e\u4e0b\u3059\u308b\u306e\u3067\u3059\u3002\u4f55\u304b\u5909\u308f\u3063\u3066\u3044\u307e\u3059\u306d\u3002\u7cd6\u8cea\u3092\u6442\u308c\u3070\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u5206\u6ccc\u3055\u308c\u308b\u306e\u3067\u5897\u52a0\u3057\u306a\u304c\u3089\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u3001\u6253\u3061\u6d88\u3057\u5408\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n

ApoC\u2162\u306f\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u3001VLDL\u3084LDL\u306b\u304f\u3063\u3064\u304f\u3053\u3068\u306b\u3088\u308a\u3001LPL\u6d3b\u6027\u304c\u4e0b\u304c\u308b\u306e\u3067\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u3092\u4f5c\u308b\u539f\u56e0\u3068\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u307e\u305fHDL\u306b\u304f\u3063\u3064\u304f\u3068\u5f15\u304d\u629c\u304d\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u6a5f\u80fd\u4e0d\u5168\u306eHDL\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n

\u3060\u3068\u3059\u308b\u3068\u3001ApoC\u2162\u306f\u300c\u60aa\u7389\u300d\u306e\u771f\u72af\u4eba\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u300c\u307b\u3068\u3093\u3069\u306e\u75c5\u6c17\u306f\u9032\u5316\u3068\u306e\u30df\u30b9\u30de\u30c3\u30c1\u3067\u3042\u308b<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u300c\u73fe\u4ee3\u306e\u98df\u751f\u6d3b\u300d\u306b\u304a\u3044\u3066\u300c\u60aa\u7389\u300d\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u79c1\u305f\u3061\u306e\u4f53\u306e\u4e2d\u306b\u305f\u304f\u3055\u3093\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u9032\u5316\u306e\u4e2d\u3067\u306f\u975e\u5e38\u306b\u91cd\u8981\u306a\u300c\u5584\u7389\u300d\u3067\u3042\u3063\u305f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u3067\u306f\u3001ApoC\u2162\u306e\u771f\u306e\u5f79\u5272\u3068\u306f\u4f55\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u6050\u3089\u304f\u306fApoC\u2162\u3092\u542b\u3081\u305fApoC\u9054\u306f\u4f53\u306e\u8102\u80aa\u306e\u8abf\u6574\u3092\u62c5\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002ApoC\u2161\u3068ApoC\u2162\uff08ApoC\u2160\u3082\u542b\u3081\u3066\uff09\u306e\u30d0\u30e9\u30f3\u30b9\u3067\u3001\u8102\u80aa\u8abf\u6574\u3092\u884c\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\uff08\u5b9f\u969b\u306b\u306f\u4ed6\u306e\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u4ed6\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3082\u8102\u80aa\u8abf\u6574\u306b\u304b\u304b\u308f\u308a\u307e\u3059\u304c\u3001\u3053\u3053\u3067\u306f\u7701\u7565\u3057\u307e\u3059\u3002\uff09\u6614\u306e\u72e9\u731f\u63a1\u96c6\u751f\u6d3b\u3067\u306f\u3001\u305d\u308c\u304c\u7d76\u5999\u306b\u50cd\u304d\u3001\u4eba\u9593\u306b\u3068\u3063\u3066\u4e01\u5ea6\u826f\u304f\u8abf\u6574\u3055\u308c\u3066\u3044\u305f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u6614\u306e\u751f\u6d3b\u3067\u306f\u4eca\u306e\u3088\u3046\u306a\u7cd6\u8cea\u306f\u307b\u3068\u3093\u3069\u306a\u304f\u3001\u3042\u3063\u305f\u306e\u306f\u679c\u5b9f\u306e\u7cd6\u8cea\u304c\u307b\u3068\u3093\u3069\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u305d\u306e\u679c\u5b9f\u306e\u7cd6\u8cea\u3082\u4eca\u306e\u3088\u3046\u306a\u679c\u7269\u3068\u9055\u3044\u3001\u7cd6\u8cea\u91cf\u306f\u975e\u5e38\u306b\u5c11\u306a\u3044\u3082\u306e\u3060\u3063\u305f\uff08\u300c\u6614\u306e\u679c\u7269\u3084\u91ce\u83dc\u306f\u4eca\u3068\u306f\u5927\u9055\u3044\uff01<\/a>\u300d\u53c2\u7167\uff09\u306e\u3067\u3059\u304c\u3001\u305d\u306e\u308f\u305a\u304b\u306a\u7cd6\u8cea\u3092\u5341\u5206\u306b\u5229\u7528\u3059\u308b\u305f\u3081\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u679c\u7269\u306b\u591a\u304f\u542b\u307e\u308c\u308b\u679c\u7cd6\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u3042\u307e\u308a\u4fc3\u9032\u3057\u307e\u305b\u3093\u3002\u7cd6\u8cea\u304c\u5165\u3063\u3066\u304d\u3066\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306f\u3042\u307e\u308a\u5206\u6ccc\u3055\u308c\u306a\u3044\u306e\u3067\u3001ApoC\u2162\u306f\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

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\u307e\u305f\u3001\u7cd6\u306e\u4ee3\u8b1d\u3068\u306f\u95a2\u9023\u305b\u305a\u3001\u4f8b\u3048\u3070\u8089\u3092\u98df\u3079\u305f\u3053\u3068\u3092\u8003\u3048\u3066\u307f\u308b\u3068\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u8102\u8cea\u304c\u5438\u53ce\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u5834\u5408\u30a4\u30f3\u30b9\u30ea\u30f3\u306f\u5206\u6ccc\u3055\u308c\u308b\u306e\u3067\u3001ApoC\u2162\u306f\u4f4e\u4e0b\u3057ApoC\u2161\u304c\u512a\u4f4d\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u3046\u3059\u308b\u3068LPL\u304c\u6d3b\u6027\u5316\u3057\u8102\u80aa\u7d30\u80de\u3067\u306e\u8102\u8cea\u306e\u53d6\u8fbc\u307f\u304c\u4fc3\u9032\u3055\u308c\u3066\u3001\u52b9\u7387\u3088\u304f\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u305f\u3081\u8fbc\u3080\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3068\u306b\u304b\u304f\u72e9\u731f\u63a1\u96c6\u751f\u6d3b\u3067\u306f\u3001\u7cd6\u8cea\u3067\u3042\u308d\u3046\u3068\u8102\u8cea\u3067\u3042\u308d\u3046\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u5341\u5206\u306b\u305f\u3081\u8fbc\u3080\u3053\u3068\u304c\u6700\u91cd\u8981\u8ab2\u984c\u3067\u3042\u3063\u305f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u5f79\u5272\u306e\u3072\u3068\u3064\u3092ApoC\u9054\u304c\u62c5\u3063\u3066\u3044\u305f\u306e\u3067\u306f\u3068\u8003\u3048\u307e\u3059\u3002<\/p>\n

\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u3001\u6614\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3068\u308f\u305a\u304b\u306a\u7cd6\u8cea\u3068ApoC\u2162\u3084ApoC\u2161\u306a\u3069\u304c\u975e\u5e38\u306b\u3046\u307e\u304f\u9023\u643a\u3057\u5408\u3063\u3066\u3001\u4f53\u8102\u80aa\u91cf\u3001\u8102\u8cea\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u8abf\u6574\u3057\u3066\u3044\u305f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u7cd6\u8cea\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u3067\u306fApoC\u2162\u306b\u5bfe\u3057\u3066\u53cd\u5bfe\u306e\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u306f\u3001\u30d0\u30e9\u30f3\u30b9\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3057\u304b\u3057\u3001\u73fe\u4ee3\u306e\u98df\u4e8b\u3067\u306f\u7cd6\u8cea\u306f\u904e\u5270\u306b\u6442\u53d6\u3055\u308c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u8d77\u3053\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u3046\u3059\u308b\u3068\u7d76\u5999\u306a\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3001\u305d\u308c\u304c\u8102\u80aa\u84c4\u7a4d\u306b\u3088\u308b\u80a5\u6e80\u3084\u3001ApoC\u2162\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3067\u30ec\u30e0\u30ca\u30f3\u30c8\u304c\u5897\u52a0\u3057\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u306e\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u73fe\u4ee3\u306e\u98df\u4e8b\u3067\u306fApoC\u2162\u306f\u300c\u60aa\u7389\u300d\u3067\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u304cApoC\u2162\u306e\u7570\u5e38\u306a\u5897\u52a0\u3092\u751f\u3093\u3067\u3044\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u3060\u304b\u3089\u3068\u8a00\u3063\u3066\u3001ApoC\u2162\u3092\u963b\u5bb3\u3059\u308b\u3088\u3046\u306a\u85ac\u3092\u6295\u4e0e\u3059\u308c\u3070\u4e0a\u624b\u304f\u884c\u304f\u3068\u306f\u601d\u3048\u307e\u305b\u3093\u3002\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u3001ApoC\u2162\u304c\u6b20\u640d\u3057\u3066\u3044\u308b\u3068\u8102\u80aa\u306e\u7570\u5e38\u306a\u84c4\u7a4d\u3001\u4f53\u91cd\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002\u4f53\u304c\u9032\u5316\u306e\u4e2d\u3067\u7372\u5f97\u3057\u305f\u30d0\u30e9\u30f3\u30b9\u3092\u5d29\u3057\u3066\u3057\u307e\u3046\u304b\u3089\u3067\u3059\u3002<\/p>\n

\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u540c\u3058\u3067\u3001ApoC\u2162\u305d\u306e\u3082\u306e\u304c\u300c\u60aa\u7389\u300d\u3067\u306f\u306a\u304f\u3001\u6050\u3089\u304f\u4f53\u306b\u3068\u3063\u3066\u306f\u5fc5\u9808\u306e\u3082\u306e\u3067\u3059\u3002ApoC\u2162\u306b\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u306a\u3069\u3001\u305d\u306e\u4ed6\u306e\u91cd\u8981\u306a\u5f79\u5272\u3082\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u73fe\u4ee3\u306e\u98df\u751f\u6d3b\u3068\u30df\u30b9\u30de\u30c3\u30c1\u3092\u8d77\u3053\u3057\u3066\u3044\u308b\u304b\u3089\u3068\u8a00\u3063\u3066\u3001\u6291\u3048\u8fbc\u3081\u3070\u3059\u3079\u3066\u304c\u3046\u307e\u304f\u884c\u304f\u308f\u3051\u304c\u306a\u3044\u306e\u3067\u3059\u3002<\/p>\n

ApoC\u2162\u3092\u3044\u304f\u3089\u304b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306f\u3001\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u306e\u6cbb\u7642\u306b\u6709\u76ca\u3067\u3042\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u304c\u3001\u305d\u306e\u767a\u73fe\u3092\u5b8c\u5168\u306b\u6b62\u3081\u3066\u3057\u307e\u3063\u305f\u308a\u3001\u5927\u304d\u304f\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306f\u3001\u4eba\u9593\u306e\u5065\u5eb7\u306b\u91cd\u8981\u306a\u4ed6\u306e\u751f\u7406\u5b66\u7684\u5f79\u5272\u306b\u6709\u5bb3\u306a\u4f5c\u7528\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u5341\u5206\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u304c\u5927\u3057\u305f\u52b9\u679c\u3082\u306a\u304f\u3001\u305d\u306e\u88cf\u3067\u69d8\u3005\u306a\u526f\u4f5c\u7528\u3001\u6709\u5bb3\u4f5c\u7528\u3092\u8a8d\u3081\u305f\u3053\u3068\u3068\u540c\u3058\u3067ApoC\u2162\u963b\u5bb3\u5264\u306f\u304d\u3063\u3068\u79c1\u305f\u3061\u306e\u4f53\u306b\u60aa\u5f71\u97ff\u304c\u3042\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n

 <\/p>\n

\u300cWhy Is Apolipoprotein CIII Emerging as a Novel Therapeutic Target to Reduce the Burden of Cardiovascular Disease?\u300d<\/span><\/p>\n

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