{"id":4070,"date":"2018-04-11T00:03:39","date_gmt":"2018-04-10T15:03:39","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=4070"},"modified":"2018-04-11T00:03:39","modified_gmt":"2018-04-10T15:03:39","slug":"post-4070","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=4070","title":{"rendered":"\u30db\u30fc\u30ad\u30f3\u30b0\u535a\u58eb\u3068\u30b9\u30bf\u30c1\u30f3"},"content":{"rendered":"

\u5148\u65e53\u670814\u65e5\u3001\u5049\u5927\u306a\u79d1\u5b66\u8005\u3067\u3042\u308b\u30b9\u30c6\u30a3\u30fc\u30d6\u30f3\u30fb\u30db\u30fc\u30ad\u30f3\u30b0\u535a\u58eb\u304c\u4ea1\u304f\u306a\u308a\u307e\u3057\u305f\u300276\u6b73\u3067\u3057\u305f\u3002<\/p>\n

\u5f7c\u306f\u3054\u5b58\u77e5\u306e\u3088\u3046\u306b\u300121\u6b73\u3067ALS\uff08\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff09\u3068\u3044\u3046\u75c5\u6c17\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u4f53\u304c\u3069\u3093\u3069\u3093\u52d5\u304b\u306a\u304f\u306a\u3063\u305f\u5f8c\u3082\u5148\u9032\u7684\u306a\u5b87\u5b99\u8ad6\u3092\u793a\u3057\u7d9a\u3051\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n

ALS\u306f\u91cd\u7be4\u306a\u7b4b\u8089\u306e\u840e\u7e2e\u3068\u7b4b\u529b\u4f4e\u4e0b\u3092\u304d\u305f\u3059\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3059\u3002\u3044\u307e\u3060\u306b\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3057\u3001\u539f\u56e0\u3082\u306f\u3063\u304d\u308a\u3068\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u30025\uff5e10\uff05\u3050\u3089\u3044\u306f\u907a\u4f1d\u306e\u3088\u3046\u3067\u3059\u3002<\/p>\n

\u984c\u540d\u306e\u30db\u30fc\u30ad\u30f3\u30b0\u535a\u58eb\u3068\u30b9\u30bf\u30c1\u30f3\u3068\u306f\u3069\u306e\u3088\u3046\u306a\u95a2\u4fc2\u304c\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u535a\u58eb\u3068\u306f\u5b9f\u969b\u306f\u76f4\u63a5\u95a2\u4fc2\u306a\u304f\u3001ALS\u3068\u30b9\u30bf\u30c1\u30f3\u304c\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u5148\u65e5\u65b0\u3057\u3044\u885d\u6483\u7684\u306a\u5831\u544a\u304c\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002\u30b9\u30bf\u30c1\u30f3\u304cALS\u306b\u5927\u304d\u304d\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u304c\u795e\u7d4c\u7d30\u80de\u3092\u640d\u50b7\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u306f\u9577\u3044\u9593\u8a00\u308f\u308c\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u795e\u7d4c\u306e\u30b7\u30ca\u30d7\u30b9\u306f\u3001\u4e3b\u306b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3067\u4f5c\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u795e\u7d4c\u7d30\u80de\u3092\u56f2\u3093\u3067\u4fdd\u8b77\u3059\u308b\u30df\u30a8\u30ea\u30f3\u9798\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u304a\u305d\u3089\u304f\u3001\u30b9\u30bf\u30c1\u30f3\u304c\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5408\u6210\u3092\u963b\u5bb3\u3059\u308b\u76f4\u63a5\u7684\u306a\u52b9\u679c\u306b\u3088\u308a\u3001\u795e\u7d4c\u7d30\u80de\u3092\u640d\u50b7\u3055\u305b\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u3063\u3066\u3069\u308c\u307b\u3069ALS\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u306e\u304b\uff1f<\/p>\n\n\n\n\n\n\n\n\n
\u30b9\u30bf\u30c1\u30f3\u306e\u7a2e\u985e<\/td>\n\u30aa\u30c3\u30ba\u6bd4\uff08ROR)<\/td>\n<\/tr>\n
\u30ed\u30b9\u30d0\u30b9\u30bf\u30c1\u30f3\uff08\u30af\u30ec\u30b9\u30c8\u30fc\u30eb\uff09<\/td>\n9.09<\/td>\n<\/tr>\n
\u30d7\u30e9\u30d0\u30b9\u30bf\u30c1\u30f3\uff08\u30e1\u30d0\u30ed\u30c1\u30f3\uff09<\/td>\n16.2<\/td>\n<\/tr>\n
\u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f3\uff08\u30ea\u30d4\u30c8\u30fc\u30eb\uff09<\/td>\n17.0<\/td>\n<\/tr>\n
\u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3\uff08\u30ea\u30dd\u30d0\u30b9\uff09<\/td>\n23.0<\/td>\n<\/tr>\n
\u30ed\u30d0\u30b9\u30bf\u30c1\u30f3\uff08\u30e1\u30d0\u30b3\u30fc\u30eb\uff09<\/td>\n107<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

1.2\u500d\u30842.3\u500d\u306a\u3069\u3068\u3044\u3046\u304b\u308f\u3044\u3044\u6570\u5b57\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u30029\u500d\uff5e107\u500d\u3067\u3059\u3002<\/p>\n

ALS\u306f\u4e16\u754c\u4e2d\u3067\u5897\u52a0\u3057\u3066\u3044\u308b\u3068\u3082\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u539f\u56e0\u306f\u306f\u3063\u304d\u308a\u306f\u3057\u306a\u3044\u306e\u3067\u3059\u304c\u3001\u3053\u306e\u3088\u3046\u306a\u660e\u3089\u304b\u306a\u3001\u975e\u5e38\u306b\u5927\u304d\u306a\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3092\u8a8d\u3081\u308b\u3068\u306a\u308c\u3070\u3001\u30b9\u30bf\u30c1\u30f3\u304c\u539f\u56e0\u306e\u4e00\u3064\u3068\u8a00\u3063\u3066\u3044\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u305d\u3057\u3066\u3001\u6050\u3089\u304f\u306f\u3053\u306e\u3053\u3068\u3092\u88fd\u85ac\u4f1a\u793e\u306f\u3059\u3067\u306b\u77e5\u3063\u3066\u3044\u308b\u306f\u305a\u3067\u3059\u3002\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5408\u6210\u3092\u963b\u5bb3\u3057\u3066\u826f\u3044\u308f\u3051\u304c\u306a\u3044\u306e\u3067\u3059\u3002\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u4f53\u306b\u91cd\u8981\u306a\u7269\u8cea\u3067\u3059\u304b\u3089\u3002<\/p>\n

\u7686\u3055\u3093\u306fALS\u306b\u602f\u3048\u306a\u304c\u3089\u30b9\u30bf\u30c1\u30f3\u3092\u7d9a\u3051\u307e\u3059\u304b\uff1f\u30b9\u30bf\u30c1\u30f3\u3092\u3084\u3081\u3066\u7cd6\u8cea\u5236\u9650\u3092\u3057\u3066\u5065\u5eb7\u3092\u76ee\u6307\u3057\u307e\u3059\u304b\uff1f<\/p>\n

 <\/p>\n

\u300cAmyotrophic Lateral Sclerosis Associated with Statin Use: A Disproportionality Analysis of the FDA’s Adverse Event Reporting System\u300d<\/span><\/p>\n

\u300c\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u306b\u95a2\u9023\u3059\u308b\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff1aFDA\u306e\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\u306e\u4e0d\u5747\u8861\u5206\u6790\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n

\u8981\u7d04<\/span><\/p>\n

\u524d\u66f8\u304d\uff1a<\/span>
\n \u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u306b\u95a2\u9023\u3059\u308b\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u69d8\u75c7\u72b6\u306e\u5831\u544a\u306b\u304a\u3051\u308b\u660e\u3089\u304b\u306a\u4e0a\u6607\u306f\u3001\u7c73\u56fd\u304a\u3088\u3073\u6b27\u5dde\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u4ecb\u3057\u3066\u5f97\u3089\u308c\u305f\u30c7\u30fc\u30bf\u304b\u3089\u4ee5\u524d\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u76ee\u7684\uff1a<\/span>
\n \u3053\u306e\u7814\u7a76\u306e\u76ee\u7684\u306f\u3001\u5404\u30b9\u30bf\u30c1\u30f3\u3068\u306e\u9593\u306eALS\u3068ALS\u69d8\u306e\u72b6\u614b\u306e\u5831\u544a\u30aa\u30c3\u30ba\u6bd4\uff08ROR\uff09\u3092\u6bd4\u8f03\u3059\u308b\u305f\u3081\u306e\u7c73\u56fdFDA\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\uff08FAERS\uff09\u30c7\u30fc\u30bf\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3042\u3063\u305f\u3002<\/span><\/p>\n

\u65b9\u6cd5\uff1a<\/span>
\n \u6211\u3005\u306f\u3001ROR\u306e\u5f0f\u3092\u4f7f\u7528\u3057\u3066\u3001\u30b9\u30bf\u30c1\u30f3\u7cfb\u85ac\u5264\u3054\u3068\u306b\u5225\u3005\u306b\u5831\u544a\u3055\u308c\u305fALS\u304a\u3088\u3073ALS\u95a2\u9023\u6761\u4ef6\u306e\u4e0d\u5747\u8861\u7387\u3092\u8a55\u4fa1\u3057\u305f\u3002FAERS\u30c7\u30fc\u30bf\u306f2015\u5e749\u6708\u307e\u3067\u5206\u6790\u3055\u308c\u305f\u3002<\/span><\/p>\n

\u7d50\u679c\uff1a<\/span>
\n ALS\u306eROR\u306f\u3001\u3059\u3079\u3066\u306e\u30b9\u30bf\u30c1\u30f3\u306b\u3064\u3044\u3066\u4e0a\u6607\u3057\u3001\u89aa\u6cb9\u6027\u30b9\u30bf\u30c1\u30f3\u306b\u3064\u3044\u3066\u306f\u304a\u305d\u3089\u304f\u4e0a\u6607\u304c\u9ad8\u304b\u3063\u305f\u3002ROR\u306e\u7bc4\u56f2\u306f\u30ed\u30b9\u30d0\u30b9\u30bf\u30c1\u30f3\u304a\u3088\u3073\u30d7\u30e9\u30d0\u30b9\u30bf\u30c1\u30f3\uff08\u89aa\u6c34\u6027\uff09\u306e9.09\uff086.57-12.6\uff09\u304a\u3088\u307316.2\uff089.56-27.5\uff09\u3001\u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f3\u3001\u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3\u304a\u3088\u3073\u30ed\u30d0\u30b9\u30bf\u30c1\u30f3\uff08\u89aa\u6cb9\u6027\uff09\u306717.0\uff0814.1-20.4\uff09\u300123.0\uff0818.3-29.1\uff09\u304a\u3088\u3073107\uff0868.5-167\uff09\u3067\u3042\u3063\u305f\u3002\u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3\u306b\u3064\u3044\u3066\u306f\u300157.1\uff0839.5-82.7\uff09\u306eROR\u304c\u3001\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u75be\u60a3\u306b\u95a2\u3057\u3066\u5225\u500b\u306b\u5b58\u5728\u3057\u305f\u3002<\/span><\/p>\n

\u7d50\u8ad6\uff1a<\/span>
\n \u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u6709\u610f\u306b\u4e0a\u6607\u3057\u305fALS\u5831\u544a\u304c\u500b\u3005\u306e\u30b9\u30bf\u30c1\u30f3\u5264\u306b\u53ca\u3076\u3053\u3068\u3092\u793a\u3059\u4ee5\u524d\u306e\u8a3c\u62e0\u3092\u62e1\u5f35\u3057\u3001\u30b9\u30bf\u30c1\u30f3\u306e\u4f7f\u7528\u306b\u95a2\u9023\u3057\u305fALS\u69d8\u75c7\u72b6\u306e\u6f5c\u5728\u7684\u306a\u4e0a\u6607\u306e\u61f8\u5ff5\u3092\u8ffd\u52a0\u3059\u308b\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u5148\u65e53\u670814\u65e5\u3001\u5049\u5927\u306a\u79d1\u5b66\u8005\u3067\u3042\u308b\u30b9\u30c6\u30a3\u30fc\u30d6\u30f3\u30fb\u30db\u30fc\u30ad\u30f3\u30b0\u535a\u58eb\u304c\u4ea1\u304f\u306a\u308a\u307e\u3057\u305f\u300276\u6b73\u3067\u3057\u305f\u3002 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