{"id":4439,"date":"2018-05-25T00:11:45","date_gmt":"2018-05-24T15:11:45","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=4439"},"modified":"2020-01-10T08:44:21","modified_gmt":"2020-01-09T23:44:21","slug":"post-4439","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=4439","title":{"rendered":"\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u98df\u5f8c12\u6642\u9593\u7d4c\u3063\u3066\u3082\u5927\u91cf\u306b\u6b8b\u3063\u3066\u3044\u308b"},"content":{"rendered":"<p>\u901a\u5e38\u306e\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30e9\u30a4\u30d5\u30b5\u30a4\u30af\u30eb\u306f\u975e\u5e38\u306b\u77ed\u304f\u3001VLDL\u306f30\uff5e60\u5206\u7a0b\u5ea6\u3067IDL\u3068\u306a\u308a\u3001IDL\u308230\u5206\u7a0b\u5ea6\u3067LDL\u3068\u306a\u308a\u3001LDL\u306f2\uff5e4\u65e5\u9593\u4f53\u3092\u3081\u3050\u3063\u3066\u3044\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u308260\u5206\u3067\u534a\u5206\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3001\u975e\u5e38\u306b\u77ed\u3044\u9593\u306b\u6d88\u5931\u3057\u307e\u3059\u3002<\/p>\n<p>\u3057\u304b\u3057\u3001\u4ee3\u8b1d\u304c\u4e0a\u624b\u304f\u884c\u3063\u3066\u3044\u306a\u3044\u3068\u3001\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u3084VLDL\u306f\u306a\u304b\u306a\u304b\u6d88\u3048\u3066\u304f\u308c\u307e\u305b\u3093\u3002\u3044\u308f\u3086\u308b\u30ec\u30e0\u30ca\u30f3\u30c8\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/p>\n<p>\u4ee5\u524d\u306e\u8a18\u4e8b\u300c<a href=\"http:\/\/promea2014.com\/blog\/?p=3584\" target=\"_blank\" rel=\"noopener noreferrer\">\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5fc3\u81d3\u306b\u60aa\u3044\uff01\u3000\u3060\u3063\u305f\u3089\u3001\u7cd6\u8cea\u5236\u9650\u3067\u3057\u3087\uff01<\/a>\u300d\u3067\u3082\u66f8\u3044\u305f\u3088\u3046\u306b\u30ec\u30e0\u30ca\u30f3\u30c8\u306f\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306a\u3069\u306e\u30ea\u30b9\u30af\u3092\u975e\u5e38\u306b\u9ad8\u3081\u307e\u3059\u3002<\/p>\n<p>\u3067\u306f\u3001\u5b9f\u969b\u306b\u306f\u3069\u308c\u307b\u3069\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u304c\u5b58\u5728\u3057\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p>12\u6642\u9593\u306e\u7d76\u98df\u3068\u300136\u6642\u9593\u306e\u7981\u9152\u306e\u5f8c\u306e\u8840\u6db2\u306e\u30c7\u30fc\u30bf\u3067\u3059\u3002\uff08\u8868\u306e\u7565\u8a9e\u306f\u3001RLP\uff0dC\uff1a\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001CM\uff1a\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u3001RLP\uff0dTG\uff1a\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u4e2d\u6027\u8102\u80aa\u3067\u3059\u3002\u8868\u306f\u539f\u6587\u3088\u308a\u6539\u5909\uff09<\/p>\n<p>\u9ad8\u4e2d\u6027\u8102\u80aa\u306f\u7d04177mg\/dL\u4ee5\u4e0a\u3001\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u7d04131mg\/dL\u4ee5\u4e0a\u3001\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u7d0435mg\/dL\u4ee5\u4e0b\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305d\u306e\u5024\u306b\u5fdc\u3058\u3066\u3001\u6b63\u5e38\u306a\u8102\u8cea\u306e\u7fa4\u3068\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u9ad8\u4e2d\u6027\u8102\u80aa\u306e\u5408\u4f75\u306e\u7fa4\u3001\u9ad8\u4e2d\u6027\u8102\u80aa\u3068\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u7fa4\u306b\u5206\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n<div class=\"table-overflow\">\n<table style=\"height: 990px; width: 638px;\" width=\"649\">\n<thead align=\"\">\n<tr style=\"height: 53px;\">\n<th style=\"width: 116px; height: 53px;\"><\/th>\n<th style=\"width: 145px; height: 53px;\">\u6b63\u5e38\u306a\u8102\u8cea\u306e\u7fa4(n = 10)<\/th>\n<th style=\"width: 174px; height: 53px;\">\u9ad8LDL-C\u3068\u9ad8\u4e2d\u6027\u8102\u80aa\u306e\u5408\u4f75\u306e\u7fa4(n = 14)<\/th>\n<th style=\"width: 157px; height: 53px;\">\u9ad8\u4e2d\u6027\u8102\u80aa\u3068\u4f4eHDL-C\u306e\u7fa4(n = 8)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"height: 72px;\">\n<td style=\"width: 116px; height: 72px;\">\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb(mg\/dL)<\/td>\n<td style=\"width: 145px; height: 72px;\">175.68<\/td>\n<td style=\"width: 174px; height: 72px;\">232.05<\/td>\n<td style=\"width: 157px; height: 72px;\">202.70<\/td>\n<\/tr>\n<tr style=\"height: 72px;\">\n<td style=\"width: 116px; height: 72px;\">\u8840\u6f3f RLP-C (mg\/dL)<\/td>\n<td style=\"width: 145px; height: 72px;\">6.56<\/td>\n<td style=\"width: 174px; height: 72px;\">11.20<\/td>\n<td style=\"width: 157px; height: 72px;\">25.87<\/td>\n<\/tr>\n<tr style=\"height: 72px;\">\n<td style=\"width: 116px; height: 72px;\">CM RLP-C (mg\/dL)<\/td>\n<td style=\"width: 145px; height: 72px;\">0.77<\/td>\n<td style=\"width: 174px; height: 72px;\">1.16<\/td>\n<td style=\"width: 157px; height: 72px;\">8.49<\/td>\n<\/tr>\n<tr style=\"height: 72px;\">\n<td style=\"width: 116px; height: 72px;\">VLDL RLP-C (mg\/dL)<\/td>\n<td style=\"width: 145px; height: 72px;\">1.93<\/td>\n<td style=\"width: 174px; height: 72px;\">5.79<\/td>\n<td style=\"width: 157px; height: 72px;\">16.99<\/td>\n<\/tr>\n<tr style=\"height: 99px;\">\n<td style=\"width: 116px; height: 99px;\">IDL+ LDL+ HDL RLP-C (mg\/dL)<\/td>\n<td style=\"width: 145px; height: 99px;\">4.63<\/td>\n<td style=\"width: 174px; height: 99px;\">4.63<\/td>\n<td style=\"width: 157px; height: 99px;\">3.47<\/td>\n<\/tr>\n<tr style=\"height: 72px;\">\n<td style=\"width: 116px; height: 72px;\">\u4e2d\u6027\u8102\u80aa(mg\/dL)<\/td>\n<td style=\"width: 145px; height: 72px;\">118.58<\/td>\n<td style=\"width: 174px; height: 72px;\">265.49<\/td>\n<td style=\"width: 157px; height: 72px;\">456.64<\/td>\n<\/tr>\n<tr style=\"height: 72px;\">\n<td style=\"width: 116px; height: 72px;\">\u8840\u6f3fRLP-TG (mg\/dL)<\/td>\n<td style=\"width: 145px; height: 72px;\">19.47<\/td>\n<td style=\"width: 174px; height: 72px;\">61.06<\/td>\n<td style=\"width: 157px; height: 72px;\">138.05<\/td>\n<\/tr>\n<tr style=\"height: 73px;\">\n<td style=\"width: 116px; height: 73px;\">CM RLP-TG (mg\/dL)<\/td>\n<td style=\"width: 145px; height: 73px;\">9.73<\/td>\n<td style=\"width: 174px; height: 73px;\">29.20<\/td>\n<td style=\"width: 157px; height: 73px;\">61.95<\/td>\n<\/tr>\n<tr style=\"height: 73px;\">\n<td style=\"width: 116px; height: 73px;\">VLDL RLP-TG (mg\/dL)<\/td>\n<td style=\"width: 145px; height: 73px;\">6.19<\/td>\n<td style=\"width: 174px; height: 73px;\">29.20<\/td>\n<td style=\"width: 157px; height: 73px;\">80.53<\/td>\n<\/tr>\n<tr style=\"height: 100px;\">\n<td style=\"width: 116px; height: 100px;\">IDL+ LDL+ HDL RLP-TG (mg\/dL)<\/td>\n<td style=\"width: 145px; height: 100px;\">7.08<\/td>\n<td style=\"width: 174px; height: 100px;\">5.31<\/td>\n<td style=\"width: 157px; height: 100px;\">7.96<\/td>\n<\/tr>\n<tr style=\"height: 73px;\">\n<td style=\"width: 116px; height: 73px;\">\u8840\u6f3f RLP-C\/\u8840\u6f3f RLP-TG<\/td>\n<td style=\"width: 145px; height: 73px;\">1.07<\/td>\n<td style=\"width: 174px; height: 73px;\">0.50<\/td>\n<td style=\"width: 157px; height: 73px;\">0.44<\/td>\n<\/tr>\n<tr style=\"height: 10px;\">\n<td style=\"width: 116px; height: 10px;\"><\/td>\n<td style=\"width: 145px; height: 10px;\"><\/td>\n<td style=\"width: 174px; height: 10px;\"><\/td>\n<td style=\"width: 157px; height: 10px;\"><\/td>\n<\/tr>\n<tr style=\"height: 26px;\">\n<td style=\"width: 116px; height: 26px;\">Apo B100 (mg\/L)<\/td>\n<td style=\"width: 145px; height: 26px;\">35.8<\/td>\n<td style=\"width: 174px; height: 26px;\">83.8<\/td>\n<td style=\"width: 157px; height: 26px;\">141.4<\/td>\n<\/tr>\n<tr style=\"height: 26px;\">\n<td style=\"width: 116px; height: 26px;\">Apo B48 (mg\/L)<\/td>\n<td style=\"width: 145px; height: 26px;\">1.0<\/td>\n<td style=\"width: 174px; height: 26px;\">2.3<\/td>\n<td style=\"width: 157px; height: 26px;\">6.5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>\u8868\u3092\u898b\u3066\u307f\u308b\u3068\u3001\u6b63\u5e38\u306e\u4eba\u3068\u6bd4\u3079\u308b\u3068\u4ed6\u306e2\u7fa4\u306f\u7d76\u98df\u306b\u3082\u95a2\u308f\u3089\u305a\u30ec\u30e0\u30ca\u30f3\u30c8\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u4e2d\u6027\u8102\u80aa\u3068\u3082\u975e\u5e38\u306b\u9ad8\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u7279\u306b\u9ad8\u4e2d\u6027\u8102\u80aa\u3068\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u7fa4\u3067\u306f\u3001\u6b63\u5e38\u3068\u6bd4\u3079\u3066\u8840\u6f3f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u7d044\u500d\u3001\u8840\u6f3f\u30ec\u30e0\u30ca\u30f3\u30c8\u4e2d\u6027\u8102\u80aa\u306f\u5b9f\u306b7\u500d\u306b\u3082\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>\u9a5a\u304f\u3053\u3068\u306b\u3059\u3050\u306b\u6d88\u5931\u3059\u308b\u306f\u305a\u306e\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u3082VLDL\u3082\u5927\u91cf\u306b\u30ec\u30e0\u30ca\u30f3\u30c8\u3068\u3057\u3066\u6b8b\u5b58\u3057\u3066\u3044\u307e\u3059\u3002\u9ad8\u4e2d\u6027\u8102\u80aa\u3068\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u7fa4\u3067\u306f\u3001\u6b63\u5e38\u3068\u6bd4\u3079\u3066\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u7d0411\u500d\u3001VLDL\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u7d049\u500d\u3001\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u4e2d\u6027\u8102\u80aa\u306f\u7d046\u500d\u3001VLDL\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u4e2d\u6027\u8102\u80aa\u306f\u7d0413\u500d\u306b\u3082\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u4e2d\u6027\u8102\u80aa\u5024\u306b\u5bfe\u3059\u308b\u30ec\u30e0\u30ca\u30f3\u30c8\u306e\u4e2d\u6027\u8102\u80aa\u304c\u5360\u3081\u308b\u5272\u5408\u306f\u6b63\u5e38\u3067\u7d0416\uff05\u3001\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u9ad8\u4e2d\u6027\u8102\u80aa\u306e\u5408\u4f75\u306e\u7fa4\u3067\u7d0423\uff05\u3001\u9ad8\u4e2d\u6027\u8102\u80aa\u3068\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u7fa4\u3067\u306f\u7d0430\uff05\u306b\u3082\u306a\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/p>\n<p>ApoB100\u306fVLDL\u3001IDL\u3001LDL\u306e\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u3067\u3059\u3002ApoB48\u306f\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u306e\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u3067\u3059\u3002\u305d\u306eApoB48\u306f\u9ad8\u4e2d\u6027\u8102\u80aa\u3068\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u7fa4\u3067\u306f\u3001\u6b63\u5e38\u3068\u6bd4\u3079\u30666.5\u500d\u3082\u5897\u52a0\u3057\u3066\u3057\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u3060\u3051\u30ec\u30e0\u30ca\u30f3\u30c8\u304c\u6b8b\u5b58\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u3053\u3068\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u4f4e\u3044\u3053\u3068\u306f\u3053\u308c\u307b\u3069\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5897\u3084\u3057\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/p>\n<p>\u4e2d\u6027\u8102\u80aa\u3092\u4f4e\u4e0b\u3055\u305b\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5897\u52a0\u3055\u305b\u3066\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u3092\u5c11\u306a\u304f\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #0000ff;\">\u300cPostprandial remnant-like lipoproteins in hypertriglyceridemia\u300d<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u300c\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u306b\u304a\u3051\u308b\u98df\u5f8c\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u69d8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u300d\uff08\u539f\u6587\u306f<a style=\"color: #0000ff;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11443178\" target=\"_blank\" rel=\"noopener 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