{"id":4851,"date":"2018-07-12T08:58:43","date_gmt":"2018-07-11T23:58:43","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=4851"},"modified":"2020-01-10T08:40:23","modified_gmt":"2020-01-09T23:40:23","slug":"post-4851","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=4851","title":{"rendered":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u672c\u5f53\u306b\u52d5\u8108\u306e\u8840\u7ba1\u5185\u8154\u304b\u3089\u8840\u7ba1\u5185\u76ae\u3092\u901a\u3063\u3066\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u8d77\u3053\u3059\u306e\u304b\uff1f\u3000\u305d\u306e9\u3000\u5225\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u904b\u3073\u5c4b"},"content":{"rendered":"<p>\u52d5\u8108\u786c\u5316\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u672c\u5f53\u306bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3088\u3063\u3066\u3082\u305f\u3089\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p>\u3053\u308c\u307e\u3067\u306e\u4eee\u8aac\u3067\u306f\u3001\u8840\u7ba1\u306e\u5185\u8154\u3088\u308aLDL\u304c\u8840\u7ba1\u58c1\u3092\u901a\u308a\u3001\u8840\u7ba1\u58c1\u306e\u4e2d\u3067\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3001\u305d\u306e\u5f8c\u6ce1\u6cab\u7d30\u80de\u3068\u306a\u308a\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u3092\u5f62\u6210\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u3057\u304b\u3057\u3001\u5b9f\u969b\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u306e\u4e2d\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5206\u6790\u3059\u308b\u3068\u3001\u610f\u5916\u306a\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u6ce1\u6cab\u7d30\u80de\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u3044\u3046\u306e\u306f\u4e3b\u306b\u30a8\u30b9\u30c6\u30eb\u5316\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u65e9\u671f\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u3092\u5206\u6790\u3059\u308b\u3068\u3001\u904a\u96e2\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u3044\u3046\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u542b\u91cf\u304c\u8457\u3057\u304f\u9ad8\u304f\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5168\u4f53\u306e\u5e73\u5747\u306763\uff05\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u306e\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u306b\u542b\u307e\u308c\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3059\u3079\u3066\u6ce1\u6cab\u7d30\u80de\u306e\u307f\u306b\u7531\u6765\u3059\u308b\u3068\u306f\u8003\u3048\u306b\u304f\u304f\u300140\uff05\u5f31\u306f\u78ba\u304b\u306b\u6ce1\u6cab\u7d30\u80de\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u300160\uff05\u4ee5\u4e0a\u306f\u4ed6\u306b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u904b\u3076\u904b\u3073\u5c4b\u304c\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u306e\u3067\u3059\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n<p><a 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data-image-title=\"\u30a2\u30c6\u30ed\u30fc\u30e0\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/07\/f492364104820b4678b85e651382028a.jpg?fit=300%2C270&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/07\/f492364104820b4678b85e651382028a.jpg?fit=640%2C575&amp;ssl=1\" class=\"alignnone size-medium wp-image-4958\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/07\/f492364104820b4678b85e651382028a.jpg?resize=300%2C270\" alt=\"\" width=\"300\" height=\"270\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/07\/f492364104820b4678b85e651382028a.jpg?resize=300%2C270&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/07\/f492364104820b4678b85e651382028a.jpg?resize=768%2C690&amp;ssl=1 768w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/07\/f492364104820b4678b85e651382028a.jpg?resize=320%2C288&amp;ssl=1 320w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/07\/f492364104820b4678b85e651382028a.jpg?w=985&amp;ssl=1 985w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u56f3\u306f\u75c5\u5909\u90e8\u4f4d\u306e\u5168\u3066\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u5bfe\u3059\u308b\u904a\u96e2\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5272\u5408\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u8102\u80aa\u7dda\u6761\u306e\u6bb5\u968e\u3067\u308240\uff05\u7a0b\u5ea6\u304c\u904a\u96e2\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3067\u3059\u3002\u305d\u3057\u3066\u65e9\u671f\u306e\u3061\u3087\u3063\u3068\u3057\u305f\u9686\u8d77\u75c5\u5909\uff08\u56f3\u306e\u771f\u3093\u4e2d\uff09\u3067\u306f60\uff05\u7a0b\u5ea6\u304c\u904a\u96e2\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u5360\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3067\u306f\u3001\u8ab0\u304c\u904a\u96e2\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u904b\u3093\u3067\u304d\u305f\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p>\u51a0\u72b6\u52d5\u8108\u306e\u539f\u56e0\u3067\u7a81\u7136\u6b7b\u4ea1\u3057\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u9032\u884c\u3057\u305f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u306e\u30d7\u30e9\u30fc\u30af\u3092\u8abf\u3079\u3066\u307f\u308b\u3068\u305d\u3053\u306b\u306f\u8d64\u8840\u7403\u819c\u3092\u542b\u307f\u3001\u8d64\u8840\u7403\u304c\u30d7\u30e9\u30fc\u30af\u306e\u5897\u6b96\u306b\u7a4d\u6975\u7684\u306b\u5bc4\u4e0e\u3057\u5f97\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u8d64\u8840\u7403\u819c\u4e2d\u306e\u904a\u96e2\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u542b\u6709\u91cf\u306f\u8d64\u8840\u7403\u306e\u7dcf\u91cd\u91cf\u306e\u7d0440\uff05\u306b\u3082\u306a\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u8d64\u8840\u7403\u306f\u3001LDL\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u7372\u5f97\u3057\u3001HDL\u3068\u4f5c\u7528\u3057\u3066\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5931\u3046\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8d64\u8840\u7403\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u8d64\u8840\u7403\u306e\u5b89\u5b9a\u6027\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u306a\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 33.3333%;\" colspan=\"3\">\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u30d7\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u91cf<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\"><\/td>\n<td style=\"width: 33.3333%;\">mg\/\u4f53\u91cdkg<\/td>\n<td style=\"width: 33.3333%;\">g\uff08\u4f53\u91cd\u304c50kg\u306e\u4eba\u306e\u5834\u5408\uff09<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">\u809d\u81d3<\/td>\n<td style=\"width: 33.3333%;\">27.0<\/td>\n<td style=\"width: 33.3333%;\">1.35<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">\u8d64\u8840\u7403<\/td>\n<td style=\"width: 33.3333%;\">37.0<\/td>\n<td style=\"width: 33.3333%;\">1.85<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea<\/td>\n<td style=\"width: 33.3333%;\">20.3<\/td>\n<td style=\"width: 33.3333%;\">1.02<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">\u672b\u68a2\u306e\u7d44\u7e54<\/td>\n<td style=\"width: 33.3333%;\">133.7<\/td>\n<td style=\"width: 33.3333%;\">6.69<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>(\u4e0a\u306e\u8868\u306f<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24362356\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u306e\u6587\u732e<\/a>\u3088\u308a\u6539\u5909\uff09<\/p>\n<p>\u4e0a\u306e\u8868\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u3069\u3053\u306b\u30d7\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u304b\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u8d64\u8840\u7403\u306b\u3042\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306fLDL\u306a\u3069\u306e\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3088\u308a\u3082\u304b\u306a\u308a\u591a\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n<p>\u30a2\u30c6\u30ed\u30fc\u30e0\u306b\u306f\u8d64\u8840\u7403\u304c\u5b58\u5728\u3057\u3001\u305d\u306e\u8d64\u8840\u7403\u304c\u904b\u3093\u3067\u3044\u308b\u904a\u96e2\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u5927\u91cf\u306b\u3042\u308a\u307e\u3059\u3002\u81ea\u7136\u306b\u8003\u3048\u308c\u3070\u30a2\u30c6\u30ed\u30fc\u30e0\u306b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u904b\u3093\u3067\u3044\u308b\u904b\u3073\u5c4b\u306fLDL\u306a\u3069\u306e\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u8d64\u8840\u7403\u304c\u5927\u304d\u304f\u304b\u304b\u308f\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>\u305d\u3046\u3067\u3042\u308b\u3068\u3059\u308b\u3068\u3001\u307e\u3059\u307e\u3059\u8840\u7ba1\u306e\u5185\u8154\u304b\u3089\u8840\u7ba1\u58c1\u3092\u901a\u3063\u3066\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u904b\u3070\u308c\u3066\u30a2\u30c6\u30ed\u30fc\u30e0\u3092\u5f62\u6210\u3059\u308b\u3068\u3044\u3046\u4eee\u8aac\u306f\u4fe1\u3058\u3089\u308c\u306a\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u5c0f\u3055\u306aLDL\u306e\u5927\u304d\u3055\u306f25nm\u7a0b\u5ea6\u3067\u3059\u3002VLDL\u3068\u306a\u308c\u3070\u305d\u306e\u500d\u306e50nm\u3088\u308a\u5927\u304d\u3044\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002\u4e00\u65b9\u3067\u8d64\u8840\u7403\u306e\u5927\u304d\u3055\u306f7\uff5e8\u03bcm\u3067\u3059\u30027\u03bcm\u306f7000nm\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u8d64\u8840\u7403\u3068\u3044\u3046\u306e\u306f\u5c0f\u3055\u306aLDL\u306e300\u500d\u524d\u5f8c\u306e\u5927\u304d\u3055\u306a\u306e\u3067\u3059\u3002\u305d\u3093\u306a\u5927\u304d\u306a\u3082\u306e\u304c\u901a\u308b\u3088\u3046\u306a\u7a74\u304c\u8840\u7ba1\u306e\u58c1\u306b\u958b\u3044\u3066\u3044\u305f\u3089\u5927\u5909\u306a\u3053\u3068\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u3067\u3057\u3087\u3046\u3002\u8840\u7ba1\u58c1\u3068\u3057\u3066\u306e\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p>\u30a2\u30c6\u30ed\u30fc\u30e0\u3092\u5f62\u6210\u3059\u308b\u3068\u304d\u306bLDL\u306a\u3069\u306e\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u8840\u7ba1\u306e\u5185\u8154\u304b\u3089\u3001\u8d64\u8840\u7403\u306f\u5225\u306e\u5834\u6240\u304b\u3089\u3068\u3044\u3046\u5225\u3005\u306e\u7d4c\u8def\u304c\u3042\u308b\u53ef\u80fd\u6027\u306f\u5426\u5b9a\u306f\u3067\u304d\u307e\u305b\u3093\u304c\u3001\u540c\u3058\u7d4c\u8def\u3092\u305f\u3069\u3063\u3066\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u904b\u3070\u308c\u308b\u3068\u8003\u3048\u305f\u65b9\u304c\u81ea\u7136\u306a\u6c17\u304c\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #0000ff;\">\u300cDevelopment of the lipid-rich core in human atherosclerosis\u300d<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u300c\u30d2\u30c8\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306b\u304a\u3051\u308b\u8102\u8cea\u8c4a\u5bcc\u306a\u30b3\u30a2\u306e\u958b\u767a\u300d\uff08\u539f\u6587\u306f<a style=\"color: #0000ff;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8548424\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u3053<\/a>\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u52d5\u8108\u786c\u5316\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u672c\u5f53\u306bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3088\u3063\u3066\u3082\u305f\u3089\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f 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