{"id":4977,"date":"2018-07-25T12:00:29","date_gmt":"2018-07-25T03:00:29","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=4977"},"modified":"2018-07-25T12:00:29","modified_gmt":"2018-07-25T03:00:29","slug":"post-4977","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=4977","title":{"rendered":"HDL\u306e\u7cd6\u5316\u306f\u6a5f\u80fd\u969c\u5bb3\u3092\u8d77\u3053\u3059"},"content":{"rendered":"

HDL \u306f\u306e\u52d5\u8108\u786c\u5316\u3092\u6291\u5236\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u3066\u3001\u305d\u306e\u4f5c\u7528\u306e\u3072\u3068\u3064\u306b\u6297\u9178\u5316\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002HDL \u306b\u5b58\u5728\u3059\u308b\u30d1\u30e9\u30aa\u30ad\u30bd\u30ca\u30fc\u30bc1\uff08PON1\uff09\u3068\u3044\u3046\u3082\u306e\u304c\u3053\u306e\u6297\u9178\u5316\u4f5c\u7528\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001PON\uff11\u306e\u6d3b\u6027\u304c\u4f4e\u4e0b\u3057\u3066\u3057\u307e\u3046\u3068HDL\u306f\u6297\u9178\u5316\u4f5c\u7528\u3092\u767a\u63ee\u3067\u304d\u306a\u304f\u306a\u308a\u3001\u6a5f\u80fd\u969c\u5bb3\u3092\u8d77\u3053\u3059\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u3067\u306f\u3001\u3069\u306e\u3088\u3046\u306a\u5834\u5408\u306bPON1\u306e\u6d3b\u6027\u306f\u4f4e\u4e0b\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u305d\u306e\u5927\u304d\u306a\u539f\u56e0\u306e\u4e00\u3064\u304c\u7cd6\u5316\u3067\u3059\u3002\u3053\u306e\u7814\u7a76\u3067\u306f2\u578b\u7cd6\u5c3f\u75c5\u3068\u51a0\u52d5\u8108\u75be\u60a3\u306e\u4eba\u3068\u5bfe\u8c61\u7fa4\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\uff08\u8868\u3001\u56f3\u306f\u539f\u6587\u3088\u308a\u3001\u4e00\u90e8\u6539\u5909\uff09<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc<\/th>\n\u5bfe\u7167<\/th>\n2\u578b\u7cd6\u5c3f\u75c5<\/th>\n\u51a0\u52d5\u8108\u75be\u60a3<\/th>\n<\/tr>\n<\/thead>\n
\u4eba\u6570<\/i>\uff08\u7537\u6027\uff09<\/td>\n19\uff0810\uff09<\/td>\n36\uff0821\uff09<\/td>\n37\uff0822\uff09<\/td>\n<\/tr>\n
\u5e74\u9f62\uff08\u5e74\uff09<\/td>\n57.7<\/td>\n57.7<\/td>\n57.7<\/td>\n<\/tr>\n
BMI\uff08kg\/m\u00a02<\/sup>\uff09<\/td>\n21.2<\/td>\n28.8\u00a0<\/span><\/td>\n25.3<\/td>\n<\/tr>\n
HbA\u00a01c<\/sub>\uff08\uff05\uff09<\/td>\n–<\/td>\n7.6<\/td>\n–<\/td>\n<\/tr>\n
\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08mg\/dL\uff09<\/td>\n185<\/td>\n197<\/td>\n170<\/td>\n<\/tr>\n
\u4e2d\u6027\u8102\u80aa\uff08mg\/dL\uff09<\/td>\n93<\/td>\n198\u00a0<\/span><\/td>\n153\u00a0<\/span><\/td>\n<\/tr>\n
HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08mg\/dL\uff09<\/td>\n60<\/td>\n50<\/td>\n41<\/span><\/td>\n<\/tr>\n
ApoB\uff08mg \/ dl\uff09<\/td>\n78.0<\/td>\n88.0<\/td>\n82.3<\/td>\n<\/tr>\n
ApoA1\uff08mg \/ dl\uff09<\/td>\n110.5<\/td>\n128.7<\/td>\n85.1<\/span><\/td>\n<\/tr>\n
PON1\u6d3b\u6027\uff08nmol \/\u5206\/ ml\uff09<\/td>\n269.4<\/td>\n113.6<\/span><\/td>\n150.9<\/span><\/td>\n<\/tr>\n
PON1\u91cf\uff08\u03bcg\/ ml\uff09<\/td>\n113.1<\/td>\n90.1<\/span><\/td>\n83.5<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e0a\u306e\u8868\u3067\u308f\u304b\u308b\u3088\u3046\u306b\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u3069\u306e\u7fa4\u3067\u3082\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u51a0\u52d5\u8108\u75be\u60a3\u306e\u307f\u4f4e\u5024\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u5927\u304d\u306a\u9055\u3044\u306f\u4e2d\u6027\u8102\u80aa\u3067\u3059\u3002\u5bfe\u7167\u3068\u6bd4\u8f03\u3059\u308b\u3068\u7cd6\u5c3f\u75c5\u7fa4\u3067\u3082\u51a0\u52d5\u8108\u75be\u60a3\u7fa4\u3067\u3082\u304b\u306a\u308a\u9ad8\u3044\u5024\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u30b0\u30e9\u30d5\u306f\u7e26\u8ef8\u304c\u7cd6\u5316\u3057\u305fPON1\u306e\u5272\u5408\u3067\u3059\u3002\u6a2a\u8ef8\u306f\u5de6\u304b\u3089\u5bfe\u7167\u7fa4\u3001\u51a0\u52d5\u8108\u75be\u60a3\u7fa4\u30012\u578b\u7cd6\u5c3f\u75c5\u7fa4\u3067\u3059\u3002\u51a0\u52d5\u8108\u75be\u60a3\u3067\u306f\u5bfe\u7167\u7fa4\u306e\u7d041.5\u500d\u3001\u7cd6\u5c3f\u75c5\u7fa4\u3067\u306f\u7d042\u500d\u7cd6\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

\u4e0a\u306e\u30b0\u30e9\u30d5\u306e\u7e26\u8ef8\u306fPON1\u306e\u6d3b\u6027\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002\u6a2a\u8ef8\u306f\u5de6\u304b\u3089\u901a\u5e38\u306eHDL\u3001\u7cd6\u5316\u3057\u305fHDL\u3001\u7cd6\u9178\u5316\u3057\u305fHDL\u3067\u3059\u3002\u7cd6\u5316\u3059\u308b\u3068PON1\u306e\u6d3b\u6027\u306f\u7d0460\uff05\u6e1b\u3001\u7cd6\u9178\u5316\u3059\u308b\u3068\u6d3b\u6027\u306f80\uff05\u4ee5\u4e0a\u6e1b\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

HDL\u306f\u5bfe\u7167\u7fa4\u3068\u7cd6\u5c3f\u75c5\u7fa4\u3067\u306f\u82e5\u5e72\u7cd6\u5c3f\u75c5\u7fa4\u3067\u5c11\u306a\u3044\u3067\u3059\u304c\u3001\u5dee\u306f\u306a\u3044\u306b\u3082\u95a2\u308f\u3089\u305a\u3001PON1\u306e\u6d3b\u6027\u306b\u95a2\u3057\u3066\u306f\u534a\u5206\u4ee5\u4e0b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u7cd6\u5316\u3092\u53d7\u3051\u305fHDL\u306f\u6a5f\u80fd\u7684\u306b\u306f\u975e\u5e38\u306b\u4f4e\u4e0b\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3044\u304f\u3089HDL\u306e\u6570\u304c\u591a\u304f\u3066\u3082\u3001\u98df\u5f8c\u9ad8\u8840\u7cd6\u306a\u3069\u3067\u7cd6\u5316\u3001\u9178\u5316\u3092\u4fc3\u9032\u3057\u3066\u3057\u307e\u3048\u3070\u3001HDL\u304c\u3046\u307e\u304f\u50cd\u304b\u306a\u3044\u306e\u3067\u3059\u3002\u7cd6\u8cea\u5236\u9650\u3092\u3057\u3066\u8840\u7cd6\u5024\u304c\u843d\u3061\u7740\u3044\u3066\u3044\u308c\u3070\u3001\u305d\u308c\u307b\u3069\u7cd6\u5316\u3001\u9178\u5316\u306f\u8d77\u3053\u3089\u306a\u3044\u306e\u3067\u306f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3060\u3051\u3092\u898b\u3066\u3082\u3001\u305d\u306e\u6a5f\u80fd\u306e\u826f\u3057\u60aa\u3057\u307e\u3067\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u3002\u666e\u6bb5\u306e\u98df\u751f\u6d3b\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n

 <\/p>\n

\u300cGlycation of paraoxonase-1 inhibits its activity and impairs the ability of high-density lipoprotein to metabolize membrane lipid hydroperoxides\u300d<\/span><\/p>\n

\u300cPON-1\u306e\u7cd6\u5316\u306f\u3001\u305d\u306e\u6d3b\u6027\u3092\u963b\u5bb3\u3057\u3001\u819c\u8102\u8cea\u30d2\u30c9\u30ed\u30da\u30eb\u30aa\u30ad\u30b7\u30c9\u3092\u4ee3\u8b1d\u3059\u308bHDL\u306e\u80fd\u529b\u3092\u640d\u306a\u3046\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

HDL \u306f\u306e\u52d5\u8108\u786c\u5316\u3092\u6291\u5236\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u3066\u3001\u305d\u306e\u4f5c\u7528\u306e\u3072\u3068\u3064\u306b\u6297\u9178\u5316\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002HDL \u306b\u5b58\u5728\u3059\u308b\u30d1\u30e9\u30aa\u30ad\u30bd\u30ca\u30fc\u30bc1\uff08PON1\uff09\u3068\u3044\u3046\u3082\u306e\u304c\u3053\u306e\u6297\u9178\u5316\u4f5c\u7528\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001PON\uff11\u306e\u6d3b\u6027\u304c\u4f4e\u4e0b\u3057\u3066\u3057\u307e\u3046\u3068H<\/p>\n","protected":false},"author":1,"featured_media":4980,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[8,15],"tags":[],"class_list":["post-4977","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-8","category-15","two-columns"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/07\/7a937672cff0d34c7c982035fbece3e2_s.jpg?fit=640%2C427&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p9cBot-1ih","jetpack-related-posts":[{"id":11695,"url":"https:\/\/promea2014.com\/blog\/?p=11695","url_meta":{"origin":4977,"position":0},"title":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3044\u3060\u3051\u3067\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u306f\u8d77\u3053\u3089\u306a\u3044\u3000\u305d\u306e2","author":"Dr.Shimizu","date":"2020\u5e743\u670813\u65e5","format":false,"excerpt":"\u4ee5\u524d\u306e\u8a18\u4e8b\u300cLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3044\u3060\u3051\u3067\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u306f\u8d77\u3053\u3089\u306a\u3044\u3000\u305d\u306e1\u300d\u3067\u306f\u3001LO\u2026","rel":"","context":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb","block_context":{"text":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb","link":"https:\/\/promea2014.com\/blog\/?cat=145"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/03\/6b852813cb0a20e0ba775d25899c2020_s.jpg?fit=545%2C640&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2020\/03\/6b852813cb0a20e0ba775d25899c2020_s.jpg?fit=545%2C640&ssl=1&resize=350%2C200 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1.5x"},"classes":[]},{"id":20986,"url":"https:\/\/promea2014.com\/blog\/?p=20986","url_meta":{"origin":4977,"position":1},"title":"\u9ad8HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5065\u5eb7\u7684\u306a\u306e\u304b\uff1f\u3000\u305d\u306e1","author":"Dr.Shimizu","date":"2022\u5e7412\u670812\u65e5","format":false,"excerpt":"LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u300c\u60aa\u7389\u300d\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u300c\u5584\u7389\u300d\u3068\u3044\u3046\u6c7a\u3081\u3064\u3051\u304c\u4e00\u822c\u7684\u306b\u5e83\u304c\u3063\u3066\u3044\u308b\u3060\u2026","rel":"","context":"\u7cd6\u8cea\u5236\u9650","block_context":{"text":"\u7cd6\u8cea\u5236\u9650","link":"https:\/\/promea2014.com\/blog\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2022\/12\/24422220_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2022\/12\/24422220_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200 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1.5x"},"classes":[]},{"id":22970,"url":"https:\/\/promea2014.com\/blog\/?p=22970","url_meta":{"origin":4977,"position":2},"title":"\u6709\u9178\u7d20\u904b\u52d5\u306f\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u306eHDL\u306e\u6a5f\u80fd\u3092\u6539\u5584\u3059\u308b","author":"Dr.Shimizu","date":"2023\u5e746\u670822\u65e5","format":false,"excerpt":"HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3044\u308f\u3086\u308b\u300c\u5584\u7389\u300d\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3082\u3061\u308d\u3093\u305d\u306e\u4e00\u65b9\u3067\u300c\u60aa\u7389\u300d\u306fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u2026","rel":"","context":"\u7cd6\u8cea\u5236\u9650","block_context":{"text":"\u7cd6\u8cea\u5236\u9650","link":"https:\/\/promea2014.com\/blog\/?cat=8"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/06\/1692853_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2023\/06\/1692853_s.jpg?fit=640%2C427&ssl=1&resize=350%2C200 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