{"id":5643,"date":"2018-09-25T20:18:00","date_gmt":"2018-09-25T11:18:00","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=5643"},"modified":"2020-01-10T08:43:45","modified_gmt":"2020-01-09T23:43:45","slug":"post-5643","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=5643","title":{"rendered":"\u809d\u81d3\u3060\u3051\u3067\u306f\u306a\u3044\uff1f\u3000\u03b3-GT\uff08\u03b3-GTP)\uff08\u30ac\u30f3\u30de\u30b0\u30eb\u30bf\u30df\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7"},"content":{"rendered":"<p>\u03b3-GT\uff08\u03b3-GTP\u3084GGT\u3068\u3044\u3046\u3053\u3068\u3082\u3042\u308a\u307e\u3059\uff09\u306f\u3001\u809d\u81d3\u3084\u80c6\u7ba1\u306e\u7d30\u80de\u304c\u58ca\u308c\u308b\u3068\u8840\u6db2\u4e2d\u306b\u03b3-GT\u304c\u8840\u6db2\u306e\u4e2d\u306b\u6d41\u308c\u51fa\u3066\u304f\u308b\u3053\u3068\u304b\u3089\u3001\u300c\u9038\u8131\u9175\u7d20\u300d\u3068\u3044\u308f\u308c\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u91cf\u3084\u809d\u6a5f\u80fd\u969c\u5bb3\u306e\u6307\u6a19\u3068\u3057\u3066\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u03b3-GT\u306f\u6297\u9178\u5316\u7269\u8cea\u3067\u3042\u308b\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u306e\u4ee3\u8b1d\u306b\u6df1\u304f\u95a2\u4e0e\u3059\u308b\u305f\u3081\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u30de\u30fc\u30ab\u30fc\u3068\u3082\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u9ad8\u304f\u3001\u6d3b\u6027\u9178\u7d20\u304c\u5927\u91cf\u306b\u5b58\u5728\u3057\u3066\u3044\u308b\u72b6\u614b\u3067\u306f\u7d30\u80de\u5185\u306e\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u3082\u5927\u91cf\u306b\u5fc5\u8981\u3068\u306a\u308a\u3001\u03b3-GT\u3082\u305f\u304f\u3055\u3093\u751f\u6210\u3055\u308c\u3001\u8840\u6db2\u4e2d\u306b\u6f0f\u308c\u51fa\u3066\u304d\u3066\u3057\u307e\u3044\u3001\u8840\u6db2\u4e2d\u306e\u03b3-GT\u304c\u4e0a\u6607\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u3057\u304b\u3057\u3001\u5897\u52a0\u3057\u305f\u03b3-GT\u304c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u8d77\u3053\u3059\u3068\u3082\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u03b3-GT\u304c\u3042\u308b\u7bc4\u56f2\u3092\u8d85\u3048\u308b\u3068\u3001\u904e\u5270\u306a\u03b3-GT\u304c\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u3092\u5206\u89e3\u3057\u3066\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u3092\u67af\u6e07\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u304c\u6e1b\u5c11\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u81d3\u5668\u3084\u7d44\u7e54\u3092\u4fdd\u8b77\u3059\u308b\u305f\u3081\u306b\u6b8b\u3063\u3066\u3044\u308b\u91cf\u304c\u4e0d\u5341\u5206\u3067\u3042\u308b\u3068\u3001\u81d3\u5668\u3084\u7d44\u7e54\u306e\u969c\u5bb3\u304c\u8d77\u3053\u308a\u59cb\u3081\u307e\u3059\u3002<\/p>\n<p>\u6d3b\u6027\u5316\u3057\u305f\u03b3-GT\u306f\u52d5\u8108\u306e\u30d7\u30e9\u30fc\u30af\u5185\u3067\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u306a\u305c\u3001\u30d7\u30e9\u30fc\u30af\u5185\u306b\u03b3-GT\u304c\u84c4\u7a4d\u3057\u3066\u3044\u308b\u306e\u304b\u3068\u3044\u3046\u3053\u3068\u306f\u306f\u3063\u304d\u308a\u3068\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/e0b31e6dca91535c94ec8aae1c8a5452.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"5644\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=5644\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/e0b31e6dca91535c94ec8aae1c8a5452.jpg?fit=435%2C652&amp;ssl=1\" data-orig-size=\"435,652\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;Yasuyuki&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;1537392066&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"\u30d7\u30e9\u30fc\u30af\u5185\u306eGGT\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/e0b31e6dca91535c94ec8aae1c8a5452.jpg?fit=200%2C300&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/e0b31e6dca91535c94ec8aae1c8a5452.jpg?fit=435%2C652&amp;ssl=1\" class=\"alignnone size-medium wp-image-5644\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/e0b31e6dca91535c94ec8aae1c8a5452.jpg?resize=200%2C300\" alt=\"\" width=\"200\" height=\"300\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/e0b31e6dca91535c94ec8aae1c8a5452.jpg?resize=200%2C300&amp;ssl=1 200w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/e0b31e6dca91535c94ec8aae1c8a5452.jpg?resize=320%2C480&amp;ssl=1 320w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/e0b31e6dca91535c94ec8aae1c8a5452.jpg?w=435&amp;ssl=1 435w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u56f3\u306e\u4e0a\u306e\u5199\u771f\u306f\u51a0\u52d5\u8108\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u75c5\u5909\u3067\u3059\u3002\u8d64\u304f\u67d3\u307e\u3063\u305f\u3068\u3053\u308d\u304c\u03b3-GT\u306e\u9175\u7d20\u6d3b\u6027\u304c\u8a8d\u3081\u3089\u308c\u308b\u3068\u3053\u308d\u3067\u3042\u308a\u3001\u540c\u6642\u306b\u30a2\u30c6\u30ed\u30fc\u30e0\u306e\u30b3\u30a2\u306e\u90e8\u5206\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u5185\u819c\u306e\u6df1\u3044\u3068\u3053\u308d\u306b\u3057\u304b\u8a8d\u3081\u307e\u305b\u3093\u3002<\/p>\n<p>\u4e0b\u306e\u56f3\u306f\u03b3-GT\u304c\u30d7\u30e9\u30fc\u30af\u5185\u3067\u3069\u306e\u3088\u3046\u306b\u95a2\u4e0e\u3059\u308b\u304b\u3092\u56f3\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u7d30\u304b\u3044\u3053\u3068\u306f\u66f8\u304d\u307e\u305b\u3093\u304c\u3001\u03b3-GT\u306f\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u307e\u3059\u304c\u3001\u305d\u306e\u53cd\u5fdc\u306f\u9244\u3092\u5fc5\u8981\u3068\u3057\u3001\u305d\u306e\u53cd\u5fdc\u306e\u4e2d\u3067\u3001LDL\u306e\u9178\u5316\u304c\u8d77\u3053\u308a\u3001\u30d7\u30e9\u30fc\u30af\u306e\u767a\u9054\u3068\u7834\u88c2\u306a\u3069\u306b\u95a2\u9023\u3057\u3046\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/cc07edd260041819abd99500565e50e2.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"5646\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=5646\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/cc07edd260041819abd99500565e50e2.jpg?fit=667%2C436&amp;ssl=1\" data-orig-size=\"667,436\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;Yasuyuki&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;1537394863&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"GGT\u3068\u9178\u5316LDL\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/cc07edd260041819abd99500565e50e2.jpg?fit=300%2C196&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/cc07edd260041819abd99500565e50e2.jpg?fit=640%2C418&amp;ssl=1\" class=\"alignnone size-medium wp-image-5646\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/cc07edd260041819abd99500565e50e2.jpg?resize=300%2C196\" alt=\"\" width=\"300\" height=\"196\" srcset=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/cc07edd260041819abd99500565e50e2.jpg?resize=300%2C196&amp;ssl=1 300w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/cc07edd260041819abd99500565e50e2.jpg?resize=320%2C209&amp;ssl=1 320w, https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/cc07edd260041819abd99500565e50e2.jpg?w=667&amp;ssl=1 667w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u4e0a\u306e\u5199\u771f\u306f\u9838\u52d5\u8108\u306e\u30d7\u30e9\u30fc\u30af\u3067\u3059\u304c\u3001A\u304c\u03b3-GT\u306e\u6d3b\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\uff08\u8336\u8272\u306b\u67d3\u307e\u3063\u305f\u90e8\u5206\uff09\u3002B\u306f\u9178\u5316LDL\u304c\u86cd\u5149\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u03b3-GT\u3068\u9178\u5316LDL\u306e\u5b58\u5728\u3059\u308b\u3068\u3053\u308d\u306f\u307b\u307c\u540c\u3058\u90e8\u5206\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\uff08\u5199\u771f\u306f<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11935077\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u306e\u8ad6\u6587<\/a>\u3088\u308a\uff09<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/GGT.jpg\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"5645\" data-permalink=\"https:\/\/promea2014.com\/blog\/?attachment_id=5645\" data-orig-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/GGT.jpg?fit=238%2C172&amp;ssl=1\" data-orig-size=\"238,172\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;Yasuyuki&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;1537394035&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"GGT\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/GGT.jpg?fit=238%2C172&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/GGT.jpg?fit=238%2C172&amp;ssl=1\" class=\"alignnone size-full wp-image-5645\" src=\"https:\/\/i0.wp.com\/promea2014.com\/blog\/wp-content\/uploads\/2018\/09\/GGT.jpg?resize=238%2C172\" alt=\"\" width=\"238\" height=\"172\" \/><\/a><\/p>\n<p>\u3055\u3089\u306b\u4e0a\u306e\u5199\u771f\u3082\u8336\u8272\u304f\u67d3\u307e\u3063\u305f\u3068\u3053\u308d\u304c\u03b3-GT\u3067\u3059\u304c\u3001\u3053\u306e\u90e8\u4f4d\u306b\u306f\u9178\u5316\u3055\u308c\u305f\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u542b\u3093\u3060\u6ce1\u6cab\u7d30\u80de\u3092\u8a8d\u3081\u307e\u3059\u3002\u3053\u308c\u3082\u307e\u305f\u30b3\u30a2\u306e\u90e8\u5206\u3067\u3059\u3002\uff08\u5199\u771f\u306f<a href=\"https:\/\/www.ahajournals.org\/doi\/abs\/10.1161\/01.CIR.0000120558.41356.E6\" target=\"_blank\" rel=\"noopener noreferrer\">\u3053\u306e\u8ad6\u6587<\/a>\u3088\u308a\uff09<\/p>\n<p>\u51a0\u52d5\u8108\u30d7\u30e9\u30fc\u30af\u5185\u306e\u03b3-GT\u304c\u3053\u306e\u3088\u3046\u306b\u30b3\u30a2\u306b\u306e\u307f\u5b58\u5728\u3059\u308b\u306e\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u767a\u751f\u304a\u3088\u3073\u51a0\u52d5\u8108\u75be\u60a3\u306e\u9032\u884c\u306b\u304a\u3044\u3066\u3001LDL\u306e\u9178\u5316\u306b\u304a\u3051\u308b\u03b3-GT\u306e\u76f4\u63a5\u7684\u306a\u95a2\u4e0e\u306e\u4eee\u8aac\u306b\u5bfe\u3059\u308b\u75c5\u7406\u5b66\u7684\u6839\u62e0\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u03b3-GT\u304c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u8d77\u3053\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>\u03b3-GT\u306e\u5024\u3068\u3044\u3046\u306e\u306f\u4e00\u822c\u7684\u306a\u6b63\u5e38\u7bc4\u56f2\u5185\u306e\u4e2d\u3067\u3042\u3063\u3066\u3082\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3060\u3051\u3067\u306a\u304f\u3001\u69d8\u3005\u306a\u75be\u60a3\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3092\u793a\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u03b3-GT\u306e\u5897\u52a0\u304c\u539f\u56e0\u306a\u306e\u304b\u7d50\u679c\u306a\u306e\u304b\u306f\u79c1\u306b\u306f\u307e\u3060\u3088\u304f\u308f\u304b\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u03b3-GT\u306f\u4f4e\u3044\u306b\u8d8a\u3057\u305f\u3053\u3068\u306f\u306a\u3044\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #0000ff;\">\u300cGamma-glutamyltransferase, atherosclerosis, and cardiovascular disease: triggering oxidative stress within the plaque\u300d<\/span><\/p>\n<p><span style=\"color: #0000ff;\">\u300c\u30ac\u30f3\u30de &#8211; \u30b0\u30eb\u30bf\u30df\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3001\u304a\u3088\u3073\u5fc3\u81d3\u8840\u7ba1\u75be\u60a3\uff1a\u30d7\u30e9\u30fc\u30af\u5185\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3059\u300d\uff08\u539f\u6587\u306f<a style=\"color: #0000ff;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16203922\" target=\"_blank\" rel=\"noopener 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