{"id":704,"date":"2016-07-13T08:07:56","date_gmt":"2016-07-12T23:07:56","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=704"},"modified":"2016-09-07T13:55:36","modified_gmt":"2016-09-07T04:55:36","slug":"post-704","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=704","title":{"rendered":"\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85acSGLT2\u963b\u5bb3\u85ac\u306f\u4e0b\u80a2\u5207\u65ad\u3092\u5897\u52a0\u3055\u305b\u308b\u304b\u3082\u3057\u308c\u306a\u3044\uff01"},"content":{"rendered":"

\u7cd6\u5c3f\u75c5\u306e\u91cd\u5927\u5408\u4f75\u75c7\u306e\u4e00\u3064\u3067\u3042\u308b\u4e0b\u80a2\u5207\u65ad\u304c\u3001\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85acSGLT2\u963b\u5bb3\u85ac\u306b\u3088\u3063\u3066\u5897\u52a0\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3044\u3046\u30cb\u30e5\u30fc\u30b9\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u307e\u3060\u95a2\u9023\u306f\u4e0d\u660e\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3082\u3057\u672c\u5f53\u3060\u3063\u305f\u3089\u4f55\u306e\u305f\u3081\u306e\u6cbb\u7642\u85ac\u306a\u306e\u304b\u308f\u304b\u3089\u306a\u304f\u306a\u308a\u307e\u3059\u306d\u3002\u5922\u306e\u3088\u3046\u306a\u6cbb\u7642\u85ac\u307f\u305f\u3044\u306a\u96f0\u56f2\u6c17\u3092\u6f02\u308f\u305b\u3066\u767a\u58f2\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u767a\u58f2\u76f4\u5f8c\u304b\u3089\u91cd\u5927\u5408\u4f75\u75c7\u306e\u5d50\u3002\u8133\u6897\u585e\u3092\u8d77\u3053\u3057\u305f\u308a\u6b7b\u8005\u3082\u591a\u6570\u3002\u6700\u8fd1\u306f\u76ae\u819a\u969c\u5bb3\u3082\u591a\u3044\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u6025\u6027\u814e\u4e0d\u5168\u3082\u8d77\u3053\u3057\u305f\u308a\u3068\u3001\u672c\u5f53\u306b\u826f\u3044\u85ac\u306a\u3093\u3067\u3057\u3087\u3046\u304b\uff1f\u4f59\u5206\u306a\u7cd6\u3092\u5c3f\u3068\u4e00\u7dd2\u306b\u6392\u51fa\u3059\u308b\u3088\u3046\u306a\u85ac\u306a\u3093\u3067\u3059\u304c\u3001\u98df\u3079\u3066\u51fa\u3059\u3050\u3089\u3044\u306a\u3089\u3001\u6700\u521d\u304b\u3089\u98df\u3079\u306a\u304d\u3083\u3044\u3044\u3093\u3067\u3059\u304c\u306d\uff1f<\/p>\n

\u305d\u3057\u3066\u3001\u4eca\u56de\u6cbb\u9a13\u4e2d\u306b\u51fa\u3066\u304d\u305f\u4e0b\u80a2\u5207\u65ad\u5897\u52a0\u3068\u3044\u3046\u5408\u4f75\u75c7\u3002\u30d7\u30e9\u30bb\u30dc\u306b\u6bd4\u3079\u3066\u7d042\u500d\u3068\u3044\u3046\u591a\u3055\u3002\u6c17\u306b\u306a\u308a\u307e\u3059\u306d\u3002<\/p>\n

\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3067\u4e0b\u80a2\u5207\u65ad\u5897\u304b<\/span><\/h1>\n

CANVAS\u8a66\u9a13\u4e2d\u9593\u89e3\u6790\u53d7\u3051FDA\u304c\u5b89\u5168\u6027\u60c5\u5831\u3001\u95a2\u9023\u4e0d\u660e<\/span><\/p>\n

2016\u5e74<\/span>5\u670823\u65e5 (\u6708)<\/span>\u914d\u4fe1<\/span> \u3000m3.com\u3088\u308a\u629c\u7c8b<\/span><\/span><\/div>\n
\n

\u3000\u7c73\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u306f5\u670818\u65e5\u3001SGLT2\u963b\u5bb3\u85ac\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\uff08\u7c73\u56fd\u3067\u306e\u8ca9\u58f2\u540dInvokana\u3001Invokamet\uff09\u306b\u3088\u308b\u4e0b\u80a2\u5207\u65ad\u30ea\u30b9\u30af\u4e0a\u6607\u306b\u95a2\u3059\u308b\u5b89\u5168\u6027\u60c5\u5831\u3092\u767a\u51fa\u3057\u305f\u3002\u73fe\u5728\u9032\u884c\u4e2d\u306e\u540c\u85ac\u3092\u7528\u3044\u305f\u81e8\u5e8a\u8a66\u9a13CANVAS\uff08Canagliflozin Cardiovascular Assessment Study\uff09\u306e\u72ec\u7acb\u30c7\u30fc\u30bf\u76e3\u8996\u59d4\u54e1\u4f1a\u304c\u3001\u8a66\u9a13\u958b\u59cb\u304b\u30891\u5e74\u6642\u70b9\u306e\u4e2d\u9593\u89e3\u6790\u306b\u304a\u3044\u3066\u3001\u540c\u85ac\u7fa4\u3067\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u6bd4\u3079\u4e0b\u80a2\u5207\u65ad\u306e\u5272\u5408\u304c\u7d042\u500d\u306b\u5897\u52a0\u3057\u3066\u3044\u305f\u3053\u3068\u3092\u5831\u544a\u3057\u305f\u3002FDA\u306f\u540c\u85ac\u304c\u4e0b\u80a2\u5207\u65ad\u30ea\u30b9\u30af\u3092\u4e0a\u6607\u3055\u305b\u308b\u3068\u306f\u7d50\u8ad6\u3057\u3066\u304a\u3089\u305a\u3001\u95a2\u9023\u3092\u5f15\u304d\u7d9a\u304d\u8abf\u67fb\u3059\u308b\u3068\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u3000\u4eca\u56de\u306e\u5b89\u5168\u6027\u60c5\u5831\u306b\u3088\u308b\u3068\u3001\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u7fa4\u306e\u4e0b\u80a2\u5207\u65ad\u4f8b\u306e\u307b\u3068\u3093\u3069\u306f\u8db3\u8dbe\u90e8\u306e\u5c0f\u5207\u65ad\u3060\u3063\u305f\u3002\u30c7\u30fc\u30bf\u76e3\u8996\u59d4\u54e1\u4f1a\u306f\u3001\u540c\u8a66\u9a13\u958b\u59cb\u304b\u30891\u5e74\u6642\u70b9\u306e\u4e2d\u9593\u89e3\u6790\u306b\u304a\u3051\u308b\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u4e0b\u80a2\u5207\u65ad\u30ea\u30b9\u30af\u306f1000\u60a3\u8005\u5f53\u305f\u308a3\u4f8b\u306b\u5bfe\u3057\u3001\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u7fa4\u3067\u306f100mg\/\u65e5\u3067\u540c7\u4f8b\u3001300mg\/\u65e5\u3067\u540c5\u4f8b\u3068\u63a8\u8a08\u3057\u3066\u3044\u308b\u3002\u306a\u304a\u3001\u5225\u306e\u540c\u85ac\u306b\u95a2\u9023\u3057\u305f\u81e8\u5e8a\u8a66\u9a13CANVAS-R\u3067\u306f\u5e73\u5747\u8ffd\u8de1\u671f\u95939\u30ab\u6708\u306e\u6642\u70b9\u3067\u4e0b\u80a2\u5207\u65ad\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306f\u898b\u3089\u308c\u3066\u3044\u306a\u3044\u3002\u540c\u59d4\u54e1\u4f1a\u306f\u7dcf\u5408\u7684\u306a\u5224\u65ad\u306b\u57fa\u3065\u304d\u3001\u81e8\u5e8a\u8a66\u9a13\u306e\u7d9a\u884c\u3092\u52e7\u544a\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u3000FDA\u306f\u540c\u85ac\u4f7f\u7528\u3068\u4e0b\u80a2\u5207\u65ad\u30ea\u30b9\u30af\u4e0a\u6607\u306e\u95a2\u9023\u306f\u5224\u65ad\u3067\u304d\u306a\u3044\u3068\u3057\u3066\u304a\u308a\u3001\u60a3\u8005\u306e\u81ea\u5df1\u5224\u65ad\u3067\u540c\u85ac\u4f7f\u7528\u3092\u4e2d\u6b62\u3057\u306a\u3044\u3053\u3068\u3001\u533b\u7642\u95a2\u4fc2\u8005\u306b\u306f\u6dfb\u4ed8\u6587\u66f8\u306b\u5f93\u3063\u305f\u51e6\u65b9\u3092\u884c\u3046\u3088\u3046\u6c42\u3081\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u540c\u85ac\u4f7f\u7528\u4e2d\u3001\u8db3\u306b\u75db\u307f\u3084\u5727\u75db\u3001\u816b\u308c\u3084\u6f70\u760d\u3001\u611f\u67d3\u306e\u75c7\u72b6\u304c\u751f\u3058\u305f\u5834\u5408\u306b\u306f\u533b\u7642\u6a5f\u95a2\u3092\u53d7\u8a3a\u3059\u308b\u3088\u3046\u6ce8\u610f\u559a\u8d77\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/span><\/p>\n

 <\/p>\n

\u3055\u3089\u306b\u3001\u305d\u306e\u5831\u544a\u3092\u53d7\u3051\u3066\u6b27\u5dde\u3067\u3082\u3001\u540c\u69d8\u306e\u4ed6\u306e\u85ac\u306b\u3082\u62e1\u5927\u3057\u3066\u5b89\u5168\u6027\u306e\u8a55\u4fa1\u3092\u3059\u308b\u3068\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002SGLT2\u963b\u5bb3\u85ac\u3067\u306f\u9ad8\u8840\u7cd6\u306e\u8840\u7ba1\u3078\u306e\u969c\u5bb3\u304c\u6e1b\u308b\u3069\u3053\u308d\u304b\u306a\u305c\u304b\u5897\u52a0\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u306d\uff1f<\/p>\n

 <\/p>\n

SGLT2i\u306e\u8db3\u8dbe\u5207\u65ad\u8a55\u4fa1\u30923\u6210\u5206\u306b\u62e1\u5927<\/span><\/h1>\n

EMA\u3001CANVAS\u8a66\u9a13\u3067\u306e\u5897\u52a0\u3092\u91cd\u8996<\/span><\/p>\n

2016\u5e74<\/span>7\u670812\u65e5 (\u706b)<\/span>\u914d\u4fe1<\/span> \u3000m3.com\u3088\u308a\u629c\u7c8b<\/span><\/span><\/div>\n
\n

\u3000\u6b27\u5dde\u533b\u85ac\u54c1\u5e81\uff08EMA\uff09\u306f7\u67088\u65e5\u3001\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85acSGLT2\u963b\u5bb3\u85ac\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u304a\u3088\u3073\u540c\u6210\u5206\u306e\u914d\u5408\u85ac\u3067\u884c\u308f\u308c\u3066\u3044\u308b\u8db3\u8dbe\u5207\u65ad\u306b\u95a2\u3059\u308b\u5b89\u5168\u6027\u8a55\u4fa1\u306b\u3064\u3044\u3066\u3001\u4ed6\u306e\u540c\u30af\u30e9\u30b9\u85ac2\u6210\u5206\uff08\u30c0\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\uff09\u306b\u3064\u3044\u3066\u3082\u540c\u69d8\u306e\u8a55\u4fa1\u3092\u958b\u59cb\u3059\u308b\u3068\u767a\u8868\u3057\u305f\u3002<\/span><\/p>\n

\u3000\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u4f7f\u7528\u3068\u8db3\u8dbe\u5207\u65ad\u306b\u95a2\u3059\u308b\u5b89\u5168\u6027\u8a55\u4fa1\u306f\u3001\u6b27\u5dde\u5404\u56fd\u3067\u9032\u884c\u4e2d\u306e\u81e8\u5e8a\u8a66\u9a13CANVAS\u3067\u78ba\u8a8d\u3055\u308c\u305f\u5b9f\u85ac\u7fa4\u306b\u304a\u3051\u308b\u8db3\u8dbe\u5207\u65ad\u4f8b\u306e\u5897\u52a0\u3092\u53d7\u3051\u3066\u958b\u59cb\u3055\u308c\u305f\u3002\u4e00\u65b9\u3001EMA\u306b\u3088\u308b\u3068\u540c\u85ac\u306b\u95a2\u9023\u3057\u3066\u7d42\u4e86\u3057\u305f12\u4ef6\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u5b9f\u85ac\u7fa4\u306b\u304a\u3051\u308b\u540c\u5207\u65ad\u4f8b\u306e\u5897\u52a0\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u306a\u3044\u3002<\/span><\/p>\n

\u3000CANVAS\u8a66\u9a13\u3068\u540c\u69d8\u306b\u5fc3\u8840\u7ba1\u9ad8\u30ea\u30b9\u30af\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u305fCANVAS-R\u8a66\u9a13\u3067\u3082\u3001\u5bfe\u7167\u7fa4\u306b\u6bd4\u3079\u6709\u610f\u3067\u306f\u306a\u3044\u3082\u306e\u306e\u3001\u8db3\u8dbe\u5207\u65ad\u4f8b\u306e\u5897\u52a0\u304c\u898b\u3089\u308c\u3066\u3044\u308b\u304c\u3001\u72ec\u7acb\u30c7\u30fc\u30bf\u76e3\u8996\u59d4\u54e1\u4f1a\u306f\u3053\u308c\u3089\u306e\u8a66\u9a13\u306e\u4e2d\u6b62\u306f\u5fc5\u8981\u306a\u3044\u3068\u306e\u5224\u65ad\u3092\u793a\u3057\u3066\u3044\u308b\u3002EMA\u306f\u7cd6\u5c3f\u75c5\u60a3\u8005\u3001\u7279\u306b\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u4e0d\u826f\u3067\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u3092\u5408\u4f75\u3059\u308b\u5834\u5408\u306b\u306f\u611f\u67d3\u3084\u4e0b\u80a2\u5207\u65ad\u306b\u81f3\u308b\u8db3\u90e8\u6f70\u760d\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3068\u8aac\u660e\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u3000\u3053\u3046\u3057\u305f\u80cc\u666f\u304b\u3089\u3001EMA\u306e\u5c02\u9580\u59d4\u54e1\u4f1a\u306f\u540c\u5730\u57df\u5185\u3067\u627f\u8a8d\u3092\u53d6\u5f97\u3057\u3066\u3044\u308b\u30c0\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306b\u3064\u3044\u3066\u3082\u540c\u69d8\u306e\u5b89\u5168\u6027\u8a55\u4fa1\u3092\u958b\u59cb\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3068\u5224\u65ad\u3057\u305f\u3002<\/span><\/p>\n

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