{"id":7382,"date":"2025-03-11T16:46:05","date_gmt":"2025-03-11T07:46:05","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=7382"},"modified":"2025-03-11T16:46:05","modified_gmt":"2025-03-11T07:46:05","slug":"%e5%b0%bf%e9%85%b8%e3%82%92%e4%b8%8b%e3%81%92%e3%82%8b%e8%96%ac%e3%83%95%e3%82%a7%e3%83%96%e3%83%aa%e3%82%af%ef%bc%88%e3%83%95%e3%82%a7%e3%83%96%e3%82%ad%e3%82%bd%e3%82%b9%e3%82%bf%e3%83%83%e3%83%88","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=7382","title":{"rendered":"\u5c3f\u9178\u3092\u4e0b\u3052\u308b\u85ac\u30d5\u30a7\u30d6\u30ea\u30af\uff08\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\uff09\u306f\u5371\u306a\u3044\uff1f"},"content":{"rendered":"

\u5c3f\u9178\u3092\u4e0b\u3052\u308b\u85ac\u3001\u30d5\u30a7\u30d6\u30ea\u30af\uff08\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\uff09\u3092\u98f2\u3093\u3067\u3044\u308b\u65e5\u672c\u4eba\u306f\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u6050\u3089\u304f\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u3088\u308a\u3082\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u306e\u51e6\u65b9\u304c\u591a\u3044\u306e\u306f\u65e5\u672c\u304f\u3089\u3044\u3067\u3057\u3087\u3046\u304b\u3089\u3002\u30d5\u30a7\u30d6\u30ea\u30af\u306f\u65e5\u672c\u306e\u85ac\u3067\u3059\u304b\u3089\u3001\u6709\u80fd\u306a\u30bb\u30fc\u30eb\u30b9\u30de\u30f3\u304c\u9811\u5f35\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3057\u304b\u3057\u3001\u30a2\u30e1\u30ea\u30ab\u3067\u306f\u3053\u306e\u85ac\u306fBoxed Warning\uff08\u67a0\u7d44\u307f\u8b66\u544a\uff09\u304c\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002Boxed Warning\u306f\u533b\u85ac\u54c1\u306e\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u30e9\u30d9\u30eb\u306b\u8a18\u8f09\u3055\u308c\u308b\u8b66\u544a\u6587\u3067\u3001\u6df1\u523b\u3067\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u547d\u306e\u5371\u967a\u304c\u3042\u308b\u526f\u4f5c\u7528\u3092\u5f15\u304d\u8d77\u3053\u3059\u30ea\u30b9\u30af\u304c\u8003\u3048\u3089\u308c\u308b\u5834\u5408\u306b\u4ed8\u3051\u3089\u308c\u307e\u3059\u3002\u8b66\u544a\u6587\u304c\u9ed2\u67a0\u3067\u56f2\u307e\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u9ed2\u67a0\u8b66\u544a\uff08black box warning\uff09\u3068\u3082\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002FDA\u306b\u3088\u308b\u6700\u3082\u5f37\u3044\u8b66\u544a\u3067\u3059\u3002<\/p>\n

\u5b9f\u969b\u306b\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u4eba\u306f\u77e5\u3063\u3066\u3044\u308b\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u306a\u305c\u3001\u3053\u306e\u85ac\u306b\u5f37\u3044\u8b66\u544a\u304c\u4ed8\u3051\u3089\u308c\u3066\u3044\u308b\u304b\u3068\u3044\u3046\u3068\u3001\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6b7b\u4ea1\u7387\u304c\u9ad8\u3044\u3068\u3044\u3046\u7814\u7a76\u304c\u3042\u308b\u304b\u3089\u3067\u3059\u3002\u305d\u306e\u7814\u7a76\u3001CARES\u8a66\u9a13\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u3053\u306e\u7814\u7a76\u306e\u30b9\u30dd\u30f3\u30b5\u30fc\u306f\u6b66\u7530\u85ac\u54c1\u3067\u3059\u3002\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\uff08\u30d5\u30a7\u30d6\u30ea\u30af\uff09\u304c\u5e1d\u4eba\u30d5\u30a1\u30fc\u30de\u304c\u5275\u88fd\u3057\u3001\u6b66\u7530\u304c\u30a2\u30e1\u30ea\u30ab\u3067\u306e\u72ec\u5360\u7684\u958b\u767a\u30fb\u8ca9\u58f2\u6a29\u3092\u4fdd\u6709\u3057\u3066\u3044\u308b\u85ac\u3067\u3059\u3002\u30b9\u30dd\u30f3\u30b5\u30fc\u3068\u3057\u3066\u306f\u4f55\u3068\u3057\u3066\u3082\u826f\u3044\u7d50\u679c\u304c\u6b32\u3057\u3044\u3067\u3059\u3088\u306d\u3002<\/p>\n

\u5bfe\u8c61\u306f\u75db\u98a8\u306e\u8a3a\u65ad\u3092\u53d7\u3051\u3066\u304a\u308a\u3001\u30e9\u30f3\u30c0\u30e0\u5316\u524d\u306b\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u75c5\u6b74\u304c\u3042\u308b6190\u4eba\u3067\u3059\u3002<\/p>\n

\u60a3\u8005\u306f\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u307e\u305f\u306f\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u30921\u65e51\u56de\u6295\u4e0e\u3055\u308c\u308b\u3088\u3046\u7121\u4f5c\u70ba\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u307e\u3057\u305f\u3002\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u306e\u6295\u4e0e\u91cf\u306f\u3001\u814e\u6a5f\u80fd\u306b\u5fdc\u3058\u3066\u5909\u66f4\u3055\u308c\u307e\u3057\u305f\u3002\u814e\u6a5f\u80fd\u304c\u554f\u984c\u306a\u3044\u5834\u5408\u3001\u8840\u6e05\u5c3f\u9178\u5024\u304c6.0mg\/dL\u672a\u6e80\u306b\u306a\u308b\u304b\u3001600 mg \u306e\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u3092\u6295\u4e0e\u3055\u308c\u308b\u307e\u3067\u3001\u6bce\u6708100mg \u305a\u3064\u5897\u91cf\u3057\u307e\u3057\u305f\u3002\u814e\u6a5f\u80fd\u304c\u3084\u3084\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u60a3\u8005\u306b\u306f\u3001\u8840\u6e05\u5c3f\u9178\u5024\u304c6.0mg\/dL\u672a\u6e80\u306b\u306a\u308b\u304b\u3001400mg\u306e\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u3092\u6295\u4e0e\u3055\u308c\u308b\u307e\u3067\u3001100mg\u305a\u3064\u5897\u91cf\u3057\u307e\u3057\u305f\u3002
\n\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u306e\u6295\u4e0e\u91cf\u306f\u814e\u6a5f\u80fd\u306b\u5fdc\u3058\u3066\u5909\u66f4\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u306e\u6295\u4e0e\u3092\u30e9\u30f3\u30c0\u30e0\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u305f\u60a3\u8005\u306f\u3001\u6700\u521d\u306b1\u65e51\u56de40mg \u3092\u6295\u4e0e\u3055\u308c\u30012 \u9031\u9593\u306e\u6cbb\u7642\u5f8c\u306b\u8840\u6e05\u5c3f\u9178\u5024\u304c6.0mg\/dL\u672a\u6e80\u3067\u3042\u308c\u3070\u3001\u3053\u306e\u6295\u4e0e\u91cf\u3092\u7d99\u7d9a\u3057\u307e\u3057\u305f\u30022\u9031\u76ee\u306e\u8a3a\u5bdf\u6642\u306b\u8840\u6e05\u5c3f\u9178\u5024\u304c6.0mg\/dL\u3092\u8d85\u3048\u3066\u3044\u305f\u5834\u5408\u3001\u6b8b\u308a\u306e\u8a66\u9a13\u671f\u9593\u4e2d\u3001\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u306e\u6295\u4e0e\u91cf\u306f1\u65e51\u56de80mg \u306b\u5897\u52a0\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u7fa4\u3067\u306f\u3001\u6700\u7d42\u7528\u91cf\u3068\u3057\u3066\u3001\u60a3\u8005\u306e61.0%\u304c1\u65e540mg\u3092\u300139.0%\u304c1\u65e580mg\u3092\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u7fa4\u3067\u306f\u3001\u60a3\u8005\u306e21.8%\u304c200mg\u300144.6%\u304c300mg\u300125.2%\u304c400mg\u30014.3%\u304c500mg\u30014.1%\u304c600mg\u3092\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u4e0d\u601d\u8b70\u306a\u3053\u3068\u306b\u3001\u5168\u4f53\u3067\u306f\u60a3\u8005\u306e56.6%\u304c\u6cbb\u9a13\u6cbb\u7642\u3092\u65e9\u671f\u306b\u4e2d\u6b62\u3057\u307e\u3057\u305f\u3002\u4f55\u304c\u3042\u3063\u305f\u306e\u3067\u3057\u3087\u3046\uff1f<\/p>\n

\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u3078\u306e\u66dd\u9732\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f728\u65e5\u3001\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u3078\u306e\u66dd\u9732\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f719\u65e5\u3067\u3057\u305f\u3002\u8ffd\u8de1\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u3001\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u7fa4\u3067968\u65e5\u3001\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u7fa4\u3067942\u65e5\u3067\u3057\u305f\u3002<\/p>\n

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\u3057\u304b\u3057\u3001\u554f\u984c\u306a\u306e\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1\u3001\u5168\u539f\u56e0\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u3067\u3059\u3002\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u7fa4\u3067\u5fc3\u8840\u7ba1\u6b7b\u304c1.34\u500d\u3001\u5168\u539f\u56e0\u6b7b\u4ea1\u304c1.22\u500d\u306b\u3082\u306a\u3063\u3066\u3057\u307e\u3063\u305f\u306e\u3067\u3059\u3002\u5fc3\u8840\u7ba1\u6b7b\u306e\u539f\u56e0\u306e\u3046\u3061\u3001\u5fc3\u81d3\u7a81\u7136\u6b7b\u304c\u6700\u3082\u591a\u304f\u3001\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u7fa4\u306783\u4eba\uff082.7\uff05\uff09\u3001\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u7fa4\u306756\u4eba\uff081.8\uff05\uff09\u306b\u767a\u751f\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u30b9\u30dd\u30f3\u30b5\u30fc\u304c\u884c\u3063\u305f\u7814\u7a76\u3067\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30c8\u30f3\u30c7\u30e2\u30ca\u30a4\u7d50\u679c\u304c\u51fa\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002<\/p>\n

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\u98f2\u307e\u306a\u304f\u3066\u826f\u3044\u306e\u3067\u3042\u308c\u3070\u98f2\u307f\u305f\u304f\u306a\u3044\u3067\u3059\u3088\u306d\u3002\u7279\u306b\u7121\u75c7\u5019\u6027\u9ad8\u5c3f\u9178\u8840\u75c7\u306e\u5834\u5408\u3067\u3042\u308c\u3070\u3001\u5c3f\u9178\u5024\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u3067\u5f97\u3089\u308c\u308b\u30e1\u30ea\u30c3\u30c8\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u306a\u3044\u306e\u3067\u3001\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u5897\u52a0\u306e\u53ef\u80fd\u6027\u306b\u76ee\u3092\u3064\u3076\u3063\u3066\u307e\u3067\u3001\u98f2\u307e\u306a\u304d\u3083\u3044\u3051\u306a\u3044\u85ac\u3060\u3068\u306f\u601d\u3048\u307e\u305b\u3093\u3002\u300c\u5c3f\u9178\u5024\u304c\u9ad8\u3044\u304b\u3089\u300d\u3068\u3044\u3046\u7406\u7531\u3060\u3051\u3067\u98f2\u3080\u307b\u3069\u5b89\u5168\u6027\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u85ac\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u3057\u3066\u3001\u85ac\u3067\u5c3f\u9178\u5024\u3092\u5909\u3048\u308b\u3053\u3068\u304c\u3069\u3093\u306a\u3053\u3068\u3092\u62db\u304f\u304b\u2026\u305d\u308c\u306f\u6b21\u56de\u4ee5\u964d\u3067\u3002<\/p>\n

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\u300cCardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout\u300d<\/span><\/p>\n

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