{"id":7892,"date":"2019-04-29T11:29:07","date_gmt":"2019-04-29T02:29:07","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=7892"},"modified":"2020-01-10T08:42:40","modified_gmt":"2020-01-09T23:42:40","slug":"post-7892","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=7892","title":{"rendered":"\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3067\u30b9\u30bf\u30c1\u30f3\u3092\u98f2\u3080\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c\u6e1b\u5c11\u3059\u308b\u305d\u3046\u3060\u30000.8\uff05\u3060\u3051\u3069\u2026"},"content":{"rendered":"

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\u7d71\u8a08\u306f\u975e\u5e38\u306b\u6709\u7528\u306a\u3082\u306e\u3067\u3059\u304c\u3001\u305d\u308c\u306f\u4f7f\u3044\u65b9\u6b21\u7b2c\u3067\u3059\u3002\u6570\u5b57\u3068\u8a00\u3046\u306e\u306f\u975e\u5e38\u306b\u932f\u899a\u3092\u8d77\u3053\u3057\u3084\u3059\u304f\u3001\u4e0a\u624b\u304f\u4f7f\u3048\u3070\u4eba\u3092\u9a19\u3059\u3053\u3068\u3082\u53ef\u80fd\u3067\u3059\u3002<\/p>\n

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\u4eca\u56de\u306e\u7814\u7a76\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u306b\u30b9\u30bf\u30c1\u30f3\uff08\u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f340\u338e\uff09\u3092\u4f7f\u7528\u3057\u305f\u5834\u5408\u3068\u30d7\u30e9\u30bb\u30dc\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u3055\u3066\u305d\u306e\u5dee\u306f\uff1f<\/p>\n

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\u60a3\u8005\u3055\u3093\u306f50\u6b73\u4ee5\u4e0a\u307e\u305f\u306f\u30ea\u30a6\u30de\u30c1\u306e\u6301\u7d9a\u671f\u9593\u304c10\u5e74\u4ee5\u4e0a\u306e\u6210\u4eba3,002\u3067\u3001\u5e73\u5747\u5e74\u9f62\u306f61\u6b73\u3001\u8ffd\u8de1\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f2.51\u6b73\u3067\u3057\u305f\u3002\u305d\u308c\u3092\u30b9\u30bf\u30c1\u30f3\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e2\u3064\u306b\u30e9\u30f3\u30c0\u30e0\u306b\u5206\u3051\u307e\u3057\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u6b7b\u4ea1\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u3001\u4e00\u904e\u6027\u865a\u8840\u767a\u4f5c\u3001\u307e\u305f\u306f\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3067\u3057\u305f\u3002 \uff08\u56f3\u306f\u539f\u6587\u3088\u308a\uff09<\/p>\n

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\"\"<\/figure>\n

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\u4e0a\u306e\u56f3\u306f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u8d77\u3053\u3055\u305a\u306b\u7d4c\u904e\u3057\u305f\u671f\u9593\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u4e8c\u3064\u306e\u30b0\u30e9\u30d5\u306f\u307b\u3068\u3093\u3069\u91cd\u306a\u3063\u3066\u304a\u308a\u3001\u79c1\u306b\u306f\u9055\u3044\u304c\u308f\u304b\u308a\u307e\u305b\u3093\u3002<\/p>\n

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\u30b9\u30bf\u30c1\u30f3\u7fa4\u306e24\u4eba\u306e\u60a3\u8005\uff081.6\uff05\uff09\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e36\u4eba\uff082.4\uff05\uff09\u304c\u5fc3\u8840\u7ba1\u7cfb\u306e\u30a4\u30d9\u30f3\u30c8\u3092\u8d77\u3053\u3057\u307e\u3057\u305f\u3002\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08\uff28\uff32\uff090.66\u3067\u3059\u300295\uff05CI\u306f0.39\u22121.11\u3001\uff50\uff1d0.115\u3067\u3042\u308a\u3001\u7d71\u8a08\u7684\u306b\u306f\u6709\u610f\u5dee\u306a\u3057\u3067\u3059\u3002 \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5dee\u7570\u3001\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u3001\u304a\u3088\u3073\u3053\u306e\u7814\u7a76\u4ee5\u5916\u306e\u30b9\u30bf\u30c1\u30f3\u306e\u4f7f\u7528\u306b\u3064\u3044\u3066\u8abf\u6574\u3057\u305f\u5f8c\u3001HR\u306f0.60\u3067\u3057\u305f\uff0895\uff05CI 0.32-1.15\u3001p = 0.127\uff09\u3002 \u5927\u3052\u3055\u306b\u8868\u73fe\u3059\u308c\u3070\u30b9\u30bf\u30c1\u30f3\u306740\uff05\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c\u4f4e\u4e0b\u3057\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5b9f\u969b\u306b\u306f2.4\uff05\u30681.6\uff05\u306e\u9055\u3044\u306a\u306e\u3067\u30012.4\uff0d1.6\uff1d0.8\uff05\u306e\u9055\u3044\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

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NNT\uff08\u6cbb\u7642\u5fc5\u8981\u6570\uff09\u306f121\u3067\u3059\u3002120\u4eba\u306f\u30b9\u30bf\u30c1\u30f3\u306e\u6069\u6075\u3092\u53d7\u3051\u306a\u3044\u306e\u3067\u3059\u3002<\/p>\n

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\"\"<\/figure>\n

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\u4e0a\u306e\u56f3\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u7d2f\u7a4d\u767a\u751f\u7387\u3067\u3059\u30023\u5e74\u76ee\u4ee5\u964d\u5927\u304d\u304f\u9055\u3044\u304c\u3042\u308b\u3088\u3046\u306b\u3082\u898b\u3048\u307e\u3059\u304c\u3001\u3069\u3093\u3069\u3093\u8ffd\u8de1\u3057\u3066\u3044\u4eba\u6570\u304c\u5927\u304d\u304f\u6e1b\u5c11\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u7cbe\u5ea6\u306e\u554f\u984c\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n

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LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u30b9\u30bf\u30c1\u30f3\u3067\u30d9\u30fc\u30b9\u30e9\u30a4\u30f33.2mmol\/L\uff08\u7d04124mg\/dL\uff09\u21922.21mmol\/L\uff08\u7d0486mg\/dL\uff09\u306b\u4f4e\u4e0b\u3002\u30d7\u30e9\u30bb\u30dc\u3067\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f33.2mmol\/L\uff08\u7d04124mg\/dL\uff09\u21922.98mmol\/L\uff08\u7d04115mg\/dL\uff09\u306b\u4f4e\u4e0b\u3002\u3069\u3046\u3057\u3066\u30d7\u30e9\u30bb\u30dc\u3067\u3082\u4e0b\u304c\u308b\u306e\uff1f\u307e\u3042\u308f\u305a\u304b\u306a\u306e\u3067\u3001\u8aa4\u5dee\u3084\u305d\u306e\u3068\u304d\u306e\u98df\u4e8b\u306a\u3069\u306e\u69d8\u3005\u306a\u8981\u56e0\u3067\u591a\u5c11\u306f\u5909\u5316\u3057\u3046\u308b\u306e\u3067\u3057\u3087\u3046\u3002\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u30b9\u30bf\u30c1\u30f3\u3067\u306f0.77mmol\/L\uff08\u7d0430mg\/dL\uff09\u591a\u304f\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002<\/p>\n

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LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e1mmol\/L\uff08\u7d0438.7mg\/dL\uff09\u6e1b\u5c11\u3042\u305f\u308a\u306e\u63a8\u5b9a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u6e1b\u5c11\u306f42\uff05\u3060\u305d\u3046\u3067\u3059\u3002\u5927\u3052\u3055\u306b\u898b\u305b\u307e\u3059\u306d\u3002<\/p>\n

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\u7dcf\u6b7b\u4ea1\u7387\u304a\u3088\u3073\u539f\u56e0\u5225\u6b7b\u4ea1\u7387\uff08\u51a0\u52d5\u8108\u75be\u60a3\u3067\u306e\u6b7b\u4ea1\u3001\u305d\u306e\u4ed6\u306e\u8840\u7ba1\u6027\u6b7b\u4ea1\u304a\u3088\u3073\u975e\u8840\u7ba1\u6027\u6b7b\u4ea1\uff09\u306f2\u3064\u306e\u7fa4\u9593\u3067\u5dee\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u30b9\u30bf\u30c1\u30f3\u7fa4\u306725\u4eba\uff081.7\uff05\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306727\u4eba\uff081.8\uff05\uff09\uff09\u3002\u6709\u5bb3\u4e8b\u8c61\u3082\u5dee\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

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\u3053\u306e\u3088\u3046\u306b\u3001\u975e\u5e38\u306b\u308f\u305a\u304b\u306e\u5dee\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3057\u3001\u6709\u610f\u5dee\u3082\u306a\u3044\u306e\u306b\u3001\u7121\u7406\u77e2\u7406LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u6e1b\u5c11\u3068\u30ea\u30b9\u30af\u306e\u6e1b\u5c11\u3092\u5927\u304d\u304f\u898b\u305b\u3088\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u7d50\u8ad6\u3067\u306f\u3001<\/p>\n

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\u300c\u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f340mg \/\u65e5\u306f\u5b89\u5168\u3067\u3042\u308a\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u3067\u306f\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3057\u305f\u300240\uff05\uff08\u8abf\u6574\u6e08\u307f\uff09\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306e\u6e1b\u5c11\u306f\u3001\u4ed6\u306e\u96c6\u56e3\u306b\u304a\u3051\u308b\u30b9\u30bf\u30c1\u30f3\u306e\u52b9\u679c\u306b\u95a2\u3059\u308bthe Cholesterol Treatment Trialists\u2019 Collaboration\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3068\u4e00\u81f4\u3057\u3066\u3044\u308b\u3002 \u300d<\/p>\n

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\u3068\u8a33\u306e\u5206\u304b\u3089\u306a\u3044\u7d50\u8ad6\u3092\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u7d50\u5c40\u306f\u30b9\u30bf\u30c1\u30f3\u306f\u4f55\u306e\u5229\u76ca\u3082\u3082\u305f\u3089\u3055\u306a\u3044\u3068\u7d50\u8ad6\u3059\u3079\u304d\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u3057\u304b\u305740\uff05\u3092\u5f37\u8abf\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u9a19\u305d\u3046\u3068\u3057\u3066\u3044\u308b\u610f\u56f3\u304c\u3046\u304b\u304c\u3048\u307e\u3059\u3002\u3053\u306e40\uff05\u3060\u3051\u304c\u72ec\u308a\u6b69\u304d\u3092\u59cb\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3057\u3087\u3046\u3002<\/p>\n

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\u4ee5\u524d\u306e\u8a18\u4e8b\u300c\u30b9\u30bf\u30c1\u30f3\u306f\u8a87\u5927\u5e83\u544a\u3067\u6210\u308a\u7acb\u3063\u3066\u3044\u308b\uff1f<\/a>\u300d\u3067\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u30b9\u30bf\u30c1\u30f3\u306f\u3053\u306e\u3088\u3046\u306a\u7d71\u8a08\u306e\u30c8\u30ea\u30c3\u30af\u3092\u4f7f\u308f\u306a\u3044\u3068\u3001\u6709\u52b9\u6027\u304c\u3042\u308b\u3088\u3046\u306b\u898b\u305b\u3089\u308c\u306a\u3044\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

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\u3055\u3089\u306b\u3001\u30b9\u30bf\u30c1\u30f3\u3068\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u95a2\u4fc2\u306f\u3082\u3063\u3068\u602a\u3057\u3044\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u306f\u6b21\u56de\u306e\u8a18\u4e8b\u3067\u3002<\/p>\n

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\u300cTrial of atorvastatin for the primary prevention of cardiovascular events in patients with rheumatoid arthritis (TRACE RA): A multicenter, randomized, placebo controlled trial\u300d<\/p>\n

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\u300c\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u4e00\u6b21\u4e88\u9632\u306e\u305f\u3081\u306e\u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f3\u306e\u8a66\u9a13\uff08TRACE RA\uff09\uff1a\u591a\u65bd\u8a2d\u5171\u540c\u7121\u4f5c\u70ba\u5316\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u300d\uff08\u539f\u6587\u306f\u3053\u3053<\/a>\uff09<\/p>\n

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