{"id":8295,"date":"2019-06-03T08:05:22","date_gmt":"2019-06-02T23:05:22","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=8295"},"modified":"2020-01-05T14:17:24","modified_gmt":"2020-01-05T05:17:24","slug":"post-8295","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=8295","title":{"rendered":"\u767d\u8840\u75c5\u3082\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4\u3067\u3042\u308b\u3000\u305d\u306e1"},"content":{"rendered":"<p><\/p>\n<p>\u6c60\u6c5f\u7483\u82b1\u5b50\u9078\u624b\u304c\u767d\u8840\u75c5\u3092\u767a\u8868\u3057\u3066\u3001\u304b\u306a\u308a\u306e\u6642\u9593\u304c\u7d4c\u3061\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u6700\u8fd1\u8efd\u3044\u904b\u52d5\u3092\u958b\u59cb\u3057\u305f\u3068\u8a00\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u6b21\u306e\u3088\u3046\u306a\u3064\u3076\u3084\u304d\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<blockquote class=\"twitter-tweet\" data-lang=\"ja\">\n<p lang=\"ja\" dir=\"ltr\">\u30dd\u30c3\u30d7\u30b3\u30fc\u30f3\u304c\u7f8e\u5473\u3057\u304b\u3063\u305f\u3002<br \/>\u7f8e\u5473\u3057\u3044\u30c1\u30e3\u30fc\u30cf\u30f3\u98df\u3079\u305f\u3044\u3002<br \/>\u30c1\u30fc\u30ba\u30c9\u30c3\u30af\u3082\u30de\u30c3\u30af\u306e\u30dd\u30c6\u30c8\u3082\u98df\u3079\u305f\u3044\u2026&#x1f35f;<br \/>\u7f8e\u5473\u3057\u3044\u304a\u5bff\u53f8&#x1f363;\u30a2\u30dc\u30ab\u30c9&#x1f951;<br \/>\u3068\u3001\u304b\u3089\u307f\u30c1\u30ad\u30f3<br \/>\u98df\u3079\u305f\u3044\u3082\u306e\u3068\u884c\u304d\u305f\u3044\u3068\u3053\u304c\u591a\u3059\u304e\u308b&#x1f42d;&#x1f3f0;<\/p>\n<p>\u2014 \u6c60\u6c5f \u7483\u82b1\u5b50 (@rikakoikee) <a href=\"https:\/\/twitter.com\/rikakoikee\/status\/1135127518258667520?ref_src=twsrc%5Etfw\">2019\u5e746\u67082\u65e5<\/a><\/p><\/blockquote>\n<p><script async=\"\" src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><br \/>\n<\/p>\n<p><\/p>\n<p>\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001\u591a\u304f\u306e\u4eba\u304c\u52b1\u307e\u3057\u3084\u826f\u304b\u3063\u305f\u3068\u3044\u3046\u5185\u5bb9\u306e\u30e1\u30c3\u30bb\u30fc\u30b8\u3092\u9001\u3063\u3066\u3044\u307e\u3059\u3002\u300c\u98df\u3079\u305f\u3044\u3082\u306e\u3092\u98df\u3079\u308c\u308b\u3088\u3046\u306b\u306a\u308b\u3068\u826f\u3044\u306d\u300d\u3068\u3044\u3046\u5185\u5bb9\u306e\u30e1\u30c3\u30bb\u30fc\u30b8\u3082\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u672c\u5f53\u306b\u98df\u3079\u305f\u3044\u3082\u306e\u3092\u98df\u3079\u308b\u3053\u3068\u304c\u826f\u3044\u304b\u3069\u3046\u304b\u306f\u975e\u5e38\u306b\u96e3\u3057\u3044\u554f\u984c\u3067\u3059\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u4eca\u56de\u306e\u8457\u66f8<a rel=\"noreferrer noopener\" aria-label=\"\u300c\u7cd6\u8cea\u904e\u5270\u300d\u75c7\u5019\u7fa4 (opens in a new tab)\" href=\"https:\/\/www.amazon.co.jp\/gp\/product\/433404414X\/ref=as_li_tl?ie=UTF8&amp;camp=247&amp;creative=1211&amp;creativeASIN=433404414X&amp;linkCode=as2&amp;tag=medmiss-22&amp;linkId=76c07cb5a42dd5a09e45e1f4b1ac18b4\" target=\"_blank\">\u300c\u7cd6\u8cea\u904e\u5270\u300d\u75c7\u5019\u7fa4<\/a>\u3067\u306f\u3001\u69d8\u3005\u306a\u75be\u60a3\u3068\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306b\u3064\u3044\u3066\u53d6\u308a\u4e0a\u3052\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u4e2d\u306b\u300c\u304c\u3093\u300d\u3082\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u307b\u3068\u3093\u3069\u306e\u304c\u3093\u306f\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4\u3060\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u3082\u3057\u304b\u3057\u305f\u3089\u5168\u3066\u306e\u304c\u3093\u304c\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u304c\u3093\u3082\u7a2e\u985e\u304c\u591a\u3044\u306e\u3067\u3001\u73fe\u5728\u306e\u3068\u3053\u308d\u5168\u3066\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u305d\u306e\u4e2d\u3067\u767d\u8840\u75c5\u306f\u7cd6\u8cea\u904e\u5270\u75c7\u5019\u7fa4\u306a\u306e\u304b\u306f\u3001\u672c\u3092\u66f8\u3044\u3066\u3044\u308b\u6bb5\u968e\u3067\u306f\u78ba\u4fe1\u3092\u6301\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u3057\u304b\u3057\u3001\u539f\u7a3f\u3092\u66f8\u304d\u4e0a\u3052\u3066\u304b\u3089\u3001\u6b21\u306e\u3088\u3046\u306a\u8ad6\u6587\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p class=\"has-text-color has-vivid-cyan-blue-color\">\u300cType I insulin-like growth factor receptor signaling in hematological malignancies\u300d<\/p>\n<p><\/p>\n<p><\/p>\n<p class=\"has-text-color has-vivid-cyan-blue-color\">\u300c<a rel=\"noreferrer noopener\" aria-label=\"\u8840\u6db2\u60aa\u6027\u816b\u760d\u306b\u304a\u3051\u308bI\u578b\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054 (opens in a new tab)\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27661006\" target=\"_blank\">\u8840\u6db2\u60aa\u6027\u816b\u760d\u306b\u304a\u3051\u308bI\u578b\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/a>\u300d\uff08\u539f\u6587\u306f<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27661006\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"\u3053\u3053 (opens in a new tab)\">\u3053\u3053<\/a>\uff09<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u8840\u6db2\u306e\u304c\u3093\u3067\u3042\u308b\u767d\u8840\u75c5\u3084\u30ea\u30f3\u30d1\u816b\u306bIGF-1\u304c\u5927\u304d\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002IGF-1\u306f\u4e73\u304c\u3093\u3092\u306f\u3058\u3081\u3001\u69d8\u3005\u306a\u304c\u3093\u3001\u75c5\u6c17\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u8a73\u3057\u304f\u306f\u300c\u7cd6\u8cea\u904e\u5270\u300d\u75c7\u5019\u7fa4\u3092\u8aad\u3093\u3067\u3044\u305f\u3060\u3051\u308b\u3068\u52a9\u304b\u308a\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>IGF-1 \u306e\u53d7\u5bb9\u4f53\uff08IGF-1R\uff09\u3068IGF-1\u306f\u3001\u4e3b\u306b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u6291\u5236\u3068\u7d30\u80de\u306e\u5f62\u8cea\u8ee2\u63db\u306e\u8a98\u5c0e\u306b\u3088\u3063\u3066\u3001\u816b\u760d\u306e\u78ba\u7acb\u3068\u9032\u884c\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3068\u591a\u304f\u306e\u7814\u7a76\u304c\u7d50\u8ad6\u3065\u3051\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u767d\u8840\u75c5\u306a\u3069\u306e\u8840\u6db2\u306e\u304c\u3093\u306b\u5bfe\u3059\u308bIGF-1R\u3084IGF-1\u306e\u5f79\u5272\u306e\u7814\u7a76\u306f\u975e\u5e38\u306b\u5c11\u306a\u3044\u3088\u3046\u3067\u3059\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p> IGF-1R\u304c\u904e\u5270\u306b\u767a\u73fe\u3059\u308b\u3053\u3068\u306f\u3001\u816b\u760d\u306e\u767a\u751f\u304a\u3088\u3073\u9032\u884c\u3001\u8ee2\u79fb\u3001\u304a\u3088\u3073\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u62b5\u6297\u6027\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u3092\u88cf\u4ed8\u3051\u308b\u8a3c\u62e0\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002 <\/p>\n<p><\/p>\n<p><\/p>\n<p>\u6025\u6027\u767d\u8840\u75c5\u3082\u6162\u6027\u767d\u8840\u75c5\u3082\u5168\u3066\u306e\u30bf\u30a4\u30d7\u3068\u306f\u8a00\u3048\u306a\u3044\u307e\u3067\u3082\u3001\u3044\u304f\u3064\u304b\u306e\u30bf\u30a4\u30d7\u3067IGF-1R\u3001IGF-1 \u304c\u975e\u5e38\u306b\u5897\u52a0\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u4f8b\u3048\u3070\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306e\u7d30\u80de\u3067\u306fIGF-1R\u304c\u975e\u5e38\u306b\u5897\u52a0\u3057\u3001\u305d\u3057\u3066IGF-1R\u306e\u767a\u73fe\u306f\u305d\u306e\u767d\u8840\u75c5\u306e\u9032\u884c\u3068\u76f4\u63a5\u76f8\u95a2\u3059\u308b\u3088\u3046\u306a\u306e\u3067\u3059\u3002IGF-1R\u306f\u3001\u6162\u6027\u671f\u306e\u60a3\u8005\u3067\u306f30\uff05\u306e\u767a\u73fe\u7387\u3060\u3063\u305f\u306e\u304c\u3001\u6025\u6027\u8ee2\u5316\u671f\u306b\u306a\u3063\u305f\u60a3\u8005\u306b\u304a\u3044\u306673\uff05\u307e\u3067\u5897\u52a0\u3057\u305f\u306e\u3067\u3059\u3002 <\/p>\n<p><\/p>\n<p><\/p>\n<p>\u3064\u307e\u308a\u3001IGF-1\u3092\u5897\u52a0\u3055\u305b\u308b\u3088\u3046\u306a\u3053\u3068\u306f\u907f\u3051\u308b\u3079\u304d\u306a\u306e\u3067\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3067\u306f\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u306b\u306a\u308a\u3001\u3055\u3089\u306b\u9ad8IGF-1\u306b\u3082\u306a\u308a\u307e\u3059\u3002\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u306f\u591a\u304f\u306e\u304c\u3093\u306b\u30a8\u30b5\u3092\u3042\u3052\u3066\u3044\u308b\u306e\u3068\u540c\u3058\u306a\u306e\u3067\u3059\u3002\u305d\u308c\u306f\u767d\u8840\u75c5\u306b\u3082\u5f53\u3066\u306f\u307e\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u306e\u3067\u3059\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u300c\u597d\u304d\u306a\u3082\u306e\u3092\u597d\u304d\u306a\u3060\u3051\u98df\u3079\u308b\u300d\u3068\u3044\u3046\u306e\u306f\u5065\u5eb7\u3068\u3044\u3046\u5e7b\u60f3\u3001\u5984\u60f3\u306e\u4e2d\u3067\u3042\u308c\u3070\u554f\u984c\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u73fe\u5b9f\u306e\u69d8\u3005\u306a\u75c5\u6c17\u304c\u9854\u3092\u8868\u3057\u305f\u306e\u3067\u3042\u308c\u3070\u3001\u300c\u597d\u304d\u306a\u3082\u306e\u300d\u3092\u98df\u3079\u3066\u3044\u308b\u3053\u3068\u306f\u3001\u305d\u306e\u98df\u6750\u306b\u3088\u3063\u3066\u306f\u75c5\u6c17\u3092\u4fc3\u9032\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u547d\u304c\u304b\u304b\u308f\u308b\u75c5\u6c17\u3067\u3082\u3046\u4f55\u3092\u3084\u3063\u3066\u3082\u30c0\u30e1\u3067\u3001\u300c\u6b7b\u300d\u3092\u53d7\u3051\u5165\u308c\u305f\u306e\u3067\u3042\u308c\u3070\u3001\u4f55\u3092\u98df\u3079\u3066\u3082\u826f\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u300c\u751f\u304d\u308b\u300d\u3068\u3044\u3046\u5e0c\u671b\u3092\u6301\u3063\u3066\u3044\u308b\u9650\u308a\u4f55\u3092\u98df\u3079\u3066\u3082\u826f\u3044\u3068\u306f\u5230\u5e95\u8a00\u3048\u307e\u305b\u3093\u3002<\/p>\n<p><\/p>\n<p><\/p>\n<p>\u3057\u304b\u3057\u3001\u73fe\u5b9f\u306e\u4e16\u754c\u3067\u306f\u300c<a 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