{"id":837,"date":"2016-10-19T14:27:41","date_gmt":"2016-10-19T05:27:41","guid":{"rendered":"http:\/\/promea2014.com\/blog\/?p=837"},"modified":"2016-10-19T14:39:37","modified_gmt":"2016-10-19T05:39:37","slug":"post-837","status":"publish","type":"post","link":"https:\/\/promea2014.com\/blog\/?p=837","title":{"rendered":"\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u5065\u5eb7\u306b\u60aa\u3044\uff01"},"content":{"rendered":"

\u5168\u3066\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u5426\u5b9a\u3059\u308b\u3064\u3082\u308a\u306f\u307e\u3063\u305f\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u3082\u3061\u308d\u3093\u3001\u826f\u3044\u3082\u306e\u3082\u3042\u308b\u3068\u601d\u3044\u307e\u3059\u3057\u3001\u30b5\u30d7\u30ea\u3067\u3057\u304b\u4e0a\u624b\u304f\u6442\u308c\u306a\u3044\u6210\u5206\u3082\u3042\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u6804\u990a\u306e\u4e0d\u8db3\u3092\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u88dc\u304a\u3046\u3068\u8003\u3048\u308b\u4eba\u304c\u3044\u307e\u3059\u304c\u3001\u79c1\u306f\u53cd\u5bfe\u3067\u3059\u3002\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u5982\u4f55\u306b\u3082\u5065\u5eb7\u306b\u826f\u3055\u305d\u3046\u306a\u5ba3\u4f1d\u6587\u53e5\u304c\u4e26\u3093\u3067\u3044\u307e\u3059\u304c\u3001\u672c\u5f53\u306b\u5065\u5eb7\u306b\u826f\u3044\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

 <\/p>\n

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2016\u5e749\u670824\u65e509\u664241\u5206\u3000\u671d\u65e5\u65b0\u805e\u30c7\u30b8\u30bf\u30eb\u3088\u308a\u629c\u7c8b<\/span><\/p>\n

\n

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\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u7531\u6765\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u3001\u5fc3\u81d3\u306b\u30c0\u30e1\u30fc\u30b8\u304b<\/span><\/h1>\n

2016.10.17 \u30ea\u30f3\u30af\u3067\u30c0\u30a4\u30a8\u30c3\u30c8\u3088\u308a\u629c\u7c8b<\/span><\/p>\n

\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304b\u3089\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u52d5\u8108\u306b\u30d7\u30e9\u30fc\u30af\u304c\u84c4\u7a4d\u3057\u3001\u5fc3\u81d3\u306b\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u3002\u53cd\u5bfe\u306b\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u8c4a\u5bcc\u306a\u98df\u54c1\u3092\u591a\u304f\u6442\u308b\u98df\u751f\u6d3b\u306b\u306f\u5fc3\u81d3\u306e\u4fdd\u8b77\u52b9\u679c\u304c\u3042\u308b\u3068\u306e\u3053\u3068\u3002\u7c73\u56fd\u30b8\u30e7\u30f3\u30ba\u30fb\u30db\u30d7\u30ad\u30f3\u30b9\u5927\u5b66\u306e\u7814\u7a76\u3002<\/span><\/p>\n

\u7814\u7a76\u8005\u3089\u306b\u3088\u308b\u3068\u3001\u4eca\u56de\u306e\u8abf\u67fb\u7d50\u679c\u306f\u30ab\u30eb\u30b7\u30a6\u30e0\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306b\u3064\u3044\u3066\u89b3\u5bdf\u3057\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u56e0\u679c\u95a2\u4fc2\u306e\u8a3c\u660e\u306b\u306f\u81f3\u3089\u306a\u3044\u3068\u3044\u3046\u3002\u3068\u306f\u3044\u3048\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6f5c\u5728\u7684\u6709\u5bb3\u6027\u306b\u3064\u3044\u3066\u5897\u3048\u3064\u3064\u3042\u308b\u79d1\u5b66\u7684\u61f8\u5ff5\u3092\u3055\u3089\u306b\u5897\u3059\u3082\u306e\u3060\u3068\u3057\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u5229\u7528\u3059\u308b\u969b\u306b\u306f\u3001\u77e5\u8b58\u306e\u3042\u308b\u533b\u5e2b\u306e\u8a3a\u5bdf\u3092\u53d7\u3051\u308b\u3088\u3046\u8a34\u3048\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u7c73\u56fd\u3067\u306f\u6210\u4eba\u306e43%\u304c\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u542b\u3080\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u5229\u7528\u3057\u3066\u3044\u308b\u3002\u300c\u30d3\u30bf\u30df\u30f3\u3084\u30df\u30cd\u30e9\u30eb\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3001\u7279\u306b\u30ab\u30eb\u30b7\u30a6\u30e0\u306f\u9aa8\u306e\u5065\u5eb7\u306e\u305f\u3081\u306b\u6442\u53d6\u3055\u308c\u3066\u304a\u308a\u3001\u591a\u304f\u306e\u56fd\u6c11\u306f\u305f\u304f\u3055\u3093\u6442\u308b\u307b\u3069\u826f\u3044\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u300d\u3068\u3001\u7814\u7a76\u8005\u306e\u30de\u30a4\u30b3\u30b9\u533b\u5e2b\u306f\u8a71\u3057\u3066\u3044\u308b\u3002\u300c\u3057\u304b\u3057\u3001\u79c1\u305f\u3061\u306e\u7814\u7a76\u3067\u306f\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u5f62\u614b\u3067\u306e\u904e\u5270\u306a\u30ab\u30eb\u30b7\u30a6\u30e0\u306f\u3001\u5fc3\u81d3\u3084\u5faa\u74b0\u5668\u7cfb\u306e\u5bb3\u3068\u306a\u308b\u3068\u3044\u3046\u8a3c\u62e0\u306e\u6839\u5e79\u306b\u306a\u308b\u3082\u306e\u3067\u3059\u300d<\/span><\/p>\n

\u5148\u884c\u7814\u7a76\u304b\u3089\u7279\u306b\u9ad8\u9f62\u8005\u306b\u304a\u3044\u3066\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6442\u53d6\u3057\u3066\u3082\u3001\u305d\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u9aa8\u683c\u307e\u3067\u305f\u3069\u308a\u3064\u304b\u306a\u304b\u3063\u305f\u308a\u3001\u5c3f\u306b\u6392\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u308a\u3057\u305f\u7d50\u679c\u3001\u8eab\u4f53\u306e\u8edf\u90e8\u7d44\u7e54\u306b\u84c4\u7a4d\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u305d\u306e\u305f\u3081\u4eca\u56de\u306e\u7814\u7a76\u8005\u3089\u306f\u5fc3\u81d3\u3084\u5faa\u74b0\u5668\u7cfb\u306b\u304a\u3044\u3066\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u6301\u3064\u306e\u304b\u8208\u5473\u3092\u6301\u3063\u3066\u3044\u305f\u3068\u3044\u3046\u3002<\/span><\/p>\n

\u306a\u304a\u3001\u3053\u308c\u307e\u3067\u306b\u3001\u52a0\u9f62\u306b\u3068\u3082\u306a\u3063\u3066\u30ab\u30eb\u30b7\u30a6\u30e0\u7cfb\u30d7\u30e9\u30fc\u30af\u304c\u5927\u52d5\u8108\u306a\u3069\u306e\u52d5\u8108\u306b\u84c4\u7a4d\u3057\u3001\u8840\u6d41\u3092\u59a8\u3052\u3066\u5fc3\u81d3\u767a\u4f5c\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u3082\u308f\u304b\u3063\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u3055\u3066\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u30012700\u4eba\u4ee5\u4e0a\u3092\u5bfe\u8c61\u306b\u98df\u4e8b\u30a2\u30f3\u30b1\u30fc\u30c8\u3068\u3001CT\u30b9\u30ad\u30e3\u30f3\u30922\u56de\uff08\u5404\u56de\u306e\u9593\u9694\u306f10\u5e74\u3068\u3057\u305f\uff09\u53d7\u3051\u3066\u3082\u3089\u3063\u305f\u3002\u88ab\u9a13\u8005\u306e\u5e74\u9f62\u306f45-84\u6b73\u3001\u7537\u5973\u6bd4\u306f\u7d04\u534a\u3005\u3060\u3063\u305f\u3002<\/span><\/p>\n

\u98df\u4e8b\u30a2\u30f3\u30b1\u30fc\u30c8\u3067\u306f\u3001\u3069\u306e\u3088\u3046\u306a\u98df\u54c1\u304b\u3089\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u6442\u3063\u3066\u3044\u308b\u304b\u3092\u8a0a\u306d\u308b\u305f\u3081120\u306e\u8a2d\u554f\u306b\u7b54\u3048\u3066\u3082\u3089\u3063\u305f\u3002\u4ed6\u306b\u3001\u85ac\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6442\u53d6\u72b6\u6cc1\u306b\u3064\u3044\u3066\u3082\u8a18\u9332\u3057\u305f\u3002<\/span><\/p>\n

\u4e00\u65e5\u3042\u305f\u308a\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u5e73\u5747\u6442\u53d6\u91cf\u306b\u3088\u3063\u3066\u88ab\u9a13\u8005\u30925\u7fa4\u306b\u5206\u3051\u305f\u3068\u3053\u308d\u3001\u6700\u3082\u6442\u53d6\u91cf\u306e\u591a\u3044\u7fa4\uff081400mg\/\u65e5\uff09\u306f\u6700\u3082\u5c11\u306a\u3044\u7fa4\uff08400mg\/\u65e5\uff09\u3088\u308a\u3082\u3001\u51a0\u52d5\u8108\u77f3\u7070\u5316\u306e\u5ea6\u5408\u3044\uff08\u30ab\u30eb\u30b7\u30a6\u30e0\u6c88\u7740\u306e\u76ee\u5b89\u3068\u306a\u308b\u3002CT\u691c\u67fb\u3067\u6e2c\u5b9a\uff09\u304c\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c27%\u5c11\u306a\u304b\u3063\u305f\u3002\u6b21\u306b\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u4f9b\u7d66\u6e90\u304c\u98df\u4e8b\u306e\u307f\u306e\u4eba\u3068\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3082\u6442\u53d6\u3057\u3066\u3044\u308b\u4eba\u3068\u3067\u3001\u3069\u306e\u3088\u3046\u306a\u5dee\u304c\u751f\u3058\u308b\u304b\u3092\u5206\u6790\u3057\u305f\u3002<\/span><\/p>\n

\u88ab\u9a13\u8005\u306e46%\u306f\u30ab\u30eb\u30b7\u30a6\u30e0\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u5229\u7528\u3057\u3066\u3044\u305f\u304c\u3001\u89e3\u6790\u306e\u7d50\u679c\u3001\u5f7c\u3089\u306f\u51a0\u52d5\u8108\u77f3\u7070\u5316\u306e\u5ea6\u5408\u3044\u304c10\u5e74\u9593\u306722%\u9ad8\u307e\u3063\u305f\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u3053\u308c\u306f\u5fc3\u81d3\u75c5\u306e\u767a\u75c7\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u3088\u3046\u306a\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306e\u539f\u56e0\u3068\u3057\u3066\u3001\u7814\u7a76\u8005\u306f\u300c\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u30ab\u30eb\u30b7\u30a6\u30e0\u5869\u3092\u542b\u3080\u3053\u3068\u3001\u307e\u305f\u306f\u9ad8\u7528\u91cf\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u8eab\u4f53\u304c\u51e6\u7406\u3057\u304d\u308c\u306a\u3044\u3053\u3068\u300d\u3067\u306f\u306a\u3044\u304b\u3068\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u4e00\u65b9\u3067\u3001\u98df\u4e8b\u7531\u6765\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u6442\u53d6\u91cf\u304c\u6700\u3082\u591a\u304b\u3063\u305f\u7fa4\u306e\u4eba\u305f\u3061\u306f\u4e00\u65e5\u5e73\u57471022mg\u4ee5\u4e0a\u3060\u3063\u305f\u3068\u3044\u3046\u304c\u3001\u5f7c\u3089\u306b\u5fc3\u81d3\u75c5\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3002\u7814\u7a76\u8005\u306f\u300c\u3053\u306e\u8a3c\u62e0\u306b\u3088\u308c\u3070\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u8c4a\u5bcc\u306a\u98df\u54c1\u3092\u542b\u3080\u5065\u5eb7\u7684\u306a\u98df\u4e8b\u3092\u6442\u308b\u3053\u3068\u306f\u3001\u4f55\u306e\u554f\u984c\u3082\u306a\u3044\u3070\u304b\u308a\u304b\u5fc3\u81d3\u306b\u6709\u76ca\u3060\u3068\u3082\u3044\u3048\u308b\u3067\u3057\u3087\u3046\u3002\u300d\u3068\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u539f\u6587\u306f\u4e0b\u8a18\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n

Calcium Intake From Diet and Supplements and the Risk of Coronary Artery Calcification and its Progression Among Older Adults: 10\u2010Year Follow\u2010up of the Multi\u2010Ethnic Study of Atherosclerosis (MESA)<\/span><\/h2>\n

J Am Heart Assoc.<\/i> 2016; <\/i><\/span> 5: <\/i><\/span> e003815 <\/i><\/span> originally published October 11, 2016<\/span> doi: 10.1161\/JAHA.116.003815<\/span><\/span><\/span><\/p>\n

Abstract<\/span><\/h2>\n
\n

Background<\/strong> Recent randomized data suggest that calcium supplements may be associated with increased risk of cardiovascular disease (CVD<\/span>) events. Using a longitudinal cohort study, we assessed the association between calcium intake, from both foods and supplements, and atherosclerosis, as measured by coronary artery calcification (CAC<\/span>).<\/span><\/p>\n<\/div>\n

\n

Methods and Results<\/strong> We studied 5448 adults free of clinically diagnosed CVD<\/span> (52% female; aged 45\u201384\u00a0years) from the Multi\u2010Ethnic Study of Atherosclerosis. Baseline total calcium intake was assessed from diet (using a food frequency questionnaire) and calcium supplements (by a medication inventory) and categorized into quintiles. Baseline CAC<\/span> was measured by computed tomography, and CAC<\/span> measurements were repeated in 2742 participants \u224810\u00a0years later. At baseline, mean calcium intakes across quintiles were 313.3, 540.3, 783.0, 1168.9, and 2157.4\u00a0mg\/day. Women had higher calcium intakes than men. After adjustment for potential confounders, among 1567 participants without baseline CAC<\/span>, the relative risk (RR<\/span>) of developing incident CAC<\/span> over 10\u00a0years, by quintile 1 to 5 of calcium intake, were 1 (reference), 0.95 (0.79\u20131.14), 1.02 (0.85\u20131.23), 0.86 (0.69\u20131.05), and 0.73 (0.57\u20130.93). After accounting for total calcium intake, calcium supplement use was associated with increased risk for incident CAC<\/span> (RR<\/span>=1.22 [1.07\u20131.39]). No relation was found between baseline calcium intake and 10\u2010year changes in log\u2010transformed CAC<\/span> among those participants with baseline CAC<\/span> >0.<\/span><\/p>\n<\/div>\n

\n

Conclusions<\/strong> High total calcium intake was associated with a decreased risk of incident atherosclerosis over long\u2010term follow\u2010up,\u00a0particularly if achieved without supplement use. However, calcium supplement use may increase the risk for incident CAC<\/span>.<\/span><\/p>\n<\/div>\n

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