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<p>&nbsp;<\/p>\n<h2><span style=\"color: #0000ff;\">Open-label placebo treatment in chronic low back pain: a randomized controlled trial.<\/span><\/h2>\n<p><span style=\"color: #0000ff;\">Pain\u3088\u308a \u3000October 13, 2016<\/span><\/p>\n<div id=\"ej-article-indicator-actions-container\">\n<div id=\"ej-article-indicators\">\n<div id=\"ej-article-indicators-open\"><span style=\"color: #0000ff;\">Abstract<\/span><\/div>\n<\/div>\n<\/div>\n<div id=\"ej-article-information-abstract\">\n<div id=\"ej-article-box-text1\" class=\"ej-article-box-text\">\n<p><span style=\"color: #0000ff;\">This randomized controlled trial was performed to investigate whether placebo effects in chronic low back pain could be harnessed ethically by adding open-label placebo (OLP) treatment to treatment as usual (TAU) for 3 weeks. Pain severity was assessed on three 0- to 10-point Numeric Rating Scales, scoring maximum pain, minimum pain, and usual pain, and a composite, primary outcome, total pain score. Our other primary outcome was back-related dysfunction, assessed on the Roland-Morris Disability Questionnaire. In an exploratory follow-up, participants on TAU received placebo pills for 3 additional weeks. We randomized 97 adults reporting persistent low back pain for more than 3 months&#8217; duration and diagnosed by a board-certified pain specialist. Eighty-three adults completed the trial. Compared to TAU, OLP elicited greater pain reduction on each of the three 0- to 10-point Numeric Rating Scales and on the 0- to 10-point composite pain scale (P &lt; 0.001), with moderate to large effect sizes. Pain reduction on the composite Numeric Rating Scales was 1.5 (95% confidence interval: 1.0-2.0) in the OLP group and 0.2 (-0.3 to 0.8) in the TAU group. Open-label placebo treatment also reduced disability compared to TAU (P &lt; 0.001), with a large effect size. Improvement in disability scores was 2.9 (1.7-4.0) in the OLP group and 0.0 (-1.1 to 1.2) in the TAU group. After being switched to OLP, the TAU group showed significant reductions in both pain (1.5, 0.8-2.3) and disability (3.4, 2.2-4.5). Our findings suggest that OLP pills presented in a positive context may be helpful in chronic low back pain.<\/span><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u30d7\u30e9\u30bb\u30dc\uff08\u507d\u85ac\uff09\u52b9\u679c\u306f\u300c\u30d7\u30e9\u30bb\u30dc\uff08\u507d\u85ac\uff09\u306e\u6295\u4e0e\u306b\u3088\u3063\u3066\u307f\u3089\u308c\u308b\u6cbb\u7652\u52b9\u679c\u3002\u85ac\u7269\u305d\u306e\u3082\u306e\u306e\u52b9\u80fd\u3067\u306f\u306a\u304f\u3001\u6295\u85ac\u3055\u308c\u305f\u5b89\u5fc3\u611f\u3084\u533b\u5e2b\u3078\u306e\u4fe1\u983c\u306a\u3069\u306e\u5fc3\u7406\u4f5c\u7528\u306b\u3088\u3063\u3066\u75c7\u72b6\u304c\u6539\u5584\u3059\u308b\u72b6\u614b\u3092\u3044\u3046\u3002\u300d\uff08\u30c7\u30b8\u30bf\u30eb\u5927\u8f9e\u6cc9\u3088\u308a\uff09 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