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 <\/th>\n\u82e5\u3044\u6b63\u5e38\u8010\u7cd6\u80fd<\/th>\n\u9ad8\u9f62\u6b63\u5e38\u8010\u7cd6\u80fd<\/th>\n\u9ad8\u9f62\u8010\u7cd6\u80fd\u7570\u5e38<\/th>\n<\/tr>\n
\u30d7\u30e9\u30bb\u30dc <\/th>\n\u30cb\u30b3\u30c1\u30f3\u9178 <\/th>\n\u30d7\u30e9\u30bb\u30dc <\/th>\n\u30cb\u30b3\u30c1\u30f3\u9178 <\/th>\n\u30d7\u30e9\u30bb\u30dc <\/th>\n\u30cb\u30b3\u30c1\u30f3\u9178\u3000<\/th>\n<\/tr>\n<\/thead>\n
\u7a7a\u8179\u6642\u8840\u7cd6(mg\/dL<\/span>) <\/td>\n92 <\/td>\n95<\/td>\n94<\/td>\n101<\/td>\n95<\/td>\n112<\/td>\n<\/tr>\n
\u7a7a\u8179\u6642\u30a4\u30f3\u30b9\u30ea\u30f3(\u00b5U\/mL) <\/td>\n9.9  <\/td>\n18.9<\/td>\n7.8<\/td>\n16.7<\/td>\n8.9 <\/td>\n18.3 <\/td>\n<\/tr>\n
Kg (min\u22121<\/sup>) \uff08\u9759\u8108\u5185\u30b0\u30eb\u30b3\u30fc\u30b9\u8010\u6027\u306e\u5c3a\u5ea6\uff09<\/td>\n2.3  <\/td>\n1.9  <\/td>\n1.9 <\/td>\n1.4  <\/td>\n1.5<\/td>\n0.9<\/td>\n<\/tr>\n
\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027 (10\u22125<\/sup>\u00b7min\u22121<\/sup>\/pM<\/span>) <\/td>\n2.9 <\/td>\n2.0 <\/td>\n2.7<\/td>\n1.3 <\/td>\n2.9<\/td>\n1.2<\/td>\n<\/tr>\n
\u9759\u8108\u5185\u30b0\u30eb\u30b3\u30fc\u30b9\u306b\u5bfe\u3059\u308b\u6025\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u53cd\u5fdc (pM<\/span>) <\/td>\n563  <\/td>\n680<\/td>\n395<\/td>\n532<\/td>\n187<\/td>\n167<\/td>\n<\/tr>\n
DI (AIRg\u00d7 SI<\/sub>) \uff08\u03b2\u7d30\u80de\u306e\u6a5f\u80fd\u306e\u8a55\u4fa1\uff09<\/td>\n1269 <\/td>\n1063<\/td>\n990<\/td>\n558<\/td>\n526<\/td>\n241<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

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\u7a7a\u8179\u6642\u8840\u7cd6\u306f\u3069\u306e\u30b0\u30eb\u30fc\u30d7\u3082\u3084\u3084\u5897\u52a0\u50be\u5411\u306b\u3042\u308a\u3001\u8010\u7cd6\u80fd\u7570\u5e38\u304c\u3042\u308b\u9ad8\u9f62\u8005\u3067\u306f\u304b\u306a\u308a\u306e\u5897\u52a0\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u7a7a\u8179\u6642\u30a4\u30f3\u30b9\u30ea\u30f3\u306f\u3069\u306e\u30b0\u30eb\u30fc\u30d7\u30822\u500d\u306b\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002\u7a7a\u8179\u6642\u30a4\u30f3\u30b9\u30ea\u30f3\u306718\u4ee5\u4e0a\u3068\u3044\u3046\u306e\u306f\u7d50\u69cb\u306a\u6570\u5024\u3067\u3059\u3002\u5358\u7d14\u306b\u82e5\u3044\u6b63\u5e38\u8010\u7cd6\u80fd\u306e\u6570\u5024\u3067\u8a08\u7b97\u3059\u308b\u3068HOMA-IR\u306f4.43\u3067\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3042\u308a\u3042\u308a\u3067\u3059\u3002<\/p>\n

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\"\"<\/figure>\n

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\u4e0a\u306e\u56f3\u306f\u5de6\u304c\u82e5\u3044\u6b63\u5e38\u8010\u7cd6\u80fd\u3001\u771f\u3093\u4e2d\u304c\u9ad8\u9f62\u6b63\u5e38\u8010\u7cd6\u80fd\u3001\u53f3\u304c\u9ad8\u9f62\u8010\u7cd6\u80fd\u7570\u5e38\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u3059\u3002\u4e0a\u306e3\u3064\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3001\u6b21\u306e3\u3064\u304c\u9759\u8108\u5185\u30b0\u30eb\u30b3\u30fc\u30b9\u306b\u5bfe\u3059\u308b\u6025\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u53cd\u5fdc\u3001\u4e0b\u306e3\u3064\u304c\u03b2\u7d30\u80de\u306e\u6a5f\u80fd\u306e\u9593\u63a5\u7684\u8a55\u4fa1\u3067\u3059\u3002\u305d\u3046\u3059\u308b\u3068\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306f\u4e00\u90e8\u306e\u4eba\u3067\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u591a\u304f\u306e\u4eba\u306f\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u306f\u82e5\u3044\u6b63\u5e38\u306a\u8010\u7cd6\u80fd\u3092\u6301\u3063\u3066\u3044\u308b\u4eba\u306b\u3082\u5f53\u3066\u306f\u307e\u308a\u307e\u3059\u3002\u9759\u8108\u5185\u30b0\u30eb\u30b3\u30fc\u30b9\u306b\u5bfe\u3059\u308b\u6025\u6027\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u53cd\u5fdc\u306f\u6b63\u5e38\u8010\u7cd6\u80fd\u306e2\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u5897\u52a0\u3057\u3001\u8010\u7cd6\u80fd\u7570\u5e38\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u5909\u5316\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u03b2\u7d30\u80de\u306e\u6a5f\u80fd\u306e\u8a55\u4fa1\u3068\u3057\u3066\u306f\u591a\u304f\u306e\u4eba\u3067\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

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\n
\n<\/div>\n<\/div>\n
\n\n\n\n\n\n\n\n\n\n
 <\/th>\n\u82e5\u3044\u6b63\u5e38\u8010\u7cd6\u80fd <\/span><\/th>\n\u9ad8\u9f62\u6b63\u5e38\u8010\u7cd6\u80fd<\/span><\/th>\n\u9ad8\u9f62\u8010\u7cd6\u80fd\u7570\u5e38<\/th>\n<\/tr>\n
\u30d7\u30e9\u30bb\u30dc <\/span><\/th>\n\u30cb\u30b3\u30c1\u30f3\u9178 <\/span><\/th>\n\u30d7\u30e9\u30bb\u30dc <\/span><\/th>\n\u30cb\u30b3\u30c1\u30f3\u9178 <\/span><\/th>\n\u30d7\u30e9\u30bb\u30dc <\/span><\/th>\n\u30cb\u30b3\u30c1\u30f3\u9178 <\/span><\/th>\n<\/tr>\n<\/thead>\n
\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08mg\/dL<\/span>\uff09 <\/span><\/td>\n143 <\/span><\/td>\n124 <\/span><\/td>\n158 <\/span><\/td>\n135 <\/span><\/td>\n185 <\/span><\/td>\n135 <\/span><\/td>\n<\/tr>\n
\u4e2d\u6027\u8102\u80aa\uff08mg\/dL<\/span>\uff09 <\/span><\/td>\n106<\/span><\/td>\n80<\/span><\/td>\n89 <\/span><\/td>\n71 <\/span><\/td>\n159 <\/span><\/td>\n97 <\/span><\/td>\n<\/tr>\n
\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\uff08pg\/ml\uff09 <\/span><\/td>\n185 <\/span><\/td>\n219 <\/span><\/td>\n300<\/span><\/td>\n325<\/span><\/td>\n307 <\/span><\/td>\n342 <\/span><\/td>\n<\/tr>\n
\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\uff08pg\/ml\uff09 <\/span><\/td>\n51<\/span><\/td>\n59<\/span><\/td>\n47<\/span><\/td>\n53<\/span><\/td>\n55<\/span><\/td>\n51<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

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\u4e0a\u306e\u8868\u306f\u8102\u8cea\u3084\u30ab\u30c6\u30b3\u30e9\u30df\u30f3\u306e\u53cd\u5fdc\u3067\u3059\u3002\u30cb\u30b3\u30c1\u30f3\u9178\u306b\u3088\u308a\u3069\u306e\u30b0\u30eb\u30fc\u30d7\u3082\u78ba\u304b\u306b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3084\u4e2d\u6027\u8102\u80aa\u5024\u306f\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u3002\u30ab\u30c6\u30b3\u30e9\u30df\u30f3\u306f\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u306f\u5909\u5316\u3057\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u306f\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u306f\u3044\u308f\u3086\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u62ee\u6297\u30db\u30eb\u30e2\u30f3\u3067\u3001\u7cd6\u65b0\u751f\u3092\u8d77\u3053\u3057\u307e\u3059\u3002\u78ba\u304b\u306b\u7cd6\u65b0\u751f\u3092\u4ea2\u9032\u3055\u305b\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u5b58\u5728\u3057\u305d\u3046\u3067\u3059\u3002\u7cd6\u5c3f\u75c5\u306e\u4eba\u3067\u306f\u6681\u73fe\u8c61\u304c\u8d77\u304d\u3084\u3059\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n

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\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\uff08\u30cb\u30b3\u30c1\u30f3\u9178\uff09\u306b\u3088\u308a\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306f\u4f4e\u4e0b\u3001\u3064\u307e\u308a\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u9ad8\u307e\u308a\u3001\u305d\u308c\u306b\u5bfe\u3057\u3066\u8010\u7cd6\u80fd\u304c\u6b63\u5e38\u3067\u3042\u308b\u4eba\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u91cf\u3092\u5897\u52a0\u3055\u305b\u3066\u5bfe\u5fdc\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308c\u3070\u3001\u305d\u306e\u3088\u3046\u306a\u53cd\u5fdc\u304c\u5341\u5206\u3067\u306f\u306a\u304f\u3001\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u304c\u8d77\u304d\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n

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\u8840\u7cd6\u5024\u304c\u898b\u305f\u76ee\u306b\u5909\u5316\u304c\u306a\u304f\u3066\u3082\u3001\u6700\u3082\u6c17\u306b\u306a\u308b\u3053\u3068\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u5927\u304d\u304f\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u3067\u3059\u3002\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u306f\u975e\u5e38\u306b\u6709\u5bb3\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u305f\u3060\u3057\u4e0a\u306e\u56f3\u306e\u30b0\u30e9\u30d5\u3092\u898b\u3066\u3082\u308f\u304b\u308b\u3088\u3046\u306b\u3001\u4eba\u306b\u3088\u3063\u3066\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u4eba\u3082\u3044\u307e\u3059\u3002\u4f55\u304c\u9055\u3046\u304b\u306f\u4e0d\u660e\u3067\u3059\u3002\u591a\u304f\u306e\u4eba\u306f\u611f\u53d7\u6027\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u304c\u3002<\/p>\n

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\u3064\u307e\u308a\u3001\u7cd6\u8cea\u5236\u9650\u3092\u3059\u308b\u4eba\u306b\u3068\u3063\u3066\uff08\u7cd6\u8cea\u5236\u9650\u3092\u3057\u3066\u3044\u306a\u3044\u4eba\u306b\u3082\uff09\u5927\u91cf\u306e\u30ca\u30a4\u30a2\u30b7\u30f3\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306f\u826f\u304f\u306a\u3044\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u7279\u306b\u3059\u3067\u306b\u7cd6\u5c3f\u75c5\u3092\u767a\u75c7\u3057\u3066\u3044\u308b\u4eba\u3001\u98df\u5f8c\u9ad8\u8840\u7cd6\u3092\u793a\u3059\u4eba\u306a\u3069\u306b\u306f\u6050\u3089\u304f\u6709\u5bb3\u3067\u3059\u3002\u03b2\u7d30\u80de\u306b\u3068\u3063\u3066\u826f\u304f\u306a\u3044\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u3044\u3064\u3082\u8a00\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u306e\u7814\u7a76\u306f\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u3092\u3057\u3066\u3044\u308b\u4eba\u3067\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u7cd6\u8cea\u5236\u9650\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u306f\u4e0d\u660e\u3067\u3059\u3002<\/p>\n

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\u307e\u305f\u3001\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u7d50\u679c\u306f\u30ca\u30a4\u30a2\u30b7\u30f3\u306e\u8010\u7cd6\u80fd\u306b\u5bfe\u3059\u308b\u6709\u5bb3\u6027\u3092\u652f\u6301\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u56f3\u306f\u3053\u306e\u8ad6\u6587<\/a>\u3088\u308a\uff09<\/p>\n

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\"\"<\/figure>\n

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\u3053\u306e\u7814\u7a76\u306f11\u4ef6\u306e\u8a66\u9a13\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u3059\u3002\u30ca\u30a4\u30a2\u30b7\u30f3\u3092\u98f2\u3093\u3060\u304b\u98f2\u307e\u306a\u3044\u304b\u3067\u306e\u65b0\u898f\u306e\u7cd6\u5c3f\u75c5\u767a\u75c7\u3092\u6bd4\u8f03\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u305d\u306e\u7d50\u679c\u306f\u65b0\u898f\u7cd6\u5c3f\u75c5\u767a\u75c7\u306e\u30ea\u30b9\u30af\u306f1.34\u500d\u3067\u3057\u305f\u3002\u30ca\u30a4\u30a2\u30b7\u30f3\u30675\u5e74\u9593\u6cbb\u7642\u3092\u53d7\u3051\u305f\u975e\u7cd6\u5c3f\u75c5\u60a3\u800543\u4eba\u5f53\u305f\u308a1\u4eba\u304c\u7cd6\u5c3f\u75c5\u306b\u306a\u308b\u8a08\u7b97\u3067\u3059\u3002\u591a\u3044\u3088\u3046\u306a\u5c11\u306a\u3044\u3088\u3046\u306a\u3002<\/p>\n

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\u30b9\u30bf\u30c1\u30f3\u306a\u3069\u7cd6\u5c3f\u75c5\u3092\u767a\u75c7\u3059\u308b\u85ac\u3092\u98f2\u3093\u3067\u3044\u308b\u5834\u5408\u3082\u3042\u308b\u3067\u3057\u3087\u3046\u3002\u3053\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u542b\u307e\u308c\u308b\u8a66\u9a13\u3067\u306f\u3001\u53c2\u52a0\u8005\u304c\u30b9\u30bf\u30c1\u30f3\u3001\u307e\u305f\u306f\u30e9\u30ed\u30d4\u30d7\u30e9\u30f3\u30c8\u3068\u306e\u4f75\u7528\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u305f\u3082\u306e\u3082\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u305d\u308c\u3089\u306e\u4f75\u7528\u3068\u306f\u7121\u95a2\u4fc2\u306b\u3001\u7d50\u679c\u306f\u4e00\u81f4\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u30ca\u30a4\u30a2\u30b7\u30f3\u3060\u3051\u3067\u65b0\u898f\u306e\u7cd6\u5c3f\u75c5\u767a\u75c7\u306f\u5897\u52a0\u3057\u3066\u3044\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

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\u300cImpaired \u03b2-Cell Function in Human Aging: Response to Nicotinic Acid-Induced Insulin Resistance\u300d<\/p>\n

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